#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35739	uniprotkb:P27671	intact:EBI-976667|ensembl:ENSRNOP00000018961	intact:EBI-645522|ensembl:ENSMUSP00000034912	psi-mi:ntrk1_rat(display_long)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:Slow nerve growth factor receptor(gene name synonym)|uniprotkb:Ntrk1(gene name)|psi-mi:Ntrk1(display_short)|uniprotkb:Trk(gene name synonym)|uniprotkb:Trka(gene name synonym)	psi-mi:rgrf1_mouse(display_long)|uniprotkb:Guanine nucleotide-releasing protein(gene name synonym)|uniprotkb:Ras-specific nucleotide exchange factor CDC25(gene name synonym)|uniprotkb:CDC25Mm(gene name synonym)|uniprotkb:Rasgrf1(gene name)|psi-mi:Rasgrf1(display_short)|uniprotkb:Cdc25(gene name synonym)|uniprotkb:Grf1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365144|mint:MINT-61282	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-177504|reactome:R-RNO-187042|reactome:R-RNO-198203|ensembl:ENSRNOG00000013953(gene)|ensembl:ENSRNOT00000018961(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|rgd:620144|refseq:NP_067600.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035094"(response to nicotine)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060384"(innervation)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P35739|reactome:R-RNO-170968|reactome:R-RNO-170984|dip:DIP-5716N|mint:MINT-1208174(identity)	refseq:NP_035375.1|dip:DIP-41194N|ensembl:ENSMUSG00000032356(gene)|ensembl:ENSMUST00000034912(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030745|interpro:IPR035899|interpro:IPR036964|mint:P27671|rcsb pdb:2IJE|reactome:R-MMU-5673001|mint:MINT-1208168(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B F1C F6C|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/18	2014/10/16	rogid:jpLQn/DChXe097KfGi+Ag5nRMkw10116	rogid:Y3Wcc5F9IuroG15HLFXPQkL+2is10090	intact-crc:3AB59A8D1D1CE71B|rigid:RM5C4aRxOyZ4Hh8NRqfJm0iWbiw	false	mutation decreasing interaction:510-510,547-547,509-509(MINT-1208175)|tag:?-?(MINT-1208179)	tag:?-?(MINT-1208169)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P27671	uniprotkb:P35739	intact:EBI-645522|ensembl:ENSMUSP00000034912	intact:EBI-976667|ensembl:ENSRNOP00000018961	psi-mi:rgrf1_mouse(display_long)|uniprotkb:Guanine nucleotide-releasing protein(gene name synonym)|uniprotkb:Ras-specific nucleotide exchange factor CDC25(gene name synonym)|uniprotkb:CDC25Mm(gene name synonym)|uniprotkb:Rasgrf1(gene name)|psi-mi:Rasgrf1(display_short)|uniprotkb:Cdc25(gene name synonym)|uniprotkb:Grf1(gene name synonym)	psi-mi:ntrk1_rat(display_long)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:Slow nerve growth factor receptor(gene name synonym)|uniprotkb:Ntrk1(gene name)|psi-mi:Ntrk1(display_short)|uniprotkb:Trk(gene name synonym)|uniprotkb:Trka(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365289|mint:MINT-61291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035375.1|dip:DIP-41194N|ensembl:ENSMUSG00000032356(gene)|ensembl:ENSMUST00000034912(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030745|interpro:IPR035899|interpro:IPR036964|mint:P27671|rcsb pdb:2IJE|reactome:R-MMU-5673001|mint:MINT-1208193(identity)	reactome:R-RNO-177504|reactome:R-RNO-187042|reactome:R-RNO-198203|ensembl:ENSRNOG00000013953(gene)|ensembl:ENSRNOT00000018961(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|rgd:620144|refseq:NP_067600.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035094"(response to nicotine)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060384"(innervation)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P35739|reactome:R-RNO-170968|reactome:R-RNO-170984|dip:DIP-5716N|mint:MINT-1208189(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7C|comment:mint	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2005/07/18	2014/10/16	rogid:Y3Wcc5F9IuroG15HLFXPQkL+2is10090	rogid:jpLQn/DChXe097KfGi+Ag5nRMkw10116	intact-crc:41E7C1E6C11203E5|rigid:RM5C4aRxOyZ4Hh8NRqfJm0iWbiw	false	tag:?-?