#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15385	uniprotkb:P78352	intact:EBI-631417	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	comment:PDZ2 domain of PSD-95 has the strongest binding but binds slightly less tightly to Kv1.4C than the fragment containing all three PDZ. PDZ1 domain alone shows a weak binding. PDZ3 shows no binding.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	intact-crc:5D828B739F63B0CA|rigid:5YtaxAP5vvKKSU51TPS+acffhks	false	sufficient binding region:?-?	sufficient binding region:41-355(IPR001478)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15385	uniprotkb:P78352	intact:EBI-631417	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631164	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	comment:PDZ2 domain of PSD-95 has the strongest binding but binds slighty less tightly to Kv1.4C than the fragment containing all three PDZ. PDZ1 domain alone shows a weak binding. PDZ3 shows no binding.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	intact-crc:34744E704A544C7B|rigid:5YtaxAP5vvKKSU51TPS+acffhks	false	sufficient binding region:?-?	sufficient binding region:89-299(IPR001478)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15385	uniprotkb:Q12959	intact:EBI-631417	intact:EBI-357481|ensembl:ENSP00000391732|ensembl:ENSP00000407531|ensembl:ENSP00000499437|uniprotkb:Q12958|uniprotkb:A5YKK7|uniprotkb:B7ZMM0|uniprotkb:B9EIQ5|uniprotkb:D3DXB8|uniprotkb:D3DXB9|uniprotkb:B4DGU1|uniprotkb:B4DGZ8|uniprotkb:E7EWL7|uniprotkb:E9PG21	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:dlg1_human(display_long)|uniprotkb:DLG1(gene name)|psi-mi:DLG1(display_short)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:hDlg(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631202	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	reactome:R-HSA-9617324|reactome:R-HSA-9620244|ensembl:ENST00000419354(transcript)|ensembl:ENST00000448528(transcript)|ensembl:ENST00000670935(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|ensembl:ENSG00000075711(gene)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|refseq:NP_001091894.1|refseq:NP_001191315.1|refseq:NP_001191316.1|refseq:NP_001191317.1|refseq:NP_004078.2|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030432"(peristalsis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034629"|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|interpro:IPR019583|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q12959|rcsb pdb:1PDR|rcsb pdb:2M3M|rcsb pdb:2OQS|rcsb pdb:2X7Z|rcsb pdb:3LRA|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3W9Y|rcsb pdb:4AMH|rcsb pdb:4G69|reactome:R-HSA-399719|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|reactome:R-HSA-438066|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-8849932|reactome:R-HSA-9609736|refseq:XP_011510804.1|refseq:XP_011510807.1|refseq:XP_011510808.1|refseq:XP_005269346.1|refseq:NP_001277912.1|refseq:XP_016861289.1|refseq:XP_016861290.1|refseq:XP_016861291.1|refseq:XP_016861292.1|refseq:XP_016861294.1|refseq:XP_016861295.1|refseq:XP_016861296.1|refseq:XP_016861297.1|refseq:XP_016861298.1|refseq:XP_016861305.1|refseq:XP_016861306.1|refseq:XP_016861307.1|refseq:XP_016861308.1|refseq:XP_016861309.1|dip:DIP-33957N|refseq:XP_011510805.1|refseq:XP_016861299.1	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	rogid:ax5sUROdL8kF59RhocRWG6tUUkc9606	intact-crc:095796601A8BFE2A|rigid:ybiCoowwstO4HGdKmCouk4QEvZc	false	sufficient binding region:?-?	sufficient binding region:147-545	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15700	uniprotkb:P15385	intact:EBI-80426|ensembl:ENSP00000381355|uniprotkb:Q59G57|uniprotkb:Q68CQ8|uniprotkb:Q6ZTA8|uniprotkb:B7WNY8|uniprotkb:F8W9V6|uniprotkb:Q5H9Q4	intact:EBI-631417	psi-mi:dlg2_human(display_long)|uniprotkb:DLG2(gene name)|psi-mi:DLG2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631210	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150672(gene)|ensembl:ENST00000398309(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR008144(Guanylate kinase)|rcsb pdb:2BYG|rcsb pdb:2HE2|reactome:R-HSA-438066|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|reactome:R-HSA-442982|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|reactome:R-HSA-5673001|reactome:R-HSA-6794361|interpro:IPR035759|reactome:R-HSA-9609736|reactome:R-HSA-9617324|interpro:IPR036028|reactome:R-HSA-9620244|refseq:NP_001355.2|refseq:NP_001136171.1|refseq:NP_001136172.1|refseq:NP_001136174.1|refseq:NP_001193698.1	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:hBuRCYIzH2etGCJINoeHIYFGTrc9606	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	intact-crc:17C8D665E64588E1|rigid:aVaD+ZC59moJyN/88YyKhSE9da4	false	sufficient binding region:193..193-501..501(IPR001478)	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15385	uniprotkb:P78352	intact:EBI-631417	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631177	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	comment:PDZ2 domain of PSD-95 has the strongest binding but binds slightly less tightly to Kv1.4C than the fragment containing all three PDZ. PDZ1 domain alone shows a weak binding. PDZ3 shows no binding.