#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P80206	uniprotkb:Q91ZK4	intact:EBI-7628620|intact:MINT-1347226	intact:EBI-7628582|ensembl:ENSMUSP00000081366|uniprotkb:Q91ZK3|uniprotkb:Q8VHG8|intact:MINT-1347271|uniprotkb:Q8CH43|uniprotkb:B1ASG1|uniprotkb:Q8K4U6	psi-mi:otx2_mouse(display_long)|uniprotkb:Otx2(gene name)|psi-mi:Otx2(display_short)|uniprotkb:Otx-2(gene name synonym)|uniprotkb:Orthodenticle homolog 2(gene name synonym)	psi-mi:dmbx1_mouse(display_long)|uniprotkb:Dmbx1(gene name)|psi-mi:Dmbx1(display_short)|uniprotkb:Otx3(gene name synonym)|uniprotkb:Cdmx(gene name synonym)|uniprotkb:Mbx(gene name synonym)|uniprotkb:PaxB(gene name synonym)|uniprotkb:Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein(gene name synonym)|uniprotkb:Paired-like homeobox protein DMBX1(gene name synonym)|uniprotkb:Paired-type homeobox Atx(gene name synonym)|uniprotkb:Orthodenticle homolog 3(gene name synonym)	psi-mi:"MI:0045"(experimental interaction detection)	Kimura et al. (2005)	pubmed:15890343|imex:IM-11051|mint:MINT-5217729	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7628575|mint:MINT-58693|imex:IM-11051-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000543"(positive regulation of gastrulation)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|rcsb pdb:2DMS|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007492"(endoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0022037"(metencephalon development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042706"(eye photoreceptor cell fate commitment)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0030426"(growth cone)|mint:MINT-1347297(identity)	ensembl:ENSMUSG00000028707(gene)|ensembl:ENSMUST00000084338(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048589"(developmental growth)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|go:"GO:0003677"(DNA binding)|refseq:XP_017175447.1|refseq:XP_017175448.1|refseq:NP_570935.3|refseq:NP_001020738.1|mint:MINT-1347290(identity)	-	function:"Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'"|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:"Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability"|comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:experimental=EMSA|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/17	2014/10/16	rogid:HnMETTJoqGaon6Bb+BtoDXiUTLw10090	rogid:8gVbhAQwTa+0DnUM3XCn24yAoQY10090	intact-crc:BCF19D4EFC899465|rigid:ZU4o5Kj4XiepUkt6HqZ5Pp0G/xA	false	tag:?-?(MINT-1347298)	tag:?-?(MINT-1347291)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91ZK4	uniprotkb:Q91ZK4	intact:EBI-7628582|ensembl:ENSMUSP00000081366|uniprotkb:Q91ZK3|uniprotkb:Q8VHG8|intact:MINT-1347271|uniprotkb:Q8CH43|uniprotkb:B1ASG1|uniprotkb:Q8K4U6	intact:EBI-7628582|ensembl:ENSMUSP00000081366|uniprotkb:Q91ZK3|uniprotkb:Q8VHG8|intact:MINT-1347271|uniprotkb:Q8CH43|uniprotkb:B1ASG1|uniprotkb:Q8K4U6	psi-mi:dmbx1_mouse(display_long)|uniprotkb:Dmbx1(gene name)|psi-mi:Dmbx1(display_short)|uniprotkb:Otx3(gene name synonym)|uniprotkb:Cdmx(gene name synonym)|uniprotkb:Mbx(gene name synonym)|uniprotkb:PaxB(gene name synonym)|uniprotkb:Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein(gene name synonym)|uniprotkb:Paired-like homeobox protein DMBX1(gene name synonym)|uniprotkb:Paired-type homeobox Atx(gene name synonym)|uniprotkb:Orthodenticle homolog 3(gene name synonym)	psi-mi:dmbx1_mouse(display_long)|uniprotkb:Dmbx1(gene name)|psi-mi:Dmbx1(display_short)|uniprotkb:Otx3(gene name synonym)|uniprotkb:Cdmx(gene name synonym)|uniprotkb:Mbx(gene name synonym)|uniprotkb:PaxB(gene name synonym)|uniprotkb:Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein(gene name synonym)|uniprotkb:Paired-like homeobox protein DMBX1(gene name synonym)|uniprotkb:Paired-type homeobox Atx(gene name synonym)|uniprotkb:Orthodenticle homolog 3(gene name synonym)	psi-mi:"MI:0045"(experimental interaction detection)	Kimura et al. (2005)	pubmed:15890343|imex:IM-11051|mint:MINT-5217729	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7628666|mint:MINT-58694|imex:IM-11051-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028707(gene)|ensembl:ENSMUST00000084338(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048589"(developmental