#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25114	uniprotkb:P25114	intact:EBI-728132|ensembl:ENSRNOP00000028039|ensembl:ENSRNOP00000074158	intact:EBI-728132|ensembl:ENSRNOP00000028039|ensembl:ENSRNOP00000074158	psi-mi:f264_rat(display_long)|uniprotkb:Pfkfb4(gene name)|psi-mi:Pfkfb4(display_short)|uniprotkb:6PF-2-K/Fru-2,6-P2ase testis-type isozyme(gene name synonym)	psi-mi:f264_rat(display_long)|uniprotkb:Pfkfb4(gene name)|psi-mi:Pfkfb4(display_short)|uniprotkb:6PF-2-K/Fru-2,6-P2ase testis-type isozyme(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hasemann et al. (1996)	pubmed:8805587|imex:IM-23586	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-728143|rcsb pdb:1BIF|imex:IM-23586-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3310|refseq:NP_062206.1|refseq:XP_008764785.1|refseq:XP_017459205.1|ensembl:ENSRNOG00000020656(gene)|ensembl:ENSRNOT00000028039(transcript)|ensembl:ENSRNOT00000090164(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1BIF|rcsb pdb:2BIF|rcsb pdb:3BIF|reactome:R-RNO-9634600|dip:DIP-2904N|psi-mi:"MI:0465"(dip)|imex:IM-23586-1(imex-primary)|dip:DIP-3921E(identity)	rgd:3310|refseq:NP_062206.1|refseq:XP_008764785.1|refseq:XP_017459205.1|ensembl:ENSRNOG00000020656(gene)|ensembl:ENSRNOT00000028039(transcript)|ensembl:ENSRNOT00000090164(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1BIF|rcsb pdb:2BIF|rcsb pdb:3BIF|reactome:R-RNO-9634600|dip:DIP-2904N|psi-mi:"MI:0465"(dip)|imex:IM-23586-1(imex-primary)|dip:DIP-3921E(identity)	go:"GO:0042803"(protein homodimerization activity)	-	-	3d-resolution:working 18.3%, free 25.0%|3d-resolution:2.00�|3d-structure:Monomers associate in a head-to-head fashion with the 6-phosphofructo-2-kinase domain making contact.|comment:Sequence has all trytophans mutated to phenylalanine. Also His256Ala results in enzyme being catalytically inactive.|comment:Structure also shows position of ATPgammaS and inorganic phosphate in the molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/18	2017/06/30	rogid:dEE8FcAQywg30OCy/w4c/peE64Y10116	rogid:dEE8FcAQywg30OCy/w4c/peE64Y10116	intact-crc:FFCC122430584E80|rigid:xypKiI8GpNT8i6pRo6gvPaCs+Vk	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)