#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29473	uniprotkb:Q7JFY6	intact:EBI-7636493|intact:MINT-1347838	intact:EBI-7636483|intact:MINT-1347854	psi-mi:nos3_bovin(display_long)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:q7jfy6_equas(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Martínez-Moreno et al. (2005)	pubmed:15922337|imex:IM-11158|mint:MINT-5217751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9793(donkey)|taxid:9793(Equus asinus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7636596|mint:MINT-60109|imex:IM-11158-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1ZZT|rcsb pdb:3N5S|rcsb pdb:3N5T|rcsb pdb:3NLD|rcsb pdb:3NLE|rcsb pdb:3NLF|rcsb pdb:3NLG|rcsb pdb:3NLH|rcsb pdb:2G6O|rcsb pdb:3NLI|rcsb pdb:3NLT|rcsb pdb:3NLU|rcsb pdb:2HX2|rcsb pdb:3NSE|rcsb pdb:2NSE|rcsb pdb:3PNH|rcsb pdb:3RQO|rcsb pdb:3RQP|rcsb pdb:4C3A|rcsb pdb:4CAR|rcsb pdb:4CFT|rcsb pdb:4CTY|rcsb pdb:4CTZ|rcsb pdb:3DQS|rcsb pdb:4CU0|rcsb pdb:4CU1|rcsb pdb:4CUL|rcsb pdb:3DQT|rcsb pdb:4CUM|rcsb pdb:4CUN|rcsb pdb:4CVG|rcsb pdb:4CWV|rcsb pdb:4CWW|rcsb pdb:4CWX|rcsb pdb:3E7S|rcsb pdb:4CWY|rcsb pdb:4CWZ|rcsb pdb:4CX0|rcsb pdb:4CX1|rcsb pdb:4CX2|rcsb pdb:4D33|rcsb pdb:4D34|rcsb pdb:4D35|rcsb pdb:4D36|rcsb pdb:4D37|rcsb pdb:4D38|rcsb pdb:4D39|rcsb pdb:4D3A|rcsb pdb:4IMX|rcsb pdb:4JSK|rcsb pdb:4JSL|rcsb pdb:4JSM|rcsb pdb:4K5H|rcsb pdb:4K5I|rcsb pdb:4K5J|rcsb pdb:3JWW|rcsb pdb:4K5K|rcsb pdb:4KCP|rcsb pdb:4KCQ|rcsb pdb:4KCR|rcsb pdb:4KCS|rcsb pdb:4LUW|rcsb pdb:4NSE|rcsb pdb:4UH7|rcsb pdb:4UH8|rcsb pdb:4UH9|rcsb pdb:4UHA|rcsb pdb:4UPQ|rcsb pdb:4UPR|rcsb pdb:4UPS|rcsb pdb:3JWX|rcsb pdb:4UPT|rcsb pdb:3JWY|rcsb pdb:3JWZ|rcsb pdb:5ADJ|rcsb pdb:5ADK|rcsb pdb:5ADL|rcsb pdb:5ADM|rcsb pdb:5ADN|rcsb pdb:5FJ2|rcsb pdb:3N5P|rcsb pdb:5FJ3|rcsb pdb:5FVY|rcsb pdb:5FVZ|rcsb pdb:3N5Q|rcsb pdb:5NSE|rcsb pdb:5UOD|rcsb pdb:5VV6|rcsb pdb:5VV7|rcsb pdb:5VV8|rcsb pdb:5VV9|rcsb pdb:5VVA|rcsb pdb:5VVG|rcsb pdb:5VVN|rcsb pdb:3N5R|rcsb pdb:6NSE|rcsb pdb:7NSE|rcsb pdb:8NSE|rcsb pdb:9NSE|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010181"(FMN binding)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1D0C|rcsb pdb:1D0O|rcsb pdb:1D1V|rcsb pdb:1D1W|rcsb pdb:1D1X|rcsb pdb:1D1Y|rcsb pdb:1DM6|rcsb pdb:1DM7|rcsb pdb:1DM8|rcsb pdb:1DMI|rcsb pdb:1DMJ|rcsb pdb:1DMK|rcsb pdb:1ED4|rcsb pdb:1ED5|rcsb