#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03497	uniprotkb:P29366	intact:EBI-18285|uniprotkb:D3DKQ8|ensemblfungi:YHL007C	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:ste20_yeast(display_long)|uniprotkb:STE20(gene name)|psi-mi:STE20(display_short)|uniprotkb:YHL007C(locus name)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0018"(two hybrid)	Winters et al. (2005)	pubmed:15743816|mint:MINT-5217565	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525793	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011856.1|sgd:S000000999|ensemblfungi:YHL007C(gene)|ensemblfungi:YHL007C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|reactome:R-SCE-389359|interpro:IPR036936|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406|rcsb pdb:2KYM|rcsb pdb:2LCS|rcsb pdb:2RQW|reactome:R-SCE-2029482|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003729"(mRNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044025"("histone kinase activity (H2B-S14 specific)")|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|dip:DIP-712N|mint:Q03497	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:69C1C12F5B87733C	crc64:FB6C525AE9A19181	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/06	2014/10/16	rogid:ammX6PwJCeyVjNxJ2UJUBrZt9mM559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	intact-crc:5C7C08C561E55B63|rigid:QCJqHrvfSXBiFYAe6jPo48g8k5Y	false	binding-associated region:434-499	binding-associated region:157-551	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03497	uniprotkb:P29366	intact:EBI-18285|uniprotkb:D3DKQ8|ensemblfungi:YHL007C	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:ste20_yeast(display_long)|uniprotkb:STE20(gene name)|psi-mi:STE20(display_short)|uniprotkb:YHL007C(locus name)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0018"(two hybrid)	Winters et al. (2005)	pubmed:15743816|mint:MINT-5217565	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525798	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011856.1|sgd:S000000999|ensemblfungi:YHL007C(gene)|ensemblfungi:YHL007C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|reactome:R-SCE-389359|interpro:IPR036936|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406|rcsb pdb:2KYM|rcsb pdb:2LCS|rcsb pdb:2RQW|reactome:R-SCE-2029482|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003729"(mRNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044025"("histone kinase activity (H2B-S14 specific)")|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|dip:DIP-712N|mint:Q03497	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:69C1C12F5B87733C	crc64:FB6C525AE9A19181	comment:"Analysis of the mutants interaction Bem1 with by B-gal measurement compared to wild type ste20 (=100%): K478A=43%, S473A=16%, P479A=5%, all others mutants <2%."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/06	2014/10/16	rogid:ammX6PwJCeyVjNxJ2UJUBrZt9mM559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	intact-crc:9A8AB1E0A7D9EE0F|rigid:QCJqHrvfSXBiFYAe6jPo48g8k5Y	false	mutation decreasing interaction:475-475,477-477|binding-associated region:1-499|mutation decreasing interaction:470-470|mutation decreasing interaction:471-471|mutation decreasing interaction:472-472|mutation decreasing interaction:473-473|mutation decreasing interaction:474-474|mutation decreasing interaction:475-475|mutation decreasing interaction:476-476|mutation decreasing interaction:477-477|mutation decreasing interaction:479-479|mutation decreasing interaction:480-480	binding-associated region:157-551	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19073	uniprotkb:Q03497	intact:EBI-4274|uniprotkb:Q05978|uniprotkb:D6VYN1|ensemblfungi:YLR229C	intact:EBI-18285|uniprotkb:D3DKQ8|ensemblfungi:YHL007C	psi-mi:cdc42_yeast(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:SRO2(gene name synonym)|uniprotkb:YLR229C(locus name)|uniprotkb:L8083.13(orf name)|uniprotkb:Suppressor of RHO3 protein 2(gene name synonym)	psi-mi:ste20_yeast(display_long)|uniprotkb:STE20(gene name)|psi-mi:STE20(display_short)|uniprotkb:YHL007C(locus name)	psi-mi:"MI:0018"(two hybrid)	Winters et al. (2005)	pubmed:15743816|mint:MINT-5217565	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525807	