#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07141	uniprotkb:P05480	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-298680|ensembl:ENSMUSP00000029175|ensembl:ENSMUSP00000105157|ensembl:ENSMUSP00000105159|uniprotkb:Q2M4I4|intact:EBI-7361449|intact:MINT-142018|uniprotkb:F8WI90	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:src_mouse(display_long)|uniprotkb:Src(gene name)|psi-mi:Src(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777167|imex:IM-16654-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P05480|rcsb pdb:6F3F|reactome:R-MMU-1227986|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-177929|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-191650|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418885|reactome:R-MMU-430116|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-456926|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-6811558|reactome:R-MMU-69231|reactome:R-MMU-8853659|reactome:R-MMU-8874081|reactome:R-MMU-8934903|reactome:R-MMU-8941858|reactome:R-MMU-9009391|reactome:R-MMU-9603381|ensembl:ENSMUSG00000027646(gene)|ensembl:ENSMUST00000029175(transcript)|ensembl:ENSMUST00000109531(transcript)|ensembl:ENSMUST00000109533(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|refseq:NP_001020566.1|refseq:NP_033297.2|dip:DIP-31071N	-	-	-	comment:"The tyrosine phosphorylated (phos-GST-CSF-1R) form of the colony stimulating factor protein (CSF1) interacted with Src."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:SY8bQUpE/ni7hRMp4F02ygRsU7Q10090	intact-crc:8DF1C0892B74068F|rigid:C1te7jIpIFxYJ34JtmBKtjAsfa4	false	binding-associated region:?-?|glutathione s tranferase tag:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07141	uniprotkb:P05480	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-298680|ensembl:ENSMUSP00000029175|ensembl:ENSMUSP00000105157|ensembl:ENSMUSP00000105159|uniprotkb:Q2M4I4|intact:EBI-7361449|intact:MINT-142018|uniprotkb:F8WI90	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:src_mouse(display_long)|uniprotkb:Src(gene name)|psi-mi:Src(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777183|imex:IM-16654-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P05480|rcsb pdb:6F3F|reactome:R-MMU-1227986|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-177929|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-191650|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418885|reactome:R-MMU-430116|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-456926|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-6811558|reactome:R-MMU-69231|reactome:R-MMU-8853659|reactome:R-MMU-8874081|reactome:R-MMU-8934903|reactome:R-MMU-8941858|reactome:R-MMU-9009391|reactome:R-MMU-9603381|ensembl:ENSMUSG00000027646(gene)|ensembl:ENSMUST00000029175(transcript)|ensembl:ENSMUST00000109531(transcript)|ensembl:ENSMUST00000109533(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|refseq:NP_001020566.1|refseq:NP_033297.2|dip:DIP-31071N	-	-	-	comment:"The cell line was treated with CSF-1 (5000 U/mL) for 4 min prior to immunoprecipitation."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:SY8bQUpE/ni7hRMp4F02ygRsU7Q10090	intact-crc:039E4DC821D9E4A9|rigid:C1te7jIpIFxYJ34JtmBKtjAsfa4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07141	uniprotkb:Q91ZI0	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777614|uniprotkb:E9QLD7|uniprotkb:Q9ESD0|ensembl:ENSMUSP00000024238	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:celr3_mouse(display_long)|uniprotkb:Celsr3(gene name)|psi-mi:Celsr3(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_536685.2|ensembl:ENSMUSG00000023473(gene)|ensembl:ENSMUST00000024238(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0036514"(dopaminergic neuron axon guidance)|go:"GO:0036515"(serotonergic neuron axon guidance)|go:"GO:0060271"(cilium assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904938"(planar cell polarity pathway involved in axon guidance)|interpro:IPR000203(GPS)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001791(Laminin G)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002126(Cadherin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR017981|interpro:IPR017983|interpro:IPR020894|interpro:IPR032471|interpro:IPR036445	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:ixVvroqu1zJRLFI4OtCrPiJtBD010090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q61879	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-400918|uniprotkb:Q5SV63|ensembl:ENSMUSP00000099671	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:myh10_mouse(display_long)|uniprotkb:Myh10(gene name)|psi-mi:Myh10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_780469.1|ensembl:ENSMUSG00000020900(gene)|ensembl:ENSMUST00000102611(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006887"(exocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007155"(cell adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0021592"(fourth ventricle development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021678"(third ventricle development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035904"(aorta development)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070650"(actin filament bundle distribution)|go:"GO:0097513"(myosin II filament)|dip:DIP-31956N|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q61879|reactome:R-MMU-5627123	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:DE0ILvXp+FsQ8J8yXJ38FaeQtzM10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q5SUA5	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777663|ensembl:ENSMUSP00000003459|uniprotkb:Q8BJ17|uniprotkb:Q8BJ65|uniprotkb:Q8R019|uniprotkb:Q91ZI1|uniprotkb:Q8BIT8	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:myo1g_mouse(display_long)|uniprotkb:Myo1g(gene name)|psi-mi:Myo1g(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	ensembl:ENSMUSG00000020437(gene)|ensembl:ENSMUST00000003459(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_848534.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0071976"(cell gliding)|go:"GO:0120117"(T cell meandering migration)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961|mint:Q5SUA5	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:mIzhibZW73U3Fz9pkzll2qGaTPs10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q8VDD5	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-400906|intact:EBI-777674|uniprotkb:Q3UHT9|uniprotkb:Q3UHU4|uniprotkb:Q6KAN6|uniprotkb:Q811I2|ensembl:ENSMUSP00000016771	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:myh9_mouse(display_long)|uniprotkb:Myh9(gene name)|psi-mi:Myh9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_071855.2|ensembl:ENSMUSG00000022443(gene)|ensembl:ENSMUST00000016771(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0097513"(myosin II filament)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q8VDD5|reactome:R-MMU-2029482|reactome:R-MMU-5627123|dip:DIP-29546N	go:"GO:0043235"(receptor complex)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:AAAC0E83A0A4F24A	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:qYfcGuWOF9npzsKD3zXTuLeP9iE10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q8CDB0	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	intact:EBI-777680	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	-	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:q8r384_mouse(display_short)|psi-mi:EBI-777680(display_long)|uniprotkb:Myh11(gene name)|psi-mi:Myh11(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	uniprotkb:Q8R384(uniprot-removed-ac)	go:"GO:0043235"(receptor complex)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:TxiIMpGdH+OGcNqJuULBYMH7gsk10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q60625	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777635|intact:EBI-2935094|uniprotkb:Q2KHL7|uniprotkb:Q3UY19|ensembl:ENSMUSP00000019616|uniprotkb:G5E826	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:icam5_mouse(display_long)|uniprotkb:Telencephalin(gene name synonym)|uniprotkb:Icam5(gene name)|psi-mi:Icam5(display_short)|uniprotkb:Tlcn(gene name synonym)|uniprotkb:Icam3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	reactome:R-MMU-198933|reactome:R-MMU-216083|ensembl:ENSMUSG00000032174(gene)|ensembl:ENSMUST00000019616(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q60625|refseq:NP_032345.2	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:A5LktyV63FCm8TYD3ChcBoYslPc10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q05512	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-771728|uniprotkb:Q3T9L3|uniprotkb:Q6PDR4|uniprotkb:Q8BR95	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:mark2_mouse(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:Mark2(gene name)|psi-mi:Mark2(display_short)|uniprotkb:Emk(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_001073857.1|refseq:NP_001073858.1|refseq:NP_001073859.1|refseq:NP_031954.2|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028375|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001764"(neuron migration)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045180"(basal cortex)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:RiipGX3uA3cvQACWclxzpLcJQVU10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P97492	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777515|uniprotkb:Q8K2R4|uniprotkb:Q9DCD1|ensembl:ENSMUSP00000068731	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:rgs14_mouse(display_long)|uniprotkb:RAP1/RAP2-interacting protein(gene name synonym)|uniprotkb:Rgs14(gene name)|psi-mi:Rgs14(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_058038.2|ensembl:ENSMUSG00000052087(gene)|ensembl:ENSMUST00000063771(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0010070"(zygote