pdb:1ED6|rcsb pdb:1FOI|rcsb pdb:1FOJ|rcsb pdb:1FOL|rcsb pdb:1FOO|rcsb pdb:1FOP|rcsb pdb:1I83|rcsb pdb:1NSE|rcsb pdb:1P6L|rcsb pdb:1P6M|rcsb pdb:1P6N|rcsb pdb:1Q2O|rcsb pdb:1RS8|rcsb pdb:1RS9|rcsb pdb:1ZZS|dip:DIP-42217N|mint:MINT-1347896(identity)	go:"GO:0005262"(calcium channel activity)|go:"GO:0016020"(membrane)|interpro:IPR000699(Intracellular calcium-release channel)|mint:MINT-1347900(identity)	-	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"|comment:"Stoichiometry: 1.0"	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:BIOSOURCE=BAEC cells. <br>For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovine-baec)|taxid:9913(Bos taurus)	-	2005/07/06	2014/10/16	rogid:sAK/x37YPMbuDb8wNCCw31kGXwE9913	rogid:/T8v9HBzYsi8xSAzNN+I9E+1cow9793	intact-crc:F3BA97FFCA12034D|rigid:xhjMOIVqWqB5am0zCyO0VIZ7UlQ	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P29473	uniprotkb:Q7JFY6	intact:EBI-7636493|intact:MINT-1347838	intact:EBI-7636483|intact:MINT-1347854	psi-mi:nos3_bovin(display_long)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:q7jfy6_equas(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Martínez-Moreno et al. (2005)	pubmed:15922337|imex:IM-11158|mint:MINT-5217751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9793(donkey)|taxid:9793(Equus asinus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7636639|mint:MINT-60111|imex:IM-11158-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1ZZT|rcsb pdb:3N5S|rcsb pdb:3N5T|rcsb pdb:3NLD|rcsb pdb:3NLE|rcsb pdb:3NLF|rcsb pdb:3NLG|rcsb pdb:3NLH|rcsb pdb:2G6O|rcsb pdb:3NLI|rcsb pdb:3NLT|rcsb pdb:3NLU|rcsb pdb:2HX2|rcsb pdb:3NSE|rcsb pdb:2NSE|rcsb pdb:3PNH|rcsb pdb:3RQO|rcsb pdb:3RQP|rcsb pdb:4C3A|rcsb pdb:4CAR|rcsb pdb:4CFT|rcsb pdb:4CTY|rcsb pdb:4CTZ|rcsb pdb:3DQS|rcsb pdb:4CU0|rcsb pdb:4CU1|rcsb pdb:4CUL|rcsb pdb:3DQT|rcsb pdb:4CUM|rcsb pdb:4CUN|rcsb pdb:4CVG|rcsb pdb:4CWV|rcsb pdb:4CWW|rcsb pdb:4CWX|rcsb pdb:3E7S|rcsb pdb:4CWY|rcsb pdb:4CWZ|rcsb pdb:4CX0|rcsb pdb:4CX1|rcsb pdb:4CX2|rcsb pdb:4D33|rcsb pdb:4D34|rcsb pdb:4D35|rcsb pdb:4D36|rcsb pdb:4D37|rcsb pdb:4D38|rcsb pdb:4D39|rcsb pdb:4D3A|rcsb pdb:4IMX|rcsb pdb:4JSK|rcsb pdb:4JSL|rcsb pdb:4JSM|rcsb pdb:4K5H|rcsb pdb:4K5I|rcsb pdb:4K5J|rcsb pdb:3JWW|rcsb pdb:4K5K|rcsb pdb:4KCP|rcsb pdb:4KCQ|rcsb pdb:4KCR|rcsb pdb:4KCS|rcsb pdb:4LUW|rcsb