#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9CQ33	uniprotkb:O00238	intact:EBI-7527167|intact:MINT-1342142|ensembl:ENSMUSP00000023444	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:lztr1_mouse(display_long)|uniprotkb:Lztr1(gene name)|psi-mi:Lztr1(display_short)|uniprotkb:Tcfl2(gene name synonym)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527240|mint:MINT-58531	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001318155.1|refseq:NP_001318156.1|refseq:NP_080084.2|ensembl:ENSMUSG00000022761(gene)|ensembl:ENSMUST00000023444(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0012505"(endomembrane system)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011498(Kelch repeat type 2)|interpro:IPR015915(Kelch-type beta propeller)|mint:MINT-1342172(identity)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-1342166(identity)	-	comment:mint|function:Probable transcriptional regulator that may play a crucial role in embryogenesis|comment:"Stoichiometry: 1.0"	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"|comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:9in43Ek99/4ry0+EGvUfofnsUCI10090	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:DB21AB8376704F28|rigid:OsQnn5K3Vh+WuX7wY06lQFjRNZM	false	tag:?-?(MINT-1342173)	tag:?-?(MINT-1342167)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BQA9	uniprotkb:P36897	intact:EBI-7527297|intact:MINT-1340163	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:q8bqa9_mouse(display_long)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527293|mint:MINT-58520	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:MINT-1340196(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340190(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:/uttFdwy1dgrtQuOAuihjNk6Fzo10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:69ED1CC83CF6D286|rigid:wWIPYIXq7FVnNJBMAwkXIVyQtz4	false	tag:?-?(MINT-1340197)	tag:?-?(MINT-1340191)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97348	uniprotkb:Q04771	intact:EBI-7527344|uniprotkb:O09104|intact:MINT-1340205|ensembl:ENSMUSP00000036031	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:rhod_mouse(display_long)|uniprotkb:Rhod(gene name)|psi-mi:Rhod(display_short)|uniprotkb:Arhd(gene name synonym)|uniprotkb:Rhom(gene name synonym)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527339|mint:MINT-58491	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031511.1|ensembl:ENSMUSG00000041845(gene)|ensembl:ENSMUST00000048197(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-5663220|reactome:R-MMU-9013405|mint:MINT-1340226(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1340220(identity)	-	comment:mint|function:Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:FRwPCPAwwUap1HahZo7SwpNvILU10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:B6CDE01AA1169732|rigid:7EsxK00riR6gjQSUPNpZpBzq3Uc	false	tag:?-?(MINT-1340227)	tag:?-?(MINT-1340221)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O00238	uniprotkb:P97348	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-7527344|uniprotkb:O09104|intact:MINT-1340205|ensembl:ENSMUSP00000036031	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:rhod_mouse(display_long)|uniprotkb:Rhod(gene name)|psi-mi:Rhod(display_short)|uniprotkb:Arhd(gene name synonym)|uniprotkb:Rhom(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527377|mint:MINT-58492	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-1340267(identity)	refseq:NP_031511.1|ensembl:ENSMUSG00000041845(gene)|ensembl:ENSMUST00000048197(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-5663220|reactome:R-MMU-9013405|mint:MINT-1340273(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"|comment:"Stoichiometry: 1.0"	comment:mint|function:Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton|comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:FRwPCPAwwUap1HahZo7SwpNvILU10090	intact-crc:5A447C7F384B7726|rigid:5uc6V//fT8pvTjDULMOPh2XB0O0	false	tag:?-?(MINT-1340268)	tag:?-?(MINT-1340274)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97348	uniprotkb:Q15796	intact:EBI-7527344|uniprotkb:O09104|intact:MINT-1340205|ensembl:ENSMUSP00000036031	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:rhod_mouse(display_long)|uniprotkb:Rhod(gene name)|psi-mi:Rhod(display_short)|uniprotkb:Arhd(gene name synonym)|uniprotkb:Rhom(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527409|mint:MINT-58488	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031511.1|ensembl:ENSMUSG00000041845(gene)|ensembl:ENSMUST00000048197(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-5663220|reactome:R-MMU-9013405|mint:MINT-1340288(identity)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N|mint:MINT-1340282(identity)	-	comment:mint|function:Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:FRwPCPAwwUap1HahZo7SwpNvILU10090	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:3642CF69CFF4D242|rigid:dgDXFP7ZDTXlKBmSCoKsRwo6Fus	false	tag:?-?(MINT-1340289)	tag:?-?(MINT-1340283)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97348	uniprotkb:Q9HAU4	intact:EBI-7527344|uniprotkb:O09104|intact:MINT-1340205|ensembl:ENSMUSP00000036031	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:rhod_mouse(display_long)|uniprotkb:Rhod(gene name)|psi-mi:Rhod(display_short)|uniprotkb:Arhd(gene name synonym)|uniprotkb:Rhom(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527426|mint:MINT-58493	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031511.1|ensembl:ENSMUSG00000041845(gene)|ensembl:ENSMUST00000048197(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-5663220|reactome:R-MMU-9013405|mint:MINT-1340303(identity)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-1340297(identity)	-	comment:mint|function:Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:FRwPCPAwwUap1HahZo7SwpNvILU10090	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:CB824F387C8C4F76|rigid:+MLK44GTm845F0BZYnp8xjKa3I0	false	tag:?-?(MINT-1340304)	tag:?-?(MINT-1340298)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97348	uniprotkb:P36897	intact:EBI-7527344|uniprotkb:O09104|intact:MINT-1340205|ensembl:ENSMUSP00000036031	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:rhod_mouse(display_long)|uniprotkb:Rhod(gene name)|psi-mi:Rhod(display_short)|uniprotkb:Arhd(gene name synonym)|uniprotkb:Rhom(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527478|mint:MINT-58490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031511.1|ensembl:ENSMUSG00000041845(gene)|ensembl:ENSMUST00000048197(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-5663220|reactome:R-MMU-9013405|mint:MINT-1340318(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340312(identity)	-	comment:mint|function:Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:FRwPCPAwwUap1HahZo7SwpNvILU10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:261D89099341F7FD|rigid:S5aI2U9YEzz+0I0oNfXaHYIwTRc	false	tag:?-?(MINT-1340319)	tag:?-?(MINT-1340313)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97348	uniprotkb:Q13485	intact:EBI-7527344|uniprotkb:O09104|intact:MINT-1340205|ensembl:ENSMUSP00000036031	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:rhod_mouse(display_long)|uniprotkb:Rhod(gene name)|psi-mi:Rhod(display_short)|uniprotkb:Arhd(gene name synonym)|uniprotkb:Rhom(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527495|mint:MINT-58489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031511.1|ensembl:ENSMUSG00000041845(gene)|ensembl:ENSMUST00000048197(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-5663220|reactome:R-MMU-9013405|mint:MINT-1340333(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1340327(identity)	-	comment:mint|function:Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:FRwPCPAwwUap1HahZo7SwpNvILU10090	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:0B5C169272F618C4|rigid:i6O4FX9hK1iJ1kd8Xh9N7BXNa+k	false	tag:?-?(MINT-1340334)	tag:?-?(MINT-1340328)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9HAU4	uniprotkb:Q9ESK4	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-1561388|uniprotkb:Q80VI5|uniprotkb:Q8BGU8|uniprotkb:Q4VAD7|ensembl:ENSMUSP00000079226	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:ing2_mouse(display_long)|uniprotkb:p33ING2(gene name synonym)|uniprotkb:Inhibitor of growth 1-like protein(gene name synonym)|uniprotkb:Ing2(gene name)|psi-mi:Ing2(display_short)|uniprotkb:Ing1l(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527544|mint:MINT-58549	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-1340371(identity)	refseq:NP_075992.2|dip:DIP-38912N|ensembl:ENSMUSG00000063049(gene)|ensembl:ENSMUST00000080353(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016602"(CCAAT-binding factor complex)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR024610|interpro:IPR028639|interpro:IPR028651|interpro:IPR042019|rcsb pdb:1WES|rcsb pdb:2G6Q|reactome:R-MMU-3899300|reactome:R-MMU-6811555|mint:MINT-1340377(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:9pxLKzNNiUMtG+a2Z4SLTaiaUNQ10090	intact-crc:7D1EE3E51FA4B159|rigid:y6u4dpKDYCTIQww7MTurawUzyF8	false	tag:?-?(MINT-1340372)	tag:?-?(MINT-1340378)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15797	uniprotkb:Q9ESK4	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-1561388|uniprotkb:Q80VI5|uniprotkb:Q8BGU8|uniprotkb:Q4VAD7|ensembl:ENSMUSP00000079226	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:ing2_mouse(display_long)|uniprotkb:p33ING2(gene name synonym)|uniprotkb:Inhibitor of growth 1-like protein(gene name synonym)|uniprotkb:Ing2(gene name)|psi-mi:Ing2(display_short)|uniprotkb:Ing1l(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527528|mint:MINT-58548	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1340356(identity)	refseq:NP_075992.2|dip:DIP-38912N|ensembl:ENSMUSG00000063049(gene)|ensembl:ENSMUST00000080353(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016602"(CCAAT-binding factor complex)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR024610|interpro:IPR028639|interpro:IPR028651|interpro:IPR042019|rcsb pdb:1WES|rcsb pdb:2G6Q|reactome:R-MMU-3899300|reactome:R-MMU-6811555|mint:MINT-1340362(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:9pxLKzNNiUMtG+a2Z4SLTaiaUNQ10090	intact-crc:98C3DEF825061481|rigid:eJe+nBW/pi1E5QkKmEh9sFvZWIM	false	tag:?-?(MINT-1340357)	tag:?-?(MINT-1340363)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PE9	uniprotkb:Q15796	intact:EBI-7527576|uniprotkb:Q9CQB1|intact:MINT-1340386|ensembl:ENSMUSP00000035918	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:arl4d_mouse(display_long)|uniprotkb:Arl4d(gene name)|psi-mi:Arl4d(display_short)|uniprotkb:Arf4l(gene name synonym)|uniprotkb:Arl5(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 4L(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 5(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527617|mint:MINT-58499	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079680.1|ensembl:ENSMUSG00000034936(gene)|ensembl:ENSMUST00000039388(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:MINT-1340428(identity)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N|mint:MINT-1340422(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:3WvyAgJx5fWZXmlnSv0Wc1xNqME10090	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:F2608753F600580F|rigid:RiV4X50u0BZk9Rp0W20nHvDnpm8	false	tag:?-?(MINT-1340429)	tag:?-?(MINT-1340423)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PE9	uniprotkb:Q15797	intact:EBI-7527576|uniprotkb:Q9CQB1|intact:MINT-1340386|ensembl:ENSMUSP00000035918	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:arl4d_mouse(display_long)|uniprotkb:Arl4d(gene name)|psi-mi:Arl4d(display_short)|uniprotkb:Arf4l(gene name synonym)|uniprotkb:Arl5(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 4L(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 5(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527600|mint:MINT-58501	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079680.1|ensembl:ENSMUSG00000034936(gene)|ensembl:ENSMUST00000039388(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:MINT-1340413(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1340407(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:3WvyAgJx5fWZXmlnSv0Wc1xNqME10090	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:F8EF9BD4F0CA575F|rigid:VEPu7mRLJWsCq4b6hVSOdBs30CE	false	tag:?-?(MINT-1340414)	tag:?-?