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-862N|refseq:NP_013330.1|sgd:S000004219|mint:P19073|ensemblfungi:YLR229C(gene)|ensemblfungi:YLR229C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005940"(septin ring)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007119"(budding cell isotropic bud growth)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031106"(septin ring organization)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0043332"(mating projection tip)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000222"(positive regulation of pseudohyphal growth)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5626467|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013148|reactome:R-SCE-9013406|reactome:R-SCE-9013409|reactome:R-SCE-983231	refseq:NP_011856.1|sgd:S000000999|ensemblfungi:YHL007C(gene)|ensemblfungi:YHL007C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|reactome:R-SCE-389359|interpro:IPR036936|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406|rcsb pdb:2KYM|rcsb pdb:2LCS|rcsb pdb:2RQW|reactome:R-SCE-2029482|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003729"(mRNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044025"("histone kinase activity (H2B-S14 specific)")|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|dip:DIP-712N|mint:Q03497	-	crc64:30BD644BA9836B2C	crc64:69C1C12F5B87733C	comment:Gly12Val Cdc42 is constitutively active GTP-bound so it can binds to effectors like ste20.|comment:Cys188Ser Cdc42 is not lipid-modified so it can be used in the Y2H system.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/06	2014/10/16	rogid:4FDrNURFjSZOYUFf/dADXTpoMTc559292	rogid:ammX6PwJCeyVjNxJ2UJUBrZt9mM559292	intact-crc:B1F3A46894747714|rigid:7L3BdeqLSKwAstxYPP8TnThrHa4	false	mutation:12-12,188-188	binding-associated region:333-370(IPR000095)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29366	uniprotkb:Q03497	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	intact:EBI-18285|uniprotkb:D3DKQ8|ensemblfungi:YHL007C	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:ste20_yeast(display_long)|uniprotkb:STE20(gene name)|psi-mi:STE20(display_short)|uniprotkb:YHL007C(locus name)	psi-mi:"MI:0018"(two hybrid)	Winters et al. (2005)	pubmed:15743816|mint:MINT-5217565	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525857	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	refseq:NP_011856.1|sgd:S000000999|ensemblfungi:YHL007C(gene)|ensemblfungi:YHL007C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|reactome:R-SCE-389359|interpro:IPR036936|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406|rcsb pdb:2KYM|rcsb pdb:2LCS|rcsb pdb:2RQW|reactome:R-SCE-2029482|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003729"(mRNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044025"("histone kinase activity (H2B-S14 specific)")|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|dip:DIP-712N|mint:Q03497	-	crc64:FB6C525AE9A19181	crc64:69C1C12F5B87733C	comment:W192A mutation in the second SH3 of Bem1 is the mutation of the SH3 highly conserved tryptophan involved in binding proline-rich ligand. The equivalent mutation in the first SH3 had no effect on interaction.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/06	2014/10/16	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rogid:ammX6PwJCeyVjNxJ2UJUBrZt9mM559292	intact-crc:FA7DB7AED85FDDB2|rigid:QCJqHrvfSXBiFYAe6jPo48g8k5Y	false	binding-associated region:1-551|mutation decreasing interaction:192-192	necessary binding region:434-499	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03497	uniprotkb:Q12163	intact:EBI-18285|uniprotkb:D3DKQ8|ensemblfungi:YHL007C	intact:EBI-34713|uniprotkb:D6VSE2|ensemblfungi:YDR162C	psi-mi:ste20_yeast(display_long)|uniprotkb:STE20(gene name)|psi-mi:STE20(display_short)|uniprotkb:YHL007C(locus name)	psi-mi:nbp2_yeast(display_long)|uniprotkb:NBP2(gene name)|psi-mi:NBP2(display_short)|uniprotkb:YDR162C(locus name)	psi-mi:"MI:0018"(two hybrid)	Winters et al. (2005)	pubmed:15743816|mint:MINT-5217565	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-526145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011856.1|sgd:S000000999|ensemblfungi:YHL007C(gene)|ensemblfungi:YHL007C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|reactome:R-SCE-389359|interpro:IPR036936|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406|rcsb