#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10415	uniprotkb:O54918	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-526067|uniprotkb:O54919|uniprotkb:O54920|uniprotkb:A2ALQ6|ensembl:ENSMUSP00000105970	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:b2l11_mouse(display_long)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707531	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:NP_033884.1|refseq:NP_997563.1|refseq:NP_997564.1|ensembl:ENSMUSG00000027381(gene)|ensembl:ENSMUST00000110341(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|rcsb pdb:1PQ1|reactome:R-MMU-111446|reactome:R-MMU-111453|reactome:R-MMU-193648|dip:DIP-29214N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:Yv0iM/Lv2orJjfRLaDKto6SFCIQ10090	intact-crc:9BECB6D3D21B7C1B|rigid:N1oduN4PasG+O7QkuMCI8ARMQOk	false	his tag:n-n|binding-associated region:1-217	binding-associated region:140-165(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54918	uniprotkb:Q07817-1	intact:EBI-526067|uniprotkb:O54919|uniprotkb:O54920|uniprotkb:A2ALQ6|ensembl:ENSMUSP00000105970	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:b2l11_mouse(display_long)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707703	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033884.1|refseq:NP_997563.1|refseq:NP_997564.1|ensembl:ENSMUSG00000027381(gene)|ensembl:ENSMUST00000110341(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|rcsb pdb:1PQ1|reactome:R-MMU-111446|reactome:R-MMU-111453|reactome:R-MMU-193648|dip:DIP-29214N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:Yv0iM/Lv2orJjfRLaDKto6SFCIQ10090	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:71A3C1CDEA95B6E3|rigid:MCrD1Wq7r+hKSMPIhfQyR0nR3wc	false	binding-associated region:140-165	binding-associated region:1-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92843	uniprotkb:O54918	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	intact:EBI-526067|uniprotkb:O54919|uniprotkb:O54920|uniprotkb:A2ALQ6|ensembl:ENSMUSP00000105970	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:b2l11_mouse(display_long)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707729	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	refseq:NP_033884.1|refseq:NP_997563.1|refseq:NP_997564.1|ensembl:ENSMUSG00000027381(gene)|ensembl:ENSMUST00000110341(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|rcsb pdb:1PQ1|reactome:R-MMU-111446|reactome:R-MMU-111453|reactome:R-MMU-193648|dip:DIP-29214N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	rogid:Yv0iM/Lv2orJjfRLaDKto6SFCIQ10090	intact-crc:68F1F7A070A8DA35|rigid:MlfIjmcmWFASITG3Fd02YHt5v/k	false	his tag:n-n|binding-associated region:?-?	binding-associated region:140-165|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:O54918	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-526067|uniprotkb:O54919|uniprotkb:O54920|uniprotkb:A2ALQ6|ensembl:ENSMUSP00000105970	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:b2l11_mouse(display_long)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707743	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_033884.1|refseq:NP_997563.1|refseq:NP_997564.1|ensembl:ENSMUSG00000027381(gene)|ensembl:ENSMUST00000110341(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|rcsb pdb:1PQ1|reactome:R-MMU-111446|reactome:R-MMU-111453|reactome:R-MMU-193648|dip:DIP-29214N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:Yv0iM/Lv2orJjfRLaDKto6SFCIQ10090	intact-crc:821D4D01D0BB57FA|rigid:+5xIzo86JBM2aQOVw+ddJ5WylaA	false	binding-associated region:152-308	binding-associated region:140-165|mutation decreasing interaction:146-146|mutation decreasing interaction:150-150|mutation decreasing interaction:153-153|mutation decreasing interaction:157-157	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54918	uniprotkb:Q07440	intact:EBI-526067|uniprotkb:O54919|uniprotkb:O54920|uniprotkb:A2ALQ6|ensembl:ENSMUSP00000105970	intact:EBI-707754|ensembl:ENSMUSP00000096086	psi-mi:b2l11_mouse(display_long)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)	psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707764	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033884.1|refseq:NP_997563.1|refseq:NP_997564.1|ensembl:ENSMUSG00000027381(gene)|ensembl:ENSMUST00000110341(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|rcsb pdb:1PQ1|reactome:R-MMU-111446|reactome:R-MMU-111453|reactome:R-MMU-193648|dip:DIP-29214N	refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:Yv0iM/Lv2orJjfRLaDKto6SFCIQ10090	rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090	intact-crc:E6D37B0AF7AFF1A2|rigid:6VNLe1cdGMVDdBeBYiYFvmbF9G8	false	binding-associated region:140-165	binding-associated region:1-152	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43521	uniprotkb:Q07817-1	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707798	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	kinetics:IC50=4.6nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:7471C48CC454D39B|rigid:Za29MZzAlAIfxbgAv8/q+ePX9T0	false	binding-associated region:142-167(IPR000712)	binding-associated region:1-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43521	uniprotkb:P10415	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707839	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	kinetics:IC50=2.6nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:B294F1D81EBC0504|rigid:sH6H+AHuNTu0woxvGjrRc1eNEtI	false	binding-associated region:142-167	binding-associated region:1-217|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92843	uniprotkb:O43521	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707852	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	-	-	-	kinetics:IC50=4.3nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	intact-crc:AF1B4B46E6EAFC02|rigid:nKGW4c5f2AtBm+khZzbnq0BsEVY	false	binding-associated region:?