(MINT-1340408)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PE9	uniprotkb:P36897	intact:EBI-7527576|uniprotkb:Q9CQB1|intact:MINT-1340386|ensembl:ENSMUSP00000035918	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:arl4d_mouse(display_long)|uniprotkb:Arl4d(gene name)|psi-mi:Arl4d(display_short)|uniprotkb:Arf4l(gene name synonym)|uniprotkb:Arl5(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 4L(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 5(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527650|mint:MINT-58500	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079680.1|ensembl:ENSMUSG00000034936(gene)|ensembl:ENSMUST00000039388(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:MINT-1340443(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340437(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:3WvyAgJx5fWZXmlnSv0Wc1xNqME10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:7455B33067CBBA68|rigid:+DJpwXkYGFUXULX+rzGh5LOnYpA	false	tag:?-?(MINT-1340444)	tag:?-?(MINT-1340438)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EPX5	uniprotkb:Q15797	intact:EBI-7527703|uniprotkb:Q8CDX0|uniprotkb:Q3UVH7|uniprotkb:Q9QZN5|uniprotkb:Q9CY04|intact:MINT-1340452|ensembl:ENSMUSP00000083650|ensembl:ENSMUSP00000119124	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:fxl12_mouse(display_long)|uniprotkb:Fbxl12(gene name)|psi-mi:Fbxl12(display_short)|uniprotkb:Fbl12(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 12(gene name synonym)|uniprotkb:F-box protein FBL12(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527725|mint:MINT-58511	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273458.1|refseq:NP_001273459.1|refseq:NP_001002846.1|refseq:NP_038939.2|ensembl:ENSMUSG00000066892(gene)|ensembl:ENSMUST00000086459(transcript)|ensembl:ENSMUST00000148631(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:XP_006510460.1|refseq:XP_006510461.1|refseq:XP_006510462.1|mint:MINT-1340477(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1340471(identity)	-	function:"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:XK9q4vqGOZD1LYwHPDgpQmF6Tsk10090	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:D4EBB6EA1B7A09A4|rigid:vfNLRUgd3akw0NqBEXWztp4f1oE	false	tag:?-?(MINT-1340478)	tag:?-?(MINT-1340472)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EPX5	uniprotkb:P36897	intact:EBI-7527703|uniprotkb:Q8CDX0|uniprotkb:Q3UVH7|uniprotkb:Q9QZN5|uniprotkb:Q9CY04|intact:MINT-1340452|ensembl:ENSMUSP00000083650|ensembl:ENSMUSP00000119124	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:fxl12_mouse(display_long)|uniprotkb:Fbxl12(gene name)|psi-mi:Fbxl12(display_short)|uniprotkb:Fbl12(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 12(gene name synonym)|uniprotkb:F-box protein FBL12(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527754|mint:MINT-58510	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273458.1|refseq:NP_001273459.1|refseq:NP_001002846.1|refseq:NP_038939.2|ensembl:ENSMUSG00000066892(gene)|ensembl:ENSMUST00000086459(transcript)|ensembl:ENSMUST00000148631(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:XP_006510460.1|refseq:XP_006510461.1|refseq:XP_006510462.1|mint:MINT-1340492(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340486(identity)	-	function:"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:XK9q4vqGOZD1LYwHPDgpQmF6Tsk10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:58519E0E8C7BE493|rigid:g5DhexI9wBFo+9fsCSNgABUEl8I	false	tag:?-?(MINT-1340493)	tag:?-?(MINT-1340487)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35292	uniprotkb:Q04771	intact:EBI-7527775|uniprotkb:Q921D2|intact:MINT-1340501|uniprotkb:Q9D723|ensembl:ENSMUSP00000027529|ensembl:ENSMUSP00000122178	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:rab17_mouse(display_long)|uniprotkb:Rab17(gene name)|psi-mi:Rab17(display_short)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527809|mint:MINT-58480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033024.1|refseq:NP_001153197.2|ensembl:ENSMUSG00000026304(gene)|ensembl:ENSMUST00000027529(transcript)|ensembl:ENSMUST00000131428(transcript)|go:"GO:0002415"(immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0032401"(establishment of melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042470"(melanosome)|go:"GO:0045056"(transcytosis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-8873719|go:"GO:0043025"(neuronal cell body)|refseq:XP_006529326.1|mint:MINT-1340523(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1340517(identity)	-	comment:mint|function:Might be involved in transcellular transport|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:RFDfU0pQ5zfRfyNQaMS3dNqsBL810090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:D0296C079E56C293|rigid:EU7WrB3sBzaRHqsUrvUdXDBwJ7Y	false	tag:?-?(MINT-1340524)	tag:?-?(MINT-1340518)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35292	uniprotkb:Q9HAU4	intact:EBI-7527775|uniprotkb:Q921D2|intact:MINT-1340501|uniprotkb:Q9D723|ensembl:ENSMUSP00000027529|ensembl:ENSMUSP00000122178	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:rab17_mouse(display_long)|uniprotkb:Rab17(gene name)|psi-mi:Rab17(display_short)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527841|mint:MINT-58481	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033024.1|refseq:NP_001153197.2|ensembl:ENSMUSG00000026304(gene)|ensembl:ENSMUST00000027529(transcript)|ensembl:ENSMUST00000131428(transcript)|go:"GO:0002415"(immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0032401"(establishment of melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042470"(melanosome)|go:"GO:0045056"(transcytosis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-8873719|go:"GO:0043025"(neuronal cell body)|refseq:XP_006529326.1|mint:MINT-1340538(identity)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-1340532(identity)	-	comment:mint|function:Might be involved in transcellular transport|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:RFDfU0pQ5zfRfyNQaMS3dNqsBL810090	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:AD66C32543CC1AD7|rigid:BJa41Q62Y85bHZXs82Z1cABC4Jo	false	tag:?-?(MINT-1340539)	tag:?-?(MINT-1340533)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P36897	uniprotkb:Q9Z101	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527858|mint:MINT-58536	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340580(identity)	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N|mint:MINT-1340586(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	intact-crc:432F614366C47866|rigid:taB3jyShbYVd6RqLJ7LRnZBYshs	false	tag:?-?(MINT-1340581)	tag:?-?(MINT-1340587)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q922Y1	uniprotkb:Q04771	intact:EBI-3648572|uniprotkb:Q3UCP8|ensembl:ENSMUSP00000133250|ensembl:ENSMUSP00000157971	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:ubxn1_mouse(display_long)|uniprotkb:Ubxn1(gene name)|psi-mi:Ubxn1(display_short)|uniprotkb:D19Ertd721e(gene name synonym)|uniprotkb:Saks1(gene name synonym)|uniprotkb:Protein 2B28(gene name synonym)|uniprotkb:SAPK substrate protein 1(gene name synonym)|uniprotkb:UBA/UBX 33.3 kDa protein(gene name synonym)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527891|mint:MINT-58507	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666205.1|refseq:XP_006526985.1|ensembl:ENSMUSG00000071655(gene)|ensembl:ENSMUST00000166407(transcript)|ensembl:ENSMUST00000238036(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071796"(K6-linked polyubiquitin modification-dependent protein binding)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|go:"GO:1904855"(proteasome regulatory particle binding)|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|interpro:IPR001012(UBX)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR041923|rcsb pdb:1WHC|reactome:R-MMU-532668|go:"GO:0005634"(nucleus)|mint:MINT-1342047(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1342041(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:G20RBAq4Xj6/LL9KLFLoFm5VzRo10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:06ABA7707F6253A1|rigid:6wLulzhnjupqjWwzSFcztgLYrdE	false	tag:?-?(MINT-1342048)	tag:?-?(MINT-1342042)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q922Y1	uniprotkb:O00238	intact:EBI-3648572|uniprotkb:Q3UCP8|ensembl:ENSMUSP00000133250|ensembl:ENSMUSP00000157971	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:ubxn1_mouse(display_long)|uniprotkb:Ubxn1(gene name)|psi-mi:Ubxn1(display_short)|uniprotkb:D19Ertd721e(gene name synonym)|uniprotkb:Saks1(gene name synonym)|uniprotkb:Protein 2B28(gene name synonym)|uniprotkb:SAPK substrate protein 1(gene name synonym)|uniprotkb:UBA/UBX 33.3 kDa protein(gene name synonym)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527924|mint:MINT-58508	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666205.1|refseq:XP_006526985.1|ensembl:ENSMUSG00000071655(gene)|ensembl:ENSMUST00000166407(transcript)|ensembl:ENSMUST00000238036(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071796"(K6-linked polyubiquitin modification-dependent protein binding)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|go:"GO:1904855"(proteasome regulatory particle binding)|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|interpro:IPR001012(UBX)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR041923|rcsb pdb:1WHC|reactome:R-MMU-532668|go:"GO:0005634"(nucleus)|mint:MINT-1342062(identity)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-1342056(identity)	-	comment:"Stoichiometry: 1.0"	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"|comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:G20RBAq4Xj6/LL9KLFLoFm5VzRo10090	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:A93573A33F4CB519|rigid:nx3PD1JIjpm+Y16dJ9Px/vzt+Zo	false	tag:?-?(MINT-1342063)	tag:?-?(MINT-1342057)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q922Y1	uniprotkb:P36897	intact:EBI-3648572|uniprotkb:Q3UCP8|ensembl:ENSMUSP00000133250|ensembl:ENSMUSP00000157971	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:ubxn1_mouse(display_long)|uniprotkb:Ubxn1(gene name)|psi-mi:Ubxn1(display_short)|uniprotkb:D19Ertd721e(gene name synonym)|uniprotkb:Saks1(gene name synonym)|uniprotkb:Protein 2B28(gene name synonym)|uniprotkb:SAPK substrate protein 1(gene name synonym)|uniprotkb:UBA/UBX 33.3 kDa protein(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7527968|mint:MINT-58505	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666205.1|refseq:XP_006526985.1|ensembl:ENSMUSG00000071655(gene)|ensembl:ENSMUST00000166407(transcript)|ensembl:ENSMUST00000238036(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071796"(K6-linked polyubiquitin modification-dependent protein binding)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|go:"GO:1904855"(proteasome regulatory particle binding)|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|interpro:IPR001012(UBX)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR041923|rcsb pdb:1WHC|reactome:R-MMU-532668|go:"GO:0005634"(nucleus)|mint:MINT-1342077(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1342071(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:G20RBAq4Xj6/LL9KLFLoFm5VzRo10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:FE2DF5A1BCED8FF5|rigid:okZcDGZQK1g0R+pJR7HiSgy4mQI	false	tag:?-?(MINT-1342078)	tag:?-?(MINT-1342072)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JM96	uniprotkb:P36897	intact:EBI-7528001|intact:MINT-1342086|uniprotkb:Q3TNF3|uniprotkb:Q9QZT8|ensembl:ENSMUSP00000060227|ensembl:ENSMUSP00000102227	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:borg4_mouse(display_long)|uniprotkb:Cdc42ep4(gene name)|psi-mi:Cdc42ep4(display_short)|uniprotkb:Borg4(gene name synonym)|uniprotkb:Cep4(gene name synonym)|uniprotkb:Binder of Rho GTPases 4(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528026|mint:MINT-58552	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156818.1|refseq:NP_064390.1|ensembl:ENSMUSG00000041598(gene)|ensembl:ENSMUST00000053536(transcript)|ensembl:ENSMUST00000106616(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR029273|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|refseq:XP_017170175.1|refseq:XP_006533880.1|refseq:XP_006533881.1|refseq:XP_006533882.1|mint:MINT-1342109(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1342103(identity)	-	comment:mint|function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:OmU/oeS362/Bwp4hTr1tlsMNLHI10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:A3C95AD49A30ABC0|rigid:4J7vvoV3jR0CjpI1xCPThGRyL1M	false	tag:?