asymmetric cell division)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR030776|interpro:IPR036305|interpro:IPR037881|mint:P97492|rcsb pdb:1WFY|reactome:R-MMU-418594	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:O73EfOPRre1FWzqHxYas4Z2pl0w10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q9JKF1	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-644633|ensembl:ENSMUSP00000128278|uniprotkb:G3UW45	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:iqga1_mouse(display_long)|uniprotkb:Iqgap1(gene name)|psi-mi:Iqgap1(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|ensembl:ENSMUSG00000030536(gene)|ensembl:ENSMUST00000167377(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0031252"(cell leading edge)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:Q9JKF1|reactome:R-MMU-373753|reactome:R-MMU-5626467|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-MMU-9013149|refseq:NP_057930.2|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:qjWT+er4GkLOlebk3zzRHh2Iqoo10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q9D8N0	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-773880|uniprotkb:Q920C5|uniprotkb:Q9CRT5|uniprotkb:Q9CSU3|uniprotkb:Q9D004|ensembl:ENSMUSP00000093955	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:ef1g_mouse(display_long)|uniprotkb:eEF-1B gamma(gene name synonym)|uniprotkb:Eef1g(gene name)|psi-mi:Eef1g(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	go:"GO:0003746"(translation elongation factor activity)|dip:DIP-32124N|refseq:NP_080283.3|ensembl:ENSMUSG00000071644(gene)|ensembl:ENSMUST00000052248(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:Q9D8N0|reactome:R-MMU-156842	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:TsONpdlsFR2YmfxQmAH4ByI5/Bg10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q3UMT1	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777536|uniprotkb:Q9CWD5|ensembl:ENSMUSP00000013886	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:pp12c_mouse(display_long)|uniprotkb:Mbs85(gene name synonym)|uniprotkb:Protein phosphatase 1 myosin-binding subunit of 85 kDa(gene name synonym)|uniprotkb:Ppp1r12c(gene name)|psi-mi:Ppp1r12c(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_084110.2|ensembl:ENSMUSG00000019254(gene)|ensembl:ENSMUST00000013886(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031205|interpro:IPR031775|interpro:IPR036770	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:P0dbzzJxTgykm70hPSpY+Be9KaU10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q9ERE9	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-74576|ensembl:ENSMUSP00000023291|uniprotkb:Q9CXI4	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:jip2_mouse(display_long)|uniprotkb:Mapk8ip2(gene name)|psi-mi:Mapk8ip2(display_short)|uniprotkb:Ib2(gene name synonym)|uniprotkb:Jip2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	ensembl:ENSMUSG00000022619(gene)|ensembl:ENSMUST00000023291(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0035176"(social behavior)|go:"GO:0007617"(mating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|interpro:IPR001452(Src homology-3)|go:"GO:0019894"(kinesin binding)|interpro:IPR006020(Phosphotyrosine interaction region)|go:"GO:0019901"(protein kinase binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q9ERE9|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|refseq:NP_068740.3	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:NUVswDC52pSAuf8BL8b9wqVc8ng10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q09143	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777580|ensembl:ENSMUSP00000046714|uniprotkb:P30824	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:sl7a1_mouse(display_long)|uniprotkb:System Y+ basic amino acid transporter(gene name synonym)|uniprotkb:Solute carrier family 7 member 1(gene name synonym)|uniprotkb:Ecotropic retroviral leukemia receptor(gene name synonym)|uniprotkb:Ecotropic retrovirus receptor(gene name synonym)|uniprotkb:Slc7a1(gene name)|psi-mi:Slc7a1(display_short)|uniprotkb:Atrc1(gene name synonym)|uniprotkb:Rec-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	ensembl:ENSMUSG00000041313(gene)|ensembl:ENSMUST00000048116(transcript)|go:"GO:0000064"(L-ornithine transmembrane transporter activity)|go:"GO:0005290"(L-histidine transmembrane transporter activity)|refseq:NP_031539.3|refseq:NP_001288353.1|refseq:XP_006504859.1|go:"GO:0005886"(plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015174"(basic amino acid transmembrane transporter activity)|go:"GO:0015181"|go:"GO:0015189"(L-lysine transmembrane transporter activity)|go:"GO:0015807"(L-amino acid transport)|go:"GO:0015809"|go:"GO:0015819"(lysine transport)|go:"GO:0015822"(ornithine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:0097638"(L-arginine