growth)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|go:"GO:0003677"(DNA binding)|refseq:XP_017175447.1|refseq:XP_017175448.1|refseq:NP_570935.3|refseq:NP_001020738.1|mint:MINT-1347316(identity)	ensembl:ENSMUSG00000028707(gene)|ensembl:ENSMUST00000084338(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048589"(developmental growth)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|go:"GO:0003677"(DNA binding)|refseq:XP_017175447.1|refseq:XP_017175448.1|refseq:NP_570935.3|refseq:NP_001020738.1|mint:MINT-1347309(identity)	-	comment:mint|function:"Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability"|comment:"Stoichiometry: 1.0"	comment:mint|function:"Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability"|comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:experimental=EMSA<br><br>nuclear extracts obtained from COS-1 cells transfected|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/17	2014/10/16	rogid:8gVbhAQwTa+0DnUM3XCn24yAoQY10090	rogid:8gVbhAQwTa+0DnUM3XCn24yAoQY10090	intact-crc:94D7279AB8A902AA|rigid:bzz/1xrS9uhO5Nin1zDAzFOsWa0	false	tag:?-?(MINT-1347317)	tag:?-?(MINT-1347310)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P80206	uniprotkb:P80206	intact:EBI-7628620|intact:MINT-1347226	intact:EBI-7628620|intact:MINT-1347226	psi-mi:otx2_mouse(display_long)|uniprotkb:Otx2(gene name)|psi-mi:Otx2(display_short)|uniprotkb:Otx-2(gene name synonym)|uniprotkb:Orthodenticle homolog 2(gene name synonym)	psi-mi:otx2_mouse(display_long)|uniprotkb:Otx2(gene name)|psi-mi:Otx2(display_short)|uniprotkb:Otx-2(gene name synonym)|uniprotkb:Orthodenticle homolog 2(gene name synonym)	psi-mi:"MI:0045"(experimental interaction detection)	Kimura et al. (2005)	pubmed:15890343|imex:IM-11051|mint:MINT-5217729	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7628705|mint:MINT-58695|imex:IM-11051-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000543"(positive regulation of gastrulation)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|rcsb pdb:2DMS|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007492"(endoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0022037"(metencephalon development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042706"(eye photoreceptor cell fate commitment)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0030426"(growth cone)|mint:MINT-1347259(identity)	go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000543"(positive regulation of gastrulation)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|rcsb pdb:2DMS|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007492"(endoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0022037"(metencephalon development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042706"(eye photoreceptor cell fate commitment)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0030426"(growth cone)|mint:MINT-1347252(identity)	-	function:"Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'"|comment:mint|comment:"Stoichiometry: 1.0"	function:"Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:experimental=EMSA<br><br>nuclear extracts obtained from COS-1 cells transfected|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/17	2014/10/16	rogid:HnMETTJoqGaon6Bb+BtoDXiUTLw10090	rogid:HnMETTJoqGaon6Bb+BtoDXiUTLw10090	intact-crc:D6768A426C62395D|rigid:EQdNqOzTal90aXSmlA1htvuY4Ks	false	tag:?-?(MINT-1347260)	tag:?-?(MINT-1347253)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91ZK4	uniprotkb:P80206	intact:EBI-7628582|ensembl:ENSMUSP00000081366|uniprotkb:Q91ZK3|uniprotkb:Q8VHG8|intact:MINT-1347271|uniprotkb:Q8CH43|uniprotkb:B1ASG1|uniprotkb:Q8K4U6	intact:EBI-7628620|intact:MINT-1347226	psi-mi:dmbx1_mouse(display_long)|uniprotkb:Dmbx1(gene name)|psi-mi:Dmbx1(display_short)|uniprotkb:Otx3(gene name synonym)|uniprotkb:Cdmx(gene name synonym)|uniprotkb:Mbx(gene name synonym)|uniprotkb:PaxB(gene name synonym)|uniprotkb:Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein(gene name synonym)|uniprotkb:Paired-like homeobox protein DMBX1(gene name synonym)|uniprotkb:Paired-type homeobox Atx(gene name synonym)|uniprotkb:Orthodenticle homolog 3(gene name synonym)	psi-mi:otx2_mouse(display_long)|uniprotkb:Otx2(gene