#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P39429	uniprotkb:P47741	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-520001	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520012|imex:IM-27308-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2019/08/22	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	intact-crc:452C5FCEA4CD2199|rigid:Xy9RYQZY1CY/6J9hfyfZY9nu6Io	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20334	uniprotkb:P39429	intact:EBI-520693|ensembl:ENSMUSP00000030808|ensembl:ENSMUSP00000101296|ensembl:ENSMUSP00000111961	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr9_mouse(display_long)|uniprotkb:4-1BB ligand receptor(gene name synonym)|uniprotkb:T-cell antigen 4-1BB(gene name synonym)|uniprotkb:Tnfrsf9(gene name)|psi-mi:Tnfrsf9(display_short)|uniprotkb:Cd137(gene name synonym)|uniprotkb:Ila(gene name synonym)|uniprotkb:Ly63(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520052|imex:IM-27308-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070977.1|refseq:NP_035742.1|refseq:XP_011248530.1|dip:DIP-1154N|ensembl:ENSMUST00000030808(transcript)|ensembl:ENSMUST00000105671(transcript)|ensembl:ENSMUST00000116257(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020413|interpro:IPR034020|mint:P20334|rcsb pdb:1D0J|rcsb pdb:5WI8|rcsb pdb:5WIW|rcsb pdb:5WJF|rcsb pdb:6MKZ|reactome:R-MMU-5669034|ensembl:ENSMUSG00000028965(gene)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2019/08/22	rogid:mDd03gtpOW/ExAtypvsm+u/cFn010090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:862D769CF95A870D|rigid:tbaS36pb0Hz7UOukT/7bys+RD7s	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20334	uniprotkb:P39428	intact:EBI-520693|ensembl:ENSMUSP00000030808|ensembl:ENSMUSP00000101296|ensembl:ENSMUSP00000111961	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tnr9_mouse(display_long)|uniprotkb:4-1BB ligand receptor(gene name synonym)|uniprotkb:T-cell antigen 4-1BB(gene name synonym)|uniprotkb:Tnfrsf9(gene name)|psi-mi:Tnfrsf9(display_short)|uniprotkb:Cd137(gene name synonym)|uniprotkb:Ila(gene name synonym)|uniprotkb:Ly63(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520129|imex:IM-27308-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070977.1|refseq:NP_035742.1|refseq:XP_011248530.1|dip:DIP-1154N|ensembl:ENSMUST00000030808(transcript)|ensembl:ENSMUST00000105671(transcript)|ensembl:ENSMUST00000116257(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020413|interpro:IPR034020|mint:P20334|rcsb pdb:1D0J|rcsb pdb:5WI8|rcsb pdb:5WIW|rcsb pdb:5WJF|rcsb pdb:6MKZ|reactome:R-MMU-5669034|ensembl:ENSMUSG00000028965(gene)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2014/10/16	rogid:mDd03gtpOW/ExAtypvsm+u/cFn010090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:862CDD86F250271C|rigid:unLsbA2NxY1DU5ydo3eq1kayhWA	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P47741	uniprotkb:Q60803	intact:EBI-520001	intact:EBI-520135|uniprotkb:B2RPW3|uniprotkb:Q62380|ensembl:ENSMUSP00000021706	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf3_mouse(display_long)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:TRAFAMN(gene name synonym)|uniprotkb:Traf3(gene name)|psi-mi:Traf3(display_short)|uniprotkb:Craf1(gene name synonym)|uniprotkb:Trafamn(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520146|imex:IM-27308-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_035762.2|ensembl:ENSMUSG00000021277(gene)|ensembl:ENSMUST00000021706(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q60803|rcsb pdb:4GHU|reactome:R-MMU-5668541|reactome:R-MMU-5676594|reactome:R-MMU-5689896|reactome:R-MMU-936964|refseq:XP_006515861.1|refseq:XP_006515862.1|refseq:XP_006515863.1|refseq:XP_006515864.1|dip:DIP-34050N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2014/10/16	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:2MrUSSGdyGB3zrZ39xovGDK6ysE10090	