import across plasma membrane)|go:"GO:1903352"(L-ornithine transmembrane transport)|go:"GO:1903810"(L-histidine import across plasma membrane)|go:"GO:1903826"(L-arginine transmembrane transport)|go:"GO:1990822"(basic amino acid transmembrane transport)|interpro:IPR002293(Amino acid/polyamine transporter I)|interpro:IPR004755(Cationic amino acid transport permease)|interpro:IPR029485|reactome:R-MMU-352230	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:x24XgCGl6nugnBQXyRfEdXcOUMI10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:O35099	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P10107	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-647848|ensembl:ENSMUSP00000025561|ensembl:ENSMUSP00000158305	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:anxa1_mouse(display_long)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Anxa1(gene name)|psi-mi:Anxa1(display_short)|uniprotkb:Anx1(gene name synonym)|uniprotkb:Lpc1(gene name synonym)|uniprotkb:Lpc-1(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_034860.2|ensembl:ENSMUSG00000024659(gene)|ensembl:ENSMUST00000025561(transcript)|ensembl:ENSMUST00000235280(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P10107|reactome:R-MMU-416476|reactome:R-MMU-418594|reactome:R-MMU-444473|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:V9sZHzXdA0iCeXidE8a0ahnWFoE10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P70336	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-771800|uniprotkb:Q8BR64|uniprotkb:Q8CBR0|uniprotkb:A5XDA7	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:rock2_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 2(gene name synonym)|uniprotkb:p164 ROCK-2(gene name synonym)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase II(gene name synonym)|uniprotkb:Rock2(gene name)|psi-mi:Rock2(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_033098.2|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR015008(Rho Binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011072(HR1 rho-binding repeat)|mint:P70336|interpro:IPR037311|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0150033"(negative regulation of protein localization to lysosome)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:XGh4GUDWts/RI6osd4zKXeh0lAE10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:O89051	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777528|uniprotkb:Q545S7|ensembl:ENSMUSP00000022704	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:itm2b_mouse(display_long)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Itm2b(gene name)|psi-mi:Itm2b(display_short)|uniprotkb:Immature BRI2(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_032436.1|ensembl:ENSMUSG00000022108(gene)|ensembl:ENSMUST00000022704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR007084(BRICHOS)|interpro:IPR040145	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:JJmwqKAmZ6AGiFHXltZdO80MUnI10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P22366	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q61084	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-446250|ensembl:ENSMUSP00000002044	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:O88329	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777541|uniprotkb:B2RW65|ensembl:ENSMUSP00000078540	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:myo1a_mouse(display_long)|uniprotkb:Brush border myosin I(gene name synonym)|uniprotkb:Myosin I heavy chain(gene name synonym)|uniprotkb:Myo1a(gene name)|psi-mi:Myo1a(display_short)|uniprotkb:Bbmi(gene name synonym)|uniprotkb:Myhl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_001074688.1|refseq:XP_006513922.1|refseq:XP_006513923.1|ensembl:ENSMUSG00000025401(gene)|ensembl:ENSMUST00000079590(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0030030"(cell projection organization)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0051015"(actin filament binding)|go:"GO:0051648"(vesicle localization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:q74WF4tGDx09AZud9paCFw53jnM10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q99104	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q62120	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-646604|uniprotkb:Q7TQD0|uniprotkb:Q62124|intact:EBI-16039126|ensembl:ENSMUSP00000025705|ensembl:ENSMUSP00000064394|ensembl:ENSMUSP00000158242|uniprotkb:G5E852	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:jak2_mouse(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:Jak2(gene name)|psi-mi:Jak2(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_001041642.1|refseq:NP_032439.2|dip:DIP-320N|ensembl:ENSMUSG00000024789(gene)|ensembl:ENSMUST00000025705(transcript)|ensembl:ENSMUST00000065796(transcript)|ensembl:ENSMUST00000238009(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097012"(response