#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P42702 uniprotkb:P26441 intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123 intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370 psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short) psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short) psi-mi:"MI:0096"(pull down) He et al. (2005) pubmed:16051226|imex:IM-10976|mint:MINT-5217847 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7702217|mint:MINT-62473|imex:IM-10976-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N|mint:MINT-1352202(identity) refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N|mint:MINT-1352211(identity) - comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A, F2B|comment:INTERACTION IN PRESENCE OF cntfR|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/19 2016/03/29 rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606 rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606 intact-crc:970DC416F4F588A4|rigid:A0O7UwlPzb4LfJGj6MYctGkPfgA false sufficient binding region:49-246(MINT-1352203)|glutathione s tranferase tag:?-?(MINT-1352206)|sufficient binding region:248-333 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P42702 uniprotkb:P15018 intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123 intact:EBI-1037189|uniprotkb:Q52LZ2|uniprotkb:B2RCW7|ensembl:ENSP00000249075|uniprotkb:B5MC23 psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short) psi-mi:lif_human(display_long)|uniprotkb:LIF(gene name)|psi-mi:LIF(display_short)|uniprotkb:HILDA(gene name synonym)|uniprotkb:Differentiation-stimulating factor(gene name synonym)|uniprotkb:Melanoma-derived LPL inhibitor(gene name synonym) psi-mi:"MI:0096"(pull down) He et al. (2005) pubmed:16051226|imex:IM-10976|mint:MINT-5217847 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7702340|mint:MINT-62475|imex:IM-10976-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N|mint:MINT-1352151(identity) refseq:NP_002300.1|refseq:NP_001244064.1|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072108"(positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901676"(positive regulation of histone H3-K27 acetylation)|go:"GO:1903025"(regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR001581(LIF/OSM)|interpro:IPR003624(Leukemia inhibitory factor)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019827|rcsb pdb:1EMR|rcsb pdb:1PVH|rcsb pdb:2Q7N|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|ensembl:ENSG00000128342(gene)|ensembl:ENST00000249075(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005146"(leukemia inhibitory factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007275"(multicellular organism development)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0007566"(embryo implantation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0060707"(trophoblast giant cell differentiation)|dip:DIP-5769N|mint:MINT-1352159(identity) - comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/19 2016/03/29 rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606 rogid:2d7GyGfcJX8JuAWYA3ZIcmwzTbY9606 intact-crc:068CB7310A7967AD|rigid:AvHfTiRwuW2ex02ynHcONUMG7rA false glutathione s tranferase tag:?-?(MINT-1352154)|sufficient binding region:248-333(MINT-1352152)|sufficient binding region:335-533 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P42702 uniprotkb:P13725 intact:EBI-7702162|ensembl:ENSP00000263409|ensembl:ENSP00000398368|uniprotkb:Q6LCD9|intact:MINT-1352123 intact:EBI-6595724|ensembl:ENSP00000215781|uniprotkb:Q6FHP8|uniprotkb:Q9UCP6 psi-mi:lifr_human(display_long)|uniprotkb:LIFR(gene name)|psi-mi:LIFR(display_short) psi-mi:oncm_human(display_long)|uniprotkb:OSM(gene name)|psi-mi:OSM(display_short) psi-mi:"MI:0096"(pull down) He et al. (2005) pubmed:16051226|imex:IM-10976|mint:MINT-5217847 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7702377|mint:MINT-62476|imex:IM-10976-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016864952.1|ensembl:ENSG00000113594(gene)|ensembl:ENST00000263409(transcript)|ensembl:ENST00000453190(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|rcsb pdb:3E0G|reactome:R-HSA-6788467|reactome:R-HSA-8939247|refseq:XP_011512342.1|refseq:XP_011512344.1|refseq:NP_001121143.1|refseq:NP_002301.1|dip:DIP-5770N|mint:MINT-1352221(identity) refseq:NP_001306037.1|ensembl:ENSG00000099985(gene)|ensembl:ENST00000215781(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005147"(oncostatin-M receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0040008"(regulation of growth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR001581(LIF/OSM)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019827|interpro:IPR039578|rcsb pdb:1EVS|reactome:R-HSA-6785807|reactome:R-HSA-6788467|refseq:NP_065391.1|dip:DIP-5785N|mint:MINT-1352229(identity) - comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells|function:"Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue"|function:"A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/19 2016/03/29 rogid:kteW2gF4cZU5b5JOkszDFWsgyN89606 rogid:FWicx3b4mpKm56zEJie/j+82rto9606 intact-crc:9E0E4556E5AE03A5|rigid:Rs0l6oAjL84Wh2wCLikkXmqS7ow false sufficient binding region:248-333(MINT-1352222)|glutathione s tranferase tag:?