#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O09106 uniprotkb:Q8BX46 intact:EBI-301912|uniprotkb:P97476|ensembl:ENSMUSP00000099657 intact:EBI-604451|ensembl:ENSMUSP00000055037|uniprotkb:Q3UYA4|uniprotkb:Q5W8I2|uniprotkb:Q8C0T2|uniprotkb:B2RQS8 psi-mi:hdac1_mouse(display_long)|uniprotkb:Hdac1(gene name)|psi-mi:Hdac1(display_short) psi-mi:skor1_mouse(display_long)|uniprotkb:Lbx1 corepressor 1(gene name synonym)|uniprotkb:Transcriptional corepressor Corl1(gene name synonym)|uniprotkb:Fussel-15 homolog(gene name synonym)|uniprotkb:Skor1(gene name)|psi-mi:Skor1(display_short)|uniprotkb:Corl1(gene name synonym)|uniprotkb:Lbxcor1(gene name synonym)|uniprotkb:Ladybird homeobox corepressor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mizuhara et al. (2005) pubmed:15528197 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-604457 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-31499N|ensembl:ENSMUSG00000028800(gene)|ensembl:ENSMUST00000102597(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_032254.1|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O09106|reactome:R-MMU-1538133|reactome:R-MMU-201722|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-3769402|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8936459|reactome:R-MMU-8943724|reactome:R-MMU-9018519|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031000"(response to caffeine)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007492"(endoderm development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0001046"(core promoter sequence-specific DNA binding) interpro:IPR003380(Transforming protein Ski)|interpro:IPR009061(Putative DNA binding)|interpro:IPR010919(SAND-like)|interpro:IPR014890(c-SKI Smad4 binding)|interpro:IPR023216|interpro:IPR028762|interpro:IPR037000|ensembl:ENSMUSG00000022245(gene)|ensembl:ENSMUST00000055281(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|refseq:NP_001157227.1|refseq:NP_001157229.1|refseq:NP_766034.2 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/06/22 2014/10/16 rogid:P7QV++FiMiNcabUkswbnNhGVU3410090 rogid:3k/hwvASB4MGdRYFeRt1iIsbafc10090 intact-crc:06474A1F835C3371|rigid:nrYO7mpVFJVUlDNiLycQ4R28YUw false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62440 uniprotkb:Q8BX46 intact:EBI-604471|uniprotkb:Q5SQA8 intact:EBI-604451|ensembl:ENSMUSP00000055037|uniprotkb:Q3UYA4|uniprotkb:Q5W8I2|uniprotkb:Q8C0T2|uniprotkb:B2RQS8 psi-mi:tle1_mouse(display_long)|uniprotkb:Groucho-related protein 1(gene name synonym)|uniprotkb:Tle1(gene name)|psi-mi:Tle1(display_short)|uniprotkb:Grg1(gene name synonym) psi-mi:skor1_mouse(display_long)|uniprotkb:Lbx1 corepressor 1(gene name synonym)|uniprotkb:Transcriptional corepressor Corl1(gene name synonym)|uniprotkb:Fussel-15 homolog(gene name synonym)|uniprotkb:Skor1(gene name)|psi-mi:Skor1(display_short)|uniprotkb:Corl1(gene name synonym)|uniprotkb:Lbxcor1(gene name synonym)|uniprotkb:Ladybird homeobox corepressor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mizuhara et al. (2005) pubmed:15528197 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-604514 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000811"(negative regulation of anoikis)|refseq:NP_001272459.1|refseq:NP_001272460.1|refseq:NP_001272461.1|refseq:NP_035729.3|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|reactome:R-MMU-3769402|reactome:R-MMU-4641265|reactome:R-MMU-201722|interpro:IPR036322 interpro:IPR003380(Transforming protein Ski)|interpro:IPR009061(Putative DNA binding)|interpro:IPR010919(SAND-like)|interpro:IPR014890(c-SKI Smad4 binding)|interpro:IPR023216|interpro:IPR028762|interpro:IPR037000|ensembl:ENSMUSG00000022245(gene)|ensembl:ENSMUST00000055281(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|refseq:NP_001157227.1|refseq:NP_001157229.1|refseq:NP_766034.2 