#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P69616	uniprotkb:O43291	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	intact:EBI-7810230|ensembl:ENSP00000301244|intact:MINT-1366946|uniprotkb:Q5TZQ3|uniprotkb:O14895|uniprotkb:B4DLU1|uniprotkb:Q969E0|uniprotkb:O00271|uniprotkb:A8K667	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:spit2_human(display_long)|uniprotkb:SPINT2(gene name)|psi-mi:SPINT2(display_short)|uniprotkb:HAI2(gene name synonym)|uniprotkb:KOP(gene name synonym)|uniprotkb:Placental bikunin(gene name synonym)|uniprotkb:Hepatocyte growth factor activator inhibitor type 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810224|mint:MINT-68726	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1366976(identity)	ensembl:ENSG00000167642(gene)|ensembl:ENST00000301244(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:4U32|reactome:R-HSA-6806942|reactome:R-HSA-8852405|refseq:NP_001159575.1|refseq:NP_066925.1|mint:MINT-1366983(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa|comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2005/10/31	2014/10/16	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	rogid:LC/m9zTMejqOhCn30qBZFKSKBws9606	intact-crc:B6AD6F923C123F9D|rigid:Y9oGaQDpR3CPOMktp5NsmTPrVCc	false	tag:?-?(MINT-1366977)	tag:?-?(MINT-1366984)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P69616	uniprotkb:P02760	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	intact:EBI-2115136|uniprotkb:P00977|uniprotkb:P02759|uniprotkb:P78491|uniprotkb:Q2TU33|uniprotkb:Q5TBD7|uniprotkb:Q9UC58|uniprotkb:Q9UDI8|ensembl:ENSP00000265132	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:ambp_human(display_long)|uniprotkb:AMBP(gene name)|psi-mi:AMBP(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:ITIL(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810311|mint:MINT-68719	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367063(identity)	refseq:NP_001624.1|ensembl:ENSG00000106927(gene)|ensembl:ENST00000265132(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019862"(IgA binding)|go:"GO:0020037"(heme binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046904"(calcium oxalate binding)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002968(Alpha-1-microglobulin)|interpro:IPR012674(Calycin)|interpro:IPR020901|interpro:IPR022272|interpro:IPR029856|interpro:IPR036880|rcsb pdb:1BIK|rcsb pdb:3QKG|rcsb pdb:4ES7|rcsb pdb:4U30|rcsb pdb:6EJ7|rcsb pdb:6EJ8|rcsb pdb:6EJ9|rcsb pdb:6EJA|rcsb pdb:6EJB|rcsb pdb:6EJC|rcsb pdb:6EJD|reactome:R-HSA-2168880|mint:MINT-1367070(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2005/10/31	2014/10/16	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	rogid:os91tgT4TUMZ1qCf3SRbW5mwlGI9606	intact-crc:5350F16582F98C21|rigid:0jH+NYF2Nwvn0gysWGCU1pHcKGI	false	tag:?-?(MINT-1367064)	binding-associated region:20-203(MINT-1367071)|tag:?-?(MINT-1367074)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P69616	uniprotkb:O43291	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	intact:EBI-7810230|ensembl:ENSP00000301244|intact:MINT-1366946|uniprotkb:Q5TZQ3|uniprotkb:O14895|uniprotkb:B4DLU1|uniprotkb:Q969E0|uniprotkb:O00271|uniprotkb:A8K667	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:spit2_human(display_long)|uniprotkb:SPINT2(gene name)|psi-mi:SPINT2(display_short)|uniprotkb:HAI2(gene name synonym)|uniprotkb:KOP(gene name synonym)|uniprotkb:Placental bikunin(gene name synonym)|uniprotkb:Hepatocyte growth factor activator inhibitor type 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810334|mint:MINT-68720	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367154(identity)	ensembl:ENSG00000167642(gene)|ensembl:ENST00000301244(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:4U32|reactome:R-HSA-6806942|reactome:R-HSA-8852405|refseq:NP_001159575.1|refseq:NP_066925.1|mint:MINT-1367163(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa|comment:"Stoichiometry: 1.0"	figure legend:F1 F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2005/10/31	2014/10/16	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	rogid:LC/m9zTMejqOhCn30qBZFKSKBws9606	intact-crc:B48EAF9602DA1337|rigid:Y9oGaQDpR3CPOMktp5NsmTPrVCc	false	binding-associated region:83-114(MINT-1367155)|tag:?