#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P07260 uniprotkb:P39935 intact:EBI-150|uniprotkb:D6W1T0|ensemblfungi:YOL139C intact:EBI-9002|ensemblfungi:YGR162W|uniprotkb:D6VUU6 psi-mi:if4e_yeast(display_long)|uniprotkb:CDC33(gene name)|psi-mi:CDC33(display_short)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:TIF45(gene name synonym)|uniprotkb:YOL139C(locus name) psi-mi:if4f1_yeast(display_long)|uniprotkb:YGR162W(locus name)|uniprotkb:TIF4631(gene name)|psi-mi:TIF4631(display_short)|uniprotkb:eIF4G1(gene name synonym)|uniprotkb:mRNA cap-binding protein complex subunit p150(gene name synonym) psi-mi:"MI:0417"(footprinting) Hershey et al. (1999) imex:IM-14466|pubmed:10409688 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-935361|imex:IM-14466-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014502.1|sgd:S000005499|mint:P07260|dip:DIP-1223N|ensemblfungi:YOL139C(gene)|ensemblfungi:YOL139C_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:1AP8|rcsb pdb:1RF8|rcsb pdb:6FC1|rcsb pdb:6FC2|rcsb pdb:6FC3|reactome:R-SCE-156827|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702 ensemblfungi:YGR162W(gene)|ensemblfungi:YGR162W_mRNA(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|go:"GO:1902280"(regulation of RNA helicase activity)|rcsb pdb:2VSO|rcsb pdb:2VSX|rcsb pdb:6Z29|reactome:R-SCE-156827|reactome:R-SCE-166208|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702|reactome:R-SCE-975956|reactome:R-SCE-975957|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022745|interpro:IPR036211|rcsb pdb:1RF8|refseq:NP_011678.3|sgd:S000003394|mint:P39935|dip:DIP-985N psi-mi:"MI:0469"(intact) crc64:5B9162E1BD0B1BDE crc64:391256802F86118E figure legend:1|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/10 2014/10/16 rogid:KMyHDLtsgyJ7kPBwQktVQKsBPug559292 rogid:l5wtszbSL7dltfdiDAVe5zYnxVc559292 intact-crc:A81EB5CA5BC11093|rigid:8y/k9EKP4TktkHmhj78g6n9uA6M false - sufficient binding region:391-488 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07260 uniprotkb:P39935 intact:EBI-150|uniprotkb:D6W1T0|ensemblfungi:YOL139C intact:EBI-9002|ensemblfungi:YGR162W|uniprotkb:D6VUU6 psi-mi:if4e_yeast(display_long)|uniprotkb:CDC33(gene name)|psi-mi:CDC33(display_short)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:TIF45(gene name synonym)|uniprotkb:YOL139C(locus name) psi-mi:if4f1_yeast(display_long)|uniprotkb:YGR162W(locus name)|uniprotkb:TIF4631(gene name)|psi-mi:TIF4631(display_short)|uniprotkb:eIF4G1(gene name synonym)|uniprotkb:mRNA cap-binding protein complex subunit p150(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Hershey et al. (1999) imex:IM-14466|pubmed:10409688 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-935377|imex:IM-14466-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014502.1|sgd:S000005499|mint:P07260|dip:DIP-1223N|ensemblfungi:YOL139C(gene)|ensemblfungi:YOL139C_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:1AP8|rcsb pdb:1RF8|rcsb pdb:6FC1|rcsb pdb:6FC2|rcsb pdb:6FC3|reactome:R-SCE-156827|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702 ensemblfungi:YGR162W(gene)|ensemblfungi:YGR162W_mRNA(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|go:"GO:1902280"(regulation of RNA helicase activity)|rcsb pdb:2VSO|rcsb pdb:2VSX|rcsb pdb:6Z29|reactome:R-SCE-156827|reactome:R-SCE-166208|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702|reactome:R-SCE-975956|reactome:R-SCE-975957|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022745|interpro:IPR036211|rcsb pdb:1RF8|refseq:NP_011678.3|sgd:S000003394|mint:P39935|dip:DIP-985N psi-mi:"MI:0469"(intact) crc64:5B9162E1BD0B1BDE crc64:391256802F86118E figure legend:2|caution:Only the nmr spectra of TIF4631 was measured. This was shown to be unstructured in the absence of TIF45 and folded in the presence of TIF45 which was taken by the suthor as experimental evidence of an interaction.