pdb:4NSE|rcsb pdb:4UH7|rcsb pdb:4UH8|rcsb pdb:4UH9|rcsb pdb:4UHA|rcsb pdb:4UPQ|rcsb pdb:4UPR|rcsb pdb:4UPS|rcsb pdb:3JWX|rcsb pdb:4UPT|rcsb pdb:3JWY|rcsb pdb:3JWZ|rcsb pdb:5ADJ|rcsb pdb:5ADK|rcsb pdb:5ADL|rcsb pdb:5ADM|rcsb pdb:5ADN|rcsb pdb:5FJ2|rcsb pdb:3N5P|rcsb pdb:5FJ3|rcsb pdb:5FVY|rcsb pdb:5FVZ|rcsb pdb:3N5Q|rcsb pdb:5NSE|rcsb pdb:5UOD|rcsb pdb:5VV6|rcsb pdb:5VV7|rcsb pdb:5VV8|rcsb pdb:5VV9|rcsb pdb:5VVA|rcsb pdb:5VVG|rcsb pdb:5VVN|rcsb pdb:3N5R|rcsb pdb:6NSE|rcsb pdb:7NSE|rcsb pdb:8NSE|rcsb pdb:9NSE|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010181"(FMN binding)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1D0C|rcsb pdb:1D0O|rcsb pdb:1D1V|rcsb pdb:1D1W|rcsb pdb:1D1X|rcsb pdb:1D1Y|rcsb pdb:1DM6|rcsb pdb:1DM7|rcsb pdb:1DM8|rcsb pdb:1DMI|rcsb pdb:1DMJ|rcsb pdb:1DMK|rcsb pdb:1ED4|rcsb pdb:1ED5|rcsb pdb:1ED6|rcsb pdb:1FOI|rcsb pdb:1FOJ|rcsb pdb:1FOL|rcsb pdb:1FOO|rcsb pdb:1FOP|rcsb pdb:1I83|rcsb pdb:1NSE|rcsb pdb:1P6L|rcsb pdb:1P6M|rcsb pdb:1P6N|rcsb pdb:1Q2O|rcsb pdb:1RS8|rcsb pdb:1RS9|rcsb pdb:1ZZS|dip:DIP-42217N|mint:MINT-1347864(identity)	go:"GO:0005262"(calcium channel activity)|go:"GO:0016020"(membrane)|interpro:IPR000699(Intracellular calcium-release channel)|mint:MINT-1347868(identity)	-	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"|comment:"Stoichiometry: 1.0"	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus<br>BIOSOURCE=BAEC cells|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovine-baec)|taxid:9913(Bos taurus)	-	2005/07/06	2014/10/16	rogid:sAK/x37YPMbuDb8wNCCw31kGXwE9913	rogid:/T8v9HBzYsi8xSAzNN+I9E+1cow9793	intact-crc:6C752545F2BFE7B3|rigid:xhjMOIVqWqB5am0zCyO0VIZ7UlQ	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q7JFY6	uniprotkb:P29473	intact:EBI-7636483|intact:MINT-1347854	intact:EBI-7636493|intact:MINT-1347838	psi-mi:q7jfy6_equas(display_long)	psi-mi:nos3_bovin(display_long)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Martínez-Moreno et al. (2005)	pubmed:15922337|imex:IM-11158|mint:MINT-5217751	taxid:9793(donkey)|taxid:9793(Equus asinus)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7636626|mint:MINT-60110|imex:IM-11158-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005262"(calcium channel activity)|go:"GO:0016020"(membrane)|interpro:IPR000699(Intracellular calcium-release