#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q62165 uniprotkb:Q05793 intact:EBI-2878952|uniprotkb:Q61094|uniprotkb:Q61141|uniprotkb:Q61497|ensembl:ENSMUSP00000079294|ensembl:ENSMUSP00000128531|ensembl:ENSMUSP00000130626|ensembl:ENSMUSP00000142109 intact:EBI-1032089 psi-mi:dag1_mouse(display_long)|uniprotkb:Dag1(gene name)|psi-mi:Dag1(display_short)|uniprotkb:Dystrophin-associated glycoprotein 1(gene name synonym)|uniprotkb:Dystroglycan(gene name synonym) psi-mi:pgbm_mouse(display_long)|uniprotkb:Hspg2(gene name)|psi-mi:Hspg2(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Kanagawa et al. (2005) pubmed:16098969|imex:IM-11032|mint:MINT-5217908|doi:10.1016/j.febslet.2005.07.059 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7783638|mint:MINT-62554|imex:IM-11032-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001263410.1|refseq:NP_001263411.1|refseq:NP_001263414.1|refseq:NP_001263415.1|refseq:NP_001263421.1|refseq:NP_001263422.1|refseq:NP_034147.1|refseq:XP_006511699.1|ensembl:ENSMUSG00000039952(gene)|ensembl:ENSMUST00000080435(transcript)|ensembl:ENSMUST00000166905(transcript)|ensembl:ENSMUST00000171412(transcript)|ensembl:ENSMUST00000191899(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016011"(dystroglycan complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016203"(muscle attachment)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017166"(vinculin binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0021675"(nerve development)|go:"GO:0021682"(nerve maturation)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0070938"(contractile ring)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0071711"(basement membrane organization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR006644(Dystroglycan-type cadherin-like)|interpro:IPR008465(Dystroglycan)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015919(Cadherin-like)|interpro:IPR027468|interpro:IPR030398|interpro:IPR041631|mint:Q62165|rcsb pdb:1U2C|rcsb pdb:4WIQ|rcsb pdb:5N30|rcsb pdb:5N4H|reactome:R-MMU-3000178|reactome:R-MMU-5173105|reactome:R-MMU-9010553|mint:MINT-1365455(identity) refseq:NP_032331.2|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR000034(Laminin B)|interpro:IPR001791(Laminin G)|interpro:IPR000082(SEA)|interpro:IPR023415|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002020"(protease binding)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|rcsb pdb:1GL4|reactome:R-MMU-1474228|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-975634|mint:Q05793|interpro:IPR036055|interpro:IPR036179|mint:MINT-1365459(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/26 2014/10/16 rogid:eNEkukP8dp54BA24gR5sbtHLO6g10090 rogid:cSZXdrVzYrrPDxo2+9QWAlImMbQ10090 intact-crc:B534283ADC8D2E51|rigid:Ba9+fcCOnr8Yzeg1OiZXf3gRmPU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62165 uniprotkb:Q05793 intact:EBI-2878952|uniprotkb:Q61094|uniprotkb:Q61141|uniprotkb:Q61497|ensembl:ENSMUSP00000079294|ensembl:ENSMUSP00000128531|ensembl:ENSMUSP00000130626|ensembl:ENSMUSP00000142109 intact:EBI-1032089 psi-mi:dag1_mouse(display_long)|uniprotkb:Dag1(gene name)|psi-mi:Dag1(display_short)|uniprotkb:Dystrophin-associated glycoprotein 1(gene name synonym)|uniprotkb:Dystroglycan(gene name synonym) psi-mi:pgbm_mouse(display_long)|uniprotkb:Hspg2(gene name)|psi-mi:Hspg2(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Kanagawa et al. (2005) pubmed:16098969|imex:IM-11032|mint:MINT-5217908|doi:10.1016/j.febslet.2005.07.059 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7783650|mint:MINT-62556|imex:IM-11032-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001263410.1|refseq:NP_001263411.1|refseq:NP_001263414.1|refseq:NP_001263415.1|refseq:NP_001263421.1|refseq:NP_001263422.1|refseq:NP_034147.1|refseq:XP_006511699.1|ensembl:ENSMUSG00000039952(gene)|ensembl:ENSMUST00000080435(transcript)|ensembl:ENSMUST00000166905(transcript)|ensembl:ENSMUST00000171412(transcript)|ensembl:ENSMUST00000191899(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016011"(dystroglycan complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016203"(muscle attachment)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017166"(vinculin binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0021675"(nerve development)|go:"GO:0021682"(nerve maturation)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0070938"(contractile ring)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0071711"(basement membrane organization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR006644(Dystroglycan-type cadherin-like)|interpro:IPR008465(Dystroglycan)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015919(Cadherin-like)|interpro:IPR027468|interpro:IPR030398|interpro:IPR041631|mint:Q62165|rcsb pdb:1U2C|rcsb pdb:4WIQ|rcsb pdb:5N30|rcsb pdb:5N4H|reactome:R-MMU-3000178|reactome:R-MMU-5173105|reactome:R-MMU-9010553|mint:MINT-1365467(identity) refseq:NP_032331.2|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR000034(Laminin B)|interpro:IPR001791(Laminin G)|interpro:IPR000082(SEA)|interpro:IPR023415|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002020"(protease binding)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|rcsb pdb:1GL4|reactome:R-MMU-1474228|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-975634|mint:Q05793|interpro:IPR036055|interpro:IPR036179|mint:MINT-1365471(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/26 2014/10/16 rogid:eNEkukP8dp54BA24gR5sbtHLO6g10090 rogid:cSZXdrVzYrrPDxo2+9QWAlImMbQ10090 intact-crc:BF82C406D5973A33|rigid:Ba9+fcCOnr8Yzeg1OiZXf3gRmPU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)