#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P23528	uniprotkb:P61981	intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660	intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330	psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym)	psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dreiza et al. (2005)	pubmed:15598710|mint:MINT-5217411	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7424538|mint:MINT-51033	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N|mint:MINT-1213139(identity)	refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N|mint:MINT-1213145(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2005/01/03	2014/10/16	rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606	intact-crc:A5CBB2EB832AF0FD|rigid:cKYhKgt1m4y5tEakbS0WRkBW3FY	false	O-phospho-L-serine:23-23(MINT-1213140)	tag:?-?(MINT-1213146)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23528	uniprotkb:P61981	intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660	intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330	psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym)	psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dreiza et al. (2005)	pubmed:15598710|mint:MINT-5217411	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7424622|mint:MINT-8006825	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N|mint:MINT-8006829(identity)|uniprotkb:P23528(original identifier)	refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N|mint:MINT-8006826(identity)|uniprotkb:P61981(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2005/01/03	2014/10/16	rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606	intact-crc:D5E7CE265DE6FECA|rigid:cKYhKgt1m4y5tEakbS0WRkBW3FY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61981	uniprotkb:O14558	intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330	intact:EBI-739095|uniprotkb:O14551|uniprotkb:Q6NVI3|uniprotkb:Q96MG9|ensembl:ENSP00000004982	psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:hspb6_human(display_long)|uniprotkb:HSPB6(gene name)|psi-mi:HSPB6(display_short)|uniprotkb:Heat shock 20 kDa-like protein p20(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dreiza et al. (2005)	pubmed:15598710|mint:MINT-5217411	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7424683|mint:MINT-8006832	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N|mint:MINT-8006833(identity)|uniprotkb:P61981(original identifier)	refseq:NP_653218.1|ensembl:ENSG00000004776(gene)|ensembl:ENST00000004982(transcript)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|rcsb pdb:4JUS|rcsb pdb:4JUT|rcsb pdb:5LTW|rcsb pdb:5LU1|rcsb pdb:5LU2|rcsb pdb:5LUM|rcsb pdb:5OK9|rcsb pdb:5OKF|mint:MINT-8006836(identity)|uniprotkb:O14558(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2005/01/03	2014/10/16	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606	rogid:j4dxIh+W0/K9ofHyEuKfi2GZHBQ9606	intact-crc:D97E40D0654E0ADA|rigid:s/ohGVTDxZdJRRLOiS4atLV40dU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)