channel)|mint:MINT-1347913(identity)	rcsb pdb:1ZZT|rcsb pdb:3N5S|rcsb pdb:3N5T|rcsb pdb:3NLD|rcsb pdb:3NLE|rcsb pdb:3NLF|rcsb pdb:3NLG|rcsb pdb:3NLH|rcsb pdb:2G6O|rcsb pdb:3NLI|rcsb pdb:3NLT|rcsb pdb:3NLU|rcsb pdb:2HX2|rcsb pdb:3NSE|rcsb pdb:2NSE|rcsb pdb:3PNH|rcsb pdb:3RQO|rcsb pdb:3RQP|rcsb pdb:4C3A|rcsb pdb:4CAR|rcsb pdb:4CFT|rcsb pdb:4CTY|rcsb pdb:4CTZ|rcsb pdb:3DQS|rcsb pdb:4CU0|rcsb pdb:4CU1|rcsb pdb:4CUL|rcsb pdb:3DQT|rcsb pdb:4CUM|rcsb pdb:4CUN|rcsb pdb:4CVG|rcsb pdb:4CWV|rcsb pdb:4CWW|rcsb pdb:4CWX|rcsb pdb:3E7S|rcsb pdb:4CWY|rcsb pdb:4CWZ|rcsb pdb:4CX0|rcsb pdb:4CX1|rcsb pdb:4CX2|rcsb pdb:4D33|rcsb pdb:4D34|rcsb pdb:4D35|rcsb pdb:4D36|rcsb pdb:4D37|rcsb pdb:4D38|rcsb pdb:4D39|rcsb pdb:4D3A|rcsb pdb:4IMX|rcsb pdb:4JSK|rcsb pdb:4JSL|rcsb pdb:4JSM|rcsb pdb:4K5H|rcsb pdb:4K5I|rcsb pdb:4K5J|rcsb pdb:3JWW|rcsb pdb:4K5K|rcsb pdb:4KCP|rcsb pdb:4KCQ|rcsb pdb:4KCR|rcsb pdb:4KCS|rcsb pdb:4LUW|rcsb pdb:4NSE|rcsb pdb:4UH7|rcsb pdb:4UH8|rcsb pdb:4UH9|rcsb pdb:4UHA|rcsb pdb:4UPQ|rcsb pdb:4UPR|rcsb pdb:4UPS|rcsb pdb:3JWX|rcsb pdb:4UPT|rcsb pdb:3JWY|rcsb pdb:3JWZ|rcsb pdb:5ADJ|rcsb pdb:5ADK|rcsb pdb:5ADL|rcsb pdb:5ADM|rcsb pdb:5ADN|rcsb pdb:5FJ2|rcsb pdb:3N5P|rcsb pdb:5FJ3|rcsb pdb:5FVY|rcsb pdb:5FVZ|rcsb pdb:3N5Q|rcsb pdb:5NSE|rcsb pdb:5UOD|rcsb pdb:5VV6|rcsb pdb:5VV7|rcsb pdb:5VV8|rcsb pdb:5VV9|rcsb pdb:5VVA|rcsb pdb:5VVG|rcsb pdb:5VVN|rcsb pdb:3N5R|rcsb pdb:6NSE|rcsb pdb:7NSE|rcsb pdb:8NSE|rcsb pdb:9NSE|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010181"(FMN binding)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1D0C|rcsb pdb:1D0O|rcsb pdb:1D1V|rcsb pdb:1D1W|rcsb pdb:1D1X|rcsb pdb:1D1Y|rcsb pdb:1DM6|rcsb pdb:1DM7|rcsb pdb:1DM8|rcsb pdb:1DMI|rcsb pdb:1DMJ|rcsb pdb:1DMK|rcsb pdb:1ED4|rcsb pdb:1ED5|rcsb pdb:1ED6|rcsb pdb:1FOI|rcsb pdb:1FOJ|rcsb pdb:1FOL|rcsb pdb:1FOO|rcsb pdb:1FOP|rcsb pdb:1I83|rcsb pdb:1NSE|rcsb pdb:1P6L|rcsb pdb:1P6M|rcsb pdb:1P6N|rcsb pdb:1Q2O|rcsb pdb:1RS8|rcsb pdb:1RS9|rcsb pdb:1ZZS|dip:DIP-42217N|mint:MINT-1347909(identity)	-	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"|comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus<br>BIOSOURCE=HSC2 cells|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovine-baec)|taxid:9913(Bos taurus)	-	2005/07/06	2014/10/16	rogid:/T8v9HBzYsi8xSAzNN+I9E+1cow9793	rogid:sAK/x37YPMbuDb8wNCCw31kGXwE9913	