#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16875	uniprotkb:Q16875	intact:EBI-764464|uniprotkb:Q5VX18|uniprotkb:O43622|uniprotkb:O75902|intact:EBI-2834088|uniprotkb:Q5VX19|uniprotkb:B7Z955|uniprotkb:Q5VX15|ensembl:ENSP00000369100	intact:EBI-764464|uniprotkb:Q5VX18|uniprotkb:O43622|uniprotkb:O75902|intact:EBI-2834088|uniprotkb:Q5VX19|uniprotkb:B7Z955|uniprotkb:Q5VX15|ensembl:ENSP00000369100	psi-mi:f263_human(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme(gene name synonym)|uniprotkb:iPFK-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-56(gene name synonym)|uniprotkb:PFKFB3(gene name)|psi-mi:PFKFB3(display_short)	psi-mi:f263_human(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme(gene name synonym)|uniprotkb:iPFK-2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-56(gene name synonym)|uniprotkb:PFKFB3(gene name)|psi-mi:PFKFB3(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Kim et al. (2006)	pubmed:16316985	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-764483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004557.1|refseq:NP_001269559.1|refseq:NP_001300992.1|dip:DIP-33964N|ensembl:ENSG00000170525(gene)|ensembl:ENST00000379775(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0007420"(brain development)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:2AXN|rcsb pdb:2DWO|rcsb pdb:2DWP|rcsb pdb:2I1V|rcsb pdb:3QPU|rcsb pdb:3QPV|rcsb pdb:3QPW|rcsb pdb:4D4J|rcsb pdb:4D4K|rcsb pdb:4D4L|rcsb pdb:4D4M|rcsb pdb:4MA4|rcsb pdb:5AJV|rcsb pdb:5AJW|rcsb pdb:5AJX|rcsb pdb:5AJY|rcsb pdb:5AJZ|rcsb pdb:5AK0|rcsb pdb:6ETJ|rcsb pdb:6HVH|rcsb pdb:6HVI|rcsb pdb:6HVJ|rcsb pdb:6IBX|rcsb pdb:6IBY|rcsb pdb:6IBZ|rcsb pdb:6IC0|reactome:R-HSA-9634600|interpro:IPR013079(6-phosphofructo-2-kinase)	refseq:NP_004557.1|refseq:NP_001269559.1|refseq:NP_001300992.1|dip:DIP-33964N|ensembl:ENSG00000170525(gene)|ensembl:ENST00000379775(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0007420"(brain development)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:2AXN|rcsb pdb:2DWO|rcsb pdb:2DWP|rcsb pdb:2I1V|rcsb pdb:3QPU|rcsb pdb:3QPV|rcsb pdb:3QPW|rcsb pdb:4D4J|rcsb pdb:4D4K|rcsb pdb:4D4L|rcsb pdb:4D4M|rcsb pdb:4MA4|rcsb pdb:5AJV|rcsb pdb:5AJW|rcsb pdb:5AJX|rcsb pdb:5AJY|rcsb pdb:5AJZ|rcsb pdb:5AK0|rcsb pdb:6ETJ|rcsb pdb:6HVH|rcsb pdb:6HVI|rcsb pdb:6HVJ|rcsb pdb:6IBX|rcsb pdb:6IBY|rcsb pdb:6IBZ|rcsb pdb:6IC0|reactome:R-HSA-9634600|interpro:IPR013079(6-phosphofructo-2-kinase)	go:"GO:0042803"(protein homodimerization activity)	-	-	3d-resolution:2.1A|3d-structure:Head-to-head functional dimerization. The beta-hairpin N-terminus interacts with the 2-Pase domain to secure binding of fructose-6-phosphate to the active pocket|comment:Crystal also contains ATP, EDTA and fructose -6-phosphate|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/06	2014/10/16	rogid:BPxZYy35rU3GFHZ0+i9FpfTQh9s9606	rogid:BPxZYy35rU3GFHZ0+i9FpfTQh9s9606	intact-crc:06F8AB4F3D5EDC75|rigid:did9ShD7dNFEEFlOI68LhBogS/k	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)