#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P26678 uniprotkb:Q09013 intact:EBI-692836|ensembl:ENSP00000350132 intact:EBI-692774|ensembl:ENSP00000291270|uniprotkb:Q16205|uniprotkb:Q6P5Z6|uniprotkb:E5KR08 psi-mi:ppla_human(display_long)|uniprotkb:PLN(gene name)|psi-mi:PLN(display_short)|uniprotkb:PLB(gene name synonym) psi-mi:dmpk_human(display_long)|uniprotkb:Myotonic dystrophy protein kinase(gene name synonym)|uniprotkb:DMPK(gene name synonym)|uniprotkb:DM-kinase(gene name synonym)|uniprotkb:DMPK(gene name)|psi-mi:DMPK(display_short)|uniprotkb:MDPK(gene name synonym)|uniprotkb:DM1 protein kinase(gene name synonym)|uniprotkb:DM1PK(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Kaliman et al. (2005) pubmed:15598648 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-692834 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002658.1|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033574"(response to testosterone)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055119"(relaxation of cardiac muscle)|ensembl:ENSG00000198523(gene)|ensembl:ENST00000357525(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008015"(blood circulation)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|dip:DIP-33582N|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|rcsb pdb:1K9N|rcsb pdb:1KCH|rcsb pdb:1PLN|rcsb pdb:1PLP|rcsb pdb:1PSL|rcsb pdb:1ZLL|rcsb pdb:2HYN|rcsb pdb:6Y40|reactome:R-HSA-5578775|reactome:R-HSA-936837 ensembl:ENSG00000104936(gene)|ensembl:ENST00000291270(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006998"(nuclear envelope organization)|refseq:NP_001075029.1|refseq:NP_001075031.1|refseq:NP_001075032.1|refseq:NP_004400.4|refseq:NP_001275694.1|go:"GO:0010657"(muscle cell apoptotic process)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0014722"(regulation of skeletal muscle contraction by calcium ion signaling)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0008016"(regulation of heart contraction)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1WT6|rcsb pdb:2VD5|reactome:R-HSA-5578775 go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity) - - resulting-ptm:Phosphorylation of phospholamban on Ser-16|comment:Mutation of DMPK Lys-110 to alanine results in loss of kinase activity taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/10/04 2014/10/16 rogid:Ez0SC8EfE4K9O9JI5wNGAHJUXOw9606 rogid:7Z5L/FXqZCmN4AlKm/YUgu2mhG49606 intact-crc:361759C0EDBF9570|rigid:dSzeiJZdsp7XMKRtnP5nV2XgZAk false flag tag:?-? - - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:P26678 uniprotkb:Q09013 intact:EBI-692836|ensembl:ENSP00000350132 intact:EBI-692774|ensembl:ENSP00000291270|uniprotkb:Q16205|uniprotkb:Q6P5Z6|uniprotkb:E5KR08 psi-mi:ppla_human(display_long)|uniprotkb:PLN(gene name)|psi-mi:PLN(display_short)|uniprotkb:PLB(gene name synonym) psi-mi:dmpk_human(display_long)|uniprotkb:Myotonic dystrophy protein kinase(gene name synonym)|uniprotkb:DMPK(gene name synonym)|uniprotkb:DM-kinase(gene name synonym)|uniprotkb:DMPK(gene name)|psi-mi:DMPK(display_short)|uniprotkb:MDPK(gene name synonym)|uniprotkb:DM1 protein kinase(gene name synonym)|uniprotkb:DM1PK(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Kaliman et al. (2005) pubmed:15598648 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-692852 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002658.1|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033574"(response to testosterone)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055119"(relaxation of cardiac muscle)|ensembl:ENSG00000198523(gene)|ensembl:ENST00000357525(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008015"(blood circulation)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|dip:DIP-33582N|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|rcsb pdb:1K9N|rcsb pdb:1KCH|rcsb pdb:1PLN|rcsb pdb:1PLP|rcsb pdb:1PSL|rcsb pdb:1ZLL|rcsb pdb:2HYN|rcsb pdb:6Y40|reactome:R-HSA-5578775|reactome:R-HSA-936837 ensembl:ENSG00000104936(gene)|ensembl:ENST00000291270(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006998"(nuclear envelope organization)|refseq:NP_001075029.1|refseq:NP_001075031.1|refseq:NP_001075032.1|refseq:NP_004400.4|refseq:NP_001275694.1|go:"GO:0010657"(muscle cell apoptotic process)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0014722"(regulation of skeletal muscle contraction by calcium ion signaling)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0008016"(regulation of heart contraction)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1WT6|rcsb pdb:2VD5|reactome:R-HSA-5578775 go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity) - - resulting-ptm:Phosphorylation of phospholamban on Ser-16 taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/10/04 2014/10/16 rogid:Ez0SC8EfE4K9O9JI5wNGAHJUXOw9606 rogid:7Z5L/FXqZCmN4AlKm/YUgu2mhG49606 intact-crc:E9C266382AE00453|rigid:dSzeiJZdsp7XMKRtnP5nV2XgZAk false flag tag:?