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/06/22 2014/10/16 rogid:r3QLjGnkeRB/hWa89Eey21sS2xk10090 rogid:3k/hwvASB4MGdRYFeRt1iIsbafc10090 intact-crc:2BB997FD4087BF7A|rigid:3JibouQ9HLtahJdAudiVNTd15fU false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8BX46 uniprotkb:O88712 intact:EBI-604451|ensembl:ENSMUSP00000055037|uniprotkb:Q3UYA4|uniprotkb:Q5W8I2|uniprotkb:Q8C0T2|uniprotkb:B2RQS8 intact:EBI-604547|ensembl:ENSMUSP00000078682|uniprotkb:Q3TAT1|uniprotkb:Q3TDL5|uniprotkb:Q3TUM5|uniprotkb:Q91WI6|uniprotkb:Q91YX3|uniprotkb:Q9QYG2 psi-mi:skor1_mouse(display_long)|uniprotkb:Lbx1 corepressor 1(gene name synonym)|uniprotkb:Transcriptional corepressor Corl1(gene name synonym)|uniprotkb:Fussel-15 homolog(gene name synonym)|uniprotkb:Skor1(gene name)|psi-mi:Skor1(display_short)|uniprotkb:Corl1(gene name synonym)|uniprotkb:Lbxcor1(gene name synonym)|uniprotkb:Ladybird homeobox corepressor 1(gene name synonym) psi-mi:ctbp1_mouse(display_long)|uniprotkb:Ctbp1(gene name)|psi-mi:Ctbp1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mizuhara et al. (2005) pubmed:15528197 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-604564 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR003380(Transforming protein Ski)|interpro:IPR009061(Putative DNA binding)|interpro:IPR010919(SAND-like)|interpro:IPR014890(c-SKI Smad4 binding)|interpro:IPR023216|interpro:IPR028762|interpro:IPR037000|ensembl:ENSMUSG00000022245(gene)|ensembl:ENSMUST00000055281(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|refseq:NP_001157227.1|refseq:NP_001157229.1|refseq:NP_766034.2 go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0051726"(regulation of cell cycle)|ensembl:ENSMUSG00000037373(gene)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|ensembl:ENSMUST00000079746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029752|go:"GO:0003682"(chromatin binding)|interpro:IPR029753|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR036291|go:"GO:0005737"(cytoplasm)|interpro:IPR043322|go:"GO:0006342"|mint:O88712|reactome:R-MMU-3769402|reactome:R-MMU-3899300|reactome:R-MMU-4641265|go:"GO:0008134"(transcription factor binding)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|refseq:NP_001185788.1|refseq:NP_001185789.1|refseq:NP_001185790.1|refseq:NP_038530.1|refseq:NP_001297464.1|dip:DIP-33907N - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/06/22 2014/10/16 rogid:3k/hwvASB4MGdRYFeRt1iIsbafc10090 rogid:l2rq9ypazCscM/WbocEKgQZcEBo10090 intact-crc:392CCCA6AE7FE4B4|rigid:/EQIs1B2tMwpPyBHCiyW+m8a+ws false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62440 uniprotkb:P52955 intact:EBI-604471|uniprotkb:Q5SQA8 intact:EBI-604594|ensembl:ENSMUSP00000096997|uniprotkb:Q3UN09|uniprotkb:Q80XA3 psi-mi:tle1_mouse(display_long)|uniprotkb:Groucho-related protein 1(gene name synonym)|uniprotkb:Tle1(gene name)|psi-mi:Tle1(display_short)|uniprotkb:Grg1(gene name synonym) psi-mi:lbx1_mouse(display_long)|uniprotkb:Ladybird homeobox protein homolog 1(gene name synonym)|uniprotkb:Lbx1(gene name)|psi-mi:Lbx1(display_short)|uniprotkb:Lbx1h(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mizuhara et al. (2005) pubmed:15528197 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-604664 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000811"(negative regulation of anoikis)|refseq:NP_001272459.1|refseq:NP_001272460.1|refseq:NP_001272461.1|refseq:NP_035729.3|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|reactome:R-MMU-3769402|reactome:R-MMU-4641265|reactome:R-MMU-201722|interpro:IPR036322 ensembl:ENSMUSG00000025216(gene)|ensembl:ENSMUST00000099401(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|refseq:NP_034821.2|refseq:XP_006526785.1 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/06/22 2014/10/16 rogid:r3QLjGnkeRB/hWa89Eey21sS2xk10090 rogid:ZBiDxlRj6NFIusvbfd0sweX972g10090 intact-crc:E54E109E48782F98|rigid:A32GWt2ZfG94ktV59VB28YIuxs8 false ha tag:?