#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P51813 uniprotkb:P11309-1 intact:EBI-696657|uniprotkb:A6NIH9|uniprotkb:O60564|uniprotkb:Q12871|ensembl:ENSP00000308774|ensembl:ENSP00000340082|ensembl:ENSP00000350224 intact:EBI-1018629|ensembl:ENSP00000362608 psi-mi:bmx_human(display_long)|uniprotkb:Bone marrow tyrosine kinase gene in chromosome X protein(gene name synonym)|uniprotkb:Epithelial and endothelial tyrosine kinase(gene name synonym)|uniprotkb:NTK38(gene name synonym)|uniprotkb:BMX(gene name)|psi-mi:BMX(display_short) psi-mi:p11309-1(display_long)|uniprotkb:Pim-1(isoform synonym)|uniprotkb:PIM1(gene name)|psi-mi:PIM1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xie et al. (2006) imex:IM-14937|pubmed:16186805|mint:MINT-5217965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-783609 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001712.1|refseq:NP_975010.1|refseq:NP_001307795.1|ensembl:ENSG00000102010(gene)|ensembl:ENST00000342014(transcript)|ensembl:ENST00000348343(transcript)|ensembl:ENST00000357607(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007498"(mesoderm development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028840|interpro:IPR035875|interpro:IPR036860|rcsb pdb:2EKX|rcsb pdb:2YS2|rcsb pdb:3SXR|rcsb pdb:3SXS|rcsb pdb:6I99|reactome:R-HSA-111465|reactome:R-HSA-1660499 intact:EBI-696621(pim1_human)|ensembl:ENSG00000137193(gene)|ensembl:ENST00000373509(transcript) intact:EBI-696637(see-also) - isoform-comment:Initiates from CTG codon. figure legend:4a|comment:"BMX associates with PIM1L (UniProt identifier /FTId=PRO_0000043349) but not the shorter isoform PIM1S, prodiced by alternative promoter usage (UniProt identifier /FTId=PRO_0000043350)."|caution:"Author also performs experiments (Fig. 4B) to demonstrate binding of SH3 domain of BMX (ETK) to PIM1L. However, BMX does not contain an SH3 domain and sequence co-ordinates are not given, so this information has not been added."|negative:The interaction does not occur under these experimental conditions.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2005/10/07 2018/10/22 rogid:vEWqPrMe5xCQRPeNReXM+8Djcjg9606 rogid:wB5jDvcfExiTZHKSMOeAOMHQacs9606 intact-crc:F1E0659338A2ADE6|rigid:hIBwPhnzLK6KvN8qNbaptji7F30 true t7 tag:?-? flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P11309-1 uniprotkb:P51813 intact:EBI-1018629|ensembl:ENSP00000362608 intact:EBI-696657|uniprotkb:A6NIH9|uniprotkb:O60564|uniprotkb:Q12871|ensembl:ENSP00000308774|ensembl:ENSP00000340082|ensembl:ENSP00000350224 psi-mi:p11309-1(display_long)|uniprotkb:Pim-1(isoform synonym)|uniprotkb:PIM1(gene name)|psi-mi:PIM1(display_short) psi-mi:bmx_human(display_long)|uniprotkb:Bone marrow tyrosine kinase gene in chromosome X protein(gene name synonym)|uniprotkb:Epithelial and endothelial tyrosine kinase(gene name synonym)|uniprotkb:NTK38(gene name synonym)|uniprotkb:BMX(gene name)|psi-mi:BMX(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xie et al. (2006) imex:IM-14937|pubmed:16186805|mint:MINT-5217965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-783639 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-696621(pim1_human)|ensembl:ENSG00000137193(gene)|ensembl:ENST00000373509(transcript) refseq:NP_001712.1|refseq:NP_975010.1|refseq:NP_001307795.1|ensembl:ENSG00000102010(gene)|ensembl:ENST00000342014(transcript)|ensembl:ENST00000348343(transcript)|ensembl:ENST00000357607(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007498"(mesoderm