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	intact-crc:0DC4915A8C28BB9E|rigid:5YtaxAP5vvKKSU51TPS+acffhks	false	sufficient binding region:?-?	sufficient binding region:154-267(IPR001478)|necessary binding region:154-168	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78352	uniprotkb:P15385	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-631417	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631191	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	-	-	-	comment:PDZ2 domain of PSD-95 has the strongest binding but binds slightly less tightly to Kv1.4C than the fragment containing all three PDZ. PDZ1 domain alone shows a weak binding. PDZ3 shows no binding.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	intact-crc:AB595011A3F78B33|rigid:5YtaxAP5vvKKSU51TPS+acffhks	false	necessary binding region:154-168|sufficient binding region:41-161(IPR001478)	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78352	uniprotkb:P15385	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-631417	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631274	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	intact-crc:5A694710CDEE2CBE|rigid:5YtaxAP5vvKKSU51TPS+acffhks	false	sufficient binding region:41-355(IPR001478)	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15385	uniprotkb:P78352	intact:EBI-631417	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631332	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	intact-crc:55B311435BEF6F8B|rigid:5YtaxAP5vvKKSU51TPS+acffhks	false	sufficient binding region:?-?|mutation decreasing interaction:655-655|mutation decreasing interaction:655-655|mutation increasing interaction:653-653	sufficient binding region:41-355(IPR001478)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78352	uniprotkb:P63142	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-631446|uniprotkb:P15386|uniprotkb:Q02010|ensembl:ENSRNOP00000042653|ensembl:ENSRNOP00000075841|ensembl:ENSRNOP00000075852	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:kcna2_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.2(gene name synonym)|uniprotkb:RBK2(gene name synonym)|uniprotkb:RCK5(gene name synonym)|uniprotkb:RAK(gene name synonym)|uniprotkb:Kcna2(gene name)|psi-mi:Kcna2(display_short)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631378	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	rgd:2950|refseq:NP_037102.1|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|rcsb pdb:1DSX|rcsb pdb:1QDV|rcsb pdb:1QDW|rcsb pdb:2A79|rcsb pdb:2R9R|rcsb pdb:3LNM|rcsb pdb:3LUT|rcsb pdb:4JTA|rcsb pdb:4JTC|rcsb pdb:4JTD|rcsb pdb:5WIE|rcsb pdb:6EBK|rcsb pdb:6EBL|rcsb pdb:6EBM|interpro:IPR005821(Ion transport)|reactome:R-RNO-1296072|ensembl:ENSRNOG00000018285(gene)|ensembl:ENSRNOT00000050149(transcript)|ensembl:ENSRNOT00000092365(transcript)|ensembl:ENSRNOT00000092450(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019894"(kinesin binding)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033010"(paranodal junction)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004049(Potassium channel, voltage dependent, Kv1.2)|go:"GO:0014059"(regulation of dopamine secretion)|refseq:XP_008759593.1|refseq:XP_006233194.1|refseq:XP_006233195.1|refseq:XP_006233196.1|refseq:XP_006233197.1	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:AimFojHr+yjzzdtmfxUCRBTvJyc10116	intact-crc:D0C30D6578AD02F0|rigid:Vq5DCO6TzObaMDFyyyIDUIMPBJ8	false	sufficient binding region:41-355(IPR001478)	sufficient binding region:416-499	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78352	uniprotkb:P10499	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-631463|ensembl:ENSRNOP00000026731	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:kcna1_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.1(gene name synonym)|uniprotkb:RBKI(gene name synonym)|uniprotkb:RCK1(gene name synonym)|uniprotkb:Kcna1(gene name)|psi-mi:Kcna1(display_short)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631387	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	rgd:2949|refseq:NP_775118.1|go:"GO:0019228"(neuronal action potential)|go:"GO:0021766"(hippocampus