to granulocyte macrophage colony-stimulating factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0098794"(postsynapse)|interpro:IPR019749|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0020037"(heme binding)|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:Q62120|rcsb pdb:2HDX|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-110056|interpro:IPR020635|reactome:R-MMU-112411|reactome:R-MMU-1170546|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034050"(programmed cell death induced by symbiont)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|reactome:R-MMU-512988|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-69231|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-9020591|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912526|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|reactome:R-MMU-983231|reactome:R-MMU-1433557|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0012505"(endomembrane system)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-60238N|refseq:XP_011245457.1	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:pdjCNCHmNTiJ1gGtJyiWoGgtq4I10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q9R0Y5	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777466|uniprotkb:A2AK80|uniprotkb:Q542C5|uniprotkb:Q9R0Y4|ensembl:ENSMUSP00000108902|ensembl:ENSMUSP00000108903	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:kad1_mouse(display_long)|uniprotkb:ATP-AMP transphosphorylase 1(gene name synonym)|uniprotkb:Myokinase(gene name synonym)|uniprotkb:Ak1(gene name)|psi-mi:Ak1(display_short)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_001185719.1|refseq:NP_001185720.1|refseq:NP_001185721.1|refseq:NP_067490.1|refseq:XP_006497687.1|ensembl:ENSMUSG00000026817(gene)|ensembl:ENSMUST00000113277(transcript)|ensembl:ENSMUST00000113278(transcript)|go:"GO:0001520"(outer dense fiber)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0030017"(sarcomere)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043005"(neuron projection)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046103"(inosine biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006267(Adenylate kinase, isozyme 1)|interpro:IPR027417|interpro:IPR028582|interpro:IPR033690|mint:Q9R0Y5|reactome:R-MMU-499943	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:HTydMeIFNEaVZDs7sEN7aLieuVg10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P58281	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-776163|uniprotkb:Q3ULA5|uniprotkb:Q8BKU7|uniprotkb:Q8BLL3|uniprotkb:Q8BM08|uniprotkb:Q8R3J7|uniprotkb:A6H6Q3|ensembl:ENSMUSP00000124223	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:opa1_mouse(display_long)|uniprotkb:Optic atrophy protein 1 homolog(gene name synonym)|uniprotkb:Large GTP-binding protein(gene name synonym)|uniprotkb:Opa1(gene name)|psi-mi:Opa1(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_598513.1|refseq:XP_006522720.1|ensembl:ENSMUSG00000038084(gene)|ensembl:ENSMUST00000160597(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:P58281|reactome:R-MMU-169911	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:cj1HZs8CYUuCBy4KhYmtO/lvmUk10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q99MR9	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777504|uniprotkb:Q32MS0|uniprotkb:Q8BUJ4|uniprotkb:Q8BUL0|ensembl:ENSMUSP00000049054	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:ppr3a_mouse(display_long)|uniprotkb:Protein phosphatase 1 glycogen-associated regulatory subunit(gene name synonym)|uniprotkb:Protein phosphatase type-1 glycogen targeting subunit(gene name synonym)|uniprotkb:Ppp1r3a(gene name)|psi-mi:Ppp1r3a(display_short)|uniprotkb:Pp1g(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_536712.2|ensembl:ENSMUSG00000042717(gene)|ensembl:ENSMUST00000045096(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:2001069"(glycogen binding)|interpro:IPR005036(Putative phosphatase regulatory subunit)|interpro:IPR038175|mint:Q99MR9	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:89I6gnZquuUFCWRqj6qNp2zwh3A10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P48025	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-300116|ensembl:ENSMUSP00000060828|ensembl:ENSMUSP00000113852	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:ksyk_mouse(display_long)|uniprotkb:Syk(gene name)|psi-mi:Syk(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:Sykb(gene name synonym)|uniprotkb:ptk72(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	ensembl:ENSMUST00000055087(transcript)|ensembl:ENSMUST00000120135(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001820"(serotonin secretion)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSMUSG00000021457(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016170"(interleukin-15 