-?|his tag:n-n	binding-associated region:142-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:O43521	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707918	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	-	-	-	kinetics:IC50=2.4nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	intact-crc:BA1B33D2CCC89112|rigid:YfxnIrgJIWjz6UFxOMApTfAqVUA	false	binding-associated region:152-308	binding-associated region:142-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07440	uniprotkb:O43521	intact:EBI-707754|ensembl:ENSMUSP00000096086	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym)	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707932	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	-	-	-	kinetics:IC50=4.3nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	intact-crc:9BACA1ED8A029E56|rigid:GOxqHcHt4nr6bl7iPoTUfALyEOA	false	binding-associated region:1-152	binding-associated region:142-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXH1	uniprotkb:Q07817-1	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707945	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	kinetics:IC50=6.3nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:1A30D54FBF6DB25F|rigid:IpzWIbP3V1X+l5peIK52n9LB1xc	false	binding-associated region:131-156(IPR000712)	binding-associated region:1-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXH1	uniprotkb:P10415	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707957	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	kinetics:IC50=3.3nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:0FF5698202CD011A|rigid:IODiJDXcdtt13hzMVfdr/U+FEas	false	binding-associated region:131-156	his tag:n-n|binding-associated region:1-217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92843	uniprotkb:Q9BXH1	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707968	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	-	-	-	kinetics:IC50=5.1nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	intact-crc:D4D687A82C01C55F|rigid:k1vvcvaZ4mOadz9n69DuDey4bmc	false	binding-associated region:?-?|his tag:n-n	binding-associated region:131-156(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXH1	uniprotkb:P97287	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707980	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	kinetics:IC50=5.0nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	intact-crc:8792955A4C402995|rigid:mS+jbfScAAWrdLiWr2DZP5nqrvE	false	binding-associated region:131-156(IPR000712)	binding-associated region:152-308	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07440	uniprotkb:Q9BXH1	intact:EBI-707754|ensembl:ENSMUSP00000096086	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym)	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-707992	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	-	-	-	kinetics:IC50=5.7nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	intact-crc:69FD038367E15EBC|rigid:Au1B0f9PSiPF3TzkpJfIUwPHU6c	false	binding-associated region:1-152	binding-associated region:131-156(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10415	uniprotkb:Q91ZE9	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-708032|uniprotkb:Q8BUK0|ensembl:ENSMUSP00000159051	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:bmf_mouse(display_long)|uniprotkb:Bmf(gene name)|psi-mi:Bmf(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708044	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:NP_612186.2|refseq:XP_006498918.1|refseq:NP_001318150.1|dip:DIP-29806N|ensembl:ENSMUSG00000040093(gene)|ensembl:ENSMUST00000125860(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR028192|mint:Q91ZE9|rcsb pdb:2VOG|reactome:R-MMU-111453|reactome:R-MMU-139910	-	-	-	kinetics:IC50=3.0nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:TuX2CXkbIbnDcK+gYw7T0AyD5zo10090	intact-crc:A6DEDCA572A4DC44|rigid:RUhJdgXNpgrsycNw4t81VW6/ijI	false	his tag:n-n|binding-associated region:1-217	binding-associated region:129-152(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q91ZE9	uniprotkb:Q07817-1	intact:EBI-708032|uniprotkb:Q8BUK0|ensembl:ENSMUSP00000159051	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bmf_mouse(display_long)|uniprotkb:Bmf(gene name)|psi-mi:Bmf(display_short)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708056	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612186.2|refseq:XP_006498918.1|refseq:NP_001318150.1|dip:DIP-29806N|ensembl:ENSMUSG00000040093(gene)|ensembl:ENSMUST00000125860(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR028192|mint:Q91ZE9|rcsb pdb:2VOG|reactome:R-MMU-111453|reactome:R-MMU-139910	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	kinetics:IC50=9.7nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:TuX2CXkbIbnDcK+gYw7T0AyD5zo10090	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:B31B606CDF0DFF01|rigid:sQp5fjq+1Lp2boqRUgycJpgK1Pw	false	binding-associated region:129-152(IPR000712)	binding-associated region:1-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q91ZE9	uniprotkb:Q92843	intact:EBI-708032|uniprotkb:Q8BUK0|ensembl:ENSMUSP00000159051	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	psi-mi:bmf_mouse(display_long)|uniprotkb:Bmf(gene name)|psi-mi:Bmf(display_short)	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708066	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612186.2|refseq:XP_006498918.1|refseq:NP_001318150.1|dip:DIP-29806N|ensembl:ENSMUSG00000040093(gene)|ensembl:ENSMUST00000125860(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR028192|mint:Q91ZE9|rcsb pdb:2VOG|reactome:R-MMU-111453|reactome:R-MMU-139910	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	-	-	-	kinetics:IC50=9.8nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:TuX2CXkbIbnDcK+gYw7T0AyD5zo10090	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	intact-crc:AC701AEB2B3A1C8C|rigid:y/jC7+35z+EpvbdwaI5yIGnU+0E	false	binding-associated region:129-152(IPR000712)	binding-associated region:?