-?(MINT-1352224)|sufficient binding region:335-533 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P26441 uniprotkb:P40189 intact:EBI-1050897|uniprotkb:B2RAB2|ensembl:ENSP00000355370 intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04 psi-mi:cntf_human(display_long)|uniprotkb:CNTF(gene name)|psi-mi:CNTF(display_short) psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym) psi-mi:"MI:0096"(pull down) He et al. (2005) pubmed:16051226|imex:IM-10976|mint:MINT-5217847 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7702500|mint:MINT-62479|imex:IM-10976-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000605.1|ensembl:ENSG00000242689(gene)|ensembl:ENST00000361987(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR000151(Ciliary neurotrophic factor, CNTF)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1CNT|reactome:R-HSA-6788467|dip:DIP-5776N|mint:MINT-1352262(identity) ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N|mint:MINT-1352254(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4A, F4B|comment:INTERACTION IN PRESENCE OF cntfR|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/19 2016/03/29 rogid:QpzhYYCmOnj8h6rlN3egUhjmnl89606 rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606 intact-crc:342768087A89801E|rigid:UAGzbqFZfhxq3ZCfWzCjE5cq8ao false - glutathione s tranferase tag:?-?(MINT-1352257)|sufficient binding region:23-125(MINT-1352255)|sufficient binding region:125-321 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P40189 uniprotkb:P13725 intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04 intact:EBI-6595724|ensembl:ENSP00000215781|uniprotkb:Q6FHP8|uniprotkb:Q9UCP6 psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym) psi-mi:oncm_human(display_long)|uniprotkb:OSM(gene name)|psi-mi:OSM(display_short) psi-mi:"MI:0096"(pull down) He et al. (2005) pubmed:16051226|imex:IM-10976|mint:MINT-5217847 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7702560|mint:MINT-62481|imex:IM-10976-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N|mint:MINT-1352090(identity) refseq:NP_001306037.1|ensembl:ENSG00000099985(gene)|ensembl:ENST00000215781(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005147"(oncostatin-M receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0040008"(regulation of growth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR001581(LIF/OSM)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019827|interpro:IPR039578|rcsb pdb:1EVS|reactome:R-HSA-6785807|reactome:R-HSA-6788467|refseq:NP_065391.1|dip:DIP-5785N|mint:MINT-1352098(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/19 2016/03/29 rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606 rogid:FWicx3b4mpKm56zEJie/j+82rto9606 intact-crc:4A01E629E290117C|rigid:f7Xzg3u0j1sBXbAPfC7lz2FDXDU false sufficient binding region:23-125(MINT-1352091)|glutathione s tranferase tag:?-?(MINT-1352093)|sufficient binding region:125-321 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P40189 uniprotkb:P15018 intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04 intact:EBI-1037189|uniprotkb:Q52LZ2|uniprotkb:B2RCW7|ensembl:ENSP00000249075|uniprotkb:B5MC23 psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym) psi-mi:lif_human(display_long)|uniprotkb:LIF(gene name)|psi-mi:LIF(display_short)|uniprotkb:HILDA(gene name synonym)|uniprotkb:Differentiation-stimulating factor(gene name synonym)|uniprotkb:Melanoma-derived LPL inhibitor(gene name synonym) psi-mi:"MI:0096"(pull down) He et al. (2005) pubmed:16051226|imex:IM-10976|mint:MINT-5217847 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7702601|mint:MINT-62483|imex:IM-10976-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N|mint:MINT-1352050(identity) refseq:NP_002300.1|refseq:NP_001244064.1|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072108"(positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901676"(positive regulation of histone H3-K27 acetylation)|go:"GO:1903025"(regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR001581(LIF/OSM)|interpro:IPR003624(Leukemia inhibitory factor)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019827|rcsb pdb:1EMR|rcsb pdb:1PVH|rcsb pdb:2Q7N|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|ensembl:ENSG00000128342(gene)|ensembl:ENST00000249075(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005146"(leukemia inhibitory factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007275"(multicellular organism development)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0007566"(embryo implantation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0060707"(trophoblast giant cell differentiation)|dip:DIP-5769N|mint:MINT-1352059(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4C|comment:INTERACTION IN PRESENCE OF lifR|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/19 2014/10/16 rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606 rogid:2d7GyGfcJX8JuAWYA3ZIcmwzTbY9606 intact-crc:79DD98BFFBFF36E0|rigid:cU3+K8RHQJLxPwnVnQvmVlanUI0 false tag:?-?(MINT-1352054)|binding-associated region:125-321(MINT-1352051) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)