pdb:2KYM|rcsb pdb:2LCS|rcsb pdb:2RQW|reactome:R-SCE-2029482|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003729"(mRNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044025"("histone kinase activity (H2B-S14 specific)")|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|dip:DIP-712N|mint:Q03497	sgd:S000002569|refseq:NP_010446.3|mint:Q12163|dip:DIP-1538N|ensemblfungi:YDR162C(gene)|ensemblfungi:YDR162C_mRNA(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001452(Src homology-3)|interpro:IPR036028|rcsb pdb:1YN8|rcsb pdb:2LCS	-	crc64:69C1C12F5B87733C	crc64:A7458854D5000EA6	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/06	2014/10/16	rogid:ammX6PwJCeyVjNxJ2UJUBrZt9mM559292	rogid:rxEwkyNpxLvCh9usNVTOPCYedkU559292	intact-crc:C3249CB4E6B8C1A6|rigid:mJHtw/DcKo59/yRSk95yiijE8Vw	false	binding-associated region:434-499	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03497	uniprotkb:P29366	intact:EBI-18285|uniprotkb:D3DKQ8|ensemblfungi:YHL007C	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:ste20_yeast(display_long)|uniprotkb:STE20(gene name)|psi-mi:STE20(display_short)|uniprotkb:YHL007C(locus name)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Winters et al. (2005)	pubmed:15743816|mint:MINT-5217565	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525821	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011856.1|sgd:S000000999|ensemblfungi:YHL007C(gene)|ensemblfungi:YHL007C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|reactome:R-SCE-389359|interpro:IPR036936|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406|rcsb pdb:2KYM|rcsb pdb:2LCS|rcsb pdb:2RQW|reactome:R-SCE-2029482|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003729"(mRNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044025"("histone kinase activity (H2B-S14 specific)")|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|dip:DIP-712N|mint:Q03497	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:69C1C12F5B87733C	crc64:FB6C525AE9A19181	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/06	2014/10/16	rogid:ammX6PwJCeyVjNxJ2UJUBrZt9mM559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	intact-crc:2329093EF990FC1B|rigid:QCJqHrvfSXBiFYAe6jPo48g8k5Y	false	glutathione s tranferase tag:?-?|binding-associated region:1-499|mutation decreasing interaction:475-475,477-477|necessary binding region:434-499	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12163	uniprotkb:Q03497	intact:EBI-34713|uniprotkb:D6VSE2|ensemblfungi:YDR162C	intact:EBI-18285|uniprotkb:D3DKQ8|ensemblfungi:YHL007C	psi-mi:nbp2_yeast(display_long)|uniprotkb:NBP2(gene name)|psi-mi:NBP2(display_short)|uniprotkb:YDR162C(locus name)	psi-mi:ste20_yeast(display_long)|uniprotkb:STE20(gene name)|psi-mi:STE20(display_short)|uniprotkb:YHL007C(locus name)	psi-mi:"MI:0096"(pull down)	Winters et al. (2005)	pubmed:15743816|mint:MINT-5217565	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-526156	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002569|refseq:NP_010446.3|mint:Q12163|dip:DIP-1538N|ensemblfungi:YDR162C(gene)|ensemblfungi:YDR162C_mRNA(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001452(Src homology-3)|interpro:IPR036028|rcsb pdb:1YN8|rcsb pdb:2LCS	refseq:NP_011856.1|sgd:S000000999|ensemblfungi:YHL007C(gene)|ensemblfungi:YHL007C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|reactome:R-SCE-389359|interpro:IPR036936|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406|rcsb pdb:2KYM|rcsb pdb:2LCS|rcsb pdb:2RQW|reactome:R-SCE-2029482|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003729"(mRNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044025"("histone kinase activity (H2B-S14 specific)")|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|dip:DIP-712N|mint:Q03497	-	crc64:A7458854D5000EA6	crc64:69C1C12F5B87733C	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/06	2014/10/16	rogid:rxEwkyNpxLvCh9usNVTOPCYedkU559292	rogid:ammX6PwJCeyVjNxJ2UJUBrZt9mM559292	intact-crc:6ED16826063A1F07|rigid:mJHtw/DcKo59/yRSk95yiijE8Vw	false	myc tag:?-?	binding-associated region:1-499|mutation decreasing interaction:475-475,477-477|necessary binding region:434-499|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)