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/10 2014/10/16 rogid:KMyHDLtsgyJ7kPBwQktVQKsBPug559292 rogid:l5wtszbSL7dltfdiDAVe5zYnxVc559292 intact-crc:ADBD3520019FC6FF|rigid:8y/k9EKP4TktkHmhj78g6n9uA6M false - sufficient binding region:391-488|15n label:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07260 uniprotkb:P39935 intact:EBI-150|uniprotkb:D6W1T0|ensemblfungi:YOL139C intact:EBI-9002|ensemblfungi:YGR162W|uniprotkb:D6VUU6 psi-mi:if4e_yeast(display_long)|uniprotkb:CDC33(gene name)|psi-mi:CDC33(display_short)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:TIF45(gene name synonym)|uniprotkb:YOL139C(locus name) psi-mi:if4f1_yeast(display_long)|uniprotkb:YGR162W(locus name)|uniprotkb:TIF4631(gene name)|psi-mi:TIF4631(display_short)|uniprotkb:eIF4G1(gene name synonym)|uniprotkb:mRNA cap-binding protein complex subunit p150(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hershey et al. (1999) imex:IM-14466|pubmed:10409688 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-935393|imex:IM-14466-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014502.1|sgd:S000005499|mint:P07260|dip:DIP-1223N|ensemblfungi:YOL139C(gene)|ensemblfungi:YOL139C_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:1AP8|rcsb pdb:1RF8|rcsb pdb:6FC1|rcsb pdb:6FC2|rcsb pdb:6FC3|reactome:R-SCE-156827|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702 ensemblfungi:YGR162W(gene)|ensemblfungi:YGR162W_mRNA(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|go:"GO:1902280"(regulation of RNA helicase activity)|rcsb pdb:2VSO|rcsb pdb:2VSX|rcsb pdb:6Z29|reactome:R-SCE-156827|reactome:R-SCE-166208|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702|reactome:R-SCE-975956|reactome:R-SCE-975957|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022745|interpro:IPR036211|rcsb pdb:1RF8|refseq:NP_011678.3|sgd:S000003394|mint:P39935|dip:DIP-985N psi-mi:"MI:0469"(intact) crc64:5B9162E1BD0B1BDE crc64:391256802F86118E figure legend:5a|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/05/10 2014/10/16 rogid:KMyHDLtsgyJ7kPBwQktVQKsBPug559292 rogid:l5wtszbSL7dltfdiDAVe5zYnxVc559292 intact-crc:F38C8DDFE5F8AEB5|rigid:8y/k9EKP4TktkHmhj78g6n9uA6M false - ha tag:?-?|mutation decreasing interaction:425-425|mutation decreasing interaction:444-444|mutation decreasing interaction:457-458 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P07260 uniprotkb:P39935 intact:EBI-150|uniprotkb:D6W1T0|ensemblfungi:YOL139C intact:EBI-9002|ensemblfungi:YGR162W|uniprotkb:D6VUU6 psi-mi:if4e_yeast(display_long)|uniprotkb:CDC33(gene name)|psi-mi:CDC33(display_short)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:TIF45(gene name synonym)|uniprotkb:YOL139C(locus name) psi-mi:if4f1_yeast(display_long)|uniprotkb:YGR162W(locus name)|uniprotkb:TIF4631(gene name)|psi-mi:TIF4631(display_short)|uniprotkb:eIF4G1(gene name synonym)|uniprotkb:mRNA cap-binding protein complex subunit p150(gene name synonym) psi-mi:"MI:0096"(pull down) Hershey et al. (1999) imex:IM-14466|pubmed:10409688 