-?(MINT-1342110)	tag:?-?(MINT-1342104)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54726	uniprotkb:Q9HAU4	intact:EBI-7528059|intact:MINT-1342118	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:o54726_mouse(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528077|mint:MINT-58550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0000976"(transcription cis-regulatory region binding)|mint:MINT-1342133(identity)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-1342127(identity)	-	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:IZTCkwsE2ogWewQcfzN8tVHMQFE10090	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:6617A9C1A52B7F10|rigid:I/FxQF3rSn9+GOv7938w0gqE+Aw	false	tag:?-?(MINT-1342134)	tag:?-?(MINT-1342128)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BQA9	uniprotkb:Q04771	intact:EBI-7527297|intact:MINT-1340163	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:q8bqa9_mouse(display_long)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528094|mint:MINT-58521	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:MINT-1340181(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1340175(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:/uttFdwy1dgrtQuOAuihjNk6Fzo10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:DAF62BBE5525D551|rigid:YTSX/xpeGsDqUHyMPz8Sjhg3JLs	false	tag:?-?(MINT-1340182)	tag:?-?(MINT-1340176)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13485	uniprotkb:O35280	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-2553137|uniprotkb:O54925|uniprotkb:Q8CI40|uniprotkb:Q9D0N2|ensembl:ENSMUSP00000034625|ensembl:ENSMUSP00000134388	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:chk1_mouse(display_long)|uniprotkb:Chk1(gene name synonym)|uniprotkb:Chek1(gene name)|psi-mi:Chek1(display_short)|uniprotkb:CHK1 checkpoint homolog(gene name synonym)|uniprotkb:Checkpoint kinase-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528126|mint:MINT-58519	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1340652(identity)	go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0048096"|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034670|reactome:R-MMU-1433557|reactome:R-MMU-176187|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69473|reactome:R-MMU-69601|reactome:R-MMU-8953750|ensembl:ENSMUSG00000032113(gene)|ensembl:ENSMUST00000034625(transcript)|ensembl:ENSMUST00000172702(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006997"(nucleus organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010767"(regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035556"(intracellular signal transduction)|refseq:NP_031717.2|mint:MINT-1340658(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:AozTzir+BE8FDAvmLniUHEuFQLI10090	intact-crc:24ADB9B3833B853A|rigid:l1gc+9eKAL2ns+ybBQkkBgxX01s	false	tag:?-?(MINT-1340653)	tag:?-?(MINT-1340659)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q78GU9	uniprotkb:P36897	intact:EBI-7528205|intact:MINT-1340667	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:q78gu9_mouse(display_long)|uniprotkb:Cul5(gene name)|psi-mi:Cul5(display_short)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528201|mint:MINT-58515	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016159(Cullin repeat-like)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|mint:MINT-1340681(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340675(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:zIp6VCSezcI2nqAnoTOnOUDuim810090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:6DB1CB68064F9249|rigid:x1VDzPb+rMsY19zToODoYBnIpZ8	false	tag:?-?(MINT-1340682)	tag:?-?(MINT-1340676)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BJL1	uniprotkb:Q15797	intact:EBI-7528233|intact:MINT-1340690|uniprotkb:Q8CI21|uniprotkb:Q3UXU4|uniprotkb:Q9D9X5|ensembl:ENSMUSP00000068230|ensembl:ENSMUSP00000117687	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:fbx30_mouse(display_long)|uniprotkb:Fbxo30(gene name)|psi-mi:Fbxo30(display_short)|uniprotkb:Muscle ubiquitin ligase of SCF complex in atrophy-1(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528228|mint:MINT-58513	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161769.1|refseq:NP_082244.2|ensembl:ENSMUSG00000047648(gene)|ensembl:ENSMUST00000070300(transcript)|ensembl:ENSMUST00000129456(transcript)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031890|interpro:IPR036047|interpro:IPR043013|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:XP_006512922.1|mint:MINT-1340708(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1340702(identity)	-	function:"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:GntYTFmdAq/1zJbDgyqFPeQMzeI10090	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:0721B9554194E2A5|rigid:B1RYYzpv9NTAp4dhVj+NHDDgbn0	false	tag:?-?(MINT-1340709)	tag:?-?(MINT-1340703)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BJL1	uniprotkb:Q04771	intact:EBI-7528233|intact:MINT-1340690|uniprotkb:Q8CI21|uniprotkb:Q3UXU4|uniprotkb:Q9D9X5|ensembl:ENSMUSP00000068230|ensembl:ENSMUSP00000117687	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:fbx30_mouse(display_long)|uniprotkb:Fbxo30(gene name)|psi-mi:Fbxo30(display_short)|uniprotkb:Muscle ubiquitin ligase of SCF complex in atrophy-1(gene name synonym)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528282|mint:MINT-58514	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161769.1|refseq:NP_082244.2|ensembl:ENSMUSG00000047648(gene)|ensembl:ENSMUST00000070300(transcript)|ensembl:ENSMUST00000129456(transcript)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031890|interpro:IPR036047|interpro:IPR043013|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:XP_006512922.1|mint:MINT-1340723(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1340717(identity)	-	function:"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:GntYTFmdAq/1zJbDgyqFPeQMzeI10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:8488D515EEB8CE25|rigid:afx0wXwnpKR3GePxcJ0EvLFWofM	false	tag:?-?(MINT-1340724)	tag:?-?(MINT-1340718)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BJL1	uniprotkb:Q13485	intact:EBI-7528233|intact:MINT-1340690|uniprotkb:Q8CI21|uniprotkb:Q3UXU4|uniprotkb:Q9D9X5|ensembl:ENSMUSP00000068230|ensembl:ENSMUSP00000117687	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:fbx30_mouse(display_long)|uniprotkb:Fbxo30(gene name)|psi-mi:Fbxo30(display_short)|uniprotkb:Muscle ubiquitin ligase of SCF complex in atrophy-1(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528364|mint:MINT-58512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161769.1|refseq:NP_082244.2|ensembl:ENSMUSG00000047648(gene)|ensembl:ENSMUST00000070300(transcript)|ensembl:ENSMUST00000129456(transcript)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031890|interpro:IPR036047|interpro:IPR043013|reactome:R-MMU-8951664|reactome:R-MMU-983168|refseq:XP_006512922.1|mint:MINT-1340738(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1340732(identity)	-	function:"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:GntYTFmdAq/1zJbDgyqFPeQMzeI10090	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:A6DA0E2A3722E0AB|rigid:Ve7lvTS1ftq9oNe8qjypqFR1SM0	false	tag:?-?(MINT-1340739)	tag:?-?(MINT-1340733)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUH2	uniprotkb:Q15796	intact:EBI-309943|uniprotkb:Q9QYQ5|uniprotkb:Q9QYQ6|uniprotkb:Q9QZ00|uniprotkb:Q9WU44|uniprotkb:Q6GQU4|ensembl:ENSMUSP00000107657	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:lhx9_mouse(display_long)|uniprotkb:Lhx9(gene name)|psi-mi:Lhx9(display_short)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528437|mint:MINT-58538	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020736.1|refseq:NP_001036042.1|refseq:NP_034844.1|refseq:XP_006529234.1|refseq:XP_006529235.1|refseq:XP_006529236.1|ensembl:ENSMUSG00000019230(gene)|ensembl:ENSMUST00000112026(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0097380"(dorsal spinal cord interneuron anterior axon guidance)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR017970|refseq:XP_017174117.1|refseq:XP_017174126.1|mint:MINT-1340767(identity)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N|mint:MINT-1340761(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:s4c7v6ly14ws4h5AZTQnly7AGgc10090	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:1C047E6E7ED084C8|rigid:od2L8K0l+tq4bqy9hQ8Hkn+zW8U	false	tag:?-?(MINT-1340768)	tag:?-?(MINT-1340762)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BRG4	uniprotkb:P36897	intact:EBI-7528461|intact:MINT-1340821	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:q8brg4_mouse(display_long)|uniprotkb:Enc1(gene name)|psi-mi:Enc1(display_short)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528498|mint:MINT-58530	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0003779"(actin binding)|go:"GO:0007399"(nervous system development)|interpro:IPR030562|mint:MINT-1340839(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340833(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:XGHxq6/wijSfoGqtTp+CzlsznRg10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:44AA7C2442D835C2|rigid:ulNLXI2rRL9c1M1Bd9ZeZd4l13I	false	tag:?-?(MINT-1340840)	tag:?-?(MINT-1340834)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DD03	uniprotkb:Q9HAU4	intact:EBI-7528592|intact:MINT-1340848|ensembl:ENSMUSP00000070588	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:rab13_mouse(display_long)|uniprotkb:Rab13(gene name)|psi-mi:Rab13(display_short)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528587|mint:MINT-58479	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080953.1|ensembl:ENSMUSG00000027935(gene)|ensembl:ENSMUST00000065418(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0043005"(neuron projection)|go:"GO:0044795"(trans-Golgi network to recycling endosome transport)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9DD03|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0032456"(endocytic recycling)|mint:MINT-1340865(identity)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-1340859(identity)	-	function:Could participate in polarized transport, in the assembly and/or the activity of tight junctions|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:vFVG2hj2wT1UcE0LSh12mVhYd+010090	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:AD06E39441ED5932|rigid:sqbTzbLUwzZO7ZmC/kT4vy5/kFs	false	tag:?-?(MINT-1340866)	tag:?-?(MINT-1340860)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DD03	uniprotkb:P36897	intact:EBI-7528592|intact:MINT-1340848|ensembl:ENSMUSP00000070588	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:rab13_mouse(display_long)|uniprotkb:Rab13(gene name)|psi-mi:Rab13(display_short)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528644|mint:MINT-58478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080953.1|ensembl:ENSMUSG00000027935(gene)|ensembl:ENSMUST00000065418(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0043005"(neuron projection)|go:"GO:0044795"(trans-Golgi network to recycling endosome transport)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9DD03|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0032456"(endocytic recycling)|mint:MINT-1340880(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340874(identity)	-	function:Could participate in polarized transport, in the assembly and/or the activity of tight junctions|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:vFVG2hj2wT1UcE0LSh12mVhYd+010090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:733B1C41B5195BDE|rigid:m+7zxUXa3WzZmNwj+k3Z7jEYq5c	false	tag:?-?(MINT-1340881)	tag:?-?(MINT-1340875)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DD03	uniprotkb:Q13485	intact:EBI-7528592|intact:MINT-1340848|ensembl:ENSMUSP00000070588	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:rab13_mouse(display_long)|uniprotkb:Rab13(gene name)|psi-mi:Rab13(display_short)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528704|mint:MINT-58477	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080953.1|ensembl:ENSMUSG00000027935(gene)|ensembl:ENSMUST00000065418(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0043005"(neuron projection)|go:"GO:0044795"(trans-Golgi network to recycling endosome transport)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9DD03|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0032456"(endocytic recycling)|mint:MINT-1340895(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1340889(identity)	-	function:Could participate in polarized transport, in the assembly and/or the activity of tight junctions|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:vFVG2hj2wT1UcE0LSh12mVhYd+010090	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:5E7A83DA54AEB4E7|rigid:1Up2/mzCJ/AI52Lc4XVUfqVTTO0	false	tag:?