receptor binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P48025|rcsb pdb:2LCT|rcsb pdb:2MC1|reactome:R-MMU-114604|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-5621480|reactome:R-MMU-9020558|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-9706374|reactome:R-MMU-983695|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|refseq:NP_001185906.1|refseq:NP_035648.2|refseq:XP_006516958.1|dip:DIP-32621N	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:ojAGyI+gLZF5ThLd+bsHfMdjaM010090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P60710	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q9WTI7	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777558|ensembl:ENSMUSP00000099563|uniprotkb:Q3TBQ4|uniprotkb:Q3U231|uniprotkb:Q5ND46|uniprotkb:Q5ND48|uniprotkb:Q5ND49|uniprotkb:Q9ERB6|uniprotkb:O08571|uniprotkb:O08834|uniprotkb:Q9QW54	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:myo1c_mouse(display_long)|uniprotkb:Myosin I beta(gene name synonym)|uniprotkb:Myo1c(gene name)|psi-mi:Myo1c(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	ensembl:ENSMUSG00000017774(gene)|ensembl:ENSMUST00000102505(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0006605"(protein targeting)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007015"(actin filament organization)|mint:Q9WTI7|rcsb pdb:4R8G|reactome:R-MMU-2029482|reactome:R-MMU-5250924|interpro:IPR036961|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016604"(nuclear body)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060171"(stereocilium membrane)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|refseq:NP_001074243.1|refseq:NP_001074244.1|refseq:NP_032685.1|refseq:XP_006532492.1|dip:DIP-35498N	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:E25nufEJATQnH9pvQlkmAdEOAd810090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q9JHU4	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P21107	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-776207|uniprotkb:Q09021|uniprotkb:Q60606|uniprotkb:Q80SW6|uniprotkb:Q9EPW3	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:tpm3_mouse(display_long)|uniprotkb:Tropomyosin-3(gene name synonym)|uniprotkb:Gamma-tropomyosin(gene name synonym)|uniprotkb:Tpm3(gene name)|psi-mi:Tpm3(display_short)|uniprotkb:Tpm5(gene name synonym)|uniprotkb:Tpm-5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_001280677.2|refseq:NP_001240667.1|dip:DIP-32061N|mint:P21107|go:"GO:0001725"(stress fiber)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030426"(growth cone)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0043005"(neuron projection)|go:"GO:0051015"(actin filament binding)|interpro:IPR000533(Tropomyosin)|reactome:R-MMU-390522|reactome:R-MMU-445355|reactome:R-MMU-9013424	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:fJgTJbCwMWQpH+QngGu5tejwrOo10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P10126	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-773865|uniprotkb:Q61511|uniprotkb:Q6ZWN2|uniprotkb:Q8BMB8|uniprotkb:Q8BVS8|uniprotkb:Q99KU5|ensembl:ENSMUSP00000042457	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:ef1a1_mouse(display_long)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Eef1a1(gene name)|psi-mi:Eef1a1(display_short)|uniprotkb:Eef1a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	dip:DIP-46609N|refseq:NP_034236.2|ensembl:ENSMUSG00000037742(gene)|ensembl:ENSMUST00000042235(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P10126|reactome:R-MMU-156842|reactome:R-MMU-3371511|reactome:R-MMU-6798695|reactome:R-MMU-8876725	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:85G9Uje743KzA02bB/rmKuq2HbU10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q80X90	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-688023|intact:EBI-777273|uniprotkb:E9QNV9|uniprotkb:Q8VHX4|uniprotkb:Q8VHX7|uniprotkb:Q99KY3|ensembl:ENSMUSP00000052020	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:flnb_mouse(display_long)|uniprotkb:Flnb(gene name)|psi-mi:Flnb(display_short)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_001074896.1|ensembl:ENSMUSG00000025278(gene)|ensembl:ENSMUST00000052678(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:Q80X90|reactome:R-MMU-1169408|go:"GO:0005737"(cytoplasm)	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:A5bnyO/GwzIgn56NbxZGMkAWYk410090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P47753	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777259|uniprotkb:Q91YN7	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:caza1_mouse(display_long)|uniprotkb:CapZ alpha-1(gene name synonym)|uniprotkb:Capza1(gene name)|psi-mi:Capza1(display_short)|uniprotkb:Cappa1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	