intact-crc:2AFE62EC49EE3AB2|rigid:xhjMOIVqWqB5am0zCyO0VIZ7UlQ	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P29473	uniprotkb:Q7JFY6	intact:EBI-7636493|intact:MINT-1347838	intact:EBI-7636483|intact:MINT-1347854	psi-mi:nos3_bovin(display_long)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:q7jfy6_equas(display_long)	psi-mi:"MI:0428"(imaging technique)	Martínez-Moreno et al. (2005)	pubmed:15922337|imex:IM-11158|mint:MINT-5217751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9793(donkey)|taxid:9793(Equus asinus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7636662|mint:MINT-60112|imex:IM-11158-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1ZZT|rcsb pdb:3N5S|rcsb pdb:3N5T|rcsb pdb:3NLD|rcsb pdb:3NLE|rcsb pdb:3NLF|rcsb pdb:3NLG|rcsb pdb:3NLH|rcsb pdb:2G6O|rcsb pdb:3NLI|rcsb pdb:3NLT|rcsb pdb:3NLU|rcsb pdb:2HX2|rcsb pdb:3NSE|rcsb pdb:2NSE|rcsb pdb:3PNH|rcsb pdb:3RQO|rcsb pdb:3RQP|rcsb pdb:4C3A|rcsb pdb:4CAR|rcsb pdb:4CFT|rcsb pdb:4CTY|rcsb pdb:4CTZ|rcsb pdb:3DQS|rcsb pdb:4CU0|rcsb pdb:4CU1|rcsb pdb:4CUL|rcsb pdb:3DQT|rcsb pdb:4CUM|rcsb pdb:4CUN|rcsb pdb:4CVG|rcsb pdb:4CWV|rcsb pdb:4CWW|rcsb pdb:4CWX|rcsb pdb:3E7S|rcsb pdb:4CWY|rcsb pdb:4CWZ|rcsb pdb:4CX0|rcsb pdb:4CX1|rcsb pdb:4CX2|rcsb pdb:4D33|rcsb pdb:4D34|rcsb pdb:4D35|rcsb pdb:4D36|rcsb pdb:4D37|rcsb pdb:4D38|rcsb pdb:4D39|rcsb pdb:4D3A|rcsb pdb:4IMX|rcsb pdb:4JSK|rcsb pdb:4JSL|rcsb pdb:4JSM|rcsb pdb:4K5H|rcsb pdb:4K5I|rcsb pdb:4K5J|rcsb pdb:3JWW|rcsb pdb:4K5K|rcsb pdb:4KCP|rcsb pdb:4KCQ|rcsb pdb:4KCR|rcsb pdb:4KCS|rcsb pdb:4LUW|rcsb pdb:4NSE|rcsb pdb:4UH7|rcsb pdb:4UH8|rcsb pdb:4UH9|rcsb pdb:4UHA|rcsb pdb:4UPQ|rcsb pdb:4UPR|rcsb pdb:4UPS|rcsb pdb:3JWX|rcsb pdb:4UPT|rcsb pdb:3JWY|rcsb pdb:3JWZ|rcsb pdb:5ADJ|rcsb pdb:5ADK|rcsb pdb:5ADL|rcsb pdb:5ADM|rcsb pdb:5ADN|rcsb pdb:5FJ2|rcsb pdb:3N5P|rcsb pdb:5FJ3|rcsb pdb:5FVY|rcsb pdb:5FVZ|rcsb pdb:3N5Q|rcsb pdb:5NSE|rcsb pdb:5UOD|rcsb pdb:5VV6|rcsb pdb:5VV7|rcsb pdb:5VV8|rcsb pdb:5VV9|rcsb pdb:5VVA|rcsb pdb:5VVG|rcsb pdb:5VVN|rcsb pdb:3N5R|rcsb pdb:6NSE|rcsb pdb:7NSE|rcsb pdb:8NSE|rcsb pdb:9NSE|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010181"(FMN binding)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1D0C|rcsb pdb:1D0O|rcsb pdb:1D1V|rcsb pdb:1D1W|rcsb pdb:1D1X|rcsb pdb:1D1Y|rcsb pdb:1DM6|rcsb pdb:1DM7|rcsb pdb:1DM8|rcsb