-?(MINT-1340896)	tag:?-?(MINT-1340890)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8T3	uniprotkb:Q15797	intact:EBI-7528755|intact:MINT-1340904|ensembl:ENSMUSP00000024518	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:rebl1_mouse(display_long)|uniprotkb:Rhebl1(gene name)|psi-mi:Rhebl1(display_short)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528751|mint:MINT-58485	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081243.1|ensembl:ENSMUSG00000023755(gene)|ensembl:ENSMUST00000024518(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:MINT-1340925(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1340919(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:F7oHZA01yWq8x0tYeTDtFl+YtNA10090	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:4CC6B70ACA2F964A|rigid:aOEzN1t0MRG2ggtkdCEIFONtksM	false	tag:?-?(MINT-1340926)	tag:?-?(MINT-1340920)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8T3	uniprotkb:Q04771	intact:EBI-7528755|intact:MINT-1340904|ensembl:ENSMUSP00000024518	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:rebl1_mouse(display_long)|uniprotkb:Rhebl1(gene name)|psi-mi:Rhebl1(display_short)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528816|mint:MINT-58486	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081243.1|ensembl:ENSMUSG00000023755(gene)|ensembl:ENSMUST00000024518(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:MINT-1340940(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1340934(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:F7oHZA01yWq8x0tYeTDtFl+YtNA10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:CAE8C937BD9F7522|rigid:l/ZBa8HoeH+zGIL3bJh1pIlExdc	false	tag:?-?(MINT-1340941)	tag:?-?(MINT-1340935)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8T3	uniprotkb:O00238	intact:EBI-7528755|intact:MINT-1340904|ensembl:ENSMUSP00000024518	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:rebl1_mouse(display_long)|uniprotkb:Rhebl1(gene name)|psi-mi:Rhebl1(display_short)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528894|mint:MINT-58487	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081243.1|ensembl:ENSMUSG00000023755(gene)|ensembl:ENSMUST00000024518(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:MINT-1340955(identity)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-1340949(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"|comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:F7oHZA01yWq8x0tYeTDtFl+YtNA10090	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:161EACF5C609B127|rigid:9tChf+0jARfnJ9d5WEe4jQeEJG0	false	tag:?-?(MINT-1340956)	tag:?-?(MINT-1340950)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8T3	uniprotkb:Q15796	intact:EBI-7528755|intact:MINT-1340904|ensembl:ENSMUSP00000024518	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:rebl1_mouse(display_long)|uniprotkb:Rhebl1(gene name)|psi-mi:Rhebl1(display_short)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7528927|mint:MINT-58482	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081243.1|ensembl:ENSMUSG00000023755(gene)|ensembl:ENSMUST00000024518(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:MINT-1340970(identity)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N|mint:MINT-1340964(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:F7oHZA01yWq8x0tYeTDtFl+YtNA10090	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:E74E20AA32837F84|rigid:lrbGVGralpb8rd3dd0sJoQFRmFY	false	tag:?-?(MINT-1340971)	tag:?-?(MINT-1340965)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8T3	uniprotkb:P36897	intact:EBI-7528755|intact:MINT-1340904|ensembl:ENSMUSP00000024518	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:rebl1_mouse(display_long)|uniprotkb:Rhebl1(gene name)|psi-mi:Rhebl1(display_short)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529025|mint:MINT-58484	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081243.1|ensembl:ENSMUSG00000023755(gene)|ensembl:ENSMUST00000024518(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:MINT-1340985(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1340979(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:F7oHZA01yWq8x0tYeTDtFl+YtNA10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:ACE6E6F4644DD900|rigid:QUO8I3tBY+T7oW1Y6dsDsEUAbtU	false	tag:?-?(MINT-1340986)	tag:?-?(MINT-1340980)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8T3	uniprotkb:Q13485	intact:EBI-7528755|intact:MINT-1340904|ensembl:ENSMUSP00000024518	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:rebl1_mouse(display_long)|uniprotkb:Rhebl1(gene name)|psi-mi:Rhebl1(display_short)|uniprotkb:Ras homolog enriched in brain-like protein 1(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529073|mint:MINT-58483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081243.1|ensembl:ENSMUSG00000023755(gene)|ensembl:ENSMUST00000024518(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:MINT-1341000(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1340994(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:F7oHZA01yWq8x0tYeTDtFl+YtNA10090	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:D26F8AC56637FA4D|rigid:+wc0c36oK+44i1l+6zDiscxaPos	false	tag:?-?(MINT-1341001)	tag:?-?(MINT-1340995)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P36897	uniprotkb:O70126	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	intact:EBI-2551837|uniprotkb:Q8C6C1|ensembl:ENSMUSP00000021277|ensembl:ENSMUSP00000104306|uniprotkb:Q61882	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:aurkb_mouse(display_long)|uniprotkb:Aim1(gene name synonym)|uniprotkb:Airk2(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Aurkb(gene name)|psi-mi:Aurkb(display_short)|uniprotkb:Ark2(gene name synonym)|uniprotkb:Stk1(gene name synonym)|uniprotkb:Stk12(gene name synonym)|uniprotkb:Stk5(gene name synonym)|uniprotkb:Aik2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529130|mint:MINT-58517	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341027(identity)	go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSMUSG00000020897(gene)|ensembl:ENSMUST00000021277(transcript)|ensembl:ENSMUST00000108666(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|reactome:R-MMU-141444|reactome:R-MMU-174178|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-4615885|reactome:R-MMU-5663220|reactome:R-MMU-6804756|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR011009(Protein kinase-like)|refseq:NP_035626.1|mint:MINT-1341033(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:/Mc5Du+BYi+JlKD2zdQoWAEo5cM10090	intact-crc:3BED762915B6DEC6|rigid:aA0JpUgGptA3E34QElErPTkWtL0	false	tag:?-?(MINT-1341028)	tag:?-?(MINT-1341034)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZT8	uniprotkb:Q15797	intact:EBI-911649|uniprotkb:Q80WV9|ensembl:ENSMUSP00000003502|ensembl:ENSMUSP00000102261|uniprotkb:Q920F1	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:rab3b_mouse(display_long)|uniprotkb:Rab3b(gene name)|psi-mi:Rab3b(display_short)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529230|mint:MINT-58496	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000003411(gene)|ensembl:ENSMUST00000003502(transcript)|ensembl:ENSMUST00000106650(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|mint:Q9CZT8|reactome:R-MMU-8873719|refseq:NP_076026.1|mint:MINT-1341091(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1341085(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:4WkkwI5ty+Y60GheT3a0s2RVr2Q10090	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:BD99EBA395DCA525|rigid:RLEypDcrmgOYXmvS/kwxGi6ub9Q	false	tag:?-?(MINT-1341092)	tag:?-?(MINT-1341086)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63072	uniprotkb:P36897	intact:EBI-7529184|uniprotkb:Q4FJZ5|intact:MINT-1341042|uniprotkb:Q9WV10|ensembl:ENSMUSP00000035808	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:ubd_mouse(display_long)|uniprotkb:Ubd(gene name)|psi-mi:Ubd(display_short)|uniprotkb:Fat10(gene name synonym)|uniprotkb:Ubiquitin-like protein FAT10(gene name synonym)|uniprotkb:Diubiquitin(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529214|mint:MINT-58509	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075626.1|ensembl:ENSMUSG00000035186(gene)|ensembl:ENSMUST00000038844(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070628"(proteasome binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|interpro:IPR042969|reactome:R-MMU-8951664|mint:MINT-1341060(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341054(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:sOe/pD/h23ZC+GrdjpcxhcrNXFg10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:5FCBF57F95D593F0|rigid:uWt6NIv5abA+vCYavArinbuqgro	false	tag:?-?(MINT-1341061)	tag:?-?(MINT-1341055)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZT8	uniprotkb:Q04771	intact:EBI-911649|uniprotkb:Q80WV9|ensembl:ENSMUSP00000003502|ensembl:ENSMUSP00000102261|uniprotkb:Q920F1	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:rab3b_mouse(display_long)|uniprotkb:Rab3b(gene name)|psi-mi:Rab3b(display_short)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529263|mint:MINT-58497	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000003411(gene)|ensembl:ENSMUST00000003502(transcript)|ensembl:ENSMUST00000106650(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|mint:Q9CZT8|reactome:R-MMU-8873719|refseq:NP_076026.1|mint:MINT-1341106(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1341100(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:4WkkwI5ty+Y60GheT3a0s2RVr2Q10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:94BA1D9DCF572929|rigid:PVxWrimlEGsCNuDiv6WxRnr6S8U	false	tag:?-?(MINT-1341107)	tag:?-?(MINT-1341101)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P36897	uniprotkb:Q9CZT8	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	intact:EBI-911649|uniprotkb:Q80WV9|ensembl:ENSMUSP00000003502|ensembl:ENSMUSP00000102261|uniprotkb:Q920F1	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:rab3b_mouse(display_long)|uniprotkb:Rab3b(gene name)|psi-mi:Rab3b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529296|mint:MINT-58495	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341115(identity)	ensembl:ENSMUSG00000003411(gene)|ensembl:ENSMUST00000003502(transcript)|ensembl:ENSMUST00000106650(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|mint:Q9CZT8|reactome:R-MMU-8873719|refseq:NP_076026.1|mint:MINT-1341121(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:4WkkwI5ty+Y60GheT3a0s2RVr2Q10090	intact-crc:3123C34702DD4812|rigid:Sdg+fGHcD0LcAJ6U8zoDrrdE44Q	false	tag:?-?(MINT-1341116)	tag:?-?(MINT-1341122)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13485	uniprotkb:Q9CZT8	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-911649|uniprotkb:Q80WV9|ensembl:ENSMUSP00000003502|ensembl:ENSMUSP00000102261|uniprotkb:Q920F1	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:rab3b_mouse(display_long)|uniprotkb:Rab3b(gene name)|psi-mi:Rab3b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529333|mint:MINT-58494	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1341130(identity)	ensembl:ENSMUSG00000003411(gene)|ensembl:ENSMUST00000003502(transcript)|ensembl:ENSMUST00000106650(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|mint:Q9CZT8|reactome:R-MMU-8873719|refseq:NP_076026.1|mint:MINT-1341136(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:4WkkwI5ty+Y60GheT3a0s2RVr2Q10090	intact-crc:1C625CDCE36AA72B|rigid:d4IXGPNHs/6G1J8r1kJS1i7vNb8	false	tag:?-?(MINT-1341131)	tag:?-?