-?|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92934	uniprotkb:P10415	intact:EBI-700771|uniprotkb:O14803|uniprotkb:Q6FH21|ensembl:ENSP00000309103|ensembl:ENSP00000378040	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:bad_human(display_long)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-2-like protein 8(gene name synonym)|uniprotkb:BAD(gene name)|psi-mi:BAD(display_short)|uniprotkb:BBC6(gene name synonym)|uniprotkb:BCL2L8(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708078	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004313.1|refseq:NP_116784.1|dip:DIP-29184N|ensembl:ENSG00000002330(gene)|ensembl:ENST00000309032(transcript)|ensembl:ENST00000394532(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|mint:Q92934|rcsb pdb:1G5J|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-198323|reactome:R-HSA-5674400	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	kinetics:IC50=16.0nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:2c2kSu+3ZHnx458SDbvIcdGV4PA9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:9D6E769DF73BCF02|rigid:kX6wAP4OZZhHDEiWKX3RSA3hsI0	false	binding-associated region:104-129(IPR000712)	his tag:n-n|binding-associated region:1-217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92934	uniprotkb:Q07817-1	intact:EBI-700771|uniprotkb:O14803|uniprotkb:Q6FH21|ensembl:ENSP00000309103|ensembl:ENSP00000378040	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bad_human(display_long)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-2-like protein 8(gene name synonym)|uniprotkb:BAD(gene name)|psi-mi:BAD(display_short)|uniprotkb:BBC6(gene name synonym)|uniprotkb:BCL2L8(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708090	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004313.1|refseq:NP_116784.1|dip:DIP-29184N|ensembl:ENSG00000002330(gene)|ensembl:ENST00000309032(transcript)|ensembl:ENST00000394532(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|mint:Q92934|rcsb pdb:1G5J|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-198323|reactome:R-HSA-5674400	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	kinetics:IC50=5.3nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:2c2kSu+3ZHnx458SDbvIcdGV4PA9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:71018E0B60EE01CE|rigid:Vk3daCkKBaSWTY1baL0ES5+q9k8	false	binding-associated region:104-129(IPR000712)	binding-associated region:1-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92843	uniprotkb:Q92934	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	intact:EBI-700771|uniprotkb:O14803|uniprotkb:Q6FH21|ensembl:ENSP00000309103|ensembl:ENSP00000378040	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:bad_human(display_long)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-2-like protein 8(gene name synonym)|uniprotkb:BAD(gene name)|psi-mi:BAD(display_short)|uniprotkb:BBC6(gene name synonym)|uniprotkb:BCL2L8(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	refseq:NP_004313.1|refseq:NP_116784.1|dip:DIP-29184N|ensembl:ENSG00000002330(gene)|ensembl:ENST00000309032(transcript)|ensembl:ENST00000394532(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|mint:Q92934|rcsb pdb:1G5J|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-198323|reactome:R-HSA-5674400	-	-	-	kinetics:IC50=30nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	rogid:2c2kSu+3ZHnx458SDbvIcdGV4PA9606	intact-crc:BD6E4270A506CEB0|rigid:QF/U6RNUpns2UH2o9gBBoSK8//U	false	his tag:n-n|binding-associated region:?-?	binding-associated region:104-129(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07817-1	uniprotkb:Q13323	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-700794|uniprotkb:Q16582|uniprotkb:Q6FH93|ensembl:ENSP00000216115	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:bik_human(display_long)|uniprotkb:Apoptosis inducer NBK(gene name synonym)|uniprotkb:BP4(gene name synonym)|uniprotkb:BIP1(gene name synonym)|uniprotkb:BIK(gene name)|psi-mi:BIK(display_short)|uniprotkb:NBK(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	refseq:NP_001188.1|dip:DIP-928N|ensembl:ENSG00000100290(gene)|ensembl:ENST00000216115(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008584"(male gonad development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR020728|interpro:IPR024579|rcsb pdb:2IPE	-	-	-	kinetics:IC50=43nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:M34Yl66KzkhNSq7e3WKQMb6WDqU9606	intact-crc:E217B3321387EEFA|rigid:xHxd6wrTICkFbEL5w0b+XaG4wfw	false	binding-associated region:1-209	binding-associated region:51-75(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13323	uniprotkb:Q92843	intact:EBI-700794|uniprotkb:Q16582|uniprotkb:Q6FH93|ensembl:ENSP00000216115	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	psi-mi:bik_human(display_long)|uniprotkb:Apoptosis