#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P01023 uniprotkb:Q8IXA5 intact:EBI-640741|uniprotkb:Q13677|uniprotkb:Q59F47|uniprotkb:Q5QTS0|uniprotkb:Q68DN2|uniprotkb:Q6PIY3|uniprotkb:Q6PN97|ensembl:ENSP00000323929 intact:EBI-640732|uniprotkb:Q7Z4Y5|ensembl:ENSP00000269053 psi-mi:a2mg_human(display_long)|uniprotkb:CPAMD5(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5(gene name synonym)|uniprotkb:A2M(gene name)|psi-mi:A2M(display_short)|uniprotkb:FWP007(orf name) psi-mi:saca3_human(display_long)|uniprotkb:Sperm lysozyme-like protein 1(gene name synonym)|uniprotkb:Lysozyme-like protein 3(gene name synonym)|uniprotkb:Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17(gene name synonym)|uniprotkb:Cancer/testis antigen 54(gene name synonym)|uniprotkb:SPACA3(gene name)|psi-mi:SPACA3(display_short)|uniprotkb:LYC3(gene name synonym)|uniprotkb:LYZL3(gene name synonym)|uniprotkb:SLLP1(gene name synonym)|uniprotkb:UNQ424/PRO862(orf name)|uniprotkb:SPRASA(gene name synonym)|uniprotkb:Sperm protein reactive with antisperm antibodies(gene name synonym) psi-mi:"MI:0071"(molecular sieving) - (1988) pubmed:2467766 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-640762 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000005.2|refseq:NP_001334352.1|refseq:NP_001334353.1|refseq:NP_001334354.1|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P01023|rcsb pdb:1BV8|rcsb pdb:2P9R|rcsb pdb:4ACQ|rcsb pdb:6TAV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-1474228|reactome:R-HSA-8963896|ensembl:ENSG00000175899(gene)|ensembl:ENST00000318602(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|dip:DIP-1118N refseq:NP_776246.1|refseq:NP_001304155.1|ensembl:ENSG00000141316(gene)|ensembl:ENST00000269053(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0035036"(sperm-egg recognition)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042117"(monocyte activation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR000974(Glycoside hydrolase, family 22, lysozyme)|interpro:IPR001916(Glycoside hydrolase, family 22)|interpro:IPR019799|interpro:IPR023346|interpro:IPR030058 - - - disease:myeloid leukaemia taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/22 2014/10/16 rogid:FClLRDrtOWUx0eBBCUfAocx0Q+49606 rogid:6e2ehR7c2ANIcXYgv4/UiUpvqhI9606 intact-crc:7744A490D802F71D|rigid:ibNGVgRvlZ8tufvCFe8P3EBvQek false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot)