#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P50591	uniprotkb:O14763	intact:EBI-495373|ensembl:ENSP00000241261|uniprotkb:A1Y9B3	intact:EBI-518882|uniprotkb:Q6UXM8|uniprotkb:Q7Z360|uniprotkb:O14720|uniprotkb:O15508|uniprotkb:O15517|uniprotkb:O15531|uniprotkb:Q9BVE0|ensembl:ENSP00000276431	psi-mi:tnf10_human(display_long)|uniprotkb:TNF-related apoptosis-inducing ligand(gene name synonym)|uniprotkb:Apo-2 ligand(gene name synonym)|uniprotkb:TNFSF10(gene name)|psi-mi:TNFSF10(display_short)|uniprotkb:APO2L(gene name synonym)|uniprotkb:TRAIL(gene name synonym)	psi-mi:tr10b_human(display_long)|uniprotkb:Death receptor 5(gene name synonym)|uniprotkb:TNF-related apoptosis-inducing ligand receptor 2(gene name synonym)|uniprotkb:UNQ160/PRO186(orf name)|uniprotkb:TNFRSF10B(gene name)|psi-mi:TNFRSF10B(display_short)|uniprotkb:DR5(gene name synonym)|uniprotkb:KILLER(gene name synonym)|uniprotkb:TRAILR2(gene name synonym)|uniprotkb:TRICK2(gene name synonym)|uniprotkb:ZTNFR9(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hymowitz et al. (1999)	pubmed:10549288	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1028559|rcsb pdb:1D0G	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000241261(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000121858(gene)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070062"(extracellular exosome)|refseq:NP_003801.1|refseq:NP_001177871.1|dip:DIP-6230N|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|interpro:IPR021184|rcsb pdb:1D0G|rcsb pdb:1D2Q|rcsb pdb:1D4V|rcsb pdb:1DG6|rcsb pdb:1DU3|rcsb pdb:4N90|rcsb pdb:5CIR|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-69416|reactome:R-HSA-75158	refseq:NP_003833.4|refseq:NP_671716.2|dip:DIP-33566N|ensembl:ENSG00000120889(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0036463"(TRAIL receptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045569"(TRAIL binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020465|interpro:IPR034024|interpro:IPR034029|rcsb pdb:1D0G|rcsb pdb:1D4V|rcsb pdb:1DU3|rcsb pdb:1ZA3|rcsb pdb:2H9G|rcsb pdb:3X3F|rcsb pdb:4I9X|rcsb pdb:4N90|rcsb pdb:4OD2|rcsb pdb:6NHW|rcsb pdb:6NHY|rcsb pdb:6T3J|reactome:R-HSA-140534|reactome:R-HSA-202733|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75158|ensembl:ENST00000276431(transcript)	-	-	-	assembly:hexameric, multimeric|3d-r-factors:working 77.800%, free 73.300%|3d-resolution:2.4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:hnOC/z7IWh8JRE86qlqUdVvNDUM9606	rogid:V021Tohje+gkHyYH6iOOnN/IBJ49606	intact-crc:480AE145EB0E8378|rigid:THL/KoVweAL56Qb8mew0UpwoU08	false	sufficient binding region:114-281	sufficient binding region:54-183	3	3	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)