-? flag tag:?-?|binding-associated region:52-282 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-604706 uniprotkb:Q8BX46 - intact:EBI-604451|ensembl:ENSMUSP00000055037|uniprotkb:Q3UYA4|uniprotkb:Q5W8I2|uniprotkb:Q8C0T2|uniprotkb:B2RQS8 psi-mi:q9qvt4_9muri(display_short)|psi-mi:EBI-604706(display_long) psi-mi:skor1_mouse(display_long)|uniprotkb:Lbx1 corepressor 1(gene name synonym)|uniprotkb:Transcriptional corepressor Corl1(gene name synonym)|uniprotkb:Fussel-15 homolog(gene name synonym)|uniprotkb:Skor1(gene name)|psi-mi:Skor1(display_short)|uniprotkb:Corl1(gene name synonym)|uniprotkb:Lbxcor1(gene name synonym)|uniprotkb:Ladybird homeobox corepressor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mizuhara et al. (2005) pubmed:15528197 taxid:10095(mus)|taxid:10095(Mus sp.) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-604716 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9QVT4(uniprot-removed-ac) interpro:IPR003380(Transforming protein Ski)|interpro:IPR009061(Putative DNA binding)|interpro:IPR010919(SAND-like)|interpro:IPR014890(c-SKI Smad4 binding)|interpro:IPR023216|interpro:IPR028762|interpro:IPR037000|ensembl:ENSMUSG00000022245(gene)|ensembl:ENSMUST00000055281(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|refseq:NP_001157227.1|refseq:NP_001157229.1|refseq:NP_766034.2 - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/06/22 2014/10/16 rogid:V8QKZaBOstXOk/U0WO1HsKLFLOo10095 rogid:3k/hwvASB4MGdRYFeRt1iIsbafc10090 intact-crc:8DC0622FFA1B91E3|rigid:UMcYdq2oMLQqiXQmVDWNgHGwrHU false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P52955 uniprotkb:Q8BX46 intact:EBI-604594|ensembl:ENSMUSP00000096997|uniprotkb:Q3UN09|uniprotkb:Q80XA3 intact:EBI-604451|ensembl:ENSMUSP00000055037|uniprotkb:Q3UYA4|uniprotkb:Q5W8I2|uniprotkb:Q8C0T2|uniprotkb:B2RQS8 psi-mi:lbx1_mouse(display_long)|uniprotkb:Ladybird homeobox protein homolog 1(gene name synonym)|uniprotkb:Lbx1(gene name)|psi-mi:Lbx1(display_short)|uniprotkb:Lbx1h(gene name synonym) psi-mi:skor1_mouse(display_long)|uniprotkb:Lbx1 corepressor 1(gene name synonym)|uniprotkb:Transcriptional corepressor Corl1(gene name synonym)|uniprotkb:Fussel-15 homolog(gene name synonym)|uniprotkb:Skor1(gene name)|psi-mi:Skor1(display_short)|uniprotkb:Corl1(gene name synonym)|uniprotkb:Lbxcor1(gene name synonym)|uniprotkb:Ladybird homeobox corepressor 1(gene name synonym) psi-mi:"MI:0031"(protein cross-linking with a bifunctional reagent) Mizuhara et al. (2005) pubmed:15528197 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-604590 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025216(gene)|ensembl:ENSMUST00000099401(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|refseq:NP_034821.2|refseq:XP_006526785.1 interpro:IPR003380(Transforming protein Ski)|interpro:IPR009061(Putative DNA binding)|interpro:IPR010919(SAND-like)|interpro:IPR014890(c-SKI Smad4 binding)|interpro:IPR023216|interpro:IPR028762|interpro:IPR037000|ensembl:ENSMUSG00000022245(gene)|ensembl:ENSMUST00000055281(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|refseq:NP_001157227.1|refseq:NP_001157229.1|refseq:NP_766034.2 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/06/22 2014/10/16 rogid:ZBiDxlRj6NFIusvbfd0sweX972g10090 rogid:3k/hwvASB4MGdRYFeRt1iIsbafc10090 intact-crc:F0291796314BA5CE|rigid:CqzKnOfGanSH4mO1rQGxpvMJf+w false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P52955 uniprotkb:Q8BX46 intact:EBI-604594|ensembl:ENSMUSP00000096997|uniprotkb:Q3UN09|uniprotkb:Q80XA3 intact:EBI-604451|ensembl:ENSMUSP00000055037|uniprotkb:Q3UYA4|uniprotkb:Q5W8I2|uniprotkb:Q8C0T2|uniprotkb:B2RQS8 psi-mi:lbx1_mouse(display_long)|uniprotkb:Ladybird