(MINT-1341137)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91ZR4	uniprotkb:Q04771	intact:EBI-4282339|uniprotkb:Q3U498|uniprotkb:Q9D685|ensembl:ENSMUSP00000017549	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:nek8_mouse(display_long)|uniprotkb:Nek8(gene name)|psi-mi:Nek8(display_short)|uniprotkb:Jck(gene name synonym)|uniprotkb:Never in mitosis A-related kinase 8(gene name synonym)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529365|mint:MINT-58527	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000017405(gene)|ensembl:ENSMUST00000017549(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0097543"(ciliary inversin compartment)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044120|refseq:NP_543125.1|mint:MINT-1341176(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1341170(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:aaLad1nm9yceDiO9kCqZGghKWRc10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:27CA06687F83044E|rigid:iat+g7KkKIEnk+1hA1VHWJDRIYM	false	tag:?-?(MINT-1341177)	tag:?-?(MINT-1341171)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P36897	uniprotkb:Q91ZR4	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	intact:EBI-4282339|uniprotkb:Q3U498|uniprotkb:Q9D685|ensembl:ENSMUSP00000017549	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:nek8_mouse(display_long)|uniprotkb:Nek8(gene name)|psi-mi:Nek8(display_short)|uniprotkb:Jck(gene name synonym)|uniprotkb:Never in mitosis A-related kinase 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529382|mint:MINT-58526	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341185(identity)	ensembl:ENSMUSG00000017405(gene)|ensembl:ENSMUST00000017549(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0097543"(ciliary inversin compartment)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044120|refseq:NP_543125.1|mint:MINT-1341191(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:aaLad1nm9yceDiO9kCqZGghKWRc10090	intact-crc:61A4426EE00F6ED0|rigid:Pu44VV1pXYyeLzPcHWPAghQVi8Q	false	tag:?-?(MINT-1341186)	tag:?-?(MINT-1341192)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K3A8	uniprotkb:Q9HAU4	intact:EBI-7529419|intact:MINT-1341200	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:q8k3a8_mouse(display_long)|uniprotkb:Srsf4(gene name)|psi-mi:Srsf4(display_short)|uniprotkb:Sfrs4(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529415|mint:MINT-58551	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0003723"(RNA binding)|interpro:IPR035979|mint:MINT-1341216(identity)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-1341210(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:yYFphmXU5ZLbxCsw1OyRbr0xW+010090	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:B2A951DCE4E5EEFF|rigid:/3pgQUuwzwQMRczBprB0Noo86V8	false	tag:?-?(MINT-1341217)	tag:?-?(MINT-1341211)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35445	uniprotkb:P36897	intact:EBI-7529448|intact:MINT-1341225|ensembl:ENSMUSP00000015622	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:rnf5_mouse(display_long)|uniprotkb:Rnf5(gene name)|psi-mi:Rnf5(display_short)|uniprotkb:Ng2(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529443|mint:MINT-58541	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062276.1|ensembl:ENSMUSG00000015478(gene)|ensembl:ENSMUST00000015622(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-MMU-382556|mint:MINT-1341241(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341235(identity)	-	comment:mint|function:Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin. May be involved in regulation of cell motility and localization of PXN/paxillin|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:oTjmV12ZaztUXAmspNqKWGKdR8Y10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:A5E67E2A90686613|rigid:vL4GtJFwwjzHNRIPXHVi7GqxXCI	false	tag:?-?(MINT-1341242)	tag:?-?(MINT-1341236)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9HAU4	uniprotkb:Q9CQJ4	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529498|mint:MINT-58540	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N|mint:MINT-1341264(identity)	refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750|mint:MINT-1341270(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090	intact-crc:99EAB97695DE61F2|rigid:hhh76L+X4LSbCS1THtyEN/oriXE	false	tag:?-?(MINT-1341265)	tag:?-?(MINT-1341271)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CR14	uniprotkb:Q04771	intact:EBI-7529579|intact:MINT-1341363|ensembl:ENSMUSP00000004120|uniprotkb:Q3TGY2|uniprotkb:Q9D017	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:fancl_mouse(display_long)|uniprotkb:Fancl(gene name)|psi-mi:Fancl(display_short)|uniprotkb:Phf9(gene name synonym)|uniprotkb:Pog(gene name synonym)|uniprotkb:Fanconi anemia group L protein homolog(gene name synonym)|uniprotkb:Proliferation of germ cells protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase FANCL(gene name synonym)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529611|mint:MINT-58523	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004018(gene)|ensembl:ENSMUST00000004120(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007276"(gamete generation)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019162|interpro:IPR026848|interpro:IPR026850|interpro:IPR043003|interpro:IPR043898|interpro:IPR044037|reactome:R-MMU-6783310|refseq:NP_001264202.1|refseq:NP_080199.1|mint:MINT-1341402(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1341396(identity)	-	comment:mint|function:"Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway (By similarity). Probably essential for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth"|function:"Defects in Fancl are a cause of the gcd (germ cell deficient) mutant phenotype, which leads to reduced numbers of precursor germ cells and adult sterility, probably due to a reduced precursor germ cells proliferation"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:YZVpsXBCTfnlAGI0l+SIYOibvQ810090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:EF45944A23407FCA|rigid:W4uGab+oP8RERjEDvHAEEm0eRVg	false	tag:?-?(MINT-1341403)	tag:?-?(MINT-1341397)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O00238	uniprotkb:Q9CR14	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-7529579|intact:MINT-1341363|ensembl:ENSMUSP00000004120|uniprotkb:Q3TGY2|uniprotkb:Q9D017	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:fancl_mouse(display_long)|uniprotkb:Fancl(gene name)|psi-mi:Fancl(display_short)|uniprotkb:Phf9(gene name synonym)|uniprotkb:Pog(gene name synonym)|uniprotkb:Fanconi anemia group L protein homolog(gene name synonym)|uniprotkb:Proliferation of germ cells protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase FANCL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529681|mint:MINT-58524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-1341411(identity)	ensembl:ENSMUSG00000004018(gene)|ensembl:ENSMUST00000004120(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007276"(gamete generation)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019162|interpro:IPR026848|interpro:IPR026850|interpro:IPR043003|interpro:IPR043898|interpro:IPR044037|reactome:R-MMU-6783310|refseq:NP_001264202.1|refseq:NP_080199.1|mint:MINT-1341417(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"|comment:"Stoichiometry: 1.0"	comment:mint|function:"Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway (By similarity). Probably essential for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth"|function:"Defects in Fancl are a cause of the gcd (germ cell deficient) mutant phenotype, which leads to reduced numbers of precursor germ cells and adult sterility, probably due to a reduced precursor germ cells proliferation"|comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:YZVpsXBCTfnlAGI0l+SIYOibvQ810090	intact-crc:33B3F18858D6BBCF|rigid:ZyqPEYPOOf6hrC+M+rPDCIIEFeY	false	tag:?-?(MINT-1341412)	tag:?-?(MINT-1341418)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15797	uniprotkb:Q9QYE9	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-1127128|uniprotkb:Q9QYB3|uniprotkb:Q9QYB4|uniprotkb:Q9QYD2|uniprotkb:Q9QYD3|ensembl:ENSMUSP00000078175	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:pkhb1_mouse(display_long)|uniprotkb:Plekhb1(gene name)|psi-mi:Plekhb1(display_short)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Pleckstrin homology domain retinal protein 1(gene name synonym)|uniprotkb:PH domain-containing protein in retina 1(gene name synonym)|uniprotkb:Evt1(gene name synonym)|uniprotkb:Evectin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529729|mint:MINT-58533	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1341478(identity)	refseq:NP_001156654.1|refseq:NP_001156655.1|refseq:NP_001156656.1|refseq:NP_001156657.1|refseq:NP_001156658.1|refseq:NP_001156659.1|refseq:NP_038774.1|ensembl:ENSMUSG00000030701|ensembl:ENSMUSG00000030701|refseq:NP_001278265.1|refseq:XP_006507969.1|ensembl:ENSMUSG00000030701(gene)|ensembl:ENSMUST00000079176(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045595"(regulation of cell differentiation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039680|interpro:IPR039816|rcsb pdb:2D9V|mint:MINT-1341484(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:ulTOTTg84Zodax13dxctORWu8XQ10090	intact-crc:AFC651551C91A05C|rigid:yF8ajvZGBaw1dXVVH5uBTvyBUpE	false	tag:?-?(MINT-1341479)	tag:?-?(MINT-1341485)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CR14	uniprotkb:P36897	intact:EBI-7529579|intact:MINT-1341363|ensembl:ENSMUSP00000004120|uniprotkb:Q3TGY2|uniprotkb:Q9D017	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:fancl_mouse(display_long)|uniprotkb:Fancl(gene name)|psi-mi:Fancl(display_short)|uniprotkb:Phf9(gene name synonym)|uniprotkb:Pog(gene name synonym)|uniprotkb:Fanconi anemia group L protein homolog(gene name synonym)|uniprotkb:Proliferation of germ cells protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase FANCL(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529697|mint:MINT-58522	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004018(gene)|ensembl:ENSMUST00000004120(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007276"(gamete generation)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019162|interpro:IPR026848|interpro:IPR026850|interpro:IPR043003|interpro:IPR043898|interpro:IPR044037|reactome:R-MMU-6783310|refseq:NP_001264202.1|refseq:NP_080199.1|mint:MINT-1341432(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341426(identity)	-	comment:mint|function:"Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway (By similarity). Probably essential for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth"|function:"Defects in Fancl are a cause of the gcd (germ cell deficient) mutant phenotype, which leads to reduced numbers of precursor germ cells and adult sterility, probably due to a reduced precursor germ cells proliferation"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:YZVpsXBCTfnlAGI0l+SIYOibvQ810090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:32290BBA892B92AF|rigid:0dLoPnvfhUECeaAYkFJ9XSMtlog	false	tag:?-?(MINT-1341433)	tag:?-?(MINT-1341427)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYE9	uniprotkb:Q04771	intact:EBI-1127128|uniprotkb:Q9QYB3|uniprotkb:Q9QYB4|uniprotkb:Q9QYD2|uniprotkb:Q9QYD3|ensembl:ENSMUSP00000078175	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:pkhb1_mouse(display_long)|uniprotkb:Plekhb1(gene name)|psi-mi:Plekhb1(display_short)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Pleckstrin homology domain retinal protein 1(gene name synonym)|uniprotkb:PH domain-containing protein in retina 1(gene name synonym)|uniprotkb:Evt1(gene name synonym)|uniprotkb:Evectin-1(gene name synonym)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529746|mint:MINT-58534	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156654.1|refseq:NP_001156655.1|refseq:NP_001156656.1|refseq:NP_001156657.1|refseq:NP_001156658.1|refseq:NP_001156659.1|refseq:NP_038774.1|ensembl:ENSMUSG00000030701|ensembl:ENSMUSG00000030701|refseq:NP_001278265.1|refseq:XP_006507969.1|ensembl:ENSMUSG00000030701(gene)|ensembl:ENSMUST00000079176(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045595"(regulation of cell differentiation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039680|interpro:IPR039816|rcsb pdb:2D9V|mint:MINT-1341499(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1341493(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:ulTOTTg84Zodax13dxctORWu8XQ10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:2CBBC46D81E0F813|rigid:JlBJ4eFxrY+aSfoVgEO9M0GteYA	false	tag:?-?(MINT-1341500)	tag:?-?