#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P78955 uniprotkb:Q10159 intact:EBI-767597|ensemblfungi:"SPAC20G4.04c.1:pep" intact:EBI-767574|uniprotkb:O74679|ensemblfungi:"SPAC26A3.02.1:pep" psi-mi:hus1_schpo(display_long)|uniprotkb:hus1(gene name)|psi-mi:hus1(display_short)|uniprotkb:SPAC20G4.04c(orf name) psi-mi:myh1_schpo(display_long)|uniprotkb:myh1(gene name)|psi-mi:myh1(display_short)|uniprotkb:myh(gene name synonym)|uniprotkb:SPAC26A3.02(orf name) psi-mi:"MI:0096"(pull down) Chang et al. (2005) pubmed:15533944|mint:MINT-5217301 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-767593 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594739.1|interpro:IPR016580(Cell cycle checkpoint, HUS1)|interpro:IPR007150(Hus1-like protein)|reactome:R-SPO-176187|ensemblfungi:SPAC20G4.04c(gene)|ensemblfungi:SPAC20G4.04c.1(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0140445"(chromosome, telomeric repeat region) refseq:NP_594145.1|interpro:IPR011257(DNA glycosylase)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR003265(HhH-GPD)|interpro:IPR023170|interpro:IPR015797(NUDIX)|interpro:IPR000445(Helix-hairpin-helix motif)|reactome:R-SPO-110331|interpro:IPR044298|interpro:IPR029119|ensemblfungi:SPAC26A3.02(gene)|ensemblfungi:SPAC26A3.02.1(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902800"(positive regulation of phosphodiesterase I activity) - - - comment:Authors note that the results of this study indicate that HUS1 binds MYH within a central region of the protein or that a major binding region was located within residues 245 to 461 amino acids of the MYH protein. While a minor binding region was located within residues 1 to 230 amino acids of MYH. taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/14 2014/10/16 rogid:me0bMDXNBCzaaUX+QaJmFI+OS3k284812 rogid:PuUXvHTSeKIBEIortgZStG4dwls284812 intact-crc:4C04224C12445EC5|rigid:vPQAvHMr/8Khy1OJ7bgeZhyZvv4 false ha tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P78955 uniprotkb:Q10159 intact:EBI-767597|ensemblfungi:"SPAC20G4.04c.1:pep" intact:EBI-767574|uniprotkb:O74679|ensemblfungi:"SPAC26A3.02.1:pep" psi-mi:hus1_schpo(display_long)|uniprotkb:hus1(gene name)|psi-mi:hus1(display_short)|uniprotkb:SPAC20G4.04c(orf name) psi-mi:myh1_schpo(display_long)|uniprotkb:myh1(gene name)|psi-mi:myh1(display_short)|uniprotkb:myh(gene name synonym)|uniprotkb:SPAC26A3.02(orf name) psi-mi:"MI:0096"(pull down) Chang et al. (2005) pubmed:15533944|mint:MINT-5217301 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-767629 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594739.1|interpro:IPR016580(Cell cycle checkpoint, HUS1)|interpro:IPR007150(Hus1-like protein)|reactome:R-SPO-176187|ensemblfungi:SPAC20G4.04c(gene)|ensemblfungi:SPAC20G4.04c.1(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0140445"(chromosome, telomeric repeat region) refseq:NP_594145.1|interpro:IPR011257(DNA glycosylase)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR003265(HhH-GPD)|interpro:IPR023170|interpro:IPR015797(NUDIX)|interpro:IPR000445(Helix-hairpin-helix motif)|reactome:R-SPO-110331|interpro:IPR044298|interpro:IPR029119|ensemblfungi:SPAC26A3.02(gene)|ensemblfungi:SPAC26A3.02.1(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902800"(positive regulation of phosphodiesterase I activity) - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/14 2014/10/16 rogid:me0bMDXNBCzaaUX+QaJmFI+OS3k284812 rogid:PuUXvHTSeKIBEIortgZStG4dwls284812 intact-crc:B0B20E67BE5AE23A|rigid:vPQAvHMr/8Khy1OJ7bgeZhyZvv4 false his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22193 uniprotkb:Q10159 