-?(MINT-1367157)	tag:?-?(MINT-1367166)|binding-associated region:1-145(MINT-1367164)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03499	uniprotkb:O43291	intact:EBI-7810404|intact:MINT-1366996	intact:EBI-7810230|ensembl:ENSP00000301244|intact:MINT-1366946|uniprotkb:Q5TZQ3|uniprotkb:O14895|uniprotkb:B4DLU1|uniprotkb:Q969E0|uniprotkb:O00271|uniprotkb:A8K667	psi-mi:orf3_hevme(display_long)|uniprotkb:ORF3(orf name)	psi-mi:spit2_human(display_long)|uniprotkb:SPINT2(gene name)|psi-mi:SPINT2(display_short)|uniprotkb:HAI2(gene name synonym)|uniprotkb:KOP(gene name synonym)|uniprotkb:Placental bikunin(gene name synonym)|uniprotkb:Hepatocyte growth factor activator inhibitor type 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:31768(hev-2)|taxid:31768("Hepatitis E virus genotype 2 (isolate Human/Mexico)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810398|mint:MINT-68722	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367002(identity)	ensembl:ENSG00000167642(gene)|ensembl:ENST00000301244(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:4U32|reactome:R-HSA-6806942|reactome:R-HSA-8852405|refseq:NP_001159575.1|refseq:NP_066925.1|mint:MINT-1367009(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2005/10/31	2014/10/16	rogid:wnWEjIMkqqeC1wh2kxYySUFyZPg31768	rogid:LC/m9zTMejqOhCn30qBZFKSKBws9606	intact-crc:0185CE1661E077C0|rigid:8Co5zXhwTHu1aulZq3ZFepXQgwg	false	tag:?-?(MINT-1367003)	tag:?-?(MINT-1367010)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P69616	uniprotkb:P69616	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:"MI:0018"(two hybrid)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810360|mint:MINT-68721	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367090(identity)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367083(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2005/10/31	2014/10/16	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	intact-crc:76CC4DFDCDA52303|rigid:k3LVMlMZLyCoKLhhZh384PQ7esc	false	tag:?-?(MINT-1367091)	tag:?-?(MINT-1367084)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P69616	uniprotkb:P02760	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	intact:EBI-2115136|uniprotkb:P00977|uniprotkb:P02759|uniprotkb:P78491|uniprotkb:Q2TU33|uniprotkb:Q5TBD7|uniprotkb:Q9UC58|uniprotkb:Q9UDI8|ensembl:ENSP00000265132	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:ambp_human(display_long)|uniprotkb:AMBP(gene name)|psi-mi:AMBP(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:ITIL(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810426|mint:MINT-68729	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367184(identity)	refseq:NP_001624.1|ensembl:ENSG00000106927(gene)|ensembl:ENST00000265132(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019862"(IgA binding)|go:"GO:0020037"(heme binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046904"(calcium oxalate binding)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002968(Alpha-1-microglobulin)|interpro:IPR012674(Calycin)|interpro:IPR020901|interpro:IPR022272|interpro:IPR029856|interpro:IPR036880|rcsb pdb:1BIK|rcsb pdb:3QKG|rcsb pdb:4ES7|rcsb pdb:4U30|rcsb pdb:6EJ7|rcsb pdb:6EJ8|rcsb pdb:6EJ9|rcsb pdb:6EJA|rcsb pdb:6EJB|rcsb pdb:6EJC|rcsb pdb:6EJD|reactome:R-HSA-2168880|mint:MINT-1367175(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2005/10/31	2014/10/16	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	rogid:os91tgT4TUMZ1qCf3SRbW5mwlGI9606	intact-crc:CBB2DC9F90090743|rigid:0jH+NYF2Nwvn0gysWGCU1pHcKGI	false	tag:?