(MINT-1341494)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O00238	uniprotkb:Q9QYE9	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-1127128|uniprotkb:Q9QYB3|uniprotkb:Q9QYB4|uniprotkb:Q9QYD2|uniprotkb:Q9QYD3|ensembl:ENSMUSP00000078175	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:pkhb1_mouse(display_long)|uniprotkb:Plekhb1(gene name)|psi-mi:Plekhb1(display_short)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Pleckstrin homology domain retinal protein 1(gene name synonym)|uniprotkb:PH domain-containing protein in retina 1(gene name synonym)|uniprotkb:Evt1(gene name synonym)|uniprotkb:Evectin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529778|mint:MINT-58535	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-1341508(identity)	refseq:NP_001156654.1|refseq:NP_001156655.1|refseq:NP_001156656.1|refseq:NP_001156657.1|refseq:NP_001156658.1|refseq:NP_001156659.1|refseq:NP_038774.1|ensembl:ENSMUSG00000030701|ensembl:ENSMUSG00000030701|refseq:NP_001278265.1|refseq:XP_006507969.1|ensembl:ENSMUSG00000030701(gene)|ensembl:ENSMUST00000079176(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045595"(regulation of cell differentiation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039680|interpro:IPR039816|rcsb pdb:2D9V|mint:MINT-1341514(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:ulTOTTg84Zodax13dxctORWu8XQ10090	intact-crc:832510BEC1CE1EAB|rigid:O9Tcf4WjFV+I3oub8kzKhwJ7joM	false	tag:?-?(MINT-1341509)	tag:?-?(MINT-1341515)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64702	uniprotkb:P36897	intact:EBI-2552433|ensembl:ENSMUSP00000026858|uniprotkb:Q78EG6|uniprotkb:Q3UVA3|uniprotkb:Q6PEP6|uniprotkb:Q9CVU6|uniprotkb:Q80UT6|uniprotkb:Q9CVR6|uniprotkb:Q8R0I5	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:plk4_mouse(display_long)|uniprotkb:Plk4(gene name)|psi-mi:Plk4(display_short)|uniprotkb:Sak(gene name synonym)|uniprotkb:Stk18(gene name synonym)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529837|mint:MINT-58529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775261.2|ensembl:ENSMUSG00000025758(gene)|ensembl:ENSMUST00000026858(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:Q64702|rcsb pdb:1MBY|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|refseq:NP_035625.2|dip:DIP-42244N|mint:MINT-1341581(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341575(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:L1/nN7/3X379zeA2OE3rfje+Cvc10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:F7A7152757FAAEA3|rigid:JolFOIj3jAsValIpwO2rApBWHwk	false	tag:?-?(MINT-1341582)	tag:?-?(MINT-1341576)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P36897	uniprotkb:Q9QYE9	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	intact:EBI-1127128|uniprotkb:Q9QYB3|uniprotkb:Q9QYB4|uniprotkb:Q9QYD2|uniprotkb:Q9QYD3|ensembl:ENSMUSP00000078175	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:pkhb1_mouse(display_long)|uniprotkb:Plekhb1(gene name)|psi-mi:Plekhb1(display_short)|uniprotkb:Phr1(gene name synonym)|uniprotkb:Pleckstrin homology domain retinal protein 1(gene name synonym)|uniprotkb:PH domain-containing protein in retina 1(gene name synonym)|uniprotkb:Evt1(gene name synonym)|uniprotkb:Evectin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529795|mint:MINT-58532	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341523(identity)	refseq:NP_001156654.1|refseq:NP_001156655.1|refseq:NP_001156656.1|refseq:NP_001156657.1|refseq:NP_001156658.1|refseq:NP_001156659.1|refseq:NP_038774.1|ensembl:ENSMUSG00000030701|ensembl:ENSMUSG00000030701|refseq:NP_001278265.1|refseq:XP_006507969.1|ensembl:ENSMUSG00000030701(gene)|ensembl:ENSMUST00000079176(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045595"(regulation of cell differentiation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039680|interpro:IPR039816|rcsb pdb:2D9V|mint:MINT-1341529(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:ulTOTTg84Zodax13dxctORWu8XQ10090	intact-crc:237C79B18B904D6B|rigid:cZD3Yd827XEsjMGz15UiNvz7hHY	false	tag:?-?(MINT-1341524)	tag:?-?(MINT-1341530)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13485	uniprotkb:Q64702	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-2552433|ensembl:ENSMUSP00000026858|uniprotkb:Q78EG6|uniprotkb:Q3UVA3|uniprotkb:Q6PEP6|uniprotkb:Q9CVU6|uniprotkb:Q80UT6|uniprotkb:Q9CVR6|uniprotkb:Q8R0I5	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:plk4_mouse(display_long)|uniprotkb:Plk4(gene name)|psi-mi:Plk4(display_short)|uniprotkb:Sak(gene name synonym)|uniprotkb:Stk18(gene name synonym)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529880|mint:MINT-58528	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1341590(identity)	refseq:NP_775261.2|ensembl:ENSMUSG00000025758(gene)|ensembl:ENSMUST00000026858(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:Q64702|rcsb pdb:1MBY|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|refseq:NP_035625.2|dip:DIP-42244N|mint:MINT-1341596(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:L1/nN7/3X379zeA2OE3rfje+Cvc10090	intact-crc:DAE68ABCB64D419A|rigid:JmDaGDxh4izVylc9MPTMZi5f5kQ	false	tag:?-?(MINT-1341591)	tag:?-?(MINT-1341597)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIY7	uniprotkb:Q13485	intact:EBI-7529912|intact:MINT-1341646|ensembl:ENSMUSP00000032073	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:nat8_mouse(display_long)|uniprotkb:Camello-like protein 4(gene name synonym)|uniprotkb:Nat8(gene name)|psi-mi:Nat8(display_short)|uniprotkb:Cml4(gene name synonym)|uniprotkb:Acetyltransferase 2(gene name synonym)|uniprotkb:Cysteinyl-conjugate N-acetyltransferase(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529969|mint:MINT-58545	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075944.1|ensembl:ENSMUSG00000030004(gene)|ensembl:ENSMUST00000032073(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0004468"(lysine N-acetyltransferase activity, acting on acetyl phosphate as donor)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018003"(peptidyl-lysine N6-acetylation)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047198"(cysteine-S-conjugate N-acetyltransferase activity)|go:"GO:0050435"(amyloid-beta metabolic process)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|go:"GO:0010628"(positive regulation of gene expression)|refseq:XP_006506598.1|refseq:XP_006506599.1|refseq:XP_006506600.1|mint:MINT-1341679(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1341673(identity)	-	comment:mint|function:Plays a role in regulation of gastrulation|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:xgFXDLW/7OPYYwYQuaqNdkZ8e7k10090	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:1FDB139B260358AB|rigid:GkGnXQ2OrgSLLRrG/DSnLjfjRqw	false	tag:?-?(MINT-1341680)	tag:?-?(MINT-1341674)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIY7	uniprotkb:P36897	intact:EBI-7529912|intact:MINT-1341646|ensembl:ENSMUSP00000032073	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:nat8_mouse(display_long)|uniprotkb:Camello-like protein 4(gene name synonym)|uniprotkb:Nat8(gene name)|psi-mi:Nat8(display_short)|uniprotkb:Cml4(gene name synonym)|uniprotkb:Acetyltransferase 2(gene name synonym)|uniprotkb:Cysteinyl-conjugate N-acetyltransferase(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7529932|mint:MINT-58546	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075944.1|ensembl:ENSMUSG00000030004(gene)|ensembl:ENSMUST00000032073(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0004468"(lysine N-acetyltransferase activity, acting on acetyl phosphate as donor)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018003"(peptidyl-lysine N6-acetylation)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047198"(cysteine-S-conjugate N-acetyltransferase activity)|go:"GO:0050435"(amyloid-beta metabolic process)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|go:"GO:0010628"(positive regulation of gene expression)|refseq:XP_006506598.1|refseq:XP_006506599.1|refseq:XP_006506600.1|mint:MINT-1341664(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341658(identity)	-	comment:mint|function:Plays a role in regulation of gastrulation|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:xgFXDLW/7OPYYwYQuaqNdkZ8e7k10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:329A8C00C7B4B792|rigid:8DyuXcBwrpw3GBH5GbswuOzsy7c	false	tag:?-?(MINT-1341665)	tag:?-?(MINT-1341659)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91V57	uniprotkb:Q04771	intact:EBI-1539191|uniprotkb:Q3UGY3|uniprotkb:Q7TQE5|uniprotkb:Q8BWU6|uniprotkb:Q9D9B3|uniprotkb:A2ATM0|ensembl:ENSMUSP00000107655	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:chin_mouse(display_long)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym)|uniprotkb:Chn1(gene name)|psi-mi:Chn1(display_short)|uniprotkb:Arhgap2(gene name synonym)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530056|mint:MINT-58503	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106717.2|refseq:NP_083992.1|refseq:NP_786928.2|ensembl:ENSMUSG00000056486(gene)|ensembl:ENSMUST00000112024(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|interpro:IPR035840|interpro:IPR036860|interpro:IPR037860|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1341731(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85|mint:MINT-1341725(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:HDylf5R3cwEjCfeZVsHwZQGWo3A10090	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:97E092546041B40B|rigid:ukLjtkgNzS/gtuydgcteS1FDseU	false	tag:?-?(MINT-1341732)	tag:?-?(MINT-1341726)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JJ78	uniprotkb:Q13485	intact:EBI-7530007|uniprotkb:Q922V2|intact:MINT-1341688|uniprotkb:Q9D184|ensembl:ENSMUSP00000022612	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:topk_mouse(display_long)|uniprotkb:Pbk(gene name)|psi-mi:Pbk(display_short)|uniprotkb:Topk(gene name synonym)|uniprotkb:T-LAK cell-originated protein kinase(gene name synonym)|uniprotkb:PDZ-binding kinase(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530002|mint:MINT-58525	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075698.1|ensembl:ENSMUSG00000022033(gene)|ensembl:ENSMUST00000022612(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0034644"(cellular response to UV)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR041989|refseq:XP_006519320.1|mint:MINT-1341709(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1341703(identity)	-	comment:mint|function:Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:xlSEEpAm3pI4WmcFL/0lz6Ce/lc10090	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:3269C582FE1AA549|rigid:VYW8fgStI+6Fay826ff1u/oMOPc	false	tag:?-?(MINT-1341710)	tag:?-?(MINT-1341704)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O00238	uniprotkb:Q91V57	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-1539191|uniprotkb:Q3UGY3|uniprotkb:Q7TQE5|uniprotkb:Q8BWU6|uniprotkb:Q9D9B3|uniprotkb:A2ATM0|ensembl:ENSMUSP00000107655	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:chin_mouse(display_long)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym)|uniprotkb:Chn1(gene name)|psi-mi:Chn1(display_short)|uniprotkb:Arhgap2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530089|mint:MINT-58504	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-1341740(identity)	refseq:NP_001106717.2|refseq:NP_083992.1|refseq:NP_786928.2|ensembl:ENSMUSG00000056486(gene)|ensembl:ENSMUST00000112024(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|interpro:IPR035840|interpro:IPR036860|interpro:IPR037860|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1341746(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:HDylf5R3cwEjCfeZVsHwZQGWo3A10090	intact-crc:387E4687206F52B3|rigid:0KOMuAYgAu4xAzu7ZMgPhcgLZAQ	false	tag:?-?(MINT-1341741)	tag:?-?(MINT-1341747)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91V57	uniprotkb:P36897	intact:EBI-1539191|uniprotkb:Q3UGY3|uniprotkb:Q7TQE5|uniprotkb:Q8BWU6|uniprotkb:Q9D9B3|uniprotkb:A2ATM0|ensembl:ENSMUSP00000107655	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:chin_mouse(display_long)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym)|uniprotkb:Chn1(gene name)|psi-mi:Chn1(display_short)|uniprotkb:Arhgap2(gene name synonym)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530106|mint:MINT-58502	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106717.2|refseq:NP_083992.1|refseq:NP_786928.2|ensembl:ENSMUSG00000056486(gene)|ensembl:ENSMUST00000112024(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|interpro:IPR035840|interpro:IPR036860|interpro:IPR037860|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1341761(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341755(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:HDylf5R3cwEjCfeZVsHwZQGWo3A10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:D030DD4D3743DC2A|rigid:lTp2aI+bjJFsmzzpQIF1/QJX1sE	false	tag:?