name)|psi-mi:Otx2(display_short)|uniprotkb:Otx-2(gene name synonym)|uniprotkb:Orthodenticle homolog 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kimura et al. (2005)	pubmed:15890343|imex:IM-11051|mint:MINT-5217729	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7628734|mint:MINT-58690|imex:IM-11051-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028707(gene)|ensembl:ENSMUST00000084338(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048589"(developmental growth)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|go:"GO:0003677"(DNA binding)|refseq:XP_017175447.1|refseq:XP_017175448.1|refseq:NP_570935.3|refseq:NP_001020738.1|mint:MINT-1347372(identity)	go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000543"(positive regulation of gastrulation)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|rcsb pdb:2DMS|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007492"(endoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0022037"(metencephalon development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042706"(eye photoreceptor cell fate commitment)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0030426"(growth cone)|mint:MINT-1347382(identity)	-	comment:mint|function:"Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability"|comment:"Stoichiometry: 1.0"	function:"Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/17	2014/10/16	rogid:8gVbhAQwTa+0DnUM3XCn24yAoQY10090	rogid:HnMETTJoqGaon6Bb+BtoDXiUTLw10090	intact-crc:523D9695AB45D7D7|rigid:ZU4o5Kj4XiepUkt6HqZ5Pp0G/xA	false	tag:?-?(MINT-1347377)|binding-associated region:1-156(MINT-1347373)	binding-associated region:98-289(MINT-1347383)|tag:?-?(MINT-1347387)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91ZK4	uniprotkb:P80206	intact:EBI-7628582|ensembl:ENSMUSP00000081366|uniprotkb:Q91ZK3|uniprotkb:Q8VHG8|intact:MINT-1347271|uniprotkb:Q8CH43|uniprotkb:B1ASG1|uniprotkb:Q8K4U6	intact:EBI-7628620|intact:MINT-1347226	psi-mi:dmbx1_mouse(display_long)|uniprotkb:Dmbx1(gene name)|psi-mi:Dmbx1(display_short)|uniprotkb:Otx3(gene name synonym)|uniprotkb:Cdmx(gene name synonym)|uniprotkb:Mbx(gene name synonym)|uniprotkb:PaxB(gene name synonym)|uniprotkb:Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein(gene name synonym)|uniprotkb:Paired-like homeobox protein DMBX1(gene name synonym)|uniprotkb:Paired-type homeobox Atx(gene name synonym)|uniprotkb:Orthodenticle homolog 3(gene name synonym)	psi-mi:otx2_mouse(display_long)|uniprotkb:Otx2(gene name)|psi-mi:Otx2(display_short)|uniprotkb:Otx-2(gene name synonym)|uniprotkb:Orthodenticle homolog 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kimura et al. (2005)	pubmed:15890343|imex:IM-11051|mint:MINT-5217729	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7628854|mint:MINT-58692|imex:IM-11051-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028707(gene)|ensembl:ENSMUST00000084338(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048589"(developmental growth)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|go:"GO:0003677"(DNA binding)|refseq:XP_017175447.1|refseq:XP_017175448.1|refseq:NP_570935.3|refseq:NP_001020738.1|mint:MINT-1347352(identity)	go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000543"(positive regulation of gastrulation)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|rcsb pdb:2DMS|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007492"(endoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0022037"(metencephalon development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042706"(eye photoreceptor cell fate commitment)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0030426"(growth cone)|mint:MINT-1347360(identity)	-	comment:mint|function:"Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability"|comment:"Stoichiometry: 1.0"	function:"Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/17	2016/10/20	rogid:8gVbhAQwTa+0DnUM3XCn24yAoQY10090	rogid:HnMETTJoqGaon6Bb+BtoDXiUTLw10090	intact-crc:86F6F4031897C922|rigid:ZU4o5Kj4XiepUkt6HqZ5Pp0G/xA	false	tag:?-?(MINT-1347355)|mutation disrupting interaction:122-122(MINT-1347353)	tag:?-?(MINT-1347363)|binding-associated region:98-289(MINT-1347361)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)