#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03122	uniprotkb:P21675	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-491289|uniprotkb:A5CVD0|uniprotkb:Q6IUZ1|uniprotkb:Q70Q86|uniprotkb:Q70Q87|uniprotkb:Q70T00|uniprotkb:Q70T01|uniprotkb:Q70T02|uniprotkb:Q70T03|uniprotkb:Q59FZ3|ensembl:ENSP00000276072|ensembl:ENSP00000362895|ensembl:ENSP00000406549|uniprotkb:A5CVC8|uniprotkb:A5CVC9|uniprotkb:A5CVD1|uniprotkb:B1Q2X3	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taf1_human(display_long)|uniprotkb:TAF1(gene name)|psi-mi:TAF1(display_short)|uniprotkb:BA2R(gene name synonym)|uniprotkb:CCG1(gene name synonym)|uniprotkb:TAF2A(gene name synonym)|uniprotkb:CCGS(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 250 kDa subunit(gene name synonym)|uniprotkb:TBP-associated factor 250 kDa(gene name synonym)|uniprotkb:Cell cycle gene 1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carrillo et al. (2004)	pubmed:15564746|mint:MINT-5217360	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7402355|mint:MINT-72604	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-1689651(identity)	refseq:NP_001273003.1|rcsb pdb:6MZM|refseq:NP_004597.2|refseq:NP_620278.1|rcsb pdb:6P38|rcsb pdb:6P39|rcsb pdb:6P3A|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGH|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7JJH|rcsb pdb:7L6X|rcsb pdb:7N42|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-167172|ensembl:ENSG00000147133(gene)|ensembl:ENST00000276072(transcript)|ensembl:ENST00000373790(transcript)|ensembl:ENST00000423759(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0002039"(p53 binding)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030901"(midbrain development)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0036369"(transcription factor catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0016301"(kinase activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071339"(MLL1 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|interpro:IPR001487(Bromodomain)|interpro:IPR009067(TAFII-230 TBP-binding)|interpro:IPR011177(Transcription initiation factor TFIID subunit 1, animal)|interpro:IPR018359|interpro:IPR022591|interpro:IPR036427|interpro:IPR036741|interpro:IPR040240|interpro:IPR041670|mint:P21675|rcsb pdb:1EQF|rcsb pdb:3AAD|rcsb pdb:3UV4|rcsb pdb:3UV5|rcsb pdb:4RGW|rcsb pdb:4YYM|rcsb pdb:4YYN|rcsb pdb:5FUR|rcsb pdb:5I1Q|rcsb pdb:5I29|rcsb pdb:5MG2|rcsb pdb:6BQD|rcsb pdb:6FIC|rcsb pdb:6MZD|rcsb pdb:6MZL|refseq:XP_005262354.1|dip:DIP-147N|mint:MINT-1689661(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/22	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:P0LoULOvon+Wp2G17lBlqn3Fo4E9606	intact-crc:F694C29A43B7531A|rigid:E1/uZ4l/5Ed3+OxgUhx/ukzyx/c	false	mutation decreasing interaction:1-79,248-410(MINT-1689652)|glutathione s tranferase tag:?-?(MINT-1689655)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06790	uniprotkb:P21675	intact:EBI-7010629|intact:MINT-95532	intact:EBI-491289|uniprotkb:A5CVD0|uniprotkb:Q6IUZ1|uniprotkb:Q70Q86|uniprotkb:Q70Q87|uniprotkb:Q70T00|uniprotkb:Q70T01|uniprotkb:Q70T02|uniprotkb:Q70T03|uniprotkb:Q59FZ3|ensembl:ENSP00000276072|ensembl:ENSP00000362895|ensembl:ENSP00000406549|uniprotkb:A5CVC8|uniprotkb:A5CVC9|uniprotkb:A5CVD1|uniprotkb:B1Q2X3	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taf1_human(display_long)|uniprotkb:TAF1(gene name)|psi-mi:TAF1(display_short)|uniprotkb:BA2R(gene name synonym)|uniprotkb:CCG1(gene name synonym)|uniprotkb:TAF2A(gene name synonym)|uniprotkb:CCGS(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 250 kDa subunit(gene name synonym)|uniprotkb:TBP-associated factor 250 kDa(gene name synonym)|uniprotkb:Cell cycle gene 1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carrillo et al. (2004)	pubmed:15564746|mint:MINT-5217360	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7402438|mint:MINT-72606	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-1609395(identity)	refseq:NP_001273003.1|rcsb pdb:6MZM|refseq:NP_004597.2|refseq:NP_620278.1|rcsb pdb:6P38|rcsb pdb:6P39|rcsb