inducer NBK(gene name synonym)|uniprotkb:BP4(gene name synonym)|uniprotkb:BIP1(gene name synonym)|uniprotkb:BIK(gene name)|psi-mi:BIK(display_short)|uniprotkb:NBK(gene name synonym)	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708122	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188.1|dip:DIP-928N|ensembl:ENSG00000100290(gene)|ensembl:ENST00000216115(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008584"(male gonad development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR020728|interpro:IPR024579|rcsb pdb:2IPE	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	-	-	-	kinetics:IC50=12nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:M34Yl66KzkhNSq7e3WKQMb6WDqU9606	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	intact-crc:15DD751E84B299FE|rigid:jX3YEo5iDxPzWyiM8/GHu0QK1Uk	false	binding-associated region:51-75(IPR000712)	his tag:n-n|binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07440	uniprotkb:Q13323	intact:EBI-707754|ensembl:ENSMUSP00000096086	intact:EBI-700794|uniprotkb:Q16582|uniprotkb:Q6FH93|ensembl:ENSP00000216115	psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym)	psi-mi:bik_human(display_long)|uniprotkb:Apoptosis inducer NBK(gene name synonym)|uniprotkb:BP4(gene name synonym)|uniprotkb:BIP1(gene name synonym)|uniprotkb:BIK(gene name)|psi-mi:BIK(display_short)|uniprotkb:NBK(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708134	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI	refseq:NP_001188.1|dip:DIP-928N|ensembl:ENSG00000100290(gene)|ensembl:ENST00000216115(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008584"(male gonad development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR020728|interpro:IPR024579|rcsb pdb:2IPE	-	-	-	kinetics:IC50=58nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090	rogid:M34Yl66KzkhNSq7e3WKQMb6WDqU9606	intact-crc:DC2B506AC466B60B|rigid:cwSJuqTvuZ1mqjFBARxMxOPyU/4	false	binding-associated region:1-152	binding-associated region:51-75(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07817-1	uniprotkb:O00198	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-701322|ensembl:ENSP00000257572	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:hrk_human(display_long)|uniprotkb:Neuronal death protein DP5(gene name synonym)|uniprotkb:BH3-interacting domain-containing protein 3(gene name synonym)|uniprotkb:HRK(gene name)|psi-mi:HRK(display_short)|uniprotkb:BID3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708144	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	refseq:NP_003797.1|refseq:XP_016875635.1|ensembl:ENSG00000135116(gene)|ensembl:ENST00000257572(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR017249(Apoptosis, activator harakiri)|interpro:IPR020728|rcsb pdb:2L58|rcsb pdb:2L5B|rcsb pdb:6XY4	-	-	-	kinetics:IC50=3.7nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:FKS9Mt5Ycxm5pl5//XAYXLc6cCI9606	intact-crc:E2938A094F9B887E|rigid:apyzVaaqRbpBY7TsMy/yXyMLULo	false	binding-associated region:1-209	binding-associated region:52-76(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00198	uniprotkb:Q92843	intact:EBI-701322|ensembl:ENSP00000257572	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	psi-mi:hrk_human(display_long)|uniprotkb:Neuronal death protein DP5(gene name synonym)|uniprotkb:BH3-interacting domain-containing protein 3(gene name synonym)|uniprotkb:HRK(gene name)|psi-mi:HRK(display_short)|uniprotkb:BID3(gene name synonym)	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708154	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003797.1|refseq:XP_016875635.1|ensembl:ENSG00000135116(gene)|ensembl:ENST00000257572(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR017249(Apoptosis, activator harakiri)|interpro:IPR020728|rcsb pdb:2L58|rcsb pdb:2L5B|rcsb pdb:6XY4	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	-	-	-	kinetics:IC50=49nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:FKS9Mt5Ycxm5pl5//XAYXLc6cCI9606	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	intact-crc:AB275B71DEADC04C|rigid:o884uMp7+JBTG+LMmyM/TDew8Bg	false	binding-associated region:52-76(IPR000712)	binding-associated region:?-?|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07440	uniprotkb:O00198	intact:EBI-707754|ensembl:ENSMUSP00000096086	intact:EBI-701322|ensembl:ENSP00000257572	psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym)	psi-mi:hrk_human(display_long)|uniprotkb:Neuronal death protein DP5(gene name synonym)|uniprotkb:BH3-interacting domain-containing protein 3(gene name synonym)|uniprotkb:HRK(gene name)|psi-mi:HRK(display_short)|uniprotkb:BID3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708166	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI	refseq:NP_003797.1|refseq:XP_016875635.1|ensembl:ENSG00000135116(gene)|ensembl:ENST00000257572(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR017249(Apoptosis, activator harakiri)|interpro:IPR020728|rcsb pdb:2L58|rcsb pdb:2L5B|rcsb pdb:6XY4	-	-	-	kinetics:IC50=46nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090	rogid:FKS9Mt5Ycxm5pl5//XAYXLc6cCI9606	intact-crc:D2288B2767659266|rigid:1RnKnmAi83cb9hP3gU0BBs0gYsI	false	binding-associated region:1-152	binding-associated region:52-76(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07817-1	uniprotkb:P55957	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-519672|uniprotkb:Q549M7|uniprotkb:Q71T04|uniprotkb:Q7Z4M9|ensembl:ENSP00000449236|ensembl:ENSP00000480414|uniprotkb:Q8IY86	