pdb:1DMI|rcsb pdb:1DMJ|rcsb pdb:1DMK|rcsb pdb:1ED4|rcsb pdb:1ED5|rcsb pdb:1ED6|rcsb pdb:1FOI|rcsb pdb:1FOJ|rcsb pdb:1FOL|rcsb pdb:1FOO|rcsb pdb:1FOP|rcsb pdb:1I83|rcsb pdb:1NSE|rcsb pdb:1P6L|rcsb pdb:1P6M|rcsb pdb:1P6N|rcsb pdb:1Q2O|rcsb pdb:1RS8|rcsb pdb:1RS9|rcsb pdb:1ZZS|dip:DIP-42217N|mint:MINT-1347881(identity)	go:"GO:0005262"(calcium channel activity)|go:"GO:0016020"(membrane)|interpro:IPR000699(Intracellular calcium-release channel)|mint:MINT-1347886(identity)	-	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"|comment:"Stoichiometry: 1.0"	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F4|comment:For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus<br>BIOSOURCE=H9C2 cells|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts)	-	2005/07/06	2014/10/16	rogid:sAK/x37YPMbuDb8wNCCw31kGXwE9913	rogid:/T8v9HBzYsi8xSAzNN+I9E+1cow9793	intact-crc:2B3A0FA9BB434057|rigid:xhjMOIVqWqB5am0zCyO0VIZ7UlQ	false	-	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P29473	uniprotkb:Q7JFY6	intact:EBI-7636493|intact:MINT-1347838	intact:EBI-7636483|intact:MINT-1347854	psi-mi:nos3_bovin(display_long)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:q7jfy6_equas(display_long)	psi-mi:"MI:0004"(affinity chromatography technology)	Martínez-Moreno et al. (2005)	pubmed:15922337|imex:IM-11158|mint:MINT-5217751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9793(donkey)|taxid:9793(Equus asinus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7636685|mint:MINT-60107|imex:IM-11158-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1ZZT|rcsb pdb:3N5S|rcsb pdb:3N5T|rcsb pdb:3NLD|rcsb pdb:3NLE|rcsb pdb:3NLF|rcsb pdb:3NLG|rcsb pdb:3NLH|rcsb pdb:2G6O|rcsb pdb:3NLI|rcsb pdb:3NLT|rcsb pdb:3NLU|rcsb pdb:2HX2|rcsb pdb:3NSE|rcsb pdb:2NSE|rcsb pdb:3PNH|rcsb pdb:3RQO|rcsb pdb:3RQP|rcsb pdb:4C3A|rcsb pdb:4CAR|rcsb pdb:4CFT|rcsb pdb:4CTY|rcsb pdb:4CTZ|rcsb pdb:3DQS|rcsb pdb:4CU0|rcsb pdb:4CU1|rcsb pdb:4CUL|rcsb pdb:3DQT|rcsb pdb:4CUM|rcsb pdb:4CUN|rcsb pdb:4CVG|rcsb pdb:4CWV|rcsb pdb:4CWW|rcsb pdb:4CWX|rcsb pdb:3E7S|rcsb pdb:4CWY|rcsb pdb:4CWZ|rcsb pdb:4CX0|rcsb pdb:4CX1|rcsb pdb:4CX2|rcsb pdb:4D33|rcsb pdb:4D34|rcsb pdb:4D35|rcsb pdb:4D36|rcsb pdb:4D37|rcsb pdb:4D38|rcsb pdb:4D39|rcsb pdb:4D3A|rcsb pdb:4IMX|rcsb pdb:4JSK|rcsb pdb:4JSL|rcsb pdb:4JSM|rcsb pdb:4K5H|rcsb