interpro:IPR017865|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR042276|interpro:IPR037282|mint:P47753|interpro:IPR042489|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0034329"(cell junction assembly)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0071203"(WASH complex)|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:RHqr2/WSAoIXWooDhXO9/TSiTJ010090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P26450	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q8C161	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777252	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:q8c161_mouse(display_long)|uniprotkb:Aar2(gene name)|psi-mi:Aar2(display_short)|uniprotkb:0610011L14Rik(gene name synonym)|uniprotkb:Protein AAR2 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	interpro:IPR007946(AAR2)|refseq:NP_001158290.1|refseq:NP_080937.3|interpro:IPR033647|interpro:IPR033648|interpro:IPR038514|interpro:IPR038516	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:mmQ8YkaEvV5DinA4ebLspxo++ng10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q60771	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-309095|uniprotkb:Q545N5|uniprotkb:Q9DB65|ensembl:ENSMUSP00000042181	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:cld11_mouse(display_long)|uniprotkb:Cldn11(gene name)|psi-mi:Cldn11(display_short)|uniprotkb:Osp(gene name synonym)|uniprotkb:Otm(gene name synonym)|uniprotkb:Oligodendrocyte transmembrane protein(gene name synonym)|uniprotkb:Oligodendrocyte-specific protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_032796.1|go:"GO:0043209"(myelin sheath)|go:"GO:0045178"(basal part of cell)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0120192"(tight junction assembly)|interpro:IPR003555(Claudin-11)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|mint:Q60771|go:"GO:0042802"(identical protein binding)|ensembl:ENSMUSG00000037625(gene)|ensembl:ENSMUST00000046174(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005811"(lipid droplet)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008366"(axon ensheathment)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:1I/ICdyJVOlbV4pOjsnnEU1xbs810090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P97797	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-644732|uniprotkb:O08907|uniprotkb:O35924|uniprotkb:O88555|uniprotkb:O88556|uniprotkb:P97796|uniprotkb:Q8R559|uniprotkb:Q9QX57|uniprotkb:Q9WTN4|ensembl:ENSMUSP00000049022|ensembl:ENSMUSP00000124048|uniprotkb:A0A0R4J1Z7|uniprotkb:E0CYM8|uniprotkb:E9QPT7	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:shps1_mouse(display_long)|uniprotkb:Inhibitory receptor SHPS-1(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-1(gene name synonym)|uniprotkb:MyD-1 antigen(gene name synonym)|uniprotkb:Brain Ig-like molecule with tyrosine-based activation motifs(gene name synonym)|uniprotkb:p84(gene name synonym)|uniprotkb:CD172 antigen-like family member A(gene name synonym)|uniprotkb:Sirp(gene name synonym)|uniprotkb:Sirpa(gene name)|psi-mi:Sirpa(display_short)|uniprotkb:Bit(gene name synonym)|uniprotkb:Myd1(gene name synonym)|uniprotkb:Shps1(gene name synonym)|uniprotkb:Ptpns1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:XP_017172050.1|refseq:NP_001277950.1|refseq:XP_006499049.1|refseq:XP_017172057.1|refseq:NP_001171118.1|refseq:NP_031573.2|ensembl:ENSMUSG00000037902(gene)|ensembl:ENSMUST00000049262(transcript)|ensembl:ENSMUST00000161620(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0071641"(negative regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0097530"(granulocyte migration)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P97797|rcsb pdb:2YZ1|reactome:R-MMU-202733|reactome:R-MMU-2172127|reactome:R-MMU-391160|reactome:R-MMU-6798695|go:"GO:0050765"(negative regulation of phagocytosis)|refseq:NP_001277948.1|refseq:NP_001277949.1|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|refseq:XP_017172058.1	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:v0FShADF6c2OXAD2gmm2P0Kkv8c10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:P16858	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-444871|uniprotkb:Q0QEU0|uniprotkb:Q3THM2|uniprotkb:Q3TUI2|uniprotkb:Q3UMT2|uniprotkb:Q4V783|uniprotkb:Q569X2|uniprotkb:Q569X5|uniprotkb:Q5U410|uniprotkb:A6H6A8|ensembl:ENSMUSP00000073289|ensembl:ENSMUSP00000113213	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:g3p_mouse(display_long)|uniprotkb:Gapdh(gene name)|psi-mi:Gapdh(display_short)|uniprotkb:Gapd(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_032110.1|refseq:XP_001476757.1|ensembl:ENSMUSG00000057666(gene)|ensembl:ENSMUST00000073605(transcript)|ensembl:ENSMUST00000118875(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031906"(late endosome lumen)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0060359"(response to ammonium ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P16858|rcsb