development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028840|interpro:IPR035875|interpro:IPR036860|rcsb pdb:2EKX|rcsb pdb:2YS2|rcsb pdb:3SXR|rcsb pdb:3SXS|rcsb pdb:6I99|reactome:R-HSA-111465|reactome:R-HSA-1660499 intact:EBI-782980(see-also) isoform-comment:Initiates from CTG codon. - figure legend:4a|comment:"BMX associates with PIM1L (UniProt identifier /FTId=PRO_0000043349) but not the shorter isoform PIM1S, prodiced by alternative promoter usage (UniProt identifier /FTId=PRO_0000043350)."|caution:"Author also performs experiments (Fig. 4B) to demonstrate binding of SH3 domain of BMX (ETK) to PIM1L. However, BMX does not contain an SH3 domain and sequence co-ordinates are not given, so this information has not been added."|negative:The interaction does not occur under these experimental conditions.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-22rv1)|taxid:9606(Homo sapiens) - 2005/10/07 2018/10/22 rogid:wB5jDvcfExiTZHKSMOeAOMHQacs9606 rogid:vEWqPrMe5xCQRPeNReXM+8Djcjg9606 intact-crc:907A1534B7BD170B|rigid:hIBwPhnzLK6KvN8qNbaptji7F30 true flag tag:n-n t7 tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P11309-1 uniprotkb:P51813 intact:EBI-1018629|ensembl:ENSP00000362608 intact:EBI-696657|uniprotkb:A6NIH9|uniprotkb:O60564|uniprotkb:Q12871|ensembl:ENSP00000308774|ensembl:ENSP00000340082|ensembl:ENSP00000350224 psi-mi:p11309-1(display_long)|uniprotkb:Pim-1(isoform synonym)|uniprotkb:PIM1(gene name)|psi-mi:PIM1(display_short) psi-mi:bmx_human(display_long)|uniprotkb:Bone marrow tyrosine kinase gene in chromosome X protein(gene name synonym)|uniprotkb:Epithelial and endothelial tyrosine kinase(gene name synonym)|uniprotkb:NTK38(gene name synonym)|uniprotkb:BMX(gene name)|psi-mi:BMX(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xie et al. (2006) imex:IM-14937|pubmed:16186805|mint:MINT-5217965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-783652 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-696621(pim1_human)|ensembl:ENSG00000137193(gene)|ensembl:ENST00000373509(transcript) refseq:NP_001712.1|refseq:NP_975010.1|refseq:NP_001307795.1|ensembl:ENSG00000102010(gene)|ensembl:ENST00000342014(transcript)|ensembl:ENST00000348343(transcript)|ensembl:ENST00000357607(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007498"(mesoderm development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028840|interpro:IPR035875|interpro:IPR036860|rcsb pdb:2EKX|rcsb pdb:2YS2|rcsb pdb:3SXR|rcsb pdb:3SXS|rcsb pdb:6I99|reactome:R-HSA-111465|reactome:R-HSA-1660499 intact:EBI-782988(see-also) isoform-comment:Initiates from CTG codon. - figure legend:4a|comment:"BMX associates with PIM1L (UniProt identifier /FTId=PRO_0000043349) but not the shorter isoform PIM1S, prodiced by alternative promoter usage (UniProt identifier /FTId=PRO_0000043350)."|caution:"Author also performs experiments (Fig. 4B) to demonstrate binding of SH3 domain of BMX (ETK) to PIM1L. However, BMX does not contain an SH3 domain and sequence co-ordinates are not given, so this information has not been added."|negative:The interaction does not occur under these experimental conditions.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-22rv1)|taxid:9606(Homo sapiens) - 2005/10/07 2018/10/22 rogid:wB5jDvcfExiTZHKSMOeAOMHQacs9606 rogid:vEWqPrMe5xCQRPeNReXM+8Djcjg9606 intact-crc:AFC6DF125B56AF2D|rigid:hIBwPhnzLK6KvN8qNbaptji7F30 true flag tag:n-n t7 tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)