#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99PM3 uniprotkb:Q8R4I4 intact:EBI-7640185|ensembl:ENSMUSP00000021345|uniprotkb:Q8C812|intact:MINT-1348159 intact:EBI-7640206|ensembl:ENSMUSP00000024970|uniprotkb:Q9DAF4|uniprotkb:Q99PM2|intact:MINT-1348145 psi-mi:tf2aa_mouse(display_long)|uniprotkb:Gtf2a1(gene name)|psi-mi:Gtf2a1(display_short)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym) psi-mi:tf2ay_mouse(display_long)|uniprotkb:Alf(gene name synonym)|uniprotkb:Gtf2a1lf(gene name synonym)|uniprotkb:Gtf2a1l(gene name)|psi-mi:Gtf2a1l(display_short)|uniprotkb:General transcription factor II A, 1-like factor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Catena et al. (2005) pubmed:15927180|imex:IM-10838|mint:MINT-5217758 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7640230|mint:MINT-62223|imex:IM-10838-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020962(gene)|ensembl:ENSMUST00000021345(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|reactome:R-MMU-674695|reactome:R-MMU-6807505|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|reactome:R-MMU-9018519|refseq:NP_113568.2|refseq:NP_780544.1|mint:MINT-1348222(identity) ensembl:ENSMUSG00000024154(gene)|ensembl:ENSMUST00000024970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0050890"(cognition)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|refseq:NP_076119.2|mint:MINT-1348218(identity) - function:TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity|comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:"May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription"|comment:"Stoichiometry: 1.0" figure legend:F1B|comment:The interaction occurs with both TFIIA alpha and beta isoforms|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2005/08/18 2014/10/16 rogid:1XALkG2DyhbEvv9NPBHJqlfg+b010090 rogid:Yo2Cl+ui7HGZ09BQs7fvPzwQt9w10090 intact-crc:B13D329EE4B5B146|rigid:qSxmVailKC3+83Mse8aG8j4lIPw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q99PM3 uniprotkb:P62340 intact:EBI-7640185|ensembl:ENSMUSP00000021345|uniprotkb:Q8C812|intact:MINT-1348159 intact:EBI-7640256|ensembl:ENSMUSP00000093470|ensembl:ENSMUSP00000114223|uniprotkb:O95753|intact:MINT-1348231|uniprotkb:Q9Z2Z0 psi-mi:tf2aa_mouse(display_long)|uniprotkb:Gtf2a1(gene name)|psi-mi:Gtf2a1(display_short)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym) psi-mi:tbpl1_mouse(display_long)|uniprotkb:Tbpl1(gene name)|psi-mi:Tbpl1(display_short)|uniprotkb:Tlp(gene name synonym)|uniprotkb:Tlp21(gene name synonym)|uniprotkb:Tlf(gene name synonym)|uniprotkb:Trf2(gene name synonym)|uniprotkb:Trp(gene name synonym)|uniprotkb:TATA box-binding protein-related factor 2(gene name synonym)|uniprotkb:TBP-like factor(gene name synonym)|uniprotkb:TBP-related protein(gene name synonym)|uniprotkb:21 kDa TBP-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Catena et al. (2005) pubmed:15927180|imex:IM-10838|mint:MINT-5217758 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7640286|mint:MINT-62225|imex:IM-10838-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020962(gene)|ensembl:ENSMUST00000021345(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|reactome:R-MMU-674695|reactome:R-MMU-6807505|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|reactome:R-MMU-9018519|refseq:NP_113568.2|refseq:NP_780544.1|mint:MINT-1348252(identity) ensembl:ENSMUSG00000071359(gene)|ensembl:ENSMUST00000095794(transcript)|ensembl:ENSMUST00000127698(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001675"(acrosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006235"(dTTP biosynthetic process)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0140223"(general transcription initiation factor activity)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR015445(TATA-Box binding protein-like)|refseq:NP_035733.1|refseq:XP_006512793.1|mint:MINT-1348256(identity) - function:TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity|comment:mint|comment:"Stoichiometry: 1.0" function:Does not bind the TATA box. Has DNA-binding ability|comment:mint|comment:"Stoichiometry: 1.0" figure legend:F1D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2005/08/18 2014/10/16 rogid:1XALkG2DyhbEvv9NPBHJqlfg+b010090 rogid:xMdqGuzUlbzGS1MsLP100y1CiVc10090 intact-crc:48BBFA19C953DD78|rigid:xXHVuw7gC0r0/XZlo+3N9NIOjjw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8R4I4 uniprotkb:Q8R4I4 intact:EBI-7640206|ensembl:ENSMUSP00000024970|uniprotkb:Q9DAF4|uniprotkb:Q99PM2|intact:MINT-1348145 intact:EBI-7640206|ensembl:ENSMUSP00000024970|uniprotkb:Q9DAF4|uniprotkb:Q99PM2|intact:MINT-1348145 psi-mi:tf2ay_mouse(display_long)|uniprotkb:Alf(gene name