pdb:6LGJ|rcsb pdb:6LGK|rcsb pdb:6LGM|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001276655.1|dip:DIP-31404N	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:SkcdXZ+143DDQFioo6mNWNpCLTI10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q8C078	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-937199|uniprotkb:Q80TS0|uniprotkb:Q8BXM8|uniprotkb:Q8C0G3|uniprotkb:Q8CH42|uniprotkb:Q8QZT7|ensembl:ENSMUSP00000107297	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:kkcc2_mouse(display_long)|uniprotkb:Camkk2(gene name)|psi-mi:Camkk2(display_short)|uniprotkb:Kiaa0787(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777246|imex:IM-16654-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_001186605.1|refseq:NP_663333.1|refseq:XP_006530293.1|refseq:XP_006530294.1|refseq:XP_017176252.1|ensembl:ENSMUSG00000029471(gene)|ensembl:ENSMUST00000111668(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q8C078|reactome:R-MMU-111932|reactome:R-MMU-442729|reactome:R-MMU-9619229	go:"GO:0043235"(receptor complex)	-	-	caution:"The participant EBI-644633(Q9JKF1) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Proteins were identified by either LC-MS/MS or MALDI-TOF (see text for details)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/21	2021/02/11	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:sfp+8Ypk+JBYWVwzYsGqAXqZVTY10090	intact-crc:9A3A453E2153E3A1|rigid:4kOtGCOxpqAagChIXNOhWDfOXAQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?|O4'-phospho-L-tyrosine:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07141	uniprotkb:Q8C161	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-777252	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:q8c161_mouse(display_long)|uniprotkb:Aar2(gene name)|psi-mi:Aar2(display_short)|uniprotkb:0610011L14Rik(gene name synonym)|uniprotkb:Protein AAR2 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777312|imex:IM-16654-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	interpro:IPR007946(AAR2)|refseq:NP_001158290.1|refseq:NP_080937.3|interpro:IPR033647|interpro:IPR033648|interpro:IPR038514|interpro:IPR038516	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2005/12/21	2014/10/16	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:mmQ8YkaEvV5DinA4ebLspxo++ng10090	intact-crc:4670B3C0C104ECB5|rigid:oDFSSnOAto3rFCZawDSna+ReCII	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07141	uniprotkb:Q9JHU4	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777326|imex:IM-16654-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2005/12/21	2014/10/16	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	intact-crc:119EAF5696215028|rigid:pMugWliFwJnq/9uuoX/rI3r2gyY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60771	uniprotkb:P07141	intact:EBI-309095|uniprotkb:Q545N5|uniprotkb:Q9DB65|ensembl:ENSMUSP00000042181	intact:EBI-777188|uniprotkb:Q8R3C8|uniprotkb:Q3U395|intact:EBI-9021585|ensembl:ENSMUSP00000014743|ensembl:ENSMUSP00000113617	psi-mi:cld11_mouse(display_long)|uniprotkb:Cldn11(gene name)|psi-mi:Cldn11(display_short)|uniprotkb:Osp(gene name synonym)|uniprotkb:Otm(gene name synonym)|uniprotkb:Oligodendrocyte transmembrane protein(gene name synonym)|uniprotkb:Oligodendrocyte-specific protein(gene name synonym)	psi-mi:csf1_mouse(display_long)|uniprotkb:Csf1(gene name)|psi-mi:Csf1(display_short)|uniprotkb:Csfm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cross et al. (2005)	pubmed:16267818|imex:IM-16654	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-777333|imex:IM-16654-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032796.1|go:"GO:0043209"(myelin sheath)|go:"GO:0045178"(basal part of cell)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0120192"(tight junction assembly)|interpro:IPR003555(Claudin-11)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|mint:Q60771|go:"GO:0042802"(identical protein binding)|ensembl:ENSMUSG00000037625(gene)|ensembl:ENSMUST00000046174(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005811"(lipid droplet)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008366"(axon ensheathment)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)	refseq:NP_001107001.1|refseq:NP_001107002.1|refseq:NP_031804.3|dip:DIP-45278N|ensembl:ENSMUSG00000014599(gene)|ensembl:ENSMUST00000014743(transcript)|ensembl:ENSMUST00000120243(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1990682"(CSF1-CSF1R complex)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:3EJJ|rcsb pdb:3UF5|rcsb pdb:4ADQ|reactome:R-MMU-381426|reactome:R-MMU-449836|reactome:R-MMU-8957275	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2005/12/21	2014/10/16	rogid:1I/ICdyJVOlbV4pOjsnnEU1xbs810090	rogid:CiLReZXSftU5lfagfLadW9BVqPE10090	intact-crc:5CD79E2F9401E47F|rigid:JeIGEf54hatn/RaXxWWD3QPnwNI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)