pdb:4K5I|rcsb pdb:4K5J|rcsb pdb:3JWW|rcsb pdb:4K5K|rcsb pdb:4KCP|rcsb pdb:4KCQ|rcsb pdb:4KCR|rcsb pdb:4KCS|rcsb pdb:4LUW|rcsb pdb:4NSE|rcsb pdb:4UH7|rcsb pdb:4UH8|rcsb pdb:4UH9|rcsb pdb:4UHA|rcsb pdb:4UPQ|rcsb pdb:4UPR|rcsb pdb:4UPS|rcsb pdb:3JWX|rcsb pdb:4UPT|rcsb pdb:3JWY|rcsb pdb:3JWZ|rcsb pdb:5ADJ|rcsb pdb:5ADK|rcsb pdb:5ADL|rcsb pdb:5ADM|rcsb pdb:5ADN|rcsb pdb:5FJ2|rcsb pdb:3N5P|rcsb pdb:5FJ3|rcsb pdb:5FVY|rcsb pdb:5FVZ|rcsb pdb:3N5Q|rcsb pdb:5NSE|rcsb pdb:5UOD|rcsb pdb:5VV6|rcsb pdb:5VV7|rcsb pdb:5VV8|rcsb pdb:5VV9|rcsb pdb:5VVA|rcsb pdb:5VVG|rcsb pdb:5VVN|rcsb pdb:3N5R|rcsb pdb:6NSE|rcsb pdb:7NSE|rcsb pdb:8NSE|rcsb pdb:9NSE|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010181"(FMN binding)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1D0C|rcsb pdb:1D0O|rcsb pdb:1D1V|rcsb pdb:1D1W|rcsb pdb:1D1X|rcsb pdb:1D1Y|rcsb pdb:1DM6|rcsb pdb:1DM7|rcsb pdb:1DM8|rcsb pdb:1DMI|rcsb pdb:1DMJ|rcsb pdb:1DMK|rcsb pdb:1ED4|rcsb pdb:1ED5|rcsb pdb:1ED6|rcsb pdb:1FOI|rcsb pdb:1FOJ|rcsb pdb:1FOL|rcsb pdb:1FOO|rcsb pdb:1FOP|rcsb pdb:1I83|rcsb pdb:1NSE|rcsb pdb:1P6L|rcsb pdb:1P6M|rcsb pdb:1P6N|rcsb pdb:1Q2O|rcsb pdb:1RS8|rcsb pdb:1RS9|rcsb pdb:1ZZS|dip:DIP-42217N|mint:MINT-1347924(identity)	go:"GO:0005262"(calcium channel activity)|go:"GO:0016020"(membrane)|interpro:IPR000699(Intracellular calcium-release channel)|mint:MINT-1347932(identity)	-	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"|comment:"Stoichiometry: 1.0"	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/06	2014/10/16	rogid:sAK/x37YPMbuDb8wNCCw31kGXwE9913	rogid:/T8v9HBzYsi8xSAzNN+I9E+1cow9793	intact-crc:6F4C3337503C2DB9|rigid:xhjMOIVqWqB5am0zCyO0VIZ7UlQ	false	binding-associated region:489-1204(MINT-1347925)|tag:?-?(MINT-1347927)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P29473	uniprotkb:P62157	intact:EBI-7636493|intact:MINT-1347838	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	psi-mi:nos3_bovin(display_long)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Martínez-Moreno et al. (2005)	pubmed:15922337|imex:IM-11158|mint:MINT-5217751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7636705|mint:MINT-60108|imex:IM-11158-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1ZZT|rcsb pdb:3N5S|rcsb pdb:3N5T|rcsb pdb:3NLD|rcsb pdb:3NLE|rcsb pdb:3NLF|rcsb pdb:3NLG|rcsb pdb:3NLH|rcsb