#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q63537 uniprotkb:P10686 intact:EBI-1638355|uniprotkb:Q9Z1H0 intact:EBI-520788 psi-mi:syn2_rat(display_long)|uniprotkb:Syn2(gene name)|psi-mi:Syn2(display_short)|uniprotkb:Synapsin II(gene name synonym) psi-mi:plcg1_rat(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short) psi-mi:"MI:0096"(pull down) Han et al. (2004) pubmed:15566963|mint:MINT-5217364 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7403675|mint:MINT-59495 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3798|refseq:NP_001029192.1|refseq:NP_062032.1|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR001359(Synapsin)|interpro:IPR020898|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|mint:Q63537|interpro:IPR028712|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045202"(synapse)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099504"(synaptic vesicle cycle)|rcsb pdb:1I7L|rcsb pdb:1I7N|reactome:R-RNO-181429|reactome:R-RNO-212676|mint:MINT-1211916(identity) rgd:3347|refseq:NP_037319.1|mint:P10686|dip:DIP-2863N|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009629"(response to gravity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1Y0M|rcsb pdb:1YWO|rcsb pdb:1YWP|rcsb pdb:2FJL|rcsb pdb:3GQI|rcsb pdb:4K44|rcsb pdb:4K45|rcsb pdb:5EG3|rcsb pdb:6PBC|reactome:R-RNO-1169408|reactome:R-RNO-1855204|reactome:R-RNO-186763|reactome:R-RNO-202433|reactome:R-RNO-2029485|reactome:R-RNO-212718|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-5218921|reactome:R-RNO-5654219|reactome:R-RNO-5654221|reactome:R-RNO-5654227|reactome:R-RNO-5654228|reactome:R-RNO-8853659|reactome:R-RNO-9026527|reactome:R-RNO-9034793|mint:MINT-1211907(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2B|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:/uqCXVO2VdZfAgfc9c8dwJQcUOY10116 rogid:yyBTZCUDTiNhcFMPYEWvf2FhOlo10116 intact-crc:A47FD9AA14E6DAFE|rigid:Q0NnOo3u4ykw4PjDWY1ilqbaIHY false - tag:?-?(MINT-1211911)|binding-associated region:668-741(MINT-1211908) - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q63537 uniprotkb:P10686 intact:EBI-1638355|uniprotkb:Q9Z1H0 intact:EBI-520788 psi-mi:syn2_rat(display_long)|uniprotkb:Syn2(gene name)|psi-mi:Syn2(display_short)|uniprotkb:Synapsin II(gene name synonym) psi-mi:plcg1_rat(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short) psi-mi:"MI:0096"(pull down) Han et al. (2004) pubmed:15566963|mint:MINT-5217364 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7403634|mint:MINT-59491 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3798|refseq:NP_001029192.1|refseq:NP_062032.1|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR001359(Synapsin)|interpro:IPR020898|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|mint:Q63537|interpro:IPR028712|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045202"(synapse)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099504"(synaptic vesicle cycle)|rcsb pdb:1I7L|rcsb pdb:1I7N|reactome:R-RNO-181429|reactome:R-RNO-212676|mint:MINT-1211900(identity) rgd:3347|refseq:NP_037319.1|mint:P10686|dip:DIP-2863N|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009629"(response to gravity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1Y0M|rcsb pdb:1YWO|rcsb pdb:1YWP|rcsb pdb:2FJL|rcsb pdb:3GQI|rcsb pdb:4K44|rcsb pdb:4K45|rcsb pdb:5EG3|rcsb pdb:6PBC|reactome:R-RNO-1169408|reactome:R-RNO-1855204|reactome:R-RNO-186763|reactome:R-RNO-202433|reactome:R-RNO-2029485|reactome:R-RNO-212718|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-5218921|reactome:R-RNO-5654219|reactome:R-RNO-5654221|reactome:R-RNO-5654227|reactome:R-RNO-5654228|reactome:R-RNO-8853659|reactome:R-RNO-9026527|reactome:R-RNO-9034793|mint:MINT-1211891(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:/uqCXVO2VdZfAgfc9c8dwJQcUOY10116 rogid:yyBTZCUDTiNhcFMPYEWvf2FhOlo10116 intact-crc:BCC7DB8C1C45695B|rigid:Q0NnOo3u4ykw4PjDWY1ilqbaIHY false - binding-associated region:794-849(MINT-1211892)|tag:?-?(MINT-1211895) - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P10686 uniprotkb:Q63537 intact:EBI-520788 intact:EBI-1638355|uniprotkb:Q9Z1H0 psi-mi:plcg1_rat(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short) psi-mi:syn2_rat(display_long)|uniprotkb:Syn2(gene name)|psi-mi:Syn2(display_short)|uniprotkb:Synapsin II(gene name synonym) psi-mi:"MI:0096"(pull down) Han et al. (2004) pubmed:15566963|mint:MINT-5217364 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7403714|mint:MINT-59506 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3347|refseq:NP_037319.1|mint:P10686|dip:DIP-2863N|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009629"(response to gravity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1Y0M|rcsb pdb:1YWO|rcsb pdb:1YWP|rcsb pdb:2FJL|rcsb pdb:3GQI|rcsb pdb:4K44|rcsb pdb:4K45|rcsb pdb:5EG3|rcsb