#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P02730 uniprotkb:P42771 intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418 intact:EBI-375053|uniprotkb:O95440|uniprotkb:Q15191|uniprotkb:Q5VVJ5|uniprotkb:Q96B52|uniprotkb:Q9NP05|uniprotkb:A5X2G7|ensembl:ENSP00000307101|uniprotkb:D3DRK1|intact:EBI-7576126|intact:MINT-1344330|uniprotkb:G3XAG3 psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym) psi-mi:cdn2a_human(display_long)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:Cyclin-dependent kinase 4 inhibitor A(gene name synonym)|uniprotkb:p16-INK4a(gene name synonym)|uniprotkb:Multiple tumor suppressor 1(gene name synonym)|uniprotkb:MTS1(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Fu et al. (2005) pubmed:15811326|imex:IM-10925|mint:MINT-5217644 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7576119|mint:MINT-58443|imex:IM-10925-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N|mint:MINT-1344338(identity) refseq:NP_000068.1|refseq:NP_478104.2|refseq:XP_011515981.1|ensembl:ENSG00000147889(gene)|ensembl:ENST00000304494(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003723"(RNA binding)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR036770|mint:P42771|rcsb pdb:1A5E|rcsb pdb:1BI7|rcsb pdb:1DC2|rcsb pdb:2A5E|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8853884|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|refseq:NP_001182061.1|refseq:XP_005251400.1|dip:DIP-6108N|mint:MINT-1344346(identity) - function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/05/30 2018/09/18 rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606 rogid:9qd+YTVorW7jBQB23jJuOuMUKCk9606 intact-crc:6D4EFB78CFAC1AC6|rigid:GJpgx++qrKI0Ckjyeb57neHqkzI false tag:?-?(MINT-1344341)|binding-associated region:880-892(MINT-1344339) tag:?-?(MINT-1344347) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0113"(western blot) uniprotkb:P02730 uniprotkb:P42771 intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418 intact:EBI-375053|uniprotkb:O95440|uniprotkb:Q15191|uniprotkb:Q5VVJ5|uniprotkb:Q96B52|uniprotkb:Q9NP05|uniprotkb:A5X2G7|ensembl:ENSP00000307101|uniprotkb:D3DRK1|intact:EBI-7576126|intact:MINT-1344330|uniprotkb:G3XAG3 psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym) psi-mi:cdn2a_human(display_long)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:Cyclin-dependent kinase 4 inhibitor A(gene name synonym)|uniprotkb:p16-INK4a(gene name synonym)|uniprotkb:Multiple tumor suppressor 1(gene name synonym)|uniprotkb:MTS1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Fu et al. (2005) pubmed:15811326|imex:IM-10925|mint:MINT-5217644 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7576330|mint:MINT-58441|imex:IM-10925-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N|mint:MINT-1344416(identity) refseq:NP_000068.1|refseq:NP_478104.2|refseq:XP_011515981.1|ensembl:ENSG00000147889(gene)|ensembl:ENST00000304494(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003723"(RNA binding)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR036770|mint:P42771|rcsb pdb:1A5E|rcsb pdb:1BI7|rcsb pdb:1DC2|rcsb pdb:2A5E|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8853884|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|refseq:NP_001182061.1|refseq:XP_005251400.1|dip:DIP-6108N|mint:MINT-1344424(identity) - function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/05/30 2018/09/18 rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606 rogid:9qd+YTVorW7jBQB23jJuOuMUKCk9606 intact-crc:B4AE26FC0BF918CF|rigid:GJpgx++qrKI0Ckjyeb57neHqkzI false binding-associated region:880-892(MINT-1344417)|tag:?-?(MINT-1344419) tag:?-?(MINT-1344425) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02730 uniprotkb:P42771 intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418 intact:EBI-375053|uniprotkb:O95440|uniprotkb:Q15191|uniprotkb:Q5VVJ5|uniprotkb:Q96B52|uniprotkb:Q9NP05|uniprotkb:A5X2G7|ensembl:ENSP00000307101|uniprotkb:D3DRK1|intact:EBI-7576126|intact:MINT-1344330|uniprotkb:G3XAG3 psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym) psi-mi:cdn2a_human(display_long)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:Cyclin-dependent kinase 4 inhibitor A(gene name synonym)|uniprotkb:p16-INK4a(gene name synonym)|uniprotkb:Multiple tumor suppressor 1(gene name synonym)|uniprotkb:MTS1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Fu et al. (2005) pubmed:15811326|imex:IM-10925|mint:MINT-5217644 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7576377|mint:MINT-58442|imex:IM-10925-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N|mint:MINT-1344358(identity) refseq:NP_000068.1|refseq:NP_478104.2|refseq:XP_011515981.1|ensembl:ENSG00000147889(gene)|ensembl:ENST00000304494(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003723"(RNA