intact:EBI-767637|ensemblfungi:"SPAC1952.07.1:pep" intact:EBI-767574|uniprotkb:O74679|ensemblfungi:"SPAC26A3.02.1:pep" psi-mi:rad1_schpo(display_long)|uniprotkb:rad1(gene name)|psi-mi:rad1(display_short)|uniprotkb:SPAC1952.07(orf name) psi-mi:myh1_schpo(display_long)|uniprotkb:myh1(gene name)|psi-mi:myh1(display_short)|uniprotkb:myh(gene name synonym)|uniprotkb:SPAC26A3.02(orf name) psi-mi:"MI:0096"(pull down) Chang et al. (2005) pubmed:15533944|mint:MINT-5217301 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-767650 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594809.1|interpro:IPR003021(Repair protein Rad1/Rec1)|interpro:IPR003011(Repair protein Rad1)|reactome:R-SPO-176187|ensemblfungi:SPAC1952.07(gene)|ensemblfungi:SPAC1952.07.1(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0033315"(meiotic G2/MI DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0140445"(chromosome, telomeric repeat region) refseq:NP_594145.1|interpro:IPR011257(DNA glycosylase)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR003265(HhH-GPD)|interpro:IPR023170|interpro:IPR015797(NUDIX)|interpro:IPR000445(Helix-hairpin-helix motif)|reactome:R-SPO-110331|interpro:IPR044298|interpro:IPR029119|ensemblfungi:SPAC26A3.02(gene)|ensemblfungi:SPAC26A3.02.1(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902800"(positive regulation of phosphodiesterase I activity) - - - comment:"Authors state that the major binding site for Rad1 is within the C-terminal (245aa - 323aa) region of the MYH protein." taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/14 2014/10/16 rogid:DhK3TCbzBuVQFN+lbcTR9NSkh24284812 rogid:PuUXvHTSeKIBEIortgZStG4dwls284812 intact-crc:B3655DB4B35C4275|rigid:ly/C+y9PyyaMNuYZNjl5TiY0zPo false ha tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22193 uniprotkb:Q10159 intact:EBI-767637|ensemblfungi:"SPAC1952.07.1:pep" intact:EBI-767574|uniprotkb:O74679|ensemblfungi:"SPAC26A3.02.1:pep" psi-mi:rad1_schpo(display_long)|uniprotkb:rad1(gene name)|psi-mi:rad1(display_short)|uniprotkb:SPAC1952.07(orf name) psi-mi:myh1_schpo(display_long)|uniprotkb:myh1(gene name)|psi-mi:myh1(display_short)|uniprotkb:myh(gene name synonym)|uniprotkb:SPAC26A3.02(orf name) psi-mi:"MI:0096"(pull down) Chang et al. (2005) pubmed:15533944|mint:MINT-5217301 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-768677 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594809.1|interpro:IPR003021(Repair protein Rad1/Rec1)|interpro:IPR003011(Repair protein Rad1)|reactome:R-SPO-176187|ensemblfungi:SPAC1952.07(gene)|ensemblfungi:SPAC1952.07.1(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0033315"(meiotic G2/MI DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0140445"(chromosome, telomeric repeat region) refseq:NP_594145.1|interpro:IPR011257(DNA glycosylase)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR003265(HhH-GPD)|interpro:IPR023170|interpro:IPR015797(NUDIX)|interpro:IPR000445(Helix-hairpin-helix motif)|reactome:R-SPO-110331|interpro:IPR044298|interpro:IPR029119|ensemblfungi:SPAC26A3.02(gene)|ensemblfungi:SPAC26A3.02.1(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902800"(positive regulation of phosphodiesterase I activity) - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/14 2014/10/16 rogid:DhK3TCbzBuVQFN+lbcTR9NSkh24284812 rogid:PuUXvHTSeKIBEIortgZStG4dwls284812 intact-crc:256401918DC527A1|rigid:ly/C+y9PyyaMNuYZNjl5TiY0zPo false his tag:?-? glutathione s tranferase tag:?-?