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-935417|imex:IM-14466-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014502.1|sgd:S000005499|mint:P07260|dip:DIP-1223N|ensemblfungi:YOL139C(gene)|ensemblfungi:YOL139C_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:1AP8|rcsb pdb:1RF8|rcsb pdb:6FC1|rcsb pdb:6FC2|rcsb pdb:6FC3|reactome:R-SCE-156827|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702 ensemblfungi:YGR162W(gene)|ensemblfungi:YGR162W_mRNA(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|go:"GO:1902280"(regulation of RNA helicase activity)|rcsb pdb:2VSO|rcsb pdb:2VSX|rcsb pdb:6Z29|reactome:R-SCE-156827|reactome:R-SCE-166208|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702|reactome:R-SCE-975956|reactome:R-SCE-975957|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022745|interpro:IPR036211|rcsb pdb:1RF8|refseq:NP_011678.3|sgd:S000003394|mint:P39935|dip:DIP-985N psi-mi:"MI:0469"(intact) crc64:5B9162E1BD0B1BDE crc64:391256802F86118E figure legend:5b|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/10 2014/10/16 rogid:KMyHDLtsgyJ7kPBwQktVQKsBPug559292 rogid:l5wtszbSL7dltfdiDAVe5zYnxVc559292 intact-crc:D73938BADA6A0272|rigid:8y/k9EKP4TktkHmhj78g6n9uA6M false - glutathione s tranferase tag:n-n|mutation decreasing interaction:425-425|mutation decreasing interaction:457-458 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P39935 uniprotkb:P07260 intact:EBI-9002|ensemblfungi:YGR162W|uniprotkb:D6VUU6 intact:EBI-150|uniprotkb:D6W1T0|ensemblfungi:YOL139C psi-mi:if4f1_yeast(display_long)|uniprotkb:YGR162W(locus name)|uniprotkb:TIF4631(gene name)|psi-mi:TIF4631(display_short)|uniprotkb:eIF4G1(gene name synonym)|uniprotkb:mRNA cap-binding protein complex subunit p150(gene name synonym) psi-mi:if4e_yeast(display_long)|uniprotkb:CDC33(gene name)|psi-mi:CDC33(display_short)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:TIF45(gene name synonym)|uniprotkb:YOL139C(locus name) psi-mi:"MI:0047"(far western blotting) Hershey et al. (1999) imex:IM-14466|pubmed:10409688 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-935437|imex:IM-14466-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YGR162W(gene)|ensemblfungi:YGR162W_mRNA(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|go:"GO:1902280"(regulation of RNA helicase activity)|rcsb pdb:2VSO|rcsb pdb:2VSX|rcsb pdb:6Z29|reactome:R-SCE-156827|reactome:R-SCE-166208|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702|reactome:R-SCE-975956|reactome:R-SCE-975957|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022745|interpro:IPR036211|rcsb pdb:1RF8|refseq:NP_011678.3|sgd:S000003394|mint:P39935|dip:DIP-985N refseq:NP_014502.1|sgd:S000005499|mint:P07260|dip:DIP-1223N|ensemblfungi:YOL139C(gene)|ensemblfungi:YOL139C_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1901195"(positive regulation of formation of translation preinitiation complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:1AP8|rcsb pdb:1RF8|rcsb pdb:6FC1|rcsb pdb:6FC2|rcsb pdb:6FC3|reactome:R-SCE-156827|reactome:R-SCE-429947|reactome:R-SCE-72649|reactome:R-SCE-72662|reactome:R-SCE-72702 psi-mi:"MI:0469"(intact) crc64:391256802F86118E crc64:5B9162E1BD0B1BDE figure legend:5c|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/10 2014/10/16 rogid:l5wtszbSL7dltfdiDAVe5zYnxVc559292 rogid:KMyHDLtsgyJ7kPBwQktVQKsBPug559292 intact-crc:A4C4CE34EF17BC04|rigid:8y/k9EKP4TktkHmhj78g6n9uA6M false mutation decreasing interaction:425-425|mutation decreasing interaction:444-444|mutation decreasing interaction:457-458|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)