pdb:6P3A|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGH|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7JJH|rcsb pdb:7L6X|rcsb pdb:7N42|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-167172|ensembl:ENSG00000147133(gene)|ensembl:ENST00000276072(transcript)|ensembl:ENST00000373790(transcript)|ensembl:ENST00000423759(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0002039"(p53 binding)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030901"(midbrain development)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0036369"(transcription factor catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0016301"(kinase activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071339"(MLL1 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|interpro:IPR001487(Bromodomain)|interpro:IPR009067(TAFII-230 TBP-binding)|interpro:IPR011177(Transcription initiation factor TFIID subunit 1, animal)|interpro:IPR018359|interpro:IPR022591|interpro:IPR036427|interpro:IPR036741|interpro:IPR040240|interpro:IPR041670|mint:P21675|rcsb pdb:1EQF|rcsb pdb:3AAD|rcsb pdb:3UV4|rcsb pdb:3UV5|rcsb pdb:4RGW|rcsb pdb:4YYM|rcsb pdb:4YYN|rcsb pdb:5FUR|rcsb pdb:5I1Q|rcsb pdb:5I29|rcsb pdb:5MG2|rcsb pdb:6BQD|rcsb pdb:6FIC|rcsb pdb:6MZD|rcsb pdb:6MZL|refseq:XP_005262354.1|dip:DIP-147N|mint:MINT-1609405(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/22	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:P0LoULOvon+Wp2G17lBlqn3Fo4E9606	intact-crc:E332C24DFA5C9280|rigid:A7OiwC7koYw+3OaU2RcCJKt3GyE	false	glutathione s tranferase tag:?-?(MINT-1609399)|binding-associated region:151-365(MINT-1609396)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P21675-1	uniprotkb:P20226	intact:EBI-7402479|intact:MINT-1211851	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:p21675-1(display_long)|uniprotkb:TAF1(gene name)|psi-mi:TAF1(display_short)|uniprotkb:BA2R(gene name synonym)|uniprotkb:CCG1(gene name synonym)|uniprotkb:CCGS(gene name synonym)|uniprotkb:Cell cycle gene 1 protein(gene name synonym)|uniprotkb:TAF2A(gene name synonym)|uniprotkb:TBP-associated factor 250 kDa(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 250 kDa subunit(gene name synonym)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carrillo et al. (2004)	pubmed:15564746|mint:MINT-5217360	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7402496|mint:MINT-72607	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-491289(isoform-parent)|mint:MINT-1588866(identity)	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N|mint:MINT-1588859(identity)	-	comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/22	2014/10/16	rogid:P0LoULOvon+Wp2G17lBlqn3Fo4E9606	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	intact-crc:6AA195D74D60A2FD|rigid:PruO1p9JV+zvFUKOiX/61uRc6Ak	false	binding-associated region:1-394(MINT-1588867)	glutathione s tranferase tag:?-?(MINT-1588860)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03122	uniprotkb:P49848	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-1560206|uniprotkb:A4D2B2|uniprotkb:A4D2B3|uniprotkb:Q6AI29|uniprotkb:D6W5U2|uniprotkb:B4DT11|ensembl:ENSP00000344537|ensembl:ENSP00000389575|ensembl:ENSP00000416396	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taf6_human(display_long)|uniprotkb:Transcription initiation factor TFIID 70 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 80 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit E(gene name synonym)|uniprotkb:TAF6(gene name)|psi-mi:TAF6(display_short)|uniprotkb:TAF2E(gene name synonym)|uniprotkb:TAFII70(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carrillo et al. (2004)	pubmed:15564746|mint:MINT-5217360	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7402549|mint:MINT-72611	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-1211806(identity)	refseq:XP_006716163.1|refseq:NP_005632.1|refseq:NP_647476.1|refseq:NP_001177344.1|dip:DIP-773N|ensembl:ENSG00000106290(gene)|ensembl:ENST00000344095(transcript)|ensembl:ENST00000452041(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005829"(cytosol)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046695"("SLIK (SAGA-like) complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0071339"(MLL1 complex)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR011442(Protein of unknown function DUF1546)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037796|rcsb pdb:5FUR|rcsb pdb:6F3T|rcsb pdb:6MZC|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGG|rcsb pdb:7EGH|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|ensembl:ENST00000453269(transcript)|mint:MINT-1211817(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/22	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:oGsdH9+tG2BXsR+jr7hBuCCAS809606	intact-crc:6F2973F5A3CD10F7|rigid:ZEt0+Usmi+zhe4T1CngRBJ8ddA4	false	binding-associated region:1-79(MINT-1211807)|mutation decreasing interaction:248-410(MINT-1211809)|glutathione s tranferase tag:?-?(MINT-1211811)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P21675-1	uniprotkb:P06790	intact:EBI-7402479|intact:MINT-1211851	intact:EBI-7010629|intact:MINT-95532	psi-mi:p21675-1(display_long)|uniprotkb:TAF1(gene name)|psi-mi:TAF1(display_short)|uniprotkb:BA2R(gene name synonym)|uniprotkb:CCG1(gene name synonym)|uniprotkb:CCGS(gene name synonym)|uniprotkb:Cell cycle gene 1 protein(gene name synonym)|uniprotkb:TAF2A(gene name synonym)|uniprotkb:TBP-associated factor 250 kDa(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 250 kDa subunit(gene name synonym)	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0096"(pull down)	Carrillo et al. (2004)	pubmed:15564746|mint:MINT-5217360	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7402515|mint:MINT-72609	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-491289(isoform-parent)|mint:MINT-1741908(identity)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-1741901(identity)	-	comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/22	2014/10/16	rogid:P0LoULOvon+Wp2G17lBlqn3Fo4E9606	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	intact-crc:A576554F3FA7E06C|rigid:A7OiwC7koYw+3OaU2RcCJKt3GyE	false	mutation decreasing interaction:1638-1872(MINT-1741909)	glutathione s tranferase tag:?-?(MINT-1741902)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06790	uniprotkb:P49848	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1560206|uniprotkb:A4D2B2|uniprotkb:A4D2B3|uniprotkb:Q6AI29|uniprotkb:D6W5U2|uniprotkb:B4DT11|ensembl:ENSP00000344537|ensembl:ENSP00000389575|ensembl:ENSP00000416396	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taf6_human(display_long)|uniprotkb:Transcription initiation factor TFIID 70 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 80 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit E(gene name synonym)|uniprotkb:TAF6(gene name)|psi-mi:TAF6(display_short)|uniprotkb:TAF2E(gene name synonym)|uniprotkb:TAFII70(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carrillo et al. (2004)	pubmed:15564746|mint:MINT-5217360	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7402592|mint:MINT-72613	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-1705454(identity)	refseq:XP_006716163.1|refseq:NP_005632.1|refseq:NP_647476.1|refseq:NP_001177344.1|dip:DIP-773N|ensembl:ENSG00000106290(gene)|ensembl:ENST00000344095(transcript)|ensembl:ENST00000452041(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005829"(cytosol)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046695"("SLIK (SAGA-like) complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0071339"(MLL1 complex)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR011442(Protein of unknown function DUF1546)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037796|rcsb pdb:5FUR|rcsb pdb:6F3T|rcsb pdb:6MZC|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGG|rcsb pdb:7EGH|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|ensembl:ENST00000453269(transcript)|mint:MINT-1705463(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/22	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:oGsdH9+tG2BXsR+jr7hBuCCAS809606	intact-crc:B23CF0F6C454BCD0|rigid:1lFl4xqWHKAgf6xDPXMAHomDvLg	false	binding-associated region:1-56(MINT-1705455)|glutathione s tranferase tag:?-?