-?(MINT-1367187)|binding-associated region:1-114(MINT-1367185)	tag:?-?(MINT-1367178)|binding-associated region:1-350(MINT-1367176)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43291	uniprotkb:P69616	intact:EBI-7810230|ensembl:ENSP00000301244|intact:MINT-1366946|uniprotkb:Q5TZQ3|uniprotkb:O14895|uniprotkb:B4DLU1|uniprotkb:Q969E0|uniprotkb:O00271|uniprotkb:A8K667	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	psi-mi:spit2_human(display_long)|uniprotkb:SPINT2(gene name)|psi-mi:SPINT2(display_short)|uniprotkb:HAI2(gene name synonym)|uniprotkb:KOP(gene name synonym)|uniprotkb:Placental bikunin(gene name synonym)|uniprotkb:Hepatocyte growth factor activator inhibitor type 2(gene name synonym)	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:"MI:0096"(pull down)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810460|mint:MINT-68723	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167642(gene)|ensembl:ENST00000301244(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:4U32|reactome:R-HSA-6806942|reactome:R-HSA-8852405|refseq:NP_001159575.1|refseq:NP_066925.1|mint:MINT-1367203(identity)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367196(identity)	-	comment:mint|function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/10/31	2014/10/16	rogid:LC/m9zTMejqOhCn30qBZFKSKBws9606	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	intact-crc:9EC4D0F98DE04E0D|rigid:Y9oGaQDpR3CPOMktp5NsmTPrVCc	false	-	his tag:?-?(MINT-1367197)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P69616	uniprotkb:P02760	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	intact:EBI-2115136|uniprotkb:P00977|uniprotkb:P02759|uniprotkb:P78491|uniprotkb:Q2TU33|uniprotkb:Q5TBD7|uniprotkb:Q9UC58|uniprotkb:Q9UDI8|ensembl:ENSP00000265132	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:ambp_human(display_long)|uniprotkb:AMBP(gene name)|psi-mi:AMBP(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:ITIL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810490|mint:MINT-68725	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367102(identity)	refseq:NP_001624.1|ensembl:ENSG00000106927(gene)|ensembl:ENST00000265132(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019862"(IgA binding)|go:"GO:0020037"(heme binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046904"(calcium oxalate binding)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002968(Alpha-1-microglobulin)|interpro:IPR012674(Calycin)|interpro:IPR020901|interpro:IPR022272|interpro:IPR029856|interpro:IPR036880|rcsb pdb:1BIK|rcsb pdb:3QKG|rcsb pdb:4ES7|rcsb pdb:4U30|rcsb pdb:6EJ7|rcsb pdb:6EJ8|rcsb pdb:6EJ9|rcsb pdb:6EJA|rcsb pdb:6EJB|rcsb pdb:6EJC|rcsb pdb:6EJD|reactome:R-HSA-2168880|mint:MINT-1367109(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/10/31	2014/10/16	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	rogid:os91tgT4TUMZ1qCf3SRbW5mwlGI9606	intact-crc:E912F89B9F509CAC|rigid:0jH+NYF2Nwvn0gysWGCU1pHcKGI	false	his tag:?-?(MINT-1367103)	binding-associated region:20-203(MINT-1367110)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P69616	uniprotkb:P02760	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	intact:EBI-2115136|uniprotkb:P00977|uniprotkb:P02759|uniprotkb:P78491|uniprotkb:Q2TU33|uniprotkb:Q5TBD7|uniprotkb:Q9UC58|uniprotkb:Q9UDI8|ensembl:ENSP00000265132	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:ambp_human(display_long)|uniprotkb:AMBP(gene name)|psi-mi:AMBP(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:ITIL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810475|mint:MINT-68724	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367211(identity)	refseq:NP_001624.1|ensembl:ENSG00000106927(gene)|ensembl:ENST00000265132(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019862"(IgA