#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N720	uniprotkb:P15498	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625537	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/07/26	2014/10/16	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	intact-crc:68DECBDB2AB7A942|rigid:cZr69G8U8XfTE8N2Ryl0y7XDOI8	false	binding-associated region:153-491	binding-associated region:623-837(IPR000980)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15498	uniprotkb:Q8N720	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625582	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/07/26	2014/10/16	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	intact-crc:C546C3E3C6D8E70B|rigid:cZr69G8U8XfTE8N2Ryl0y7XDOI8	false	binding-associated region:788-838|binding-associated region:813-838|mutation decreasing interaction:833-833|mutation decreasing interaction:836-836	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15498	uniprotkb:Q8N720	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625621	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/26	2014/10/16	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	intact-crc:39F5153504D78283|rigid:cZr69G8U8XfTE8N2Ryl0y7XDOI8	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62993	uniprotkb:P15498	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625630	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/26	2014/10/16	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	intact-crc:114913F599DD0F9D|rigid:fY5vrZnGuWIdvnSl5Yxg66UQ6+I	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11802	uniprotkb:Q8N720	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625679	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/26	2014/10/16	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	intact-crc:B20A795057B557E0|rigid:H9zvtKldproGI5DSRCUCPBNZMbY	false	-	glutathione s tranferase tag:?-?|binding-associated region:322-491	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15498	uniprotkb:Q8N720	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625655	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N	-	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/07/26	2014/10/16	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	intact-crc:A31A203AEB0CD957|rigid:cZr69G8U8XfTE8N2Ryl0y7XDOI8	false	-	binding-associated region:1-255|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15498	uniprotkb:Q8N720	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625670	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N	-	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/07/26	2014/10/16	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	intact-crc:83CDF77F0B7D6688|rigid:cZr69G8U8XfTE8N2Ryl0y7XDOI8	false	-	green fluorescent protein tag:?-?|binding-associated region:1-255	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N720	uniprotkb:P11802	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625687	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	-	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/07/26	2014/10/16	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:240205C60A36BA11|rigid:H9zvtKldproGI5DSRCUCPBNZMbY	false	binding-associated region:322-491|glutathione s tranferase tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N720	uniprotkb:P11802	intact:EBI-625509|ensembl:ENSP00000252713|ensembl:ENSP00000377718|uniprotkb:Q8IV00|uniprotkb:Q8TA89|uniprotkb:Q96EZ3|uniprotkb:A4D291|uniprotkb:B4E3M4|uniprotkb:B7Z9Q9|intact:EBI-741438|uniprotkb:Q9BQ85|uniprotkb:D6W5T4|uniprotkb:A6NGD3	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:zn655_human(display_long)|uniprotkb:Vav-interacting Krueppel-like protein(gene name synonym)|uniprotkb:ZNF655(gene name)|psi-mi:ZNF655(display_short)|uniprotkb:VIK(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Houlard et al. (2005)	pubmed:15558030|mint:MINT-5217354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-625742	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197343(gene)|ensembl:ENST00000252713(transcript)|ensembl:ENST00000394163(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001009960.1|refseq:NP_001077425.1|refseq:NP_001078835.1|refseq:NP_001078836.1|refseq:NP_001078837.1|refseq:NP_076966.1|refseq:NP_612503.1|refseq:NP_001009958.1|refseq:XP_016868092.1|refseq:XP_016868093.1|refseq:XP_016868095.1|refseq:XP_016868096.1|dip:DIP-34108N	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	-	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/07/26	2014/10/16	rogid:kz0A7h281PEWFM7dsPGoPyTAMgs9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	intact-crc:33F802FA072D038A|rigid:H9zvtKldproGI5DSRCUCPBNZMbY	false	binding-associated region:322-491|glutathione s tranferase tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)