development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033270"(paranode region of axon)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034705"(potassium channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0050905"(neuromuscular process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050976"(detection of mechanical stimulus involved in sensory perception of touch)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|go:"GO:1905030"(voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004048(Potassium channel, voltage dependent, Kv1.1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|mint:P10499|rcsb pdb:1EXB|reactome:R-RNO-1296072|ensembl:ENSRNOG00000019750(gene)|ensembl:ENSRNOT00000026731(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:tGnBP9au7V54T4OD+8yaV3c0jss10116	intact-crc:6D4C1A02CC73F6BC|rigid:IyIutCpIxZzkby0q8X6hMLlV5zQ	false	sufficient binding region:41-355(IPR001478)	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78352	uniprotkb:P15384	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-631478|ensembl:ENSRNOP00000075761	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:kcna3_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.3(gene name synonym)|uniprotkb:RGK5(gene name synonym)|uniprotkb:RCK3(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv3(gene name synonym)|uniprotkb:Kcna3(gene name)|psi-mi:Kcna3(display_short)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (1995)	pubmed:7477295	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631396	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	rgd:2951|refseq:NP_062143.3|ensembl:ENSRNOG00000062002(gene)|ensembl:ENSRNOT00000092240(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004050(Potassium channel, voltage dependent, Kv1.3)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|reactome:R-RNO-1296072	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/08	2014/10/16	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:y10hZkJ4zgRH2q54L6Cx5qFBJJU10116	intact-crc:D65920C28692FDD3|rigid:b+/LuTgDDkVleYXteO8rhKVV/Bg	false	sufficient binding region:41-355(IPR001478)	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78352	uniprotkb:P63142	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-631446|uniprotkb:P15386|uniprotkb:Q02010|ensembl:ENSRNOP00000042653|ensembl:ENSRNOP00000075841|ensembl:ENSRNOP00000075852	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:kcna2_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.2(gene name synonym)|uniprotkb:RBK2(gene name synonym)|uniprotkb:RCK5(gene name synonym)|uniprotkb:RAK(gene name synonym)|uniprotkb:Kcna2(gene name)|psi-mi:Kcna2(display_short)	psi-mi:"MI:0047"(far western blotting)	Kim et al. (1995)	pubmed:7477295	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	rgd:2950|refseq:NP_037102.1|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|rcsb pdb:1DSX|rcsb pdb:1QDV|rcsb pdb:1QDW|rcsb pdb:2A79|rcsb pdb:2R9R|rcsb pdb:3LNM|rcsb pdb:3LUT|rcsb pdb:4JTA|rcsb pdb:4JTC|rcsb pdb:4JTD|rcsb pdb:5WIE|rcsb pdb:6EBK|rcsb pdb:6EBL|rcsb pdb:6EBM|interpro:IPR005821(Ion transport)|reactome:R-RNO-1296072|ensembl:ENSRNOG00000018285(gene)|ensembl:ENSRNOT00000050149(transcript)|ensembl:ENSRNOT00000092365(transcript)|ensembl:ENSRNOT00000092450(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019894"(kinesin binding)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033010"(paranodal junction)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004049(Potassium channel, voltage dependent, Kv1.2)|go:"GO:0014059"(regulation of dopamine secretion)|refseq:XP_008759593.1|refseq:XP_006233194.1|refseq:XP_006233195.1|refseq:XP_006233196.1|refseq:XP_006233197.1	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/08	2014/10/16	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:AimFojHr+yjzzdtmfxUCRBTvJyc10116	intact-crc:B889C7FE979F65A6|rigid:Vq5DCO6TzObaMDFyyyIDUIMPBJ8	false	sufficient binding region:41-355(IPR001478)|his tag:?-?	