#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P43488 uniprotkb:P15725 intact:EBI-519690|ensembl:ENSMUSP00000028024 intact:EBI-519660|ensembl:ENSRNOP00000027251 psi-mi:tnfl4_mouse(display_long)|uniprotkb:OX40 ligand(gene name synonym)|uniprotkb:Tnfsf4(gene name)|psi-mi:Tnfsf4(display_short)|uniprotkb:Ox40l(gene name synonym)|uniprotkb:Txgp1l(gene name synonym) psi-mi:tnr4_rat(display_long)|uniprotkb:OX40L receptor(gene name synonym)|uniprotkb:OX40 antigen(gene name synonym)|uniprotkb:MRC OX40(gene name synonym)|uniprotkb:Ox40(gene name synonym)|uniprotkb:Txgp1l(gene name synonym)|uniprotkb:Tnfrsf4(gene name)|psi-mi:Tnfrsf4(display_short) psi-mi:"MI:0107"(surface plasmon resonance) al-Shamkhani et al. (1996) pubmed:8765008 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-519670 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033478.1|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0035709"(memory T cell activation)|go:"GO:0035712"(T-helper 2 cell activation)|go:"GO:0035713"(response to nitrogen dioxide)|go:"GO:0035714"(cellular response to nitrogen dioxide)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:1900281"(positive regulation of CD4-positive, alpha-beta T cell costimulation)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000525"(positive regulation of T cell costimulation)|go:"GO:2000568"(positive regulation of memory T cell activation)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|go:"GO:2000572"(positive regulation of interleukin-4-dependent isotype switching to IgE isotypes)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|interpro:IPR042338|rcsb pdb:2HEW|rcsb pdb:2HEY|reactome:R-MMU-5669034|ensembl:ENSMUSG00000026700(gene)|ensembl:ENSMUST00000028024(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002215"(defense response to nematode)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002699"(positive regulation of immune effector process)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|dip:DIP-6238N go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|ensembl:ENSRNOG00000020106(gene)|go:"GO:0045859"(regulation of protein kinase activity)|ensembl:ENSRNOT00000027251(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:0002639"(positive regulation of immunoglobulin production)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|interpro:IPR020445|interpro:IPR034022|reactome:R-RNO-5669034|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|rgd:3920|refseq:NP_037181.1 - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/03/16 2014/10/16 rogid:+B9niauBzC76tku2QclntjQViMY10090 rogid:mATr3KxMiRC/CoMQwA95ZOEju6k10116 intact-crc:B406DF19377F51BA|rigid:ayD49lWgqt9e1kOmQvd+JtrbJ9Y false binding-associated region:51-198(IPR006052)|uncategorized protein modification:n-n binding-associated region:1-164(IPR001368) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)