#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92956	uniprotkb:Q12933-2	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-355760	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:q12933-2(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523882	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	intact:EBI-355744(traf2_human)|uniprotkb:Q12933-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:R7gJwK3F/EZDSTpNCjl+ZCjrUXg9606	intact-crc:59790075D154B328|rigid:0cN2MMgNcTY0X7PxHbkJ6aew4Qk	false	-	-	-	-	psi-mi:"MI:0080"(partial dna sequence identification by hybridization)	psi-mi:"MI:0080"(partial dna sequence identification by hybridization)
uniprotkb:Q92956	uniprotkb:P39429	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523887	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:B045AB83016D2171|rigid:0eK+IX92ZaJFO5ZdfcmVWehF2hs	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0080"(partial dna sequence identification by hybridization)	psi-mi:"MI:0080"(partial dna sequence identification by hybridization)
uniprotkb:O00463	uniprotkb:Q92956	intact:EBI-523498|ensembl:ENSP00000261464|ensembl:ENSP00000336825|ensembl:ENSP00000355971|uniprotkb:Q6FHY1|uniprotkb:B4DIS9|uniprotkb:B4E0A2	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	psi-mi:traf5_human(display_long)|uniprotkb:RING finger protein 84(gene name synonym)|uniprotkb:TRAF5(gene name)|psi-mi:TRAF5(display_short)|uniprotkb:RNF84(gene name synonym)	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523893	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306136.1|refseq:XP_011508261.1|refseq:XP_011508262.1|ensembl:ENSG00000082512(gene)|ensembl:ENST00000261464(transcript)|ensembl:ENST00000336184(transcript)|ensembl:ENST00000367004(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR043211|mint:O00463|rcsb pdb:7L3L|refseq:NP_001029082.1|refseq:NP_004610.1|refseq:NP_665702.1|refseq:XP_016857710.1	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:xPAQGevMJLEAPcT6eX3n304eSOw9606	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	intact-crc:04080FE7BDD4224E|rigid:CB/Gof0wQot2bsXmUyAXiY5XPXc	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0080"(partial dna sequence identification by hybridization)	psi-mi:"MI:0080"(partial dna sequence identification by hybridization)
uniprotkb:Q92956	uniprotkb:P70191	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-523899|uniprotkb:Q61480|ensembl:ENSMUSP00000141931	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:traf5_mouse(display_long)|uniprotkb:Traf5(gene name)|psi-mi:Traf5(display_short)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523911	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	ensembl:ENSMUSG00000026637(gene)|ensembl:ENSMUST00000195815(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR037308|interpro:IPR043211|rcsb pdb:4GJH|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_035763.2|dip:DIP-34999N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:f4UiPm5V8PGnfIFBtZqLQnsYlO810090	intact-crc:C95DCF5196E6559F|rigid:PckevD+W7bMjODVh1+HlaTAwimo	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0080"(partial dna sequence identification by hybridization)	psi-mi:"MI:0080"(partial dna sequence identification by hybridization)
uniprotkb:P39429	uniprotkb:Q80WM9	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-523921|ensembl:ENSMUSP00000116757	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnr14_mouse(display_long)|uniprotkb:Tnfrsf14(gene name)|psi-mi:Tnfrsf14(display_short)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)|uniprotkb:hvem(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523932	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	ensembl:ENSMUSG00000042333(gene)|ensembl:ENSMUST00000123514(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|reactome:R-MMU-388841|reactome:R-MMU-5669034|refseq:NP_849262.1|refseq:XP_006538894.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:sWAvx7+UMH52pjW15UKPWZAMQxU10090	intact-crc:0FFE4F887B5C0220|rigid:qLeoxnLF2anWbJGyFwjsznccepA	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70191	uniprotkb:Q80WM9	intact:EBI-523899|uniprotkb:Q61480|ensembl:ENSMUSP00000141931	intact:EBI-523921|ensembl:ENSMUSP00000116757	psi-mi:traf5_mouse(display_long)|uniprotkb:Traf5(gene name)|psi-mi:Traf5(display_short)	psi-mi:tnr14_mouse(display_long)|uniprotkb:Tnfrsf14(gene name)|psi-mi:Tnfrsf14(display_short)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)|uniprotkb:hvem(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523940	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026637(gene)|ensembl:ENSMUST00000195815(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR037308|interpro:IPR043211|rcsb pdb:4GJH|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_035763.2|dip:DIP-34999N	ensembl:ENSMUSG00000042333(gene)|ensembl:ENSMUST00000123514(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|reactome:R-MMU-388841|reactome:R-MMU-5669034|refseq:NP_849262.1|refseq:XP_006538894.