pdb:2G6O|rcsb pdb:3NLI|rcsb pdb:3NLT|rcsb pdb:3NLU|rcsb pdb:2HX2|rcsb pdb:3NSE|rcsb pdb:2NSE|rcsb pdb:3PNH|rcsb pdb:3RQO|rcsb pdb:3RQP|rcsb pdb:4C3A|rcsb pdb:4CAR|rcsb pdb:4CFT|rcsb pdb:4CTY|rcsb pdb:4CTZ|rcsb pdb:3DQS|rcsb pdb:4CU0|rcsb pdb:4CU1|rcsb pdb:4CUL|rcsb pdb:3DQT|rcsb pdb:4CUM|rcsb pdb:4CUN|rcsb pdb:4CVG|rcsb pdb:4CWV|rcsb pdb:4CWW|rcsb pdb:4CWX|rcsb pdb:3E7S|rcsb pdb:4CWY|rcsb pdb:4CWZ|rcsb pdb:4CX0|rcsb pdb:4CX1|rcsb pdb:4CX2|rcsb pdb:4D33|rcsb pdb:4D34|rcsb pdb:4D35|rcsb pdb:4D36|rcsb pdb:4D37|rcsb pdb:4D38|rcsb pdb:4D39|rcsb pdb:4D3A|rcsb pdb:4IMX|rcsb pdb:4JSK|rcsb pdb:4JSL|rcsb pdb:4JSM|rcsb pdb:4K5H|rcsb pdb:4K5I|rcsb pdb:4K5J|rcsb pdb:3JWW|rcsb pdb:4K5K|rcsb pdb:4KCP|rcsb pdb:4KCQ|rcsb pdb:4KCR|rcsb pdb:4KCS|rcsb pdb:4LUW|rcsb pdb:4NSE|rcsb pdb:4UH7|rcsb pdb:4UH8|rcsb pdb:4UH9|rcsb pdb:4UHA|rcsb pdb:4UPQ|rcsb pdb:4UPR|rcsb pdb:4UPS|rcsb pdb:3JWX|rcsb pdb:4UPT|rcsb pdb:3JWY|rcsb pdb:3JWZ|rcsb pdb:5ADJ|rcsb pdb:5ADK|rcsb pdb:5ADL|rcsb pdb:5ADM|rcsb pdb:5ADN|rcsb pdb:5FJ2|rcsb pdb:3N5P|rcsb pdb:5FJ3|rcsb pdb:5FVY|rcsb pdb:5FVZ|rcsb pdb:3N5Q|rcsb pdb:5NSE|rcsb pdb:5UOD|rcsb pdb:5VV6|rcsb pdb:5VV7|rcsb pdb:5VV8|rcsb pdb:5VV9|rcsb pdb:5VVA|rcsb pdb:5VVG|rcsb pdb:5VVN|rcsb pdb:3N5R|rcsb pdb:6NSE|rcsb pdb:7NSE|rcsb pdb:8NSE|rcsb pdb:9NSE|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010181"(FMN binding)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1D0C|rcsb pdb:1D0O|rcsb pdb:1D1V|rcsb pdb:1D1W|rcsb pdb:1D1X|rcsb pdb:1D1Y|rcsb pdb:1DM6|rcsb pdb:1DM7|rcsb pdb:1DM8|rcsb pdb:1DMI|rcsb pdb:1DMJ|rcsb pdb:1DMK|rcsb pdb:1ED4|rcsb pdb:1ED5|rcsb pdb:1ED6|rcsb pdb:1FOI|rcsb pdb:1FOJ|rcsb pdb:1FOL|rcsb pdb:1FOO|rcsb pdb:1FOP|rcsb pdb:1I83|rcsb pdb:1NSE|rcsb pdb:1P6L|rcsb pdb:1P6M|rcsb pdb:1P6N|rcsb pdb:1Q2O|rcsb pdb:1RS8|rcsb pdb:1RS9|rcsb pdb:1ZZS|dip:DIP-42217N|mint:MINT-1347960(identity)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P|mint:MINT-1347968(identity)	-	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/06	2014/10/16	rogid:sAK/x37YPMbuDb8wNCCw31kGXwE9913	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	intact-crc:845BDD3BE8BF55E1|rigid:89K4L6d3s/jO+77He2Sg8lO9OuA	false	tag:?-?(MINT-1347963)|binding-associated region:489-1204(MINT-1347961)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0082"(peptide massfingerprinting)