homeobox protein homolog 1(gene name synonym)|uniprotkb:Lbx1(gene name)|psi-mi:Lbx1(display_short)|uniprotkb:Lbx1h(gene name synonym) psi-mi:skor1_mouse(display_long)|uniprotkb:Lbx1 corepressor 1(gene name synonym)|uniprotkb:Transcriptional corepressor Corl1(gene name synonym)|uniprotkb:Fussel-15 homolog(gene name synonym)|uniprotkb:Skor1(gene name)|psi-mi:Skor1(display_short)|uniprotkb:Corl1(gene name synonym)|uniprotkb:Lbxcor1(gene name synonym)|uniprotkb:Ladybird homeobox corepressor 1(gene name synonym) psi-mi:"MI:0031"(protein cross-linking with a bifunctional reagent) Mizuhara et al. (2005) pubmed:15528197 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-604608 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025216(gene)|ensembl:ENSMUST00000099401(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|refseq:NP_034821.2|refseq:XP_006526785.1 interpro:IPR003380(Transforming protein Ski)|interpro:IPR009061(Putative DNA binding)|interpro:IPR010919(SAND-like)|interpro:IPR014890(c-SKI Smad4 binding)|interpro:IPR023216|interpro:IPR028762|interpro:IPR037000|ensembl:ENSMUSG00000022245(gene)|ensembl:ENSMUST00000055281(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|refseq:NP_001157227.1|refseq:NP_001157229.1|refseq:NP_766034.2 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/06/22 2014/10/16 rogid:ZBiDxlRj6NFIusvbfd0sweX972g10090 rogid:3k/hwvASB4MGdRYFeRt1iIsbafc10090 intact-crc:C278E6D8776AE3FD|rigid:CqzKnOfGanSH4mO1rQGxpvMJf+w false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8BX46 uniprotkb:Q9QZR5 intact:EBI-604451|ensembl:ENSMUSP00000055037|uniprotkb:Q3UYA4|uniprotkb:Q5W8I2|uniprotkb:Q8C0T2|uniprotkb:B2RQS8 intact:EBI-366905|uniprotkb:O88905|uniprotkb:Q99P45|uniprotkb:Q99P46|uniprotkb:Q9D2E6|uniprotkb:Q9D474|uniprotkb:Q9EQL2|uniprotkb:Q9QZR4|ensembl:ENSMUSP00000124133 psi-mi:skor1_mouse(display_long)|uniprotkb:Lbx1 corepressor 1(gene name synonym)|uniprotkb:Transcriptional corepressor Corl1(gene name synonym)|uniprotkb:Fussel-15 homolog(gene name synonym)|uniprotkb:Skor1(gene name)|psi-mi:Skor1(display_short)|uniprotkb:Corl1(gene name synonym)|uniprotkb:Lbxcor1(gene name synonym)|uniprotkb:Ladybird homeobox corepressor 1(gene name synonym) psi-mi:hipk2_mouse(display_long)|uniprotkb:Hipk2(gene name)|psi-mi:Hipk2(display_short)|uniprotkb:Nbak1(gene name synonym)|uniprotkb:Stank(gene name synonym)|uniprotkb:Nuclear body-associated kinase 1(gene name synonym)|uniprotkb:Sialophorin tail-associated nuclear serine/threonine-protein kinase(gene name synonym) psi-mi:"MI:0428"(imaging technique) Mizuhara et al. (2005) pubmed:15528197 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-608087 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR003380(Transforming protein Ski)|interpro:IPR009061(Putative DNA binding)|interpro:IPR010919(SAND-like)|interpro:IPR014890(c-SKI Smad4 binding)|interpro:IPR023216|interpro:IPR028762|interpro:IPR037000|ensembl:ENSMUSG00000022245(gene)|ensembl:ENSMUST00000055281(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|refseq:NP_001157227.1|refseq:NP_001157229.1|refseq:NP_766034.2 refseq:NP_001129537.1|refseq:NP_034563.2|ensembl:ENSMUSG00000061436|ensembl:ENSMUSG00000061436(gene)|ensembl:ENSMUST00000161779(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9QZR5|reactome:R-MMU-3899300|reactome:R-MMU-6804756|reactome:R-MMU-8939243|reactome:R-MMU-9022692|refseq:NP_001281072.1|refseq:NP_001281073.1|dip:DIP-31712N - - crc64:5C863BE377F3AAEF comment:punctate pattern observed|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/06/22 2014/10/16 rogid:3k/hwvASB4MGdRYFeRt1iIsbafc10090 rogid:QuwURfphVnnlJdiKOk6l4fDgtQM10090 intact-crc:7C116E83479CF4CA|rigid:ZtjN46+K5/HC9xvb9ErjYaf/dac false flag tag:?-? tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)