#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62942	uniprotkb:P36897	intact:EBI-1027571|uniprotkb:P20071|uniprotkb:Q4VC47|uniprotkb:Q6FGD9|uniprotkb:Q6LEU3|uniprotkb:Q9H103|uniprotkb:Q9H566|uniprotkb:D3DVW6|ensembl:ENSP00000371138|ensembl:ENSP00000371143|ensembl:ENSP00000383003|ensembl:ENSP00000503033|ensembl:ENSP00000503152	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:fkb1a_human(display_long)|uniprotkb:FKBP1A(gene name)|psi-mi:FKBP1A(display_short)|uniprotkb:FKBP1(gene name synonym)|uniprotkb:FKBP12(gene name synonym)|uniprotkb:FK506-binding protein 1A(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP12(gene name synonym)|uniprotkb:12 kDa FK506-binding protein(gene name synonym)|uniprotkb:Calstabin-1(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Huse et al. (1999)	pubmed:10025408	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1027593|rcsb pdb:1B6C	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000088832(gene)|ensembl:ENST00000381719(transcript)|ensembl:ENST00000381724(transcript)|ensembl:ENST00000400137(transcript)|ensembl:ENST00000677335(transcript)|ensembl:ENST00000678408(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005527"(macrolide binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0014802"(terminal cisterna)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031312"(extrinsic component of organelle membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0048185"(activin binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098562"(cytoplasmic side of membrane)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1A7X|rcsb pdb:1B6C|rcsb pdb:1BKF|rcsb pdb:1BL4|rcsb pdb:1D6O|rcsb pdb:1D7H|rcsb pdb:1D7I|rcsb pdb:1D7J|rcsb pdb:1EYM|rcsb pdb:1F40|rcsb pdb:1FAP|rcsb pdb:1FKB|rcsb pdb:1FKD|rcsb pdb:1FKF|rcsb pdb:1FKG|rcsb pdb:1FKH|rcsb pdb:1FKI|rcsb pdb:2DG4|rcsb pdb:2DG9|rcsb pdb:2FAP|rcsb pdb:2FKE|rcsb pdb:2ND5|rcsb pdb:2PPN|rcsb pdb:2PPO|rcsb pdb:2PPP|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:1FKJ|rcsb pdb:3H9R|rcsb pdb:3MDY|rcsb pdb:4DH0|rcsb pdb:4FAP|rcsb pdb:1FKR|rcsb pdb:4IPX|rcsb pdb:4N19|rcsb pdb:4ODP|rcsb pdb:4ODQ|rcsb pdb:4ODR|rcsb pdb:5I7P|rcsb pdb:5I7Q|rcsb pdb:6I1S|rcsb pdb:1FKS|rcsb pdb:6M4U|rcsb pdb:6OQA|rcsb pdb:6VCU|rcsb pdb:6YF0|rcsb pdb:6YF1|rcsb pdb:6YF2|rcsb pdb:6YF3|reactome:R-HSA-166208|rcsb pdb:1FKT|reactome:R-HSA-2025928|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3656535|rcsb pdb:1J4H|rcsb pdb:1J4I|reactome:R-HSA-9679191|rcsb pdb:1J4R|rcsb pdb:1NSG|rcsb pdb:1QPF|rcsb pdb:1QPL|rcsb pdb:2DG3|refseq:NP_000792.1|refseq:NP_463460.1|dip:DIP-29710N	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N	-	-	-	assembly:dimeric, multimeric|3d-r-factors:working 75.100%, free 73.100%|3d-resolution:2.6A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:3eikHNIIVs8AFM7PYVWurI/9KUY9606	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:80246FCD686096FC|rigid:HgdaFdXmFwTMQLryKqXcu61WL5I	false	sufficient binding region:2-108	sufficient binding region:162-503	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)