pdb:6PBC|reactome:R-RNO-1169408|reactome:R-RNO-1855204|reactome:R-RNO-186763|reactome:R-RNO-202433|reactome:R-RNO-2029485|reactome:R-RNO-212718|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-5218921|reactome:R-RNO-5654219|reactome:R-RNO-5654221|reactome:R-RNO-5654227|reactome:R-RNO-5654228|reactome:R-RNO-8853659|reactome:R-RNO-9026527|reactome:R-RNO-9034793|mint:MINT-1211936(identity) rgd:3798|refseq:NP_001029192.1|refseq:NP_062032.1|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR001359(Synapsin)|interpro:IPR020898|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|mint:Q63537|interpro:IPR028712|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045202"(synapse)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099504"(synaptic vesicle cycle)|rcsb pdb:1I7L|rcsb pdb:1I7N|reactome:R-RNO-181429|reactome:R-RNO-212676|mint:MINT-1211945(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2C|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:yyBTZCUDTiNhcFMPYEWvf2FhOlo10116 rogid:/uqCXVO2VdZfAgfc9c8dwJQcUOY10116 intact-crc:EB4F4A78656BB640|rigid:Q0NnOo3u4ykw4PjDWY1ilqbaIHY false binding-associated region:668-741(MINT-1211937)|tag:?-?(MINT-1211940) tag:?-?(MINT-1211946) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P10686 uniprotkb:Q63537 intact:EBI-520788 intact:EBI-1638355|uniprotkb:Q9Z1H0 psi-mi:plcg1_rat(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short) psi-mi:syn2_rat(display_long)|uniprotkb:Syn2(gene name)|psi-mi:Syn2(display_short)|uniprotkb:Synapsin II(gene name synonym) psi-mi:"MI:0096"(pull down) Han et al. (2004) pubmed:15566963|mint:MINT-5217364 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7403693|mint:MINT-59505 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3347|refseq:NP_037319.1|mint:P10686|dip:DIP-2863N|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009629"(response to gravity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1Y0M|rcsb pdb:1YWO|rcsb pdb:1YWP|rcsb pdb:2FJL|rcsb pdb:3GQI|rcsb pdb:4K44|rcsb pdb:4K45|rcsb pdb:5EG3|rcsb pdb:6PBC|reactome:R-RNO-1169408|reactome:R-RNO-1855204|reactome:R-RNO-186763|reactome:R-RNO-202433|reactome:R-RNO-2029485|reactome:R-RNO-212718|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-5218921|reactome:R-RNO-5654219|reactome:R-RNO-5654221|reactome:R-RNO-5654227|reactome:R-RNO-5654228|reactome:R-RNO-8853659|reactome:R-RNO-9026527|reactome:R-RNO-9034793|mint:MINT-1211873(identity) rgd:3798|refseq:NP_001029192.1|refseq:NP_062032.1|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR001359(Synapsin)|interpro:IPR020898|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|mint:Q63537|interpro:IPR028712|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045202"(synapse)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099504"(synaptic vesicle cycle)|rcsb pdb:1I7L|rcsb pdb:1I7N|reactome:R-RNO-181429|reactome:R-RNO-212676|mint:MINT-1211882(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2C|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:yyBTZCUDTiNhcFMPYEWvf2FhOlo10116 rogid:/uqCXVO2VdZfAgfc9c8dwJQcUOY10116 intact-crc:9941CC96434AB8FE|rigid:Q0NnOo3u4ykw4PjDWY1ilqbaIHY false binding-associated region:794-849(MINT-1211874)|tag:?-?(MINT-1211877) tag:?-?(MINT-1211883) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q63537 uniprotkb:P10686 intact:EBI-1638355|uniprotkb:Q9Z1H0 intact:EBI-520788 psi-mi:syn2_rat(display_long)|uniprotkb:Syn2(gene name)|psi-mi:Syn2(display_short)|uniprotkb:Synapsin II(gene name synonym) psi-mi:plcg1_rat(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Han et al. (2004) pubmed:15566963|mint:MINT-5217364 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7403764|mint:MINT-59507 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3798|refseq:NP_001029192.1|refseq:NP_062032.1|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR001359(Synapsin)|interpro:IPR020898|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|mint:Q63537|interpro:IPR028712|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045202"(synapse)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099504"(synaptic vesicle cycle)|rcsb pdb:1I7L|rcsb pdb:1I7N|reactome:R-RNO-181429|reactome:R-RNO-212676|mint:MINT-1211929(identity) rgd:3347|refseq:NP_037319.1|mint:P10686|dip:DIP-2863N|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009629"(response to gravity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1Y0M|rcsb pdb:1YWO|rcsb pdb:1YWP|rcsb pdb:2FJL|rcsb pdb:3GQI|rcsb pdb:4K44|rcsb pdb:4K45|rcsb pdb:5EG3|rcsb pdb:6PBC|reactome:R-RNO-1169408|reactome:R-RNO-1855204|reactome:R-RNO-186763|reactome:R-RNO-202433|reactome:R-RNO-2029485|reactome:R-RNO-212718|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-5218921|reactome:R-RNO-5654219|reactome:R-RNO-5654221|reactome:R-RNO-5654227|reactome:R-RNO-5654228|reactome:R-RNO-8853659|reactome:R-RNO-9026527|reactome:R-RNO-9034793|mint:MINT-1211925(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3|comment:mint taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2005/06/30 2014/10/16 rogid:/uqCXVO2VdZfAgfc9c8dwJQcUOY10116 rogid:yyBTZCUDTiNhcFMPYEWvf2FhOlo10116 intact-crc:164A6AE2BEC03848|rigid:Q0NnOo3u4ykw4PjDWY1ilqbaIHY false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot)