#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04656	uniprotkb:Q5EBL8	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-1644207|uniprotkb:Q6UWE1|uniprotkb:Q9P0Q1|uniprotkb:D3DVU3|ensembl:ENSP00000239666|ensembl:ENSP00000363578	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:pdz11_human(display_long)|uniprotkb:PDZD11(gene name)|psi-mi:PDZD11(display_short)|uniprotkb:PDZK11(gene name synonym)|uniprotkb:AIPP1(gene name synonym)|uniprotkb:ATPase-interacting PDZ protein(gene name synonym)|uniprotkb:PISP(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase-interacting single-PDZ protein(gene name synonym)|uniprotkb:HSPC227(orf name)|uniprotkb:UNQ6486/PRO21335(orf name)	psi-mi:"MI:0397"(two hybrid array)	Stephenson et al. (2005)	pubmed:16051599|mint:MINT-5217853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706519|mint:MINT-66000	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1|mint:MINT-1352473(identity)	refseq:XP_011529275.1|refseq:NP_057568.1|refseq:XP_016885057.1|ensembl:ENSG00000120509(gene)|ensembl:ENST00000239666(transcript)|ensembl:ENST00000374454(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0098793"(presynapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q5EBL8|reactome:R-HSA-196780|reactome:R-HSA-199220|reactome:R-HSA-425397|reactome:R-HSA-6803544|reactome:R-HSA-936837|mint:MINT-1352482(identity)	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/10/17	2018/09/18	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:lbIwGsi2cawUe/V0/Km+ek9pOIE9606	intact-crc:B9C5ED741BE6CE2A|rigid:/LddbenyhumnDF9+a2JFTsrTtms	false	binding-associated region:1484-1500(MINT-1352474)|tag:?-?(MINT-1352477)	tag:?-?(MINT-1352486)|binding-associated region:1-139(MINT-1352483)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q04656	uniprotkb:Q5EBL8	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-1644207|uniprotkb:Q6UWE1|uniprotkb:Q9P0Q1|uniprotkb:D3DVU3|ensembl:ENSP00000239666|ensembl:ENSP00000363578	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:pdz11_human(display_long)|uniprotkb:PDZD11(gene name)|psi-mi:PDZD11(display_short)|uniprotkb:PDZK11(gene name synonym)|uniprotkb:AIPP1(gene name synonym)|uniprotkb:ATPase-interacting PDZ protein(gene name synonym)|uniprotkb:PISP(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase-interacting single-PDZ protein(gene name synonym)|uniprotkb:HSPC227(orf name)|uniprotkb:UNQ6486/PRO21335(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Stephenson et al. (2005)	pubmed:16051599|mint:MINT-5217853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706804|mint:MINT-65999	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1|mint:MINT-1352496(identity)	refseq:XP_011529275.1|refseq:NP_057568.1|refseq:XP_016885057.1|ensembl:ENSG00000120509(gene)|ensembl:ENST00000239666(transcript)|ensembl:ENST00000374454(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0098793"(presynapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q5EBL8|reactome:R-HSA-196780|reactome:R-HSA-199220|reactome:R-HSA-425397|reactome:R-HSA-6803544|reactome:R-HSA-936837|mint:MINT-1352505(identity)	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/10/17	2018/09/18	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:lbIwGsi2cawUe/V0/Km+ek9pOIE9606	intact-crc:59B7A7837A5FE12C|rigid:/LddbenyhumnDF9+a2JFTsrTtms	false	tag:?-?(MINT-1352500)|binding-associated region:1404-1500(MINT-1352497)	binding-associated region:12-139(MINT-1352506)|tag:?-?(MINT-1352509)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q04656	uniprotkb:Q5EBL8	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-1644207|uniprotkb:Q6UWE1|uniprotkb:Q9P0Q1|uniprotkb:D3DVU3|ensembl:ENSP00000239666|ensembl:ENSP00000363578	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:pdz11_human(display_long)|uniprotkb:PDZD11(gene name)|psi-mi:PDZD11(display_short)|uniprotkb:PDZK11(gene name synonym)|uniprotkb:AIPP1(gene name synonym)|uniprotkb:ATPase-interacting PDZ protein(gene name synonym)|uniprotkb:PISP(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase-interacting single-PDZ protein(gene name synonym)|uniprotkb:HSPC227(orf name)|uniprotkb:UNQ6486/PRO21335(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stephenson et al. (2005)	pubmed:16051599|mint:MINT-5217853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7706924|mint:MINT-66001	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1|mint:MINT-1352520(identity)	refseq:XP_011529275.1|refseq:NP_057568.1|refseq:XP_016885057.1|ensembl:ENSG00000120509(gene)|ensembl:ENST00000239666(transcript)|ensembl:ENST00000374454(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0098793"(presynapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q5EBL8|reactome:R-HSA-196780|reactome:R-HSA-199220|reactome:R-HSA-425397|reactome:R-HSA-6803544|reactome:R-HSA-936837|mint:MINT-1352524(identity)	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:SHORTLABEL human fibroblast|comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2005/10/17	2018/09/18	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:lbIwGsi2cawUe/V0/Km+ek9pOIE9606	intact-crc:AA96E9F5569A19B7|rigid:/LddbenyhumnDF9+a2JFTsrTtms	false	-	binding-associated region:1-139(MINT-1352525)|tag:?-?(MINT-1352528)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q04656	uniprotkb:Q5EBL8	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-1644207|uniprotkb:Q6UWE1|uniprotkb:Q9P0Q1|uniprotkb:D3DVU3|ensembl:ENSP00000239666|ensembl:ENSP00000363578	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:pdz11_human(display_long)|uniprotkb:PDZD11(gene name)|psi-mi:PDZD11(display_short)|uniprotkb:PDZK11(gene name synonym)|uniprotkb:AIPP1(gene name synonym)|uniprotkb:ATPase-interacting PDZ protein(gene name synonym)|uniprotkb:PISP(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase-interacting single-PDZ protein(gene name synonym)|uniprotkb:HSPC227(orf name)|uniprotkb:UNQ6486/PRO21335(orf name)	psi-mi:"MI:0018"(two hybrid)	Stephenson et al. (2005)	pubmed:16051599|mint:MINT-5217853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7707029|mint:MINT-1889644	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1|mint:MINT-1889645(identity)	refseq:XP_011529275.1|refseq:NP_057568.1|refseq:XP_016885057.1|ensembl:ENSG00000120509(gene)|ensembl:ENST00000239666(transcript)|ensembl:ENST00000374454(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0098793"(presynapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q5EBL8|reactome:R-HSA-196780|reactome:R-HSA-199220|reactome:R-HSA-425397|reactome:R-HSA-6803544|reactome:R-HSA-936837|mint:MINT-1889646(identity)	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/10/17	2018/09/18	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:lbIwGsi2cawUe/V0/Km+ek9pOIE9606	intact-crc:57A0D5AEE3F73E6F|rigid:/LddbenyhumnDF9+a2JFTsrTtms	false	binding-associated region:1485-1500(MINT-1889667)|tag:?-?(MINT-1889659)	tag:?-?(MINT-1889651)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q04656	uniprotkb:Q5EBL8	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-1644207|uniprotkb:Q6UWE1|uniprotkb:Q9P0Q1|uniprotkb:D3DVU3|ensembl:ENSP00000239666|ensembl:ENSP00000363578	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:pdz11_human(display_long)|uniprotkb:PDZD11(gene name)|psi-mi:PDZD11(display_short)|uniprotkb:PDZK11(gene name synonym)|uniprotkb:AIPP1(gene name synonym)|uniprotkb:ATPase-interacting PDZ protein(gene name synonym)|uniprotkb:PISP(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase-interacting single-PDZ protein(gene name synonym)|uniprotkb:HSPC227(orf name)|uniprotkb:UNQ6486/PRO21335(orf name)	psi-mi:"MI:0018"(two hybrid)	Stephenson et al. (2005)	pubmed:16051599|mint:MINT-5217853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7707055|mint:MINT-1889721	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1|mint:MINT-1889722(identity)	refseq:XP_011529275.1|refseq:NP_057568.1|refseq:XP_016885057.1|ensembl:ENSG00000120509(gene)|ensembl:ENST00000239666(transcript)|ensembl:ENST00000374454(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0098793"(presynapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q5EBL8|reactome:R-HSA-196780|reactome:R-HSA-199220|reactome:R-HSA-425397|reactome:R-HSA-6803544|reactome:R-HSA-936837|mint:MINT-1889728(identity)	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:Interaction decreases in presence of copper.|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/10/17	2018/09/18	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:lbIwGsi2cawUe/V0/Km+ek9pOIE9606	intact-crc:3543891FBC915B0C|rigid:/LddbenyhumnDF9+a2JFTsrTtms	false	binding-associated region:1404-1500(MINT-1889747)|tag:?-?(MINT-1889745)	tag:?-?(MINT-1889734)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q04656	uniprotkb:Q5EBL8	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-1644207|uniprotkb:Q6UWE1|uniprotkb:Q9P0Q1|uniprotkb:D3DVU3|ensembl:ENSP00000239666|ensembl:ENSP00000363578	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:pdz11_human(display_long)|uniprotkb:PDZD11(gene name)|psi-mi:PDZD11(display_short)|uniprotkb:PDZK11(gene name synonym)|uniprotkb:AIPP1(gene name synonym)|uniprotkb:ATPase-interacting PDZ protein(gene name synonym)|uniprotkb:PISP(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase-interacting single-PDZ protein(gene name synonym)|uniprotkb:HSPC227(orf name)|uniprotkb:UNQ6486/PRO21335(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stephenson et al. (2005)	pubmed:16051599|mint:MINT-5217853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7707216|mint:MINT-1889694	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1|mint:MINT-1889695(identity)	refseq:XP_011529275.1|refseq:NP_057568.1|refseq:XP_016885057.1|ensembl:ENSG00000120509(gene)|ensembl:ENST00000239666(transcript)|ensembl:ENST00000374454(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0098793"(presynapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q5EBL8|reactome:R-HSA-196780|reactome:R-HSA-199220|reactome:R-HSA-425397|reactome:R-HSA-6803544|reactome:R-HSA-936837|mint:MINT-1889705(identity)	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:mint	taxid:9606(human-a12h9)|taxid:9606(Homo sapiens)	-	2005/10/17	2018/09/18	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:lbIwGsi2cawUe/V0/Km+ek9pOIE9606	intact-crc:CB92C3FA37C7F5C4|rigid:/LddbenyhumnDF9+a2JFTsrTtms	false	-	myc tag:n-n(MINT-1889711)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)