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:f4UiPm5V8PGnfIFBtZqLQnsYlO810090	rogid:sWAvx7+UMH52pjW15UKPWZAMQxU10090	intact-crc:3276D0EE515D9528|rigid:DO3z9TZ8pCt1HIAXUVROCnyMkW0	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92956	uniprotkb:Q12933-2	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-355760	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:q12933-2(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523947	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	intact:EBI-355744(traf2_human)|uniprotkb:Q12933-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:R7gJwK3F/EZDSTpNCjl+ZCjrUXg9606	intact-crc:69718B5774B066C3|rigid:0cN2MMgNcTY0X7PxHbkJ6aew4Qk	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00463	uniprotkb:Q92956	intact:EBI-523498|ensembl:ENSP00000261464|ensembl:ENSP00000336825|ensembl:ENSP00000355971|uniprotkb:Q6FHY1|uniprotkb:B4DIS9|uniprotkb:B4E0A2	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	psi-mi:traf5_human(display_long)|uniprotkb:RING finger protein 84(gene name synonym)|uniprotkb:TRAF5(gene name)|psi-mi:TRAF5(display_short)|uniprotkb:RNF84(gene name synonym)	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523952	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306136.1|refseq:XP_011508261.1|refseq:XP_011508262.1|ensembl:ENSG00000082512(gene)|ensembl:ENST00000261464(transcript)|ensembl:ENST00000336184(transcript)|ensembl:ENST00000367004(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR043211|mint:O00463|rcsb pdb:7L3L|refseq:NP_001029082.1|refseq:NP_004610.1|refseq:NP_665702.1|refseq:XP_016857710.1	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:xPAQGevMJLEAPcT6eX3n304eSOw9606	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	intact-crc:6CC0C7DB3ABDFE90|rigid:CB/Gof0wQot2bsXmUyAXiY5XPXc	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00463	uniprotkb:Q92956	intact:EBI-523498|ensembl:ENSP00000261464|ensembl:ENSP00000336825|ensembl:ENSP00000355971|uniprotkb:Q6FHY1|uniprotkb:B4DIS9|uniprotkb:B4E0A2	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	psi-mi:traf5_human(display_long)|uniprotkb:RING finger protein 84(gene name synonym)|uniprotkb:TRAF5(gene name)|psi-mi:TRAF5(display_short)|uniprotkb:RNF84(gene name synonym)	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-523991	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306136.1|refseq:XP_011508261.1|refseq:XP_011508262.1|ensembl:ENSG00000082512(gene)|ensembl:ENST00000261464(transcript)|ensembl:ENST00000336184(transcript)|ensembl:ENST00000367004(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR043211|mint:O00463|rcsb pdb:7L3L|refseq:NP_001029082.1|refseq:NP_004610.1|refseq:NP_665702.1|refseq:XP_016857710.1	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:xPAQGevMJLEAPcT6eX3n304eSOw9606	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	intact-crc:0803D8279AB440D4|rigid:CB/Gof0wQot2bsXmUyAXiY5XPXc	false	-	binding-associated region:?-?|mutation decreasing interaction:271-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92956	uniprotkb:Q12933	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524003	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/29	2014/10/16	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	intact-crc:6318B3CF8AB8E949|rigid:rWs516MrSIVDqswapQmYi9EGYdE	false	mutation decreasing interaction:271-271|binding-associated region:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92956	uniprotkb:O00463	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-523498|ensembl:ENSP00000261464|ensembl:ENSP00000336825|ensembl:ENSP00000355971|uniprotkb:Q6FHY1|uniprotkb:B4DIS9|uniprotkb:B4E0A2	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:traf5_human(display_long)|uniprotkb:RING finger protein 84(gene name synonym)|uniprotkb:TRAF5(gene name)|psi-mi:TRAF5(display_short)|uniprotkb:RNF84(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524017	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	refseq:NP_001306136.1|refseq:XP_011508261.1|refseq:XP_011508262.1|ensembl:ENSG00000082512(gene)|ensembl:ENST00000261464(transcript)|ensembl:ENST00000336184(transcript)|ensembl:ENST00000367004(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR043211|mint:O00463|rcsb pdb:7L3L|refseq:NP_001029082.1|refseq:NP_004610.1|refseq:NP_665702.1|refseq:XP_016857710.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/03/29	2014/10/16	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:xPAQGevMJLEAPcT6eX3n304eSOw9606	intact-crc:2EA8C44DF3B5B784|rigid:CB/Gof0wQot2bsXmUyAXiY5XPXc	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92956	uniprotkb:Q12933-2	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-355760	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:q12933-2(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hsu et al. (1997)	pubmed:9153189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524035	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	intact:EBI-355744(traf2_human)|uniprotkb:Q12933-2(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/03/29	2014/10/16	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:R7gJwK3F/EZDSTpNCjl+ZCjrUXg9606	intact-crc:8939243DD3754C70|rigid:0cN2MMgNcTY0X7PxHbkJ6aew4Qk	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)