#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32850	uniprotkb:P05059	intact:EBI-7336000|intact:MINT-1214927|ensembl:ENSBTAP00000064870	intact:EBI-7438614|intact:MINT-1214849|uniprotkb:P79392|uniprotkb:Q2KJ52	psi-mi:stx1a_bovin(display_long)|uniprotkb:STX1A(gene name)|psi-mi:STX1A(display_short)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym)	psi-mi:cmga_bovin(display_long)|uniprotkb:CHGA(gene name)|psi-mi:CHGA(display_short)|uniprotkb:Pituitary secretory protein I(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yoo et al. (2005)	pubmed:15620717|imex:IM-11475|mint:MINT-5217439	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7438647|mint:MINT-51497|imex:IM-11475-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005225301.1|ensembl:ENSBTAG00000017075(gene)|ensembl:ENSBTAT00000084274(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0043005"(neuron projection)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:P32850|mint:MINT-1214938(identity)	refseq:NP_851348.1|rcsb pdb:1N2Y|interpro:IPR018054|rcsb pdb:1CFK|interpro:IPR001819(Chromogranin A/B)|interpro:IPR001990(Chromogranin/secretogranin)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0042583"(chromaffin granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0052338"(disruption by host of symbiont cell wall)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0086030"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:1905183"(negative regulation of protein serine/threonine phosphatase activity)|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|mint:MINT-1214934(identity)	-	comment:mint|function:Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis|comment:"Stoichiometry: 1.0"	comment:mint|function:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas|function:Chromostatin completely inhibits catecholamine release from chromaffin cells|function:Chromacin has antibacterial activity against M.luteus. Not active against E.coli|function:Catestatin inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist|function:Vasostatin-1 has antibacterial activity against Gram-positive bacteria M.luteus, B.megaterium. Not active against Gram-positive bacteria B.cereus, B.subtilis, S.pyogenes, M.fortuitum, S.aureus and L.monocytogenes and against Gram-negative bacteria E.coli, E.cloacae, S.typhimurium, K.pneumoniae and P.aeruginosa. Possesses antifungal activity against N.crassa, A.fumigatus, A.brassicicola, N.hematococca, F.culmorum and F.oxyporum and against the yeast S.cerevisiae and C.albicans. Inactive against T.mentagrophytes|comment:"Stoichiometry: 1.0"	figure legend:F3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/02	2014/10/16	rogid:dqHojUrfJV598kiWyqciw2UsqKo9913	rogid:LoxNEnFoKjv7hBsaPbobkH/uMp49913	intact-crc:34EF202937F6E96B|rigid:C/e9YextqzfSfsMlrdf11LPO4pM	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23389	uniprotkb:P48018	intact:EBI-7438671|intact:MINT-1214903|uniprotkb:O02707	intact:EBI-7336194|intact:MINT-1214882|ensembl:ENSBTAP00000065714	psi-mi:scg1_bovin(display_long)|uniprotkb:CHGB(gene name)|psi-mi:CHGB(display_short)|uniprotkb:Chromogranin-B(gene name synonym)|uniprotkb:Secretogranin I(gene name synonym)	psi-mi:syt1_bovin(display_long)|uniprotkb:SYT1(gene name)|psi-mi:SYT1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yoo et al. (2005)	pubmed:15620717|imex:IM-11475|mint:MINT-5217439	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7438691|mint:MINT-51499|imex:IM-11475-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018054|refseq:NP_851349.1|interpro:IPR001819(Chromogranin A/B)|interpro:IPR001990(Chromogranin/secretogranin)|go:"GO:0005576"(extracellular region)|go:"GO:0030141"(secretory granule)|go:"GO:0030658"(transport vesicle membrane)|mint:MINT-1214915(identity)	refseq:NP_776617.1|refseq:XP_005206087.1|ensembl:ENSBTAG00000034693(gene)|ensembl:ENSBTAT00000072222(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030276"(clathrin binding)|go:"GO:0031045"(dense core granule)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P48018|mint:MINT-1214919(identity)	-	comment:mint|function:Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites|function:Secretolytin has antibacterial activity|comment:"Stoichiometry: 1.0"	comment:mint|function:"May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2"|comment:"Stoichiometry: 1.0"	figure legend:F4|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/02	2014/10/16	rogid:zW89sTQsfwCupsPO4itKC5Rye209913	rogid:TAAVO0VVIdS86Of+Pc/HTnHQnp49913	intact-crc:12C6C904490BE8A1|rigid:UEzjFsJm+rtaM/Ed7WdB6vNnTUY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P05059	