#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O70521 uniprotkb:Q9Z254 intact:EBI-8685536|intact:MINT-191738|ensembl:ENSRNOP00000022451 intact:EBI-991162|uniprotkb:Q6GR70|uniprotkb:Q9QUQ4|ensembl:ENSRNOP00000005374 psi-mi:rgs19_rat(display_long)|uniprotkb:Rgs19(gene name)|psi-mi:Rgs19(display_short)|uniprotkb:Gaip(gene name synonym)|uniprotkb:G-alpha-interacting protein(gene name synonym) psi-mi:gipc1_rat(display_long)|uniprotkb:RGS19-interacting protein 1(gene name synonym)|uniprotkb:GAIP C-terminus-interacting protein(gene name synonym)|uniprotkb:RGS-GAIP-interacting protein(gene name synonym)|uniprotkb:GLUT1 C-terminal-binding protein(gene name synonym)|uniprotkb:Gipc1(gene name)|psi-mi:Gipc1(display_short)|uniprotkb:Gipc(gene name synonym)|uniprotkb:Rgs19ip1(gene name synonym)|uniprotkb:Synectin(gene name synonym) psi-mi:"MI:0096"(pull down) De et al. (1998) pubmed:9770488|mint:MINT-6548266 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8685560|mint:MINT-62467 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006235863.2|rgd:629471|refseq:NP_067693.1|ensembl:ENSRNOG00000016547(gene)|ensembl:ENSRNOT00000022451(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR036305|reactome:R-RNO-416476|reactome:R-RNO-418594|mint:MINT-1540021(identity) rgd:68338|refseq:NP_445793.1|ensembl:ENSRNOG00000003864(gene)|ensembl:ENSRNOT00000005374(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|go:"GO:0005903"(brush border)|refseq:XP_017456861.1|mint:MINT-1540014(identity) - comment:mint|function:"Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3|author-confidence:100%|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/16 2014/10/16 rogid:ubzOW0DZU3KKtoQQK4kBXsx6NT410116 rogid:uqwJJv2JErOO2NJR8CVIxCflozU10116 intact-crc:EE0A24032A294F23|rigid:j22HZnJB8gkB7vEiXicqPg8R3aA false tag:?-?(MINT-1540025)|binding-associated region:208-216(MINT-1540022) binding-associated region:124-226(MINT-1540015) - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O70521 uniprotkb:Q9Z254 intact:EBI-8685536|intact:MINT-191738|ensembl:ENSRNOP00000022451 intact:EBI-991162|uniprotkb:Q6GR70|uniprotkb:Q9QUQ4|ensembl:ENSRNOP00000005374 psi-mi:rgs19_rat(display_long)|uniprotkb:Rgs19(gene name)|psi-mi:Rgs19(display_short)|uniprotkb:Gaip(gene name synonym)|uniprotkb:G-alpha-interacting protein(gene name synonym) psi-mi:gipc1_rat(display_long)|uniprotkb:RGS19-interacting protein 1(gene name synonym)|uniprotkb:GAIP C-terminus-interacting protein(gene name synonym)|uniprotkb:RGS-GAIP-interacting protein(gene name synonym)|uniprotkb:GLUT1 C-terminal-binding protein(gene name synonym)|uniprotkb:Gipc1(gene name)|psi-mi:Gipc1(display_short)|uniprotkb:Gipc(gene name synonym)|uniprotkb:Rgs19ip1(gene name synonym)|uniprotkb:Synectin(gene name synonym) psi-mi:"MI:0018"(two hybrid) De et al. (1998) pubmed:9770488|mint:MINT-6548266 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8685593|mint:MINT-62466 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006235863.2|rgd:629471|refseq:NP_067693.1|ensembl:ENSRNOG00000016547(gene)|ensembl:ENSRNOT00000022451(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR036305|reactome:R-RNO-416476|reactome:R-RNO-418594|mint:MINT-1540046(identity) rgd:68338|refseq:NP_445793.1|ensembl:ENSRNOG00000003864(gene)|ensembl:ENSRNOT00000005374(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|go:"GO:0005903"(brush border)|refseq:XP_017456861.1|mint:MINT-1540037(identity) - comment:mint|function:"Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A F2C|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/09/16 2014/10/16 rogid:ubzOW0DZU3KKtoQQK4kBXsx6NT410116 rogid:uqwJJv2JErOO2NJR8CVIxCflozU10116 intact-crc:72FB7B8DB772824A|rigid:j22HZnJB8gkB7vEiXicqPg8R3aA false tag:?-?(MINT-1540050)|binding-associated region:208-216(MINT-1540047) tag:?-?(MINT-1540041)|binding-associated region:124-226(MINT-1540038) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)