sufficient binding region:416-499|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10499	uniprotkb:P78352	intact:EBI-631463|ensembl:ENSRNOP00000026731	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:kcna1_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.1(gene name synonym)|uniprotkb:RBKI(gene name synonym)|uniprotkb:RCK1(gene name synonym)|uniprotkb:Kcna1(gene name)|psi-mi:Kcna1(display_short)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Kim et al. (1995)	pubmed:7477295	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2949|refseq:NP_775118.1|go:"GO:0019228"(neuronal action potential)|go:"GO:0021766"(hippocampus development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033270"(paranode region of axon)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034705"(potassium channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0050905"(neuromuscular process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050976"(detection of mechanical stimulus involved in sensory perception of touch)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099508"(voltage-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|go:"GO:1905030"(voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004048(Potassium channel, voltage dependent, Kv1.1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|mint:P10499|rcsb pdb:1EXB|reactome:R-RNO-1296072|ensembl:ENSRNOG00000019750(gene)|ensembl:ENSRNOT00000026731(transcript)|go:"GO:0001964"(startle response)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/08	2014/10/16	rogid:tGnBP9au7V54T4OD+8yaV3c0jss10116	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	intact-crc:7C827DAC52B73892|rigid:IyIutCpIxZzkby0q8X6hMLlV5zQ	false	sufficient binding region:?-?|glutathione s tranferase tag:?-?	sufficient binding region:41-355(IPR001478)|his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15384	uniprotkb:P78352	intact:EBI-631478|ensembl:ENSRNOP00000075761	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:kcna3_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.3(gene name synonym)|uniprotkb:RGK5(gene name synonym)|uniprotkb:RCK3(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv3(gene name synonym)|uniprotkb:Kcna3(gene name)|psi-mi:Kcna3(display_short)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Kim et al. (1995)	pubmed:7477295	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631316	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2951|refseq:NP_062143.3|ensembl:ENSRNOG00000062002(gene)|ensembl:ENSRNOT00000092240(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004050(Potassium channel, voltage dependent, Kv1.3)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|reactome:R-RNO-1296072	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/08	2014/10/16	rogid:y10hZkJ4zgRH2q54L6Cx5qFBJJU10116	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	intact-crc:4F50C928425937C4|rigid:b+/LuTgDDkVleYXteO8rhKVV/Bg	false	sufficient binding region:?-?|glutathione s tranferase tag:?-?	his tag:?-?|sufficient binding region:41-355(IPR001478)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78352	uniprotkb:P15385	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-631417	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:"MI:0047"(far western blotting)	Kim et al. (1995)	pubmed:7477295	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631536	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/08	2014/10/16	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	intact-crc:26791C485A7C870D|rigid:5YtaxAP5vvKKSU51TPS+acffhks	false	his tag:?-?|sufficient binding region:41-355(IPR001478)	sufficient binding region:?-?|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15385	uniprotkb:P78352	intact:EBI-631417	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:kcna4_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.4(gene name synonym)|uniprotkb:RCK4(gene name synonym)|uniprotkb:RHK1(gene name synonym)|uniprotkb:RK3(gene name synonym)|uniprotkb:Kcna4(gene name)|psi-mi:Kcna4(display_short)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kim et al. (1995)	pubmed:7477295	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-631559	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1KN7|rcsb pdb:1ZTO|interpro:IPR005821(Ion transport)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR020467|interpro:IPR012897(Potassium channel, voltage dependent, Kv1.4, tandem inactivation)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|rgd:2952|refseq:NP_037103.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0005216"(ion channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR028325|interpro:IPR027359|interpro:IPR037065|reactome:R-RNO-1296072	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0009986"(cell surface)	-	-	comment:Kv1.4 and PSD-95 are both overexpressed|comment:Kv1.4 and PSD-95 colocalize into irregular patches on the surface of the cells. Some accumulation could also be seen intracellularly in the perinuclear region.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/08/08	2014/10/16	rogid:0e7GqlqkbH1H4oGLEmogZgTlY5410116	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	intact-crc:FFCDC203544ACA32|rigid:5YtaxAP5vvKKSU51TPS+acffhks	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)