#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19438	uniprotkb:Q15628	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shu et al. (1996)	pubmed:8943045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-531249	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	-	-	-	stimulant:This complex was detected only in tumor necrosis factor stimulated cells.|comment:"TRADD and TRAF2 association with TNF-R1 was detected after 2 minutes treatement of U937 cells with tumor necrosis factor (100ng/ml)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells)	-	2005/04/11	2014/10/16	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	intact-crc:3D343B58A28EA403|rigid:PE2bzQW1RI3Q1OA9H6kiUWhlgfo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q13490	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shu et al. (1996)	pubmed:8943045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-531249	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	-	-	-	stimulant:This complex was detected only in tumor necrosis factor stimulated cells.|comment:"TRADD and TRAF2 association with TNF-R1 was detected after 2 minutes treatement of U937 cells with tumor necrosis factor (100ng/ml)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells)	-	2005/04/11	2014/10/16	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	intact-crc:3D343B58A28EA403|rigid:PE2bzQW1RI3Q1OA9H6kiUWhlgfo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q12933	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shu et al. (1996)	pubmed:8943045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-531249	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	-	-	-	stimulant:This complex was detected only in tumor necrosis factor stimulated cells.|comment:"TRADD and TRAF2 association with TNF-R1 was detected after 2 minutes treatement of U937 cells with tumor necrosis factor (100ng/ml)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells)	-	2005/04/11	2014/10/16	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	intact-crc:3D343B58A28EA403|rigid:PE2bzQW1RI3Q1OA9H6kiUWhlgfo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q13490	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shu et al. (1996)	pubmed:8943045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528532	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	-	-	-	comment:"TRADD and TRAF2 association with TNF-R1 was detected after 2 minutes treatement of U937 cells with tumor necrosis factor (100ng/ml)."|agonist:This complex was detected only in tumor necrosis factor stimulated cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/04/11	2014/10/16	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	intact-crc:6EEE20AABDA9D05F|rigid:PE2bzQW1RI3Q1OA9H6kiUWhlgfo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q15628	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shu et al. (1996)	pubmed:8943045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528532	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	-	-	-	comment:"TRADD and TRAF2 association with TNF-R1 was detected after 2 minutes treatement of U937 cells with tumor necrosis factor (100ng/ml)."|agonist:This complex was detected only in tumor necrosis factor stimulated cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/04/11	2014/10/16	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	intact-crc:6EEE20AABDA9D05F|rigid:PE2bzQW1RI3Q1OA9H6kiUWhlgfo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q12933	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shu et al. (1996)	pubmed:8943045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528532	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	-	-	-	comment:"TRADD and TRAF2 association with TNF-R1 was detected after 2 minutes treatement of U937 cells with tumor necrosis factor (100ng/ml)."|agonist:This complex was detected only in tumor necrosis factor stimulated cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/04/11	2014/10/16	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	intact-crc:6EEE20AABDA9D05F|rigid:PE2bzQW1RI3Q1OA9H6kiUWhlgfo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)