-?|myc tag:?-? myc tag:?-? - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:P26678 uniprotkb:Q09013 intact:EBI-692836|ensembl:ENSP00000350132 intact:EBI-692774|ensembl:ENSP00000291270|uniprotkb:Q16205|uniprotkb:Q6P5Z6|uniprotkb:E5KR08 psi-mi:ppla_human(display_long)|uniprotkb:PLN(gene name)|psi-mi:PLN(display_short)|uniprotkb:PLB(gene name synonym) psi-mi:dmpk_human(display_long)|uniprotkb:Myotonic dystrophy protein kinase(gene name synonym)|uniprotkb:DMPK(gene name synonym)|uniprotkb:DM-kinase(gene name synonym)|uniprotkb:DMPK(gene name)|psi-mi:DMPK(display_short)|uniprotkb:MDPK(gene name synonym)|uniprotkb:DM1 protein kinase(gene name synonym)|uniprotkb:DM1PK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kaliman et al. (2005) pubmed:15598648 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-692868 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002658.1|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033574"(response to testosterone)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055119"(relaxation of cardiac muscle)|ensembl:ENSG00000198523(gene)|ensembl:ENST00000357525(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008015"(blood circulation)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|dip:DIP-33582N|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|rcsb pdb:1K9N|rcsb pdb:1KCH|rcsb pdb:1PLN|rcsb pdb:1PLP|rcsb pdb:1PSL|rcsb pdb:1ZLL|rcsb pdb:2HYN|rcsb pdb:6Y40|reactome:R-HSA-5578775|reactome:R-HSA-936837 ensembl:ENSG00000104936(gene)|ensembl:ENST00000291270(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006998"(nuclear envelope organization)|refseq:NP_001075029.1|refseq:NP_001075031.1|refseq:NP_001075032.1|refseq:NP_004400.4|refseq:NP_001275694.1|go:"GO:0010657"(muscle cell apoptotic process)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0014722"(regulation of skeletal muscle contraction by calcium ion signaling)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0008016"(regulation of heart contraction)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1WT6|rcsb pdb:2VD5|reactome:R-HSA-5578775 - - - - taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/10/04 2014/10/16 rogid:Ez0SC8EfE4K9O9JI5wNGAHJUXOw9606 rogid:7Z5L/FXqZCmN4AlKm/YUgu2mhG49606 intact-crc:DA7DDD61DA864DA4|rigid:dSzeiJZdsp7XMKRtnP5nV2XgZAk false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q09013 uniprotkb:P26678 intact:EBI-692774|ensembl:ENSP00000291270|uniprotkb:Q16205|uniprotkb:Q6P5Z6|uniprotkb:E5KR08 intact:EBI-692836|ensembl:ENSP00000350132 psi-mi:dmpk_human(display_long)|uniprotkb:Myotonic dystrophy protein kinase(gene name synonym)|uniprotkb:DMPK(gene name synonym)|uniprotkb:DM-kinase(gene name synonym)|uniprotkb:DMPK(gene name)|psi-mi:DMPK(display_short)|uniprotkb:MDPK(gene name synonym)|uniprotkb:DM1 protein kinase(gene name synonym)|uniprotkb:DM1PK(gene name synonym) psi-mi:ppla_human(display_long)|uniprotkb:PLN(gene name)|psi-mi:PLN(display_short)|uniprotkb:PLB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kaliman et al. (2005) pubmed:15598648 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-692875 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104936(gene)|ensembl:ENST00000291270(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006998"(nuclear envelope organization)|refseq:NP_001075029.1|refseq:NP_001075031.1|refseq:NP_001075032.1|refseq:NP_004400.4|refseq:NP_001275694.1|go:"GO:0010657"(muscle cell apoptotic process)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0014722"(regulation of skeletal muscle contraction by calcium ion signaling)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0008016"(regulation of heart contraction)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1WT6|rcsb pdb:2VD5|reactome:R-HSA-5578775 refseq:NP_002658.1|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033574"(response to testosterone)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055119"(relaxation of cardiac muscle)|ensembl:ENSG00000198523(gene)|ensembl:ENST00000357525(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008015"(blood circulation)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|dip:DIP-33582N|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|rcsb pdb:1K9N|rcsb pdb:1KCH|rcsb pdb:1PLN|rcsb pdb:1PLP|rcsb pdb:1PSL|rcsb pdb:1ZLL|rcsb pdb:2HYN|rcsb pdb:6Y40|reactome:R-HSA-5578775|reactome:R-HSA-936837 - - - - taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/10/04 2014/10/16 rogid:7Z5L/FXqZCmN4AlKm/YUgu2mhG49606 rogid:Ez0SC8EfE4K9O9JI5wNGAHJUXOw9606 intact-crc:B2FD518A4395D980|rigid:dSzeiJZdsp7XMKRtnP5nV2XgZAk false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot)