#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97480	uniprotkb:P70178	intact:EBI-349175|uniprotkb:P97768|ensembl:ENSMUSP00000078157|uniprotkb:G5E8I5	intact:EBI-645265|ensembl:ENSMUSP00000045973	psi-mi:eya3_mouse(display_long)|uniprotkb:Eya3(gene name)|psi-mi:Eya3(display_short)	psi-mi:six5_mouse(display_long)|uniprotkb:DM locus-associated homeodomain protein homolog(gene name synonym)|uniprotkb:Six5(gene name)|psi-mi:Six5(display_short)|uniprotkb:Dmahp(gene name synonym)|uniprotkb:Sine oculis homeobox homolog 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ohto et al. (1999)	pubmed:10490620|imex:IM-19884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-986485|imex:IM-19884-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034296.2|ensembl:ENSMUST00000079157(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0048856"(anatomical structure development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR006545(EYA)|interpro:IPR028472|interpro:IPR028479|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|ensembl:ENSMUSG00000028886(gene)	refseq:NP_035513.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|ensembl:ENSMUST00000049454(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000040841(gene)	go:"GO:0005634"(nucleus)	-	-	figure legend:5A|comment:Coexpression of Eya3 and Six5 in COS7 cells showed nuclear translocation of Eya3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/11	2014/10/16	rogid:0yaKFTJm3uCQYXt/sgj+aSmZOVI10090	rogid:Y6Cb3HRNXdjo2ZGZp1nX2sLcc4c10090	intact-crc:175FCC80BDA2FC7D|rigid:XSrhnArxBLivv1JxRa9hpNOoDaA	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61321	uniprotkb:O08575	intact:EBI-986524|uniprotkb:Q61322|uniprotkb:Q61323|ensembl:ENSMUSP00000036150|uniprotkb:B2RQH3	intact:EBI-986503|uniprotkb:P97925|ensembl:ENSMUSP00000066244|ensembl:ENSMUSP00000085455|uniprotkb:A2A5S4	psi-mi:six4_mouse(display_long)|uniprotkb:Sine oculis homeobox homolog 4(gene name synonym)|uniprotkb:Skeletal muscle-specific ARE-binding protein AREC3(gene name synonym)|uniprotkb:Six4(gene name)|psi-mi:Six4(display_short)|uniprotkb:Arec3(gene name synonym)	psi-mi:eya2_mouse(display_long)|uniprotkb:Eya2(gene name)|psi-mi:Eya2(display_short)|uniprotkb:Eab1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ohto et al. (1999)	pubmed:10490620|imex:IM-19884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-986610|imex:IM-19884-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034460(gene)|ensembl:ENSMUST00000043208(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030238"(male sex determination)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046661"(male sex differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0098528"(skeletal muscle fiber differentiation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|go:"GO:0061197"(fungiform papilla morphogenesis)|refseq:NP_035512.1	ensembl:ENSMUSG00000017897(gene)|ensembl:ENSMUST00000063433(transcript)|ensembl:ENSMUST00000088132(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0048856"(anatomical structure development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR006545(EYA)|interpro:IPR028472|interpro:IPR028473|interpro:IPR036412|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|refseq:NP_034295.1|refseq:NP_001258891.1|refseq:NP_001258892.1	-	-	-	figure legend:Table 4|comment:A N-terminal shorter fragment of Eya2, Eya2Ndelta2, was shown to be sufficient for interaction but the exact range was not specified. An internal fragment of Six4 comprising a conserved Six domain and the homeo domain, Six4HD, was shown to be sufficient for the interaction but the exact range was not specified.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/08/11	2014/10/16	rogid:xA8jh19jU/Po4pKrRDx4aYpmM9Q10090	rogid:pYM3Q0D4uhVNjMKJCatXk+1c92A10090	intact-crc:F985E17D96CD68DE|rigid:Ln9GMtcxthiPBJ9yui5andGjmTU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)