#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62989	uniprotkb:P51639	intact:EBI-7038538|dip:DIP-36896N|uniprotkb:Q91887|uniprotkb:Q63446|uniprotkb:Q91888|uniprotkb:P02248|uniprotkb:P02250|mint:MINT-1347800|uniprotkb:P02249|uniprotkb:Q29120	intact:EBI-7635734|ensembl:ENSRNOP00000022055|intact:MINT-1347783|uniprotkb:Q6P2A6|uniprotkb:Q64601	psi-mi:ubiq_rat(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)	psi-mi:hmdh_rat(display_long)|uniprotkb:Hmgcr(gene name)|psi-mi:Hmgcr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ness et al. (2005)	pubmed:15919082|imex:IM-11211|mint:MINT-5217747	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7635785|mint:MINT-60095|imex:IM-11211-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000019974|interpro:IPR019955|ensembl:ENSRNOG00000042271|refseq:NP_620250.1|ipi:IPI00656453|ensembl:ENSRNOG00000034246|go:"GO:0022627"(cytosolic small ribosomal subunit)|refseq:XP_002726633.1|refseq:NP_112375.1|go:"GO:0005634"(nucleus)|ensembl:ENSRNOG00000004426|interpro:IPR019956|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|refseq:NP_113875.1|ensembl:ENSRNOG00000028756|refseq:XP_002729582.1|rgd:620240|mint:MINT-1347826(identity)	ensembl:ENSRNOG00000016122(gene)|ensembl:ENSRNOT00000022055(transcript)|go:"GO:0004420"("hydroxymethylglutaryl-CoA reductase (NADPH) activity")|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006743"(ubiquinone metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:0010142"(farnesyl diphosphate biosynthetic process, mevalonate pathway)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070402"(NADPH binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0120225"(coenzyme A binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR002202(Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic)|interpro:IPR004554(Hydroxymethylglutaryl-CoA reductase, class I, catalytic)|interpro:IPR004816(Hydroxymethylglutaryl-CoA reductase, class I, metazoan)|interpro:IPR009023(Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding)|interpro:IPR009029(Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding)|interpro:IPR023074|interpro:IPR023076|interpro:IPR023282|reactome:R-RNO-191273|refseq:NP_037266.2|rgd:2803|mint:MINT-1347822(identity)	-	function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis|comment:"Stoichiometry: 1.0"	figure legend:F3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2005/07/05	2014/10/16	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10116	rogid:WAZoTQ/e+tMhf9eKSj7jhg7KvCQ10116	intact-crc:ED97346AB1D8F1C0|rigid:/s/29pITaT2eWShE0p8HnwZ30DQ	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)