-?(MINT-1341762)	tag:?-?(MINT-1341756)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DAR2	uniprotkb:P36897	intact:EBI-7530143|intact:MINT-1341770|ensembl:ENSMUSP00000051216|ensembl:ENSMUSP00000106793|ensembl:ENSMUSP00000106794|ensembl:ENSMUSP00000135982	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:q9dar2_mouse(display_long)|uniprotkb:Styxl1(gene name)|psi-mi:Styxl1(display_short)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530138|mint:MINT-58537	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083935.3|ensembl:ENSMUSG00000019178(gene)|ensembl:ENSMUST00000053906(transcript)|ensembl:ENSMUST00000111163(transcript)|ensembl:ENSMUST00000111164(transcript)|ensembl:ENSMUST00000177559(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0062030"(negative regulation of stress granule assembly)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|refseq:NP_001276483.1|refseq:NP_001276484.1|refseq:NP_001276485.1|refseq:NP_001276486.1|mint:MINT-1341789(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341783(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:rKfexMON+ycMebW/TInBko44kEw10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:75A03CDD41E4632B|rigid:S/vZbKEOtvAI/JBLWaHTgv6QuYw	false	tag:?-?(MINT-1341790)	tag:?-?(MINT-1341784)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CEL6	uniprotkb:P36897	intact:EBI-7530192|intact:MINT-1341798	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:q8cel6_mouse(display_long)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530187|mint:MINT-58516	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|mint:MINT-1341814(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341808(identity)	-	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:aXe6HYdqa2Czl8f1cWPfQXiWHmo10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:5D5119CC41F100A4|rigid:I7czPpMm8bfueEzAozsHzdOjKrE	false	tag:?-?(MINT-1341815)	tag:?-?(MINT-1341809)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K352	uniprotkb:O00238	intact:EBI-7530275|uniprotkb:Q9DBV2|uniprotkb:Q3TBX0|intact:MINT-1341823|ensembl:ENSMUSP00000033427	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:sash3_mouse(display_long)|uniprotkb:Sly(gene name synonym)|uniprotkb:SH3 protein expressed in lymphocytes(gene name synonym)|uniprotkb:Sash3(gene name)|psi-mi:Sash3(display_short)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530309|mint:MINT-58544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300678.1|refseq:NP_083049.1|ensembl:ENSMUSG00000031101(gene)|ensembl:ENSMUST00000033427(transcript)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051251"(positive regulation of lymphocyte activation)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021090|interpro:IPR035721|interpro:IPR035722|interpro:IPR036028|rcsb pdb:6FXF|rcsb pdb:6G8O|mint:MINT-1341843(identity)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-1341837(identity)	-	comment:mint|function:May function as a signaling adapter protein in lymphocytes|comment:"Stoichiometry: 1.0"	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"|comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:5ICk+KbRVRAxZBctW9bbpUL7Djg10090	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:32DD51BF82913A0F|rigid:cyMEvV0dIVtDbmjXeKTSwJ3MEV8	false	tag:?-?(MINT-1341844)	tag:?-?(MINT-1341838)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K352	uniprotkb:O15105	intact:EBI-7530275|uniprotkb:Q9DBV2|uniprotkb:Q3TBX0|intact:MINT-1341823|ensembl:ENSMUSP00000033427	intact:EBI-3861591|uniprotkb:B7Z773|uniprotkb:O14740|uniprotkb:Q6DK23|uniprotkb:K7EQ10|ensembl:ENSP00000262158	psi-mi:sash3_mouse(display_long)|uniprotkb:Sly(gene name synonym)|uniprotkb:SH3 protein expressed in lymphocytes(gene name synonym)|uniprotkb:Sash3(gene name)|psi-mi:Sash3(display_short)	psi-mi:smad7_human(display_long)|uniprotkb:SMAD7(gene name)|psi-mi:SMAD7(display_short)|uniprotkb:MADH7(gene name synonym)|uniprotkb:MADH8(gene name synonym)|uniprotkb:Mothers against decapentaplegic homolog 8(gene name synonym)|uniprotkb:SMAD family member 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530326|mint:MINT-58543	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300678.1|refseq:NP_083049.1|ensembl:ENSMUSG00000031101(gene)|ensembl:ENSMUST00000033427(transcript)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051251"(positive regulation of lymphocyte activation)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021090|interpro:IPR035721|interpro:IPR035722|interpro:IPR036028|rcsb pdb:6FXF|rcsb pdb:6G8O|mint:MINT-1341858(identity)	refseq:NP_001177750.1|refseq:NP_001177751.1|refseq:NP_001177752.1|refseq:NP_005895.1|dip:DIP-42252N|ensembl:ENSG00000101665(gene)|ensembl:ENST00000262158(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001650"(fibrillar center)|go:"GO:0001657"(ureteric bud development)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034629"|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1903043"(positive regulation of chondrocyte hypertrophy)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000317"(negative regulation of T-helper 17 type immune response)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:2DJY|rcsb pdb:2KXQ|rcsb pdb:2LTV|rcsb pdb:2LTW|rcsb pdb:2LTX|rcsb pdb:2LTY|rcsb pdb:2LTZ|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173796|reactome:R-HSA-5689603|reactome:R-HSA-5689880|go:"GO:0034333"(adherens junction assembly)|mint:MINT-1341852(identity)	-	comment:mint|function:May function as a signaling adapter protein in lymphocytes|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:5ICk+KbRVRAxZBctW9bbpUL7Djg10090	rogid:+WETgHaY6gEzNfUKzAOnvnOTpaI9606	intact-crc:4F9D85796CCCCFC7|rigid:kG9/YreJ7EWxk4auqHXSej0Bghw	false	tag:?-?(MINT-1341859)	tag:?-?(MINT-1341853)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WTX7	uniprotkb:Q15797	intact:EBI-7530396|intact:MINT-1341882|ensembl:ENSMUSP00000029922|ensembl:ENSMUSP00000103839	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:fhl5_mouse(display_long)|uniprotkb:Fhl5(gene name)|psi-mi:Fhl5(display_short)|uniprotkb:Act(gene name synonym)|uniprotkb:Activator of cAMP-responsive element modulator in testis(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530391|mint:MINT-58539	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011248382.1|refseq:NP_067293.1|ensembl:ENSMUSG00000028259(gene)|ensembl:ENSMUST00000029922(transcript)|ensembl:ENSMUST00000108204(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030018"(Z disc)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|interpro:IPR042947|mint:Q9WTX7|mint:MINT-1341901(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1341895(identity)	-	function:May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:lLm+hXQZ/+vlyIrIMcXqrDZhKmY10090	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:D55DFEC249FCA0A0|rigid:s+/PbWNXV85BCRHEHL3KuG/Jg1Y	false	tag:?-?(MINT-1341902)	tag:?-?(MINT-1341896)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K352	uniprotkb:Q13485	intact:EBI-7530275|uniprotkb:Q9DBV2|uniprotkb:Q3TBX0|intact:MINT-1341823|ensembl:ENSMUSP00000033427	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:sash3_mouse(display_long)|uniprotkb:Sly(gene name synonym)|uniprotkb:SH3 protein expressed in lymphocytes(gene name synonym)|uniprotkb:Sash3(gene name)|psi-mi:Sash3(display_short)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530358|mint:MINT-58542	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300678.1|refseq:NP_083049.1|ensembl:ENSMUSG00000031101(gene)|ensembl:ENSMUST00000033427(transcript)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051251"(positive regulation of lymphocyte activation)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021090|interpro:IPR035721|interpro:IPR035722|interpro:IPR036028|rcsb pdb:6FXF|rcsb pdb:6G8O|mint:MINT-1341873(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1341867(identity)	-	comment:mint|function:May function as a signaling adapter protein in lymphocytes|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:5ICk+KbRVRAxZBctW9bbpUL7Djg10090	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:37C1A3298C5B7AE4|rigid:y8zEMogZYjQQb+Hafz7iEcythyk	false	tag:?-?(MINT-1341874)	tag:?-?(MINT-1341868)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P47810	uniprotkb:P84022	intact:EBI-7530479|uniprotkb:Q9EPL7|intact:MINT-1341936|ensembl:ENSMUSP00000033326	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	psi-mi:wee1_mouse(display_long)|uniprotkb:Wee1(gene name)|psi-mi:Wee1(display_short)|uniprotkb:Wee1A kinase(gene name synonym)	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530474|mint:MINT-58518	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033542.2|ensembl:ENSMUSG00000031016(gene)|ensembl:ENSMUST00000033326(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051301"(cell division)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017164(Wee1-like protein kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-156711|reactome:R-MMU-69202|reactome:R-MMU-69273|reactome:R-MMU-69478|reactome:R-MMU-69656|reactome:R-MMU-75035|mint:MINT-1341954(identity)	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828|mint:MINT-1341948(identity)	-	comment:mint|function:"May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDC2 does not occur"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:cy5X25FPxYbLt3y7WPfd1bhRM+k10090	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	intact-crc:02C37F91056FB955|rigid:qolE17yzjrsrbDVuEB0pP6fEcNM	false	tag:?-?(MINT-1341955)	tag:?-?(MINT-1341949)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3UG98	uniprotkb:Q15797	intact:EBI-7530426|uniprotkb:Q8C1G5|uniprotkb:Q9D151|intact:MINT-1341910|ensembl:ENSMUSP00000099327|ensembl:ENSMUSP00000099328|ensembl:ENSMUSP00000099329|ensembl:ENSMUSP00000099330	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:nat9_mouse(display_long)|uniprotkb:Nat9(gene name)|psi-mi:Nat9(display_short)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530441|mint:MINT-58547	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079676.1|refseq:XP_006533984.1|refseq:XP_006533985.1|ensembl:ENSMUSG00000015542(gene)|ensembl:ENSMUST00000103038(transcript)|ensembl:ENSMUST00000103039(transcript)|ensembl:ENSMUST00000103040(transcript)|ensembl:ENSMUST00000103041(transcript)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0032991"(protein-containing complex)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR039135|mint:MINT-1341927(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1341921(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:YBAhw83pkEPV0tlMco8wAJphPIM10090	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:3EA57343C1DDE22F|rigid:YSfMeyizpEtOKX+SObbuJA3l8cs	false	tag:?-?(MINT-1341928)	tag:?-?(MINT-1341922)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CX84	uniprotkb:P36897	intact:EBI-987349|uniprotkb:Q99L50|ensembl:ENSMUSP00000002532|ensembl:ENSMUSP00000104406|ensembl:ENSMUSP00000129026	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	psi-mi:rgs19_mouse(display_long)|uniprotkb:Rgs19(gene name)|psi-mi:Rgs19(display_short)	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530522|mint:MINT-58553	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278135.1|refseq:NP_001278136.1|refseq:NP_001278138.1|refseq:NP_001278139.1|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUST00000165416(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0045121"(membrane raft)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|ensembl:ENSMUSG00000002458(gene)|ensembl:ENSMUST00000002532(transcript)|ensembl:ENSMUST00000108776(transcript)|refseq:NP_080722.1|mint:MINT-1341980(identity)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-1341974(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:GJvLIngTyGnfP+/ulgTT4bLb8Lo10090	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	intact-crc:FB12B0F9693212A6|rigid:5i9yWbQ36i0/O/7/N3375zRE3xw	false	tag:?-?(MINT-1341981)	tag:?