#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32389	uniprotkb:P39014	intact:EBI-10757|uniprotkb:D6W176	intact:EBI-11507|uniprotkb:D6VVN6|ensemblfungi:YIL046W	psi-mi:met4_yeast(display_long)|uniprotkb:MET4(gene name)|psi-mi:MET4(display_short)|uniprotkb:YNL103W(locus name)|uniprotkb:N2177(orf name)|uniprotkb:Methionine-requiring protein 4(gene name synonym)	psi-mi:met30_yeast(display_long)|uniprotkb:YIL046W(locus name)|uniprotkb:MET30(gene name)|psi-mi:MET30(display_short)|uniprotkb:Methionine-requiring protein 30(gene name synonym)|uniprotkb:"E3 ubiquitin ligase complex SCF(Met30) subunit MET30"(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rouillon et al. (2000)	pubmed:10637232|imex:IM-19847	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-903635|imex:IM-19847-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005047|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0089713"(Cbf1-Met4-Met28 complex)|go:"GO:0000096"(sulfur amino acid metabolic process)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0042802"(identical protein binding)|refseq:NP_014296.4|mint:P32389|dip:DIP-2241N	ensemblfungi:YIL046W_mRNA(transcript)|ensemblfungi:YIL046W(gene)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|refseq:NP_012218.1|sgd:S000001308|mint:P39014|dip:DIP-1439N	-	crc64:D65745E1FA40C09D	crc64:5135D4BCA2E1EB97	comment:Shows that Met30 protein lacking the F-box  failed to interact with Met4 and hence this region is important for interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/14	2014/10/16	rogid:SpxM+SnEmiw+uQlCEGZSto/zduw559292	rogid:B138OcWsG8zW/eFMselD2pFyy5c559292	intact-crc:41973D1A4646EA79|rigid:wI0BBJhBGohBhUh282FVK/ON83Y	false	-	necessary binding region:187-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32389	uniprotkb:P39014	intact:EBI-10757|uniprotkb:D6W176	intact:EBI-11507|uniprotkb:D6VVN6|ensemblfungi:YIL046W	psi-mi:met4_yeast(display_long)|uniprotkb:MET4(gene name)|psi-mi:MET4(display_short)|uniprotkb:YNL103W(locus name)|uniprotkb:N2177(orf name)|uniprotkb:Methionine-requiring protein 4(gene name synonym)	psi-mi:met30_yeast(display_long)|uniprotkb:YIL046W(locus name)|uniprotkb:MET30(gene name)|psi-mi:MET30(display_short)|uniprotkb:Methionine-requiring protein 30(gene name synonym)|uniprotkb:"E3 ubiquitin ligase complex SCF(Met30) subunit MET30"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rouillon et al. (2000)	pubmed:10637232|imex:IM-19847	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-903578|imex:IM-19847-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005047|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0089713"(Cbf1-Met4-Met28 complex)|go:"GO:0000096"(sulfur amino acid metabolic process)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0042802"(identical protein binding)|refseq:NP_014296.4|mint:P32389|dip:DIP-2241N	ensemblfungi:YIL046W_mRNA(transcript)|ensemblfungi:YIL046W(gene)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|refseq:NP_012218.1|sgd:S000001308|mint:P39014|dip:DIP-1439N	-	crc64:D65745E1FA40C09D	crc64:5135D4BCA2E1EB97	comment:shows strong interaction between Met4 and Met30 in cells grown in the absence of methionine.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/14	2014/10/16	rogid:SpxM+SnEmiw+uQlCEGZSto/zduw559292	rogid:B138OcWsG8zW/eFMselD2pFyy5c559292	intact-crc:16812F1FBD9FE540|rigid:wI0BBJhBGohBhUh282FVK/ON83Y	false	ha tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52286	uniprotkb:P39014	intact:EBI-4090|uniprotkb:Q07186|uniprotkb:D6VSW0|ensemblfungi:YDR328C	intact:EBI-11507|uniprotkb:D6VVN6|ensemblfungi:YIL046W	psi-mi:skp1_yeast(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:CBF3D(gene name synonym)|uniprotkb:YDR328C(locus name)|uniprotkb:D9798.14(orf name)|uniprotkb:Centromere DNA-binding protein complex CBF3 subunit D(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit SKP1(gene name synonym)	psi-mi:met30_yeast(display_long)|uniprotkb:YIL046W(locus name)|uniprotkb:MET30(gene name)|psi-mi:MET30(display_short)|uniprotkb:Methionine-requiring protein 30(gene name synonym)|uniprotkb:"E3 ubiquitin ligase complex SCF(Met30) subunit MET30"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rouillon et al. (2000)	pubmed:10637232|imex:IM-19847	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-903801|imex:IM-19847-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002736|refseq:NP_010615.3|dip:DIP-1236N|mint:P52286|ensemblfungi:YDR328C(gene)|ensemblfungi:YDR328C_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000921"(septin ring assembly)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031518"(CBF3 complex)|go:"GO:0034622"|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043291"(RAVE complex)|go:"GO:0045116"(protein neddylation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|rcsb pdb:1NEX|rcsb pdb:3MKS|rcsb pdb:3V7D|rcsb pdb:5AN3|rcsb pdb:6F07|rcsb pdb:6FE8|rcsb pdb:6GSA|rcsb pdb:6GYP|rcsb pdb:6GYS|rcsb pdb:6GYU|rcsb pdb:7K79|reactome:R-SCE-174113|reactome:R-SCE-68949|reactome:R-SCE-8854050|reactome:R-SCE-8951664|reactome:R-SCE-983168	ensemblfungi:YIL046W_mRNA(transcript)|ensemblfungi:YIL046W(gene)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|refseq:NP_012218.1|sgd:S000001308|mint:P39014|dip:DIP-1439N	-	crc64:746DDE6470A69432	crc64:5135D4BCA2E1EB97	comment:shows that the interaction between Met30 and Cbf3d is not affected by the presence of high extracellular methionine concentrations.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/14	2014/10/16	rogid:HO5Uz+KzzWNBubxoXRDNTVi8eIA559292	rogid:B138OcWsG8zW/eFMselD2pFyy5c559292	intact-crc:800B66ED8ADECF69|rigid:tO2V3hJKSIlz/6z7xKLz0ks73bo	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)