binding)|go:"GO:0020037"(heme binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046904"(calcium oxalate binding)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002968(Alpha-1-microglobulin)|interpro:IPR012674(Calycin)|interpro:IPR020901|interpro:IPR022272|interpro:IPR029856|interpro:IPR036880|rcsb pdb:1BIK|rcsb pdb:3QKG|rcsb pdb:4ES7|rcsb pdb:4U30|rcsb pdb:6EJ7|rcsb pdb:6EJ8|rcsb pdb:6EJ9|rcsb pdb:6EJA|rcsb pdb:6EJB|rcsb pdb:6EJC|rcsb pdb:6EJD|reactome:R-HSA-2168880|mint:MINT-1367218(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/10/31	2014/10/16	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	rogid:os91tgT4TUMZ1qCf3SRbW5mwlGI9606	intact-crc:B767340AC8999F77|rigid:0jH+NYF2Nwvn0gysWGCU1pHcKGI	false	his tag:?-?(MINT-1367212)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43291	uniprotkb:P69616	intact:EBI-7810230|ensembl:ENSP00000301244|intact:MINT-1366946|uniprotkb:Q5TZQ3|uniprotkb:O14895|uniprotkb:B4DLU1|uniprotkb:Q969E0|uniprotkb:O00271|uniprotkb:A8K667	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	psi-mi:spit2_human(display_long)|uniprotkb:SPINT2(gene name)|psi-mi:SPINT2(display_short)|uniprotkb:HAI2(gene name synonym)|uniprotkb:KOP(gene name synonym)|uniprotkb:Placental bikunin(gene name synonym)|uniprotkb:Hepatocyte growth factor activator inhibitor type 2(gene name synonym)	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810537|mint:MINT-68727	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167642(gene)|ensembl:ENST00000301244(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:4U32|reactome:R-HSA-6806942|reactome:R-HSA-8852405|refseq:NP_001159575.1|refseq:NP_066925.1|mint:MINT-1367129(identity)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367124(identity)	-	comment:mint|function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2005/10/31	2014/10/16	rogid:LC/m9zTMejqOhCn30qBZFKSKBws9606	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	intact-crc:DD416181DD769963|rigid:Y9oGaQDpR3CPOMktp5NsmTPrVCc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43291	uniprotkb:P69616	intact:EBI-7810230|ensembl:ENSP00000301244|intact:MINT-1366946|uniprotkb:Q5TZQ3|uniprotkb:O14895|uniprotkb:B4DLU1|uniprotkb:Q969E0|uniprotkb:O00271|uniprotkb:A8K667	intact:EBI-7810260|uniprotkb:P29325|intact:MINT-1366939	psi-mi:spit2_human(display_long)|uniprotkb:SPINT2(gene name)|psi-mi:SPINT2(display_short)|uniprotkb:HAI2(gene name synonym)|uniprotkb:KOP(gene name synonym)|uniprotkb:Placental bikunin(gene name synonym)|uniprotkb:Hepatocyte growth factor activator inhibitor type 2(gene name synonym)	psi-mi:orf3_hevbu(display_long)|uniprotkb:ORF3(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Tyagi et al. (2005)	pubmed:16140784|mint:MINT-5217939|doi:10.1128/JVI.79.18.12081-12087.2005	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31767(hevbu)|taxid:31767("Hepatitis E virus genotype 1 (isolate Human/Burma)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7810557|mint:MINT-68728	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167642(gene)|ensembl:ENST00000301244(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:4U32|reactome:R-HSA-6806942|reactome:R-HSA-8852405|refseq:NP_001159575.1|refseq:NP_066925.1|mint:MINT-1367146(identity)	go:"GO:0016021"(integral component of membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|rcsb pdb:2ZZQ|interpro:IPR003384(Hepatitis E virus ORF-2 capsid protein)|mint:MINT-1367139(identity)	go:"GO:0005737"(cytoplasm)	comment:mint|function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2005/10/31	2014/10/16	rogid:LC/m9zTMejqOhCn30qBZFKSKBws9606	rogid:HfRYA8K/pwX8H7nIbH4g7QlVpUc31767	intact-crc:05226B1754A9B9B8|rigid:Y9oGaQDpR3CPOMktp5NsmTPrVCc	false	-	tag:?-?(MINT-1367140)	-	-	psi-mi:"MI:0709"(polyclonal antibody immunostaining)	psi-mi:"MI:0708"(monoclonal antibody immunostaining)