|binding-associated region:245-461 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q10159 uniprotkb:P26306 intact:EBI-767574|uniprotkb:O74679|ensemblfungi:"SPAC26A3.02.1:pep" intact:EBI-768686|uniprotkb:Q10455|ensemblfungi:"SPAC664.07c.1:pep" psi-mi:myh1_schpo(display_long)|uniprotkb:myh1(gene name)|psi-mi:myh1(display_short)|uniprotkb:myh(gene name synonym)|uniprotkb:SPAC26A3.02(orf name) psi-mi:rad9_schpo(display_long)|uniprotkb:rad9(gene name)|psi-mi:rad9(display_short)|uniprotkb:SPAC664.07c(orf name) psi-mi:"MI:0096"(pull down) Chang et al. (2005) pubmed:15533944|mint:MINT-5217301 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-768697 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594145.1|interpro:IPR011257(DNA glycosylase)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR003265(HhH-GPD)|interpro:IPR023170|interpro:IPR015797(NUDIX)|interpro:IPR000445(Helix-hairpin-helix motif)|reactome:R-SPO-110331|interpro:IPR044298|interpro:IPR029119|ensemblfungi:SPAC26A3.02(gene)|ensemblfungi:SPAC26A3.02.1(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902800"(positive regulation of phosphodiesterase I activity) refseq:NP_593455.1|interpro:IPR007268(Rad9)|interpro:IPR026584|reactome:R-SPO-176187|ensemblfungi:SPAC664.07c(gene)|ensemblfungi:SPAC664.07c.1(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination) - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/14 2014/10/16 rogid:PuUXvHTSeKIBEIortgZStG4dwls284812 rogid:4Q+C4nzATGWtuTlHXDBoIhd1Qd0284812 intact-crc:420E79443D38F2C2|rigid:nmZdukD0X7KW6Xl5tMB/M+mCzwE false binding-associated region:245-461|glutathione s tranferase tag:?-? his tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P78955 uniprotkb:Q10159 intact:EBI-767597|ensemblfungi:"SPAC20G4.04c.1:pep" intact:EBI-767574|uniprotkb:O74679|ensemblfungi:"SPAC26A3.02.1:pep" psi-mi:hus1_schpo(display_long)|uniprotkb:hus1(gene name)|psi-mi:hus1(display_short)|uniprotkb:SPAC20G4.04c(orf name) psi-mi:myh1_schpo(display_long)|uniprotkb:myh1(gene name)|psi-mi:myh1(display_short)|uniprotkb:myh(gene name synonym)|uniprotkb:SPAC26A3.02(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chang et al. (2005) pubmed:15533944|mint:MINT-5217301 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-768714 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594739.1|interpro:IPR016580(Cell cycle checkpoint, HUS1)|interpro:IPR007150(Hus1-like protein)|reactome:R-SPO-176187|ensemblfungi:SPAC20G4.04c(gene)|ensemblfungi:SPAC20G4.04c.1(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0140445"(chromosome, telomeric repeat region) refseq:NP_594145.1|interpro:IPR011257(DNA glycosylase)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR003265(HhH-GPD)|interpro:IPR023170|interpro:IPR015797(NUDIX)|interpro:IPR000445(Helix-hairpin-helix motif)|reactome:R-SPO-110331|interpro:IPR044298|interpro:IPR029119|ensemblfungi:SPAC26A3.02(gene)|ensemblfungi:SPAC26A3.02.1(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902800"(positive regulation of phosphodiesterase I activity) go:"GO:0006979"(response to oxidative stress) - - stimulant:Hydrogen peroxide induced oxidative stress|comment:Hus1 and Myh1 interaction was found to be greatest 2 hours after hydrogen peroxide treatment. taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2005/12/14 2014/10/16 rogid:me0bMDXNBCzaaUX+QaJmFI+OS3k284812 rogid:PuUXvHTSeKIBEIortgZStG4dwls284812 intact-crc:AD6F989480B1E5A0|rigid:vPQAvHMr/8Khy1OJ7bgeZhyZvv4 false myc tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q10159 uniprotkb:Q03392 intact:EBI-767574|uniprotkb:O74679|ensemblfungi:"SPAC26A3.02.1:pep" intact:EBI-768724|ensemblfungi:"SPBC16D10.09.1:pep" psi-mi:myh1_schpo(display_long)|uniprotkb:myh1(gene name)|psi-mi:myh1(display_short)|uniprotkb:myh(gene