intact-crc:03E3C84C0CECD109|rigid:jS29cwyaL34T0isrXqW8u1zlvxw	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P47741	uniprotkb:P39428	intact:EBI-520001	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520153|imex:IM-27308-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	-	-	-	comment:The authors note that the OX40 protein demonstrated weak but reproducible interaction with TRAF1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2014/10/16	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:1FD24109E3E17D8C|rigid:3zIXvNQKY7ZOm3rtKbT2RtLIbVI	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q12933	uniprotkb:P47741	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	intact:EBI-520001	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520084|imex:IM-27308-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/03/17	2014/10/16	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	intact-crc:0B2BE1C67267B7D7|rigid:MknaYzfUe4ju8u+5aJ/la8lnm2U	false	sufficient binding region:87-501(IPR008974)	sufficient binding region:?-?|tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20334	uniprotkb:Q12933	intact:EBI-520693|ensembl:ENSMUSP00000030808|ensembl:ENSMUSP00000101296|ensembl:ENSMUSP00000111961	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:tnr9_mouse(display_long)|uniprotkb:4-1BB ligand receptor(gene name synonym)|uniprotkb:T-cell antigen 4-1BB(gene name synonym)|uniprotkb:Tnfrsf9(gene name)|psi-mi:Tnfrsf9(display_short)|uniprotkb:Cd137(gene name synonym)|uniprotkb:Ila(gene name synonym)|uniprotkb:Ly63(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520102|imex:IM-27308-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070977.1|refseq:NP_035742.1|refseq:XP_011248530.1|dip:DIP-1154N|ensembl:ENSMUST00000030808(transcript)|ensembl:ENSMUST00000105671(transcript)|ensembl:ENSMUST00000116257(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020413|interpro:IPR034020|mint:P20334|rcsb pdb:1D0J|rcsb pdb:5WI8|rcsb pdb:5WIW|rcsb pdb:5WJF|rcsb pdb:6MKZ|reactome:R-MMU-5669034|ensembl:ENSMUSG00000028965(gene)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	-	-	-	figure legend:Fig. 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/03/17	2014/10/16	rogid:mDd03gtpOW/ExAtypvsm+u/cFn010090	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	intact-crc:F5CC6FF712261B49|rigid:IZjORvUvNmVkcyu4AhU2h0mR2JQ	false	sufficient binding region:?-?|tag:n-n	sufficient binding region:87-501	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:P47741	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-520001	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520661|imex:IM-27308-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	-	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	intact-crc:29E96054C2536389|rigid:Xy9RYQZY1CY/6J9hfyfZY9nu6Io	false	-	mutation disrupting interaction strength:256-258|mutation disrupting interaction strength:259-261|mutation decreasing interaction strength:262-264|sufficient binding region:237..237-272	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60803	uniprotkb:P47741	intact:EBI-520135|uniprotkb:B2RPW3|uniprotkb:Q62380|ensembl:ENSMUSP00000021706	intact:EBI-520001	psi-mi:traf3_mouse(display_long)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:TRAFAMN(gene name synonym)|uniprotkb:Traf3(gene name)|psi-mi:Traf3(display_short)|uniprotkb:Craf1(gene name synonym)|uniprotkb:Trafamn(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:tnr4_mouse(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520685|imex:IM-27308-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035762.2|ensembl:ENSMUSG00000021277(gene)|ensembl:ENSMUST00000021706(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q60803|rcsb pdb:4GHU|reactome:R-MMU-5668541|reactome:R-MMU-5676594|reactome:R-MMU-5689896|reactome:R-MMU-936964|refseq:XP_006515861.1|refseq:XP_006515862.1|refseq:XP_006515863.1|refseq:XP_006515864.1|dip:DIP-34050N	