binding)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR036770|mint:P42771|rcsb pdb:1A5E|rcsb pdb:1BI7|rcsb pdb:1DC2|rcsb pdb:2A5E|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8853884|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|refseq:NP_001182061.1|refseq:XP_005251400.1|dip:DIP-6108N|mint:MINT-1344367(identity) - function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2B|comment:"Biosource proteins: Human-hela"|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/05/30 2018/09/18 rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606 rogid:9qd+YTVorW7jBQB23jJuOuMUKCk9606 intact-crc:E25C6159D16C7ED5|rigid:GJpgx++qrKI0Ckjyeb57neHqkzI false binding-associated region:880-892(MINT-1344359)|tag:?-?(MINT-1344362) tag:?-?(MINT-1344368) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02730 uniprotkb:P42771 intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418 intact:EBI-375053|uniprotkb:O95440|uniprotkb:Q15191|uniprotkb:Q5VVJ5|uniprotkb:Q96B52|uniprotkb:Q9NP05|uniprotkb:A5X2G7|ensembl:ENSP00000307101|uniprotkb:D3DRK1|intact:EBI-7576126|intact:MINT-1344330|uniprotkb:G3XAG3 psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym) psi-mi:cdn2a_human(display_long)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:Cyclin-dependent kinase 4 inhibitor A(gene name synonym)|uniprotkb:p16-INK4a(gene name synonym)|uniprotkb:Multiple tumor suppressor 1(gene name synonym)|uniprotkb:MTS1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Fu et al. (2005) pubmed:15811326|imex:IM-10925|mint:MINT-5217644 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7576455|mint:MINT-58444|imex:IM-10925-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N|mint:MINT-1344384(identity) refseq:NP_000068.1|refseq:NP_478104.2|refseq:XP_011515981.1|ensembl:ENSG00000147889(gene)|ensembl:ENST00000304494(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003723"(RNA binding)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR036770|mint:P42771|rcsb pdb:1A5E|rcsb pdb:1BI7|rcsb pdb:1DC2|rcsb pdb:2A5E|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8853884|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|refseq:NP_001182061.1|refseq:XP_005251400.1|dip:DIP-6108N|mint:MINT-1344380(identity) - function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/05/30 2018/09/18 rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606 rogid:9qd+YTVorW7jBQB23jJuOuMUKCk9606 intact-crc:CC2DDDEEA070A904|rigid:GJpgx++qrKI0Ckjyeb57neHqkzI false binding-associated region:880-892(MINT-1344385)|tag:?-?(MINT-1344387) - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P02730 uniprotkb:P42771 intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418 intact:EBI-375053|uniprotkb:O95440|uniprotkb:Q15191|uniprotkb:Q5VVJ5|uniprotkb:Q96B52|uniprotkb:Q9NP05|uniprotkb:A5X2G7|ensembl:ENSP00000307101|uniprotkb:D3DRK1|intact:EBI-7576126|intact:MINT-1344330|uniprotkb:G3XAG3 psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym) psi-mi:cdn2a_human(display_long)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:Cyclin-dependent kinase 4 inhibitor A(gene name synonym)|uniprotkb:p16-INK4a(gene name synonym)|uniprotkb:Multiple tumor suppressor 1(gene name synonym)|uniprotkb:MTS1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Fu et al. (2005) pubmed:15811326|imex:IM-10925|mint:MINT-5217644 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7576578|mint:MINT-58445|imex:IM-10925-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N|mint:MINT-1344405(identity) refseq:NP_000068.1|refseq:NP_478104.2|refseq:XP_011515981.1|ensembl:ENSG00000147889(gene)|ensembl:ENST00000304494(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003723"(RNA binding)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR036770|mint:P42771|rcsb pdb:1A5E|rcsb pdb:1BI7|rcsb pdb:1DC2|rcsb pdb:2A5E|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8853884|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|refseq:NP_001182061.1|refseq:XP_005251400.1|dip:DIP-6108N|mint:MINT-1344398(identity) go:"GO:0005886"(plasma membrane) function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2005/05/30 2014/10/16 rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606 rogid:9qd+YTVorW7jBQB23jJuOuMUKCk9606 intact-crc:2B4C8521CA201323|rigid:GJpgx++qrKI0Ckjyeb57neHqkzI false ha tag:?-?(MINT-1344406) green fluorescent protein tag:?-?(MINT-1344399) - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0396"(predetermined participant)