uniprotkb:P48018	intact:EBI-7438614|intact:MINT-1214849|uniprotkb:P79392|uniprotkb:Q2KJ52	intact:EBI-7336194|intact:MINT-1214882|ensembl:ENSBTAP00000065714	psi-mi:cmga_bovin(display_long)|uniprotkb:CHGA(gene name)|psi-mi:CHGA(display_short)|uniprotkb:Pituitary secretory protein I(gene name synonym)	psi-mi:syt1_bovin(display_long)|uniprotkb:SYT1(gene name)|psi-mi:SYT1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yoo et al. (2005)	pubmed:15620717|imex:IM-11475|mint:MINT-5217439	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7438659|mint:MINT-51498|imex:IM-11475-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_851348.1|rcsb pdb:1N2Y|interpro:IPR018054|rcsb pdb:1CFK|interpro:IPR001819(Chromogranin A/B)|interpro:IPR001990(Chromogranin/secretogranin)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033604"(negative regulation of catecholamine secretion)|go:"GO:0042583"(chromaffin granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0052338"(disruption by host of symbiont cell wall)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0086030"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:1905183"(negative regulation of protein serine/threonine phosphatase activity)|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|mint:MINT-1214891(identity)	refseq:NP_776617.1|refseq:XP_005206087.1|ensembl:ENSBTAG00000034693(gene)|ensembl:ENSBTAT00000072222(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030276"(clathrin binding)|go:"GO:0031045"(dense core granule)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P48018|mint:MINT-1214895(identity)	-	comment:mint|function:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas|function:Chromostatin completely inhibits catecholamine release from chromaffin cells|function:Chromacin has antibacterial activity against M.luteus. Not active against E.coli|function:Catestatin inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist|function:Vasostatin-1 has antibacterial activity against Gram-positive bacteria M.luteus, B.megaterium. Not active against Gram-positive bacteria B.cereus, B.subtilis, S.pyogenes, M.fortuitum, S.aureus and L.monocytogenes and against Gram-negative bacteria E.coli, E.cloacae, S.typhimurium, K.pneumoniae and P.aeruginosa. Possesses antifungal activity against N.crassa, A.fumigatus, A.brassicicola, N.hematococca, F.culmorum and F.oxyporum and against the yeast S.cerevisiae and C.albicans. Inactive against T.mentagrophytes|comment:"Stoichiometry: 1.0"	comment:mint|function:"May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2"|comment:"Stoichiometry: 1.0"	figure legend:F3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/02	2014/10/16	rogid:LoxNEnFoKjv7hBsaPbobkH/uMp49913	rogid:TAAVO0VVIdS86Of+Pc/HTnHQnp49913	intact-crc:2324FF9AB14E8240|rigid:nFb9GENYzGbpb2yeJI9G4ApV4U4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P23389	uniprotkb:P32850	intact:EBI-7438671|intact:MINT-1214903|uniprotkb:O02707	intact:EBI-7336000|intact:MINT-1214927|ensembl:ENSBTAP00000064870	psi-mi:scg1_bovin(display_long)|uniprotkb:CHGB(gene name)|psi-mi:CHGB(display_short)|uniprotkb:Chromogranin-B(gene name synonym)|uniprotkb:Secretogranin I(gene name synonym)	psi-mi:stx1a_bovin(display_long)|uniprotkb:STX1A(gene name)|psi-mi:STX1A(display_short)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yoo et al. (2005)	pubmed:15620717|imex:IM-11475|mint:MINT-5217439	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7438719|mint:MINT-51500|imex:IM-11475-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018054|refseq:NP_851349.1|interpro:IPR001819(Chromogranin A/B)|interpro:IPR001990(Chromogranin/secretogranin)|go:"GO:0005576"(extracellular region)|go:"GO:0030141"(secretory granule)|go:"GO:0030658"(transport vesicle membrane)|mint:MINT-1214946(identity)	refseq:XP_005225301.1|ensembl:ENSBTAG00000017075(gene)|ensembl:ENSBTAT00000084274(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0043005"(neuron projection)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:P32850|mint:MINT-1214950(identity)	-	comment:mint|function:Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites|function:Secretolytin has antibacterial activity|comment:"Stoichiometry: 1.0"	comment:mint|function:Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis|comment:"Stoichiometry: 1.0"	figure legend:F4|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/02	2014/10/16	rogid:zW89sTQsfwCupsPO4itKC5Rye209913	rogid:dqHojUrfJV598kiWyqciw2UsqKo9913	intact-crc:CFBD8BFB6F9E5A66|rigid:l+g9D7A3RHN/UgJNYdQceiwPG2o	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)