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:bid_human(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:BID(gene name)|psi-mi:BID(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708176	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	ensembl:ENSG00000015475(gene)|ensembl:ENST00000551952(transcript)|ensembl:ENST00000622694(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|mint:P55957|rcsb pdb:1ZY3|rcsb pdb:2BID|rcsb pdb:2KBW|rcsb pdb:2M5B|rcsb pdb:2M5I|rcsb pdb:4BD2|rcsb pdb:4QVE|rcsb pdb:4ZEQ|rcsb pdb:4ZIG|rcsb pdb:4ZII|rcsb pdb:5AJJ|rcsb pdb:5C3F|reactome:R-HSA-111447|reactome:R-HSA-111452|reactome:R-HSA-111453|reactome:R-HSA-114294|reactome:R-HSA-6803204|reactome:R-HSA-75108|go:"GO:0005123"(death receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|refseq:NP_001187.1|refseq:NP_932070.1|refseq:NP_001231498.1|refseq:NP_001231499.1|refseq:NP_001231501.1|refseq:NP_932071.1|refseq:NP_001231496.1|dip:DIP-34937N	-	-	-	kinetics:IC50=82nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:K7148hFL21ctiVuJRKEsddUE3tc9606	intact-crc:17F0D4932BCB0222|rigid:+LuoDOa6uVAMmhbGxzMBGDVTdjQ	false	binding-associated region:1-209	binding-associated region:51-75(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92843	uniprotkb:P55957	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	intact:EBI-519672|uniprotkb:Q549M7|uniprotkb:Q71T04|uniprotkb:Q7Z4M9|ensembl:ENSP00000449236|ensembl:ENSP00000480414|uniprotkb:Q8IY86	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:bid_human(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:BID(gene name)|psi-mi:BID(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708186	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	ensembl:ENSG00000015475(gene)|ensembl:ENST00000551952(transcript)|ensembl:ENST00000622694(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|mint:P55957|rcsb pdb:1ZY3|rcsb pdb:2BID|rcsb pdb:2KBW|rcsb pdb:2M5B|rcsb pdb:2M5I|rcsb pdb:4BD2|rcsb pdb:4QVE|rcsb pdb:4ZEQ|rcsb pdb:4ZIG|rcsb pdb:4ZII|rcsb pdb:5AJJ|rcsb pdb:5C3F|reactome:R-HSA-111447|reactome:R-HSA-111452|reactome:R-HSA-111453|reactome:R-HSA-114294|reactome:R-HSA-6803204|reactome:R-HSA-75108|go:"GO:0005123"(death receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|refseq:NP_001187.1|refseq:NP_932070.1|refseq:NP_001231498.1|refseq:NP_001231499.1|refseq:NP_001231501.1|refseq:NP_932071.1|refseq:NP_001231496.1|dip:DIP-34937N	-	-	-	kinetics:IC50=40nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	rogid:K7148hFL21ctiVuJRKEsddUE3tc9606	intact-crc:C8FB72ACABB1DF88|rigid:iSfkY72sINiq0/22waBQJzcK7b0	false	his tag:n-n|binding-associated region:?-?	binding-associated region:51-75(IPR000712)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P55957	uniprotkb:Q07440	intact:EBI-519672|uniprotkb:Q549M7|uniprotkb:Q71T04|uniprotkb:Q7Z4M9|ensembl:ENSP00000449236|ensembl:ENSP00000480414|uniprotkb:Q8IY86	intact:EBI-707754|ensembl:ENSMUSP00000096086	psi-mi:bid_human(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:BID(gene name)|psi-mi:BID(display_short)	psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708198	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000015475(gene)|ensembl:ENST00000551952(transcript)|ensembl:ENST00000622694(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|mint:P55957|rcsb pdb:1ZY3|rcsb pdb:2BID|rcsb pdb:2KBW|rcsb pdb:2M5B|rcsb pdb:2M5I|rcsb pdb:4BD2|rcsb pdb:4QVE|rcsb pdb:4ZEQ|rcsb pdb:4ZIG|rcsb pdb:4ZII|rcsb pdb:5AJJ|rcsb pdb:5C3F|reactome:R-HSA-111447|reactome:R-HSA-111452|reactome:R-HSA-111453|reactome:R-HSA-114294|reactome:R-HSA-6803204|reactome:R-HSA-75108|go:"GO:0005123"(death receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|refseq:NP_001187.1|refseq:NP_932070.1|refseq:NP_001231498.1|refseq:NP_001231499.1|refseq:NP_001231501.1|refseq:NP_932071.1|refseq:NP_001231496.1|dip:DIP-34937N	refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI	-	-	-	kinetics:IC50=9.3nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:K7148hFL21ctiVuJRKEsddUE3tc9606	rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090	intact-crc:6D5E66D9D2916243|rigid:HPqqScucIrRepd7niodtkp43rWA	false	binding-associated region:51-75(IPR000712)	binding-associated region:1-152	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:Q13794	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708211	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	-	-	-	kinetics:IC50=24.0nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	intact-crc:EC9DAD3FC62218C4|rigid:hpmBQLpeSb9e4YR8CvXOPRI0ufM	false	binding-associated region:152-308	binding-associated region:19-44	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13794	uniprotkb:Q07440	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-707754|ensembl:ENSMUSP00000096086	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-708220	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI	-	-	-	kinetics:IC50=180nM|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090	intact-crc:1E1D3AA8D27DB2E8|rigid:TehQBDTHQBiMKZ6NBY5spK5bXKo	false	binding-associated region:19-44	binding-associated region:1-152	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61337	uniprotkb:Q07817-1	intact:EBI-400328|ensembl:ENSMUSP00000025910	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bad_mouse(display_long)|uniprotkb:Bad(gene name)|psi-mi:Bad(display_short)|uniprotkb:Bbc6(gene name synonym)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031548.1|ensembl:ENSMUSG00000024959(gene)|ensembl:ENSMUST00000025910(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|rcsb pdb:2BZW|reactome:R-MMU-111447|reactome:R-MMU-111453|reactome:R-MMU-193648|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|dip:DIP-273N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	intact:EBI-709154(intact-secondary)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:s7+c8lnBrmxed496XKF41JljqRk10090	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:640D6CFAAC2B7BCB|rigid:hbsK+Mo3fY0Mgr4Zt7mB/m3R1gA	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q61337	uniprotkb:P10415	intact:EBI-400328|ensembl:ENSMUSP00000025910	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:bad_mouse(display_long)|uniprotkb:Bad(gene name)|psi-mi:Bad(display_short)|uniprotkb:Bbc6(gene name synonym)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709166	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031548.1|ensembl:ENSMUSG00000024959(gene)|ensembl:ENSMUST00000025910(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|rcsb pdb:2BZW|reactome:R-MMU-111447|reactome:R-MMU-111453|reactome:R-MMU-193648|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|dip:DIP-273N	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:s7+c8lnBrmxed496XKF41JljqRk10090	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:72FA9C958E612F53|rigid:737AL7c/Aj8fcWD6gBLqy3ae6eg	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P10415	uniprotkb:Q61337	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-400328|ensembl:ENSMUSP00000025910	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:bad_mouse(display_long)|uniprotkb:Bad(gene name)|psi-mi:Bad(display_short)|uniprotkb:Bbc6(gene name synonym)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709176	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:NP_031548.1|ensembl:ENSMUSG00000024959(gene)|ensembl:ENSMUST00000025910(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|rcsb pdb:2BZW|reactome:R-MMU-111447|reactome:R-MMU-111453|reactome:R-MMU-193648|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|dip:DIP-273N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:s7+c8lnBrmxed496XKF41JljqRk10090	intact-crc:B0875B01B32F3896|rigid:737AL7c/Aj8fcWD6gBLqy3ae6eg	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q9JM54	uniprotkb:P97287	intact:EBI-709183|ensembl:ENSMUSP00000025399	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709197	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	intact-crc:9525E822B737599F|rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q9JM54	uniprotkb:P97287	intact:EBI-709183|ensembl:ENSMUSP00000025399	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709205	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	intact-crc:57582FB68A794E5A|rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:O43521	uniprotkb:P97287	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709266	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	go:"GO:0051434"(BH3 domain binding)	-	-	comment:The actual BIM protein used in the assay appears to be an isoform, BIM-S, currently missing in UniProt.|comment:"Interaction also occurs when BH3 domain of BIM-S replaced by the corresponding domains from BBC3 (PUMA) and BAD"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	intact-crc:BAB6E6D786CB260C|rigid:YfxnIrgJIWjz6UFxOMApTfAqVUA	false	mutation decreasing interaction:155-155|mutation decreasing interaction:152-152|mutation decreasing interaction:148-148|mutation decreasing interaction:159-159	flag tag:n-n	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:O43521	uniprotkb:Q07817-1	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	go:"GO:0051434"(BH3 domain binding)	-	-	comment:The actual BIM protein used in the assay appears to be an isoform, BIM-S, currently missing in UniProt.|comment:"Interaction also occurs when BH3 domain of BIM-S replaced by the corresponding domains from BBC3 (PUMA) and BAD"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:F6BAD2DE7CA4CD87|rigid:Za29MZzAlAIfxbgAv8/q+ePX9T0	false	mutation decreasing interaction:155-155|mutation decreasing interaction:152-152|mutation decreasing interaction:148-148|mutation decreasing interaction:159-159	flag tag:n-n	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q07817-1	uniprotkb:Q13794	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709305	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	-	-	-	kinetics:"IC50=110nM (=>100,000nM in absence of mutants)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	intact-crc:0D646ABBD82B5AC1|rigid:EoDkJBBa/tBC/HRY/PHJQpOK8+8	false	-	binding-associated region:24-38|mutation increasing interaction:35-35|mutation increasing interaction:32-32	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13794	uniprotkb:Q92843	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709316	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	-	-	-	kinetics:"IC50=410nM (=>100,000nM in absence of mutants)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/09	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	intact-crc:80F692FEA79AD4CC|rigid:GuLy2WAi/4ul8q+SuJS/YDRQ8YU	false	mutation increasing interaction:35-35|mutation increasing interaction:32-32|binding-associated region:24-38	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07817-1	uniprotkb:Q13794	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709333	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	intact-crc:A5324800E71459E6|rigid:EoDkJBBa/tBC/HRY/PHJQpOK8+8	false	flag tag:n-n	mutation increasing interaction:35-35|mutation increasing interaction:32-32	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q13794	uniprotkb:Q92843	intact:EBI-707392|uniprotkb:B2R4T7|uniprotkb:Q8N589|ensembl:ENSP00000326119	intact:EBI-707714|uniprotkb:Q2M3U0|uniprotkb:Q5U0H4|uniprotkb:A8K0F4|ensembl:ENSP00000250405|ensembl:ENSP00000503012|ensembl:ENSP00000503091|ensembl:ENSP00000503368|ensembl:ENSP00000504570	psi-mi:apr_human(display_long)|uniprotkb:NOXA(gene name synonym)|uniprotkb:Immediate-early-response protein APR(gene name synonym)|uniprotkb:PMAIP1(gene name)|psi-mi:PMAIP1(display_short)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:b2cl2_human(display_long)|uniprotkb:Apoptosis regulator Bcl-W(gene name synonym)|uniprotkb:BCL2L2(gene name)|psi-mi:BCL2L2(display_short)|uniprotkb:BCLW(gene name synonym)|uniprotkb:KIAA0271(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709342	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066950.1|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051607"(defense response to virus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR024140|mint:Q13794|rcsb pdb:3MQP|reactome:R-HSA-111448|reactome:R-HSA-111453|reactome:R-HSA-6803204|ensembl:ENSG00000141682(gene)|ensembl:ENST00000316660(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043331"(response to dsRNA)	refseq:NP_001186768.1|refseq:NP_004041.1|dip:DIP-33700N|ensembl:ENSG00000129473(gene)|ensembl:ENST00000250405(transcript)|ensembl:ENST00000556100(transcript)|ensembl:ENST00000678311(transcript)|ensembl:ENST00000679000(transcript)|ensembl:ENST00000679219(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q92843|rcsb pdb:1MK3|rcsb pdb:1O0L|rcsb pdb:1ZY3|rcsb pdb:2Y6W|rcsb pdb:4CIM	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:IDaNRhZNKHvwyF0oqi9mPw+mBnc9606	rogid:sumS7dIlGDfsW71C5aJSw9ws8To9606	intact-crc:608578CE64452B75|rigid:GuLy2WAi/4ul8q+SuJS/YDRQ8YU	false	mutation increasing interaction:32-32|mutation increasing interaction:35-35	flag tag:n-n	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:O43521-2	uniprotkb:P10415	intact:EBI-526420|ensembl:ENSP00000309226|intact:EBI-7424849|intact:MINT-2590480	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:o43521-2(display_long)|uniprotkb:"Bim(L)"(isoform synonym)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709028	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-526406(bim_human)|ensembl:ENSG00000153094(gene)|ensembl:ENST00000308659(transcript)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:sadwwUEP0fTIfRQUZ1tk+sCGibU9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:DC30F5BA12063BD3|rigid:c8P80br2SHj+werq3e9y9HoyYy8	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43521-2	uniprotkb:P10415	intact:EBI-526420|ensembl:ENSP00000309226|intact:EBI-7424849|intact:MINT-2590480	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:o43521-2(display_long)|uniprotkb:"Bim(L)"(isoform synonym)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709038	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-526406(bim_human)|ensembl:ENSG00000153094(gene)|ensembl:ENST00000308659(transcript)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:sadwwUEP0fTIfRQUZ1tk+sCGibU9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:5917A4E0B543535E|rigid:c8P80br2SHj+werq3e9y9HoyYy8	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43521-1	uniprotkb:Q07817-1	intact:EBI-526416|ensembl:ENSP00000376943	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:o43521-1(display_long)|uniprotkb:"Bim(EL)"(isoform synonym)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709045	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-526406(bim_human)|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	go:"GO:0051434"(BH3 domain binding)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:29F6918F5D5D5CE9|rigid:Za29MZzAlAIfxbgAv8/q+ePX9T0	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07817-1	uniprotkb:O43521-1	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-526416|ensembl:ENSP00000376943	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:o43521-1(display_long)|uniprotkb:"Bim(EL)"(isoform synonym)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709055	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	intact:EBI-526406(bim_human)|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)	go:"GO:0051434"(BH3 domain binding)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	intact-crc:7EA7C953FD5F270C|rigid:Za29MZzAlAIfxbgAv8/q+ePX9T0	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43521	uniprotkb:P97287	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709064	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	intact-crc:7CF5599C8DF1EF92|rigid:YfxnIrgJIWjz6UFxOMApTfAqVUA	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43521	uniprotkb:P97287	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709072	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	intact-crc:D87851EA1BF0B84F|rigid:YfxnIrgJIWjz6UFxOMApTfAqVUA	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10415	uniprotkb:Q9BXH1	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709079	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	intact-crc:56A8B6A40202747C|rigid:IODiJDXcdtt13hzMVfdr/U+FEas	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXH1	uniprotkb:P10415	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709088	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:3D8FE4D125532EDB|rigid:IODiJDXcdtt13hzMVfdr/U+FEas	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07817-1	uniprotkb:Q9BXH1	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709095	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	intact-crc:2D2FEA4D28B50568|rigid:IpzWIbP3V1X+l5peIK52n9LB1xc	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07817-1	uniprotkb:Q9BXH1	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	intact-crc:A808BB178FF06DE5|rigid:IpzWIbP3V1X+l5peIK52n9LB1xc	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:Q9BXH1	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	intact-crc:76AAE7E402A442A7|rigid:mS+jbfScAAWrdLiWr2DZP5nqrvE	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:Q9BXH1	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709120	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606	intact-crc:F38DB6BEA5E12A2A|rigid:mS+jbfScAAWrdLiWr2DZP5nqrvE	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13323	uniprotkb:Q07817-1	intact:EBI-700794|uniprotkb:Q16582|uniprotkb:Q6FH93|ensembl:ENSP00000216115	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bik_human(display_long)|uniprotkb:Apoptosis inducer NBK(gene name synonym)|uniprotkb:BP4(gene name synonym)|uniprotkb:BIP1(gene name synonym)|uniprotkb:BIK(gene name)|psi-mi:BIK(display_short)|uniprotkb:NBK(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709128	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188.1|dip:DIP-928N|ensembl:ENSG00000100290(gene)|ensembl:ENST00000216115(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008584"(male gonad development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR020728|interpro:IPR024579|rcsb pdb:2IPE	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:M34Yl66KzkhNSq7e3WKQMb6WDqU9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:10D2EE8B45D9753A|rigid:xHxd6wrTICkFbEL5w0b+XaG4wfw	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13323	uniprotkb:Q07817-1	intact:EBI-700794|uniprotkb:Q16582|uniprotkb:Q6FH93|ensembl:ENSP00000216115	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bik_human(display_long)|uniprotkb:Apoptosis inducer NBK(gene name synonym)|uniprotkb:BP4(gene name synonym)|uniprotkb:BIP1(gene name synonym)|uniprotkb:BIK(gene name)|psi-mi:BIK(display_short)|uniprotkb:NBK(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709136	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188.1|dip:DIP-928N|ensembl:ENSG00000100290(gene)|ensembl:ENST00000216115(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008584"(male gonad development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR020728|interpro:IPR024579|rcsb pdb:2IPE	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:M34Yl66KzkhNSq7e3WKQMb6WDqU9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	intact-crc:95F5BFD1E29C1DB7|rigid:xHxd6wrTICkFbEL5w0b+XaG4wfw	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61337	uniprotkb:P10415	intact:EBI-400328|ensembl:ENSMUSP00000025910	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:bad_mouse(display_long)|uniprotkb:Bad(gene name)|psi-mi:Bad(display_short)|uniprotkb:Bbc6(gene name synonym)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-762178	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031548.1|ensembl:ENSMUSG00000024959(gene)|ensembl:ENSMUST00000025910(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|rcsb pdb:2BZW|reactome:R-MMU-111447|reactome:R-MMU-111453|reactome:R-MMU-193648|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|dip:DIP-273N	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:s7+c8lnBrmxed496XKF41JljqRk10090	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	intact-crc:34F267CCD87D8A29|rigid:737AL7c/Aj8fcWD6gBLqy3ae6eg	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10415	uniprotkb:Q61337	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-400328|ensembl:ENSMUSP00000025910	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:bad_mouse(display_long)|uniprotkb:Bad(gene name)|psi-mi:Bad(display_short)|uniprotkb:Bbc6(gene name synonym)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-762185	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:NP_031548.1|ensembl:ENSMUSG00000024959(gene)|ensembl:ENSMUST00000025910(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|rcsb pdb:2BZW|reactome:R-MMU-111447|reactome:R-MMU-111453|reactome:R-MMU-193648|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|dip:DIP-273N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:s7+c8lnBrmxed496XKF41JljqRk10090	intact-crc:B1D536967F38E2A4|rigid:737AL7c/Aj8fcWD6gBLqy3ae6eg	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07817-1	uniprotkb:Q61337	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-400328|ensembl:ENSMUSP00000025910	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:bad_mouse(display_long)|uniprotkb:Bad(gene name)|psi-mi:Bad(display_short)|uniprotkb:Bbc6(gene name synonym)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2005)	pubmed:15694340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-762192	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	refseq:NP_031548.1|ensembl:ENSMUSG00000024959(gene)|ensembl:ENSMUST00000025910(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|rcsb pdb:2BZW|reactome:R-MMU-111447|reactome:R-MMU-111453|reactome:R-MMU-193648|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|dip:DIP-273N	intact:EBI-762199(intact-secondary)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/09	2014/10/16	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:s7+c8lnBrmxed496XKF41JljqRk10090	intact-crc:0E5DA9B6907CE9CE|rigid:hbsK+Mo3fY0Mgr4Zt7mB/m3R1gA	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)