refseq:NP_035789.1|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020445|interpro:IPR034022|dip:DIP-6239N|reactome:R-MMU-5669034	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2014/10/16	rogid:2MrUSSGdyGB3zrZ39xovGDK6ysE10090	rogid:L9djfmkeoDYumQjVxNp/SItXL0410090	intact-crc:99B010F9BC0DEE85|rigid:jS29cwyaL34T0isrXqW8u1zlvxw	false	-	mutation disrupting interaction strength:259-261|sufficient binding region:237..237-272|mutation decreasing interaction strength:262-264|mutation disrupting interaction strength:256-258	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39429	uniprotkb:P20334	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-520693|ensembl:ENSMUSP00000030808|ensembl:ENSMUSP00000101296|ensembl:ENSMUSP00000111961	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnr9_mouse(display_long)|uniprotkb:4-1BB ligand receptor(gene name synonym)|uniprotkb:T-cell antigen 4-1BB(gene name synonym)|uniprotkb:Tnfrsf9(gene name)|psi-mi:Tnfrsf9(display_short)|uniprotkb:Cd137(gene name synonym)|uniprotkb:Ila(gene name synonym)|uniprotkb:Ly63(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520705|imex:IM-27308-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:NP_001070977.1|refseq:NP_035742.1|refseq:XP_011248530.1|dip:DIP-1154N|ensembl:ENSMUST00000030808(transcript)|ensembl:ENSMUST00000105671(transcript)|ensembl:ENSMUST00000116257(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020413|interpro:IPR034020|mint:P20334|rcsb pdb:1D0J|rcsb pdb:5WI8|rcsb pdb:5WIW|rcsb pdb:5WJF|rcsb pdb:6MKZ|reactome:R-MMU-5669034|ensembl:ENSMUSG00000028965(gene)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:mDd03gtpOW/ExAtypvsm+u/cFn010090	intact-crc:F6861920D9A728C5|rigid:tbaS36pb0Hz7UOukT/7bys+RD7s	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60803	uniprotkb:P20334	intact:EBI-520135|uniprotkb:B2RPW3|uniprotkb:Q62380|ensembl:ENSMUSP00000021706	intact:EBI-520693|ensembl:ENSMUSP00000030808|ensembl:ENSMUSP00000101296|ensembl:ENSMUSP00000111961	psi-mi:traf3_mouse(display_long)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:TRAFAMN(gene name synonym)|uniprotkb:Traf3(gene name)|psi-mi:Traf3(display_short)|uniprotkb:Craf1(gene name synonym)|uniprotkb:Trafamn(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:tnr9_mouse(display_long)|uniprotkb:4-1BB ligand receptor(gene name synonym)|uniprotkb:T-cell antigen 4-1BB(gene name synonym)|uniprotkb:Tnfrsf9(gene name)|psi-mi:Tnfrsf9(display_short)|uniprotkb:Cd137(gene name synonym)|uniprotkb:Ila(gene name synonym)|uniprotkb:Ly63(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Arch et al. (1998)	pubmed:9418902|imex:IM-27308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-520710|imex:IM-27308-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035762.2|ensembl:ENSMUSG00000021277(gene)|ensembl:ENSMUST00000021706(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q60803|rcsb pdb:4GHU|reactome:R-MMU-5668541|reactome:R-MMU-5676594|reactome:R-MMU-5689896|reactome:R-MMU-936964|refseq:XP_006515861.1|refseq:XP_006515862.1|refseq:XP_006515863.1|refseq:XP_006515864.1|dip:DIP-34050N	refseq:NP_001070977.1|refseq:NP_035742.1|refseq:XP_011248530.1|dip:DIP-1154N|ensembl:ENSMUST00000030808(transcript)|ensembl:ENSMUST00000105671(transcript)|ensembl:ENSMUST00000116257(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020413|interpro:IPR034020|mint:P20334|rcsb pdb:1D0J|rcsb pdb:5WI8|rcsb pdb:5WIW|rcsb pdb:5WJF|rcsb pdb:6MKZ|reactome:R-MMU-5669034|ensembl:ENSMUSG00000028965(gene)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/17	2019/08/22	rogid:2MrUSSGdyGB3zrZ39xovGDK6ysE10090	rogid:mDd03gtpOW/ExAtypvsm+u/cFn010090	intact-crc:0BB121DAA48192F9|rigid:s/beB0f4o/KwVpjQIqSHg5bMErc	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)