(MINT-1705457)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06790	uniprotkb:P49848	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1560206|uniprotkb:A4D2B2|uniprotkb:A4D2B3|uniprotkb:Q6AI29|uniprotkb:D6W5U2|uniprotkb:B4DT11|ensembl:ENSP00000344537|ensembl:ENSP00000389575|ensembl:ENSP00000416396	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taf6_human(display_long)|uniprotkb:Transcription initiation factor TFIID 70 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 80 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit E(gene name synonym)|uniprotkb:TAF6(gene name)|psi-mi:TAF6(display_short)|uniprotkb:TAF2E(gene name synonym)|uniprotkb:TAFII70(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carrillo et al. (2004)	pubmed:15564746|mint:MINT-5217360	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7402611|mint:MINT-72614	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-1709158(identity)	refseq:XP_006716163.1|refseq:NP_005632.1|refseq:NP_647476.1|refseq:NP_001177344.1|dip:DIP-773N|ensembl:ENSG00000106290(gene)|ensembl:ENST00000344095(transcript)|ensembl:ENST00000452041(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005829"(cytosol)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046695"("SLIK (SAGA-like) complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0071339"(MLL1 complex)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR011442(Protein of unknown function DUF1546)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037796|rcsb pdb:5FUR|rcsb pdb:6F3T|rcsb pdb:6MZC|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGG|rcsb pdb:7EGH|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|ensembl:ENST00000453269(transcript)|mint:MINT-1709165(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/22	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:oGsdH9+tG2BXsR+jr7hBuCCAS809606	intact-crc:2CA9D4F0773FBEFB|rigid:1lFl4xqWHKAgf6xDPXMAHomDvLg	false	glutathione s tranferase tag:?-?(MINT-1709159)	mutation decreasing interaction:1-403(MINT-1709166)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03122	uniprotkb:P49848	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-1560206|uniprotkb:A4D2B2|uniprotkb:A4D2B3|uniprotkb:Q6AI29|uniprotkb:D6W5U2|uniprotkb:B4DT11|ensembl:ENSP00000344537|ensembl:ENSP00000389575|ensembl:ENSP00000416396	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taf6_human(display_long)|uniprotkb:Transcription initiation factor TFIID 70 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 80 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit E(gene name synonym)|uniprotkb:TAF6(gene name)|psi-mi:TAF6(display_short)|uniprotkb:TAF2E(gene name synonym)|uniprotkb:TAFII70(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carrillo et al. (2004)	pubmed:15564746|mint:MINT-5217360	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7402630|mint:MINT-72615	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-1211789(identity)	refseq:XP_006716163.1|refseq:NP_005632.1|refseq:NP_647476.1|refseq:NP_001177344.1|dip:DIP-773N|ensembl:ENSG00000106290(gene)|ensembl:ENST00000344095(transcript)|ensembl:ENST00000452041(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005829"(cytosol)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046695"("SLIK (SAGA-like) complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0071339"(MLL1 complex)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR011442(Protein of unknown function DUF1546)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037796|rcsb pdb:5FUR|rcsb pdb:6F3T|rcsb pdb:6MZC|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGG|rcsb pdb:7EGH|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|ensembl:ENST00000453269(transcript)|mint:MINT-1211796(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/22	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:oGsdH9+tG2BXsR+jr7hBuCCAS809606	intact-crc:8F268408AC53CA51|rigid:ZEt0+Usmi+zhe4T1CngRBJ8ddA4	false	glutathione s tranferase tag:?-?(MINT-1211790)	binding-associated region:1-403(MINT-1211797)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)