synonym)|uniprotkb:Gtf2a1lf(gene name synonym)|uniprotkb:Gtf2a1l(gene name)|psi-mi:Gtf2a1l(display_short)|uniprotkb:General transcription factor II A, 1-like factor(gene name synonym) psi-mi:tf2ay_mouse(display_long)|uniprotkb:Alf(gene name synonym)|uniprotkb:Gtf2a1lf(gene name synonym)|uniprotkb:Gtf2a1l(gene name)|psi-mi:Gtf2a1l(display_short)|uniprotkb:General transcription factor II A, 1-like factor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Catena et al. (2005) pubmed:15927180|imex:IM-10838|mint:MINT-5217758 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7640243|mint:MINT-62224|imex:IM-10838-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024154(gene)|ensembl:ENSMUST00000024970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0050890"(cognition)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|refseq:NP_076119.2|mint:MINT-1348209(identity) ensembl:ENSMUSG00000024154(gene)|ensembl:ENSMUST00000024970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0050890"(cognition)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|refseq:NP_076119.2|mint:MINT-1348205(identity) - comment:mint|function:"May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription"|comment:"Stoichiometry: 1.0" comment:mint|function:"May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription"|comment:"Stoichiometry: 1.0" figure legend:F1B|comment:Interaction occurs between ALFalpha and ALF full lenght|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2005/08/18 2014/10/16 rogid:Yo2Cl+ui7HGZ09BQs7fvPzwQt9w10090 rogid:Yo2Cl+ui7HGZ09BQs7fvPzwQt9w10090 intact-crc:FE90CE6805A2BBEB|rigid:MhOSYmvyqmdKIclDySPhWAnJRhU false - - - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q99PM3 uniprotkb:Q8R4I4 intact:EBI-7640185|ensembl:ENSMUSP00000021345|uniprotkb:Q8C812|intact:MINT-1348159 intact:EBI-7640206|ensembl:ENSMUSP00000024970|uniprotkb:Q9DAF4|uniprotkb:Q99PM2|intact:MINT-1348145 psi-mi:tf2aa_mouse(display_long)|uniprotkb:Gtf2a1(gene name)|psi-mi:Gtf2a1(display_short)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym) psi-mi:tf2ay_mouse(display_long)|uniprotkb:Alf(gene name synonym)|uniprotkb:Gtf2a1lf(gene name synonym)|uniprotkb:Gtf2a1l(gene name)|psi-mi:Gtf2a1l(display_short)|uniprotkb:General transcription factor II A, 1-like factor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Catena et al. (2005) pubmed:15927180|imex:IM-10838|mint:MINT-5217758 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7640331|mint:MINT-62227|imex:IM-10838-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020962(gene)|ensembl:ENSMUST00000021345(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|reactome:R-MMU-674695|reactome:R-MMU-6807505|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|reactome:R-MMU-9018519|refseq:NP_113568.2|refseq:NP_780544.1|mint:MINT-1348172(identity) ensembl:ENSMUSG00000024154(gene)|ensembl:ENSMUST00000024970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0050890"(cognition)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|refseq:NP_076119.2|mint:MINT-1348168(identity) - function:TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity|comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:"May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription"|comment:"Stoichiometry: 1.0" figure legend:F1C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2005/08/18 2014/10/16 rogid:1XALkG2DyhbEvv9NPBHJqlfg+b010090 rogid:Yo2Cl+ui7HGZ09BQs7fvPzwQt9w10090 intact-crc:607E1111469CFFB4|rigid:qSxmVailKC3+83Mse8aG8j4lIPw false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q99PM3 uniprotkb:Q99PM3 intact:EBI-7640185|ensembl:ENSMUSP00000021345|uniprotkb:Q8C812|intact:MINT-1348159 intact:EBI-7640185|ensembl:ENSMUSP00000021345|uniprotkb:Q8C812|intact:MINT-1348159 psi-mi:tf2aa_mouse(display_long)|uniprotkb:Gtf2a1(gene name)|psi-mi:Gtf2a1(display_short)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym) psi-mi:tf2aa_mouse(display_long)|uniprotkb:Gtf2a1(gene name)|psi-mi:Gtf2a1(display_short)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Catena et al. (2005) pubmed:15927180|imex:IM-10838|mint:MINT-5217758 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7640343|mint:MINT-62228|imex:IM-10838-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020962(gene)|ensembl:ENSMUST00000021345(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|reactome:R-MMU-674695|reactome:R-MMU-6807505|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|reactome:R-MMU-9018519|refseq:NP_113568.2|refseq:NP_780544.1|mint:MINT-1348184(identity) ensembl:ENSMUSG00000020962(gene)|ensembl:ENSMUST00000021345(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|reactome:R-MMU-674695|reactome:R-MMU-6807505|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|reactome:R-MMU-9018519|refseq:NP_113568.2|refseq:NP_780544.1|mint:MINT-1348180(identity) - function:TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity|comment:mint|comment:"Stoichiometry: 1.0" function:TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity|comment:mint|comment:"Stoichiometry: 1.0" figure legend:F1E|comment:"TFIIA beta (bait) interacts with TFIIA alpha (prey)"|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2005/08/18 2014/10/16 rogid:1XALkG2DyhbEvv9NPBHJqlfg+b010090 rogid:1XALkG2DyhbEvv9NPBHJqlfg+b010090 intact-crc:B07583736DAEF5E7|rigid:VIqDVo45nsKql3IVGGFGgbQ9uVU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8R4I4 uniprotkb:Q8R4I4 intact:EBI-7640206|ensembl:ENSMUSP00000024970|uniprotkb:Q9DAF4|uniprotkb:Q99PM2|intact:MINT-1348145 intact:EBI-7640206|ensembl:ENSMUSP00000024970|uniprotkb:Q9DAF4|uniprotkb:Q99PM2|intact:MINT-1348145 psi-mi:tf2ay_mouse(display_long)|uniprotkb:Alf(gene name synonym)|uniprotkb:Gtf2a1lf(gene name synonym)|uniprotkb:Gtf2a1l(gene name)|psi-mi:Gtf2a1l(display_short)|uniprotkb:General transcription factor II A, 1-like factor(gene name synonym) psi-mi:tf2ay_mouse(display_long)|uniprotkb:Alf(gene name synonym)|uniprotkb:Gtf2a1lf(gene name synonym)|uniprotkb:Gtf2a1l(gene name)|psi-mi:Gtf2a1l(display_short)|uniprotkb:General transcription factor II A, 1-like factor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Catena et al. (2005) pubmed:15927180|imex:IM-10838|mint:MINT-5217758 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7640318|mint:MINT-62226|imex:IM-10838-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024154(gene)|ensembl:ENSMUST00000024970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0050890"(cognition)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|refseq:NP_076119.2|mint:MINT-1348268(identity) ensembl:ENSMUSG00000024154(gene)|ensembl:ENSMUST00000024970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0050890"(cognition)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|refseq:NP_076119.2|mint:MINT-1348264(identity) - comment:mint|function:"May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription"|comment:"Stoichiometry: 1.0" comment:mint|function:"May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription"|comment:"Stoichiometry: 1.0" figure legend:F1C|comment:ALF beta interacts with both ALF full lenght and ALF alpha|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2005/08/18 2014/10/16 rogid:Yo2Cl+ui7HGZ09BQs7fvPzwQt9w10090 rogid:Yo2Cl+ui7HGZ09BQs7fvPzwQt9w10090 intact-crc:33343494A62DC9BF|rigid:MhOSYmvyqmdKIclDySPhWAnJRhU false - - - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q99PM3 uniprotkb:Q8R4I4 intact:EBI-7640185|ensembl:ENSMUSP00000021345|uniprotkb:Q8C812|intact:MINT-1348159 intact:EBI-7640206|ensembl:ENSMUSP00000024970|uniprotkb:Q9DAF4|uniprotkb:Q99PM2|intact:MINT-1348145 psi-mi:tf2aa_mouse(display_long)|uniprotkb:Gtf2a1(gene name)|psi-mi:Gtf2a1(display_short)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym) psi-mi:tf2ay_mouse(display_long)|uniprotkb:Alf(gene name synonym)|uniprotkb:Gtf2a1lf(gene name synonym)|uniprotkb:Gtf2a1l(gene name)|psi-mi:Gtf2a1l(display_short)|uniprotkb:General transcription factor II A, 1-like factor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Catena et al. (2005) pubmed:15927180|imex:IM-10838|mint:MINT-5217758 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7640374|mint:MINT-62229|imex:IM-10838-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020962(gene)|ensembl:ENSMUST00000021345(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|reactome:R-MMU-674695|reactome:R-MMU-6807505|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|reactome:R-MMU-9018519|refseq:NP_113568.2|refseq:NP_780544.1|mint:MINT-1348193(identity) ensembl:ENSMUSG00000024154(gene)|ensembl:ENSMUST00000024970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0050890"(cognition)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|refseq:NP_076119.2|mint:MINT-1348197(identity) - function:TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity|comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:"May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription"|comment:"Stoichiometry: 1.0" figure legend:F1E|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2005/08/18 2014/10/16 rogid:1XALkG2DyhbEvv9NPBHJqlfg+b010090 rogid:Yo2Cl+ui7HGZ09BQs7fvPzwQt9w10090 intact-crc:6669AB6C065DCBFB|rigid:qSxmVailKC3+83Mse8aG8j4lIPw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0072"(monoclonal antibody western blot)