#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30429	uniprotkb:P41958	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0018"(two hybrid)	Wu et al. (1997)	pubmed:9027313	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494126	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	pubmed:9027313(primary-reference)	-	-	comment:This study used the ced-4S form of the ced-4 protein.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/23	2014/10/16	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	intact-crc:19FF2CAEE97230F9|rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41958	uniprotkb:P30429	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9027313	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	intact:EBI-494155(intact-secondary)|pubmed:9027313(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	intact-crc:976693A6192786E8|rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	ha tag:?-?|binding-associated region:1-249	myc tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q07817	uniprotkb:P30429	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9027313	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494146	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	intact-crc:BC3ACC2599FE289D|rigid:b45eHJ8RpItjx3ild8AH9/QzmlY	false	flag tag:?-?|binding-associated region:129-195(IPR000712)	myc tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P30429	uniprotkb:P41958	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Wu et al. (1997)	pubmed:9027313	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	pubmed:9027313(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	intact-crc:219717E9DDA045BA|rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P41958	uniprotkb:P30429	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0428"(imaging technique)	Wu et al. (1997)	pubmed:9027313	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-494180	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/23	2014/10/16	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	intact-crc:48871BD4CA9CB193|rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)