#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35348	uniprotkb:P13497	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2004)	pubmed:15525470	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-489882	author score:beta-galactosidase activity is 30 times stronger than the control	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/01	2014/10/16	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rogid:IS39foZyMR0650AjBaf1gA8YD/k9606	intact-crc:2E41113DBF048154|rigid:Xjs93k2Hhdyi6CEDCd/mRnt3fSE	false	binding-associated region:322-466	binding-associated region:c-c	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35348	uniprotkb:Q12979	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	intact:EBI-489922|uniprotkb:Q13693|uniprotkb:Q13694|uniprotkb:D3DTH4|uniprotkb:D3DTH3|uniprotkb:B3KW89|uniprotkb:F5H8B3|uniprotkb:B7Z6H7|uniprotkb:F5H3S2|ensembl:ENSP00000303909|ensembl:ENSP00000481740	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:abr_human(display_long)|uniprotkb:ABR(gene name)|psi-mi:ABR(display_short)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2004)	pubmed:15525470	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-489946	author score:beta-galactosidase is 3 times stronger than the control	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	refseq:NP_001153218.1|refseq:NP_001083.2|refseq:NP_068781.2|refseq:NP_001243776.1|refseq:NP_001269078.1|refseq:NP_001309769.1|ensembl:ENSG00000159842(gene)|ensembl:ENSG00000278741(gene)|ensembl:ENST00000302538(transcript)|ensembl:ENST00000612118(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR035892|interpro:IPR035899|interpro:IPR037769|interpro:IPR037865|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/01	2014/10/16	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rogid:BE2zC9wZOEogjE9LQ3S3D5lIqGs9606	intact-crc:D25E493D5C56A09C|rigid:x6lnv5BT+BvRv15/MkEO7tlt9C4	false	binding-associated region:322-466	binding-associated region:c-c	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35348	uniprotkb:Q14315	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2004)	pubmed:15525470	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-489983	author score:beta-galactosidase activity is 3 times stronger than the control	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/01	2014/10/16	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606	intact-crc:0F536B3999B02399|rigid:ssU4WbT+Y/6TI9lF3r7uUHo+oNg	false	binding-associated region:322-466	binding-associated region:c-c	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P25100	uniprotkb:Q14315	intact:EBI-489993|uniprotkb:Q9NPY0|ensembl:ENSP00000368766	intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145	psi-mi:ada1d_human(display_long)|uniprotkb:Alpha-1D adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1A adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1a(gene name synonym)|uniprotkb:ADRA1D(gene name)|psi-mi:ADRA1D(display_short)|uniprotkb:ADRA1A(gene name synonym)	psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2004)	pubmed:15525470	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490009	author score:beta-galactosidase activity is 2 times stronger than the control	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000669.1|ensembl:ENSG00000171873(gene)|ensembl:ENST00000379453(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000363(Adrenergic receptor, alpha-1A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482	refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/01	2014/10/16	rogid:jMKKmdeENCQ6B0ulSVJJECThmfE9606	rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606	intact-crc:63CFF134894DA25B|rigid:QCZBb2VhcudyA7cqPjUpiO8ORPA	false	binding-associated region:398-572	binding-associated region:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35368	uniprotkb:Q14315	intact:EBI-490017|uniprotkb:B0LPE1|ensembl:ENSP00000306662	intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145	psi-mi:ada1b_human(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:ADRA1B(gene name)|psi-mi:ADRA1B(display_short)	psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2004)	pubmed:15525470	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490031	author score:beta-galactosidase activity is 2 times stronger than the control	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000670.1|ensembl:ENSG00000170214(gene)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000306675(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35368|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|dip:DIP-33399N	refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/01	2014/10/16	rogid:labDfm9SIECH7JTHtwNoHTMuSS09606	rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606	intact-crc:CB77DE26BC08D4DB|rigid:GI3E8BrS2C8/IBzQR070nKXm+RE	false	binding-associated region:344-519	binding-associated region:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)