-?(MINT-1341975)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BLF9	uniprotkb:Q13485	intact:EBI-7530579|intact:MINT-1341989|ensembl:ENSMUSP00000017562	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:q8blf9_mouse(display_long)|uniprotkb:Arl5b(gene name)|psi-mi:Arl5b(display_short)|uniprotkb:Arl8(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530574|mint:MINT-58498	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000017562(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|ensembl:ENSMUSG00000017418(gene)|mint:MINT-1342009(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-1342003(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:xh0MVNRGY6y/yP+gyJLAKod7anY10090	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:678586346E0F0528|rigid:c4RV/HkMDi2JeC3hQQhH0bi5qRg	false	tag:?-?(MINT-1342010)	tag:?-?(MINT-1342004)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q922Y1	uniprotkb:Q15797	intact:EBI-3648572|uniprotkb:Q3UCP8|ensembl:ENSMUSP00000133250|ensembl:ENSMUSP00000157971	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:ubxn1_mouse(display_long)|uniprotkb:Ubxn1(gene name)|psi-mi:Ubxn1(display_short)|uniprotkb:D19Ertd721e(gene name synonym)|uniprotkb:Saks1(gene name synonym)|uniprotkb:Protein 2B28(gene name synonym)|uniprotkb:SAPK substrate protein 1(gene name synonym)|uniprotkb:UBA/UBX 33.3 kDa protein(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530623|mint:MINT-58506	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666205.1|refseq:XP_006526985.1|ensembl:ENSMUSG00000071655(gene)|ensembl:ENSMUST00000166407(transcript)|ensembl:ENSMUST00000238036(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071796"(K6-linked polyubiquitin modification-dependent protein binding)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|go:"GO:1904855"(proteasome regulatory particle binding)|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|interpro:IPR001012(UBX)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR041923|rcsb pdb:1WHC|reactome:R-MMU-532668|go:"GO:0005634"(nucleus)|mint:MINT-1342032(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-1342026(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:homomint|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:G20RBAq4Xj6/LL9KLFLoFm5VzRo10090	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:7297DD452BEC62C2|rigid:aHfnQf4ppm+l85HimShf18xA+pI	false	tag:?-?(MINT-1342033)	tag:?-?(MINT-1342027)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P36898	uniprotkb:Q9DAP3	intact:EBI-7107883|ensembl:ENSMUSP00000029948|ensembl:ENSMUSP00000096167|ensembl:ENSMUSP00000101837|ensembl:ENSMUSP00000101839|intact:MINT-124245|uniprotkb:Q3TRF2	intact:EBI-7530644|intact:MINT-1340595	psi-mi:bmr1b_mouse(display_long)|uniprotkb:Bmpr1b(gene name)|psi-mi:Bmpr1b(display_short)|uniprotkb:Acvrlk6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R6(gene name synonym)|uniprotkb:Activin receptor-like kinase 6(gene name synonym)	psi-mi:q9dap3_mouse(display_long)|uniprotkb:1700006A11Rik(gene name)|psi-mi:1700006A11Rik(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530640|mint:MINT-58711	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238303.1|refseq:XP_011238304.1|refseq:XP_006501006.1|refseq:XP_006501007.1|refseq:XP_006501002.1|refseq:XP_006501003.1|refseq:XP_006501005.1|ensembl:ENSMUSG00000052430(gene)|ensembl:ENSMUST00000029948(transcript)|ensembl:ENSMUST00000098568(transcript)|ensembl:ENSMUST00000106230(transcript)|ensembl:ENSMUST00000106232(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060348"(bone development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0071773"(cellular response to BMP stimulus)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36898|rcsb pdb:3EVS|reactome:R-MMU-201451|refseq:NP_001264149.1|refseq:NP_001264145.1|refseq:NP_001264146.1|refseq:NP_001264147.1|refseq:NP_031586.1|dip:DIP-252N|mint:MINT-1340602(identity)	go:"GO:0005096"(GTPase activator activity)|go:"GO:0007165"(signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|refseq:XP_006502184.1|mint:MINT-1340607(identity)	-	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:hBx86trRoBai1kLICygtSQyHlQs10090	rogid:io9uYfejtMRmA5Wko+gdzZai51U10090	intact-crc:C4B3C670EEB8BD75|rigid:I6NDDxGWaMg2PqyvPLZPI2SGAw8	false	tag:?-?(MINT-1340603)	tag:?-?(MINT-1340608)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C1R0	uniprotkb:Q64729	intact:EBI-7530684|uniprotkb:Q1WWK7|intact:MINT-1341605|ensembl:ENSMUSP00000071120	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	psi-mi:tssk5_mouse(display_long)|uniprotkb:Tssk5(gene name)|psi-mi:Tssk5(display_short)	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530705|mint:MINT-58713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_898922.2|ensembl:ENSMUSG00000060794(gene)|ensembl:ENSMUST00000071119(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:MINT-1341638(identity)	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N|mint:MINT-1341633(identity)	-	comment:mint|function:May be involved in a signaling pathway during male germ cell development or mature sperm function|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:eWtA1Xif0QokFK+RmTlohZPfjgA10090	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	intact-crc:E0F9DCE68F115011|rigid:0FeM3cO4QLRFttdVKPtawlEYSdU	false	tag:?-?(MINT-1341639)	tag:?-?(MINT-1341634)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2F2	uniprotkb:Q9CUN6	intact:EBI-7530740|intact:MINT-1340796|ensembl:ENSMUSP00000031542|uniprotkb:Q9D6S2	intact:EBI-2348474|uniprotkb:Q3U412|uniprotkb:Q8K300|ensembl:ENSMUSP00000082827	psi-mi:oasl2_mouse(display_long)|uniprotkb:Oasl2(gene name)|psi-mi:Oasl2(display_short)|uniprotkb:M1204(gene name synonym)|uniprotkb:54 kDa 2'-5'-oligoadenylate synthase-like protein(gene name synonym)	psi-mi:smuf1_mouse(display_long)|uniprotkb:Smurf1(gene name)|psi-mi:Smurf1(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530732|mint:MINT-58712	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029561(gene)|ensembl:ENSMUST00000031542(transcript)|go:"GO:0001730"(2'-5'-oligoadenylate synthetase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060700"(regulation of ribonuclease activity)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR006116(2-5-oligoadenylate synthetase, ubiquitin-like region)|interpro:IPR006117(2-5-oligoadenylate synthetase, conserved site)|interpro:IPR018952|interpro:IPR026774|interpro:IPR029071|interpro:IPR043518|interpro:IPR043519|refseq:NP_035984.2|refseq:XP_006530377.1|refseq:XP_006530378.1|mint:MINT-1340813(identity)	refseq:NP_001033716.1|refseq:NP_083714.3|ensembl:ENSMUSG00000038780(gene)|ensembl:ENSMUST00000085684(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9CUN6|reactome:R-MMU-201451|reactome:R-MMU-2173791|reactome:R-MMU-4608870|reactome:R-MMU-5632684|reactome:R-MMU-8941858|reactome:R-MMU-983168|mint:MINT-1340808(identity)	-	comment:mint|function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:navYtd8qotpCmpfiytxGJWlSSL010090	rogid:e/0b1gSRRvjn9kLgSmd2PBRU8Eo10090	intact-crc:0CAA95238FF14DC9|rigid:vXtIuY5AA6cW5aXAMmGtVBuZDWM	false	tag:?-?(MINT-1340814)	tag:?-?(MINT-1340809)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C1R0	uniprotkb:Q9CUN6	intact:EBI-7530684|uniprotkb:Q1WWK7|intact:MINT-1341605|ensembl:ENSMUSP00000071120	intact:EBI-2348474|uniprotkb:Q3U412|uniprotkb:Q8K300|ensembl:ENSMUSP00000082827	psi-mi:tssk5_mouse(display_long)|uniprotkb:Tssk5(gene name)|psi-mi:Tssk5(display_short)	psi-mi:smuf1_mouse(display_long)|uniprotkb:Smurf1(gene name)|psi-mi:Smurf1(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530779|mint:MINT-58714	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_898922.2|ensembl:ENSMUSG00000060794(gene)|ensembl:ENSMUST00000071119(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:MINT-1341625(identity)	refseq:NP_001033716.1|refseq:NP_083714.3|ensembl:ENSMUSG00000038780(gene)|ensembl:ENSMUST00000085684(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9CUN6|reactome:R-MMU-201451|reactome:R-MMU-2173791|reactome:R-MMU-4608870|reactome:R-MMU-5632684|reactome:R-MMU-8941858|reactome:R-MMU-983168|mint:MINT-1341620(identity)	-	comment:mint|function:May be involved in a signaling pathway during male germ cell development or mature sperm function|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:eWtA1Xif0QokFK+RmTlohZPfjgA10090	rogid:e/0b1gSRRvjn9kLgSmd2PBRU8Eo10090	intact-crc:9D6FBF5218D8573B|rigid:CckvHKBJxMFdu3NW2HjG+zZFiUo	false	tag:?-?(MINT-1341626)	tag:?-?(MINT-1341621)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37172	uniprotkb:Q9JIQ3	intact:EBI-7530835|intact:MINT-1341279|uniprotkb:Q91VF1|uniprotkb:Q3UDH5|ensembl:ENSMUSP00000056784|ensembl:ENSMUSP00000088453|ensembl:ENSMUSP00000108218|ensembl:ENSMUSP00000108220	intact:EBI-4566004|uniprotkb:Q9CZD1|uniprotkb:Q9DCD3|uniprotkb:Q542V8|ensembl:ENSMUSP00000107214|ensembl:ENSMUSP00000115045	psi-mi:acvr1_mouse(display_long)|uniprotkb:Acvr1(gene name)|psi-mi:Acvr1(display_short)|uniprotkb:Tgfb1(gene name synonym)|uniprotkb:Acvrlk2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:TSK-7L(gene name synonym)	psi-mi:dbloh_mouse(display_long)|uniprotkb:Diablo(gene name)|psi-mi:Diablo(display_short)|uniprotkb:Smac(gene name synonym)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530831|mint:MINT-58716	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031420.2|refseq:NP_001103674.1|refseq:NP_001103675.1|refseq:XP_017170494.1|refseq:XP_017170495.1|refseq:XP_006497685.1|ensembl:ENSMUSG00000026836(gene)|ensembl:ENSMUST00000056376(transcript)|ensembl:ENSMUST00000090935(transcript)|ensembl:ENSMUST00000112599(transcript)|ensembl:ENSMUST00000112601(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001655"(urogenital system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007369"(gastrulation)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0061445"(endocardial cushion cell fate commitment)|dip:DIP-5798N|mint:MINT-1341318(identity)	refseq:NP_075721.3|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR009062(Second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI-like)|interpro:IPR015142(Second mitochondria-derived activator of caspase/Direct IAP-binding protein with low PI)|mint:Q9JIQ3|reactome:R-MMU-111457|reactome:R-MMU-111463|reactome:R-MMU-111464|reactome:R-MMU-111469|reactome:R-MMU-9627069|ensembl:ENSMUSG00000029433(gene)|ensembl:ENSMUST00000111587(transcript)|ensembl:ENSMUST00000125652(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|mint:MINT-1341323(identity)	-	function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:wDboDyCukyAjssag2dCfCDm8wDo10090	rogid:qx2xbPLOYR+OCL8obFWtCdBkxXU10090	intact-crc:F67F4379AC534DDD|rigid:HOMoeC8uEEQocGE9lND54XAxhZk	false	tag:?-?(MINT-1341319)	tag:?-?(MINT-1341324)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64729	uniprotkb:Q9JIQ3	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	intact:EBI-4566004|uniprotkb:Q9CZD1|uniprotkb:Q9DCD3|uniprotkb:Q542V8|ensembl:ENSMUSP00000107214|ensembl:ENSMUSP00000115045	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:dbloh_mouse(display_long)|uniprotkb:Diablo(gene name)|psi-mi:Diablo(display_short)|uniprotkb:Smac(gene name synonym)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barrios-Rodiles et al. (2005)	pubmed:15761153|mint:MINT-5217592	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7530929|mint:MINT-58715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N|mint:MINT-1341350(identity)	refseq:NP_075721.3|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR009062(Second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI-like)|interpro:IPR015142(Second mitochondria-derived activator of caspase/Direct IAP-binding protein with low PI)|mint:Q9JIQ3|reactome:R-MMU-111457|reactome:R-MMU-111463|reactome:R-MMU-111464|reactome:R-MMU-111469|reactome:R-MMU-9627069|ensembl:ENSMUSG00000029433(gene)|ensembl:ENSMUST00000111587(transcript)|ensembl:ENSMUST00000125652(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|mint:MINT-1341355(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:ST2|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/06/06	2014/10/16	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	rogid:qx2xbPLOYR+OCL8obFWtCdBkxXU10090	intact-crc:FE61E7B22721EC0F|rigid:xZwov2AUfONIpApQ8URLpsqsRfk	false	tag:?-?(MINT-1341351)	tag:?-?(MINT-1341356)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)