name synonym)|uniprotkb:SPAC26A3.02(orf name) psi-mi:pcna_schpo(display_long)|uniprotkb:pcn1(gene name)|psi-mi:pcn1(display_short)|uniprotkb:pcn(gene name synonym)|uniprotkb:SPBC16D10.09(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chang et al. (2005) pubmed:15533944|mint:MINT-5217301 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-768733 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594145.1|interpro:IPR011257(DNA glycosylase)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR003265(HhH-GPD)|interpro:IPR023170|interpro:IPR015797(NUDIX)|interpro:IPR000445(Helix-hairpin-helix motif)|reactome:R-SPO-110331|interpro:IPR044298|interpro:IPR029119|ensemblfungi:SPAC26A3.02(gene)|ensemblfungi:SPAC26A3.02.1(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902800"(positive regulation of phosphodiesterase I activity) reactome:R-SPO-5696397|reactome:R-SPO-5696400|reactome:R-SPO-6782135|reactome:R-SPO-6782210|refseq:NP_596504.1|reactome:R-SPO-4615885|reactome:R-SPO-110312|reactome:R-SPO-69183|reactome:R-SPO-110314|reactome:R-SPO-110320|reactome:R-SPO-5358565|reactome:R-SPO-5651801|reactome:R-SPO-5655862|reactome:R-SPO-5656121|reactome:R-SPO-5656169|reactome:R-SPO-69091|reactome:R-SPO-69166|dip:DIP-33811N|ensemblfungi:SPBC16D10.09(gene)|ensemblfungi:SPBC16D10.09.1(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903459"(mitotic DNA replication lagging strand elongation)|go:"GO:1903460"(mitotic DNA replication leading strand elongation)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:6QH1|reactome:R-SPO-174437|reactome:R-SPO-8866654 - - crc64:1EE5B2A27A899C4E - taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2005/12/14 2014/10/16 rogid:PuUXvHTSeKIBEIortgZStG4dwls284812 rogid:k/4DTGZyB+IVI6lIKluopAMVgUI284812 intact-crc:4B9AB1BE0EAC2D3C|rigid:trtOL72ykxITkMkScG7rPLFDMdI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P78955 uniprotkb:Q10159 intact:EBI-767597|ensemblfungi:"SPAC20G4.04c.1:pep" intact:EBI-767574|uniprotkb:O74679|ensemblfungi:"SPAC26A3.02.1:pep" psi-mi:hus1_schpo(display_long)|uniprotkb:hus1(gene name)|psi-mi:hus1(display_short)|uniprotkb:SPAC20G4.04c(orf name) psi-mi:myh1_schpo(display_long)|uniprotkb:myh1(gene name)|psi-mi:myh1(display_short)|uniprotkb:myh(gene name synonym)|uniprotkb:SPAC26A3.02(orf name) psi-mi:"MI:0071"(molecular sieving) Chang et al. (2005) pubmed:15533944|mint:MINT-5217301 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-768742 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594739.1|interpro:IPR016580(Cell cycle checkpoint, HUS1)|interpro:IPR007150(Hus1-like protein)|reactome:R-SPO-176187|ensemblfungi:SPAC20G4.04c(gene)|ensemblfungi:SPAC20G4.04c.1(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0140445"(chromosome, telomeric repeat region) refseq:NP_594145.1|interpro:IPR011257(DNA glycosylase)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR003265(HhH-GPD)|interpro:IPR023170|interpro:IPR015797(NUDIX)|interpro:IPR000445(Helix-hairpin-helix motif)|reactome:R-SPO-110331|interpro:IPR044298|interpro:IPR029119|ensemblfungi:SPAC26A3.02(gene)|ensemblfungi:SPAC26A3.02.1(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902800"(positive regulation of phosphodiesterase I activity) - - - complex-properties:MYH1 and Hus1 associate in a complex of approximately 450kDa taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2005/12/14 2014/10/16 rogid:me0bMDXNBCzaaUX+QaJmFI+OS3k284812 rogid:PuUXvHTSeKIBEIortgZStG4dwls284812 intact-crc:B43BB70927C534E7|rigid:vPQAvHMr/8Khy1OJ7bgeZhyZvv4 false ha tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)