(MINT-1208194)	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q63604	uniprotkb:P27671	intact:EBI-7287667|intact:MINT-1204365|uniprotkb:Q63606|uniprotkb:Q63605|ensembl:ENSRNOP00000045635	intact:EBI-645522|ensembl:ENSMUSP00000034912	psi-mi:ntrk2_rat(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)	psi-mi:rgrf1_mouse(display_long)|uniprotkb:Guanine nucleotide-releasing protein(gene name synonym)|uniprotkb:Ras-specific nucleotide exchange factor CDC25(gene name synonym)|uniprotkb:CDC25Mm(gene name synonym)|uniprotkb:Rasgrf1(gene name)|psi-mi:Rasgrf1(display_short)|uniprotkb:Cdc25(gene name synonym)|uniprotkb:Grf1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365310|mint:MINT-61283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3213|refseq:NP_001156640.1|refseq:NP_036863.1|ensembl:ENSRNOG00000018839(gene)|ensembl:ENSRNOT00000042145(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0009416"(response to light stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0009986"(cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043195"(terminal bouton)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0014047"(glutamate secretion)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098794"(postsynapse)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|go:"GO:0019222"(regulation of metabolic process)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q63604|reactome:R-RNO-9026527|reactome:R-RNO-9028731|reactome:R-RNO-9032759|dip:DIP-5717N|mint:MINT-1208210(identity)	refseq:NP_035375.1|dip:DIP-41194N|ensembl:ENSMUSG00000032356(gene)|ensembl:ENSMUST00000034912(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030745|interpro:IPR035899|interpro:IPR036964|mint:P27671|rcsb pdb:2IJE|reactome:R-MMU-5673001|mint:MINT-1208204(identity)	-	function:"Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B F1C|comment:homomint|comment:mint	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2005/07/18	2014/10/16	rogid:0ft2yR2N4GNlpCk07AUqHGE81XU10116	rogid:Y3Wcc5F9IuroG15HLFXPQkL+2is10090	intact-crc:D23DCE31F1CF3DB0|rigid:axpdSnmROmfxMxHCEIBkP5pwq60	false	tag:?-?(MINT-1208211)	tag:?-?(MINT-1208205)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03351	uniprotkb:P27671	intact:EBI-7365348|intact:MINT-1208236|ensembl:ENSRNOP00000044402	intact:EBI-645522|ensembl:ENSMUSP00000034912	psi-mi:ntrk3_rat(display_long)|uniprotkb:Ntrk3(gene name)|psi-mi:Ntrk3(display_short)|uniprotkb:Trkc(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkC(gene name synonym)	psi-mi:rgrf1_mouse(display_long)|uniprotkb:Guanine nucleotide-releasing protein(gene name synonym)|uniprotkb:Ras-specific nucleotide exchange factor CDC25(gene name synonym)|uniprotkb:CDC25Mm(gene name synonym)|uniprotkb:Rasgrf1(gene name)|psi-mi:Rasgrf1(display_short)|uniprotkb:Cdc25(gene name synonym)|uniprotkb:Grf1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365343|mint:MINT-61284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001257585.1|refseq:NP_062121.1|refseq:NP_001257584.1|rgd:3214|refseq:XP_017444550.1|ensembl:ENSRNOG00000018674(gene)|ensembl:ENSRNOT00000046849(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045471"(response to ethanol)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048678"(response to axon injury)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090102"(cochlea development)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q03351|reactome:R-RNO-388844|reactome:R-RNO-9034013|reactome:R-RNO-9034793|reactome:R-RNO-9603381|dip:DIP-5718N|mint:MINT-1208307(identity)	refseq:NP_035375.1|dip:DIP-41194N|ensembl:ENSMUSG00000032356(gene)|ensembl:ENSMUST00000034912(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030745|interpro:IPR035899|interpro:IPR036964|mint:P27671|rcsb pdb:2IJE|reactome:R-MMU-5673001|mint:MINT-1208301(identity)	-	comment:mint|function:"Receptor for neurotrophin-3 (NTF3). This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLCG1. TrkC isoforms containing insertions within the kinase domain can autophosphorylate in response to NT-3, but cannot mediate downstream phenotypic responses"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:homomint|comment:mint	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2005/07/18	2014/10/16	rogid:Ej4M12oqTLvp/XK+/ScA0gARR+810116	rogid:Y3Wcc5F9IuroG15HLFXPQkL+2is10090	intact-crc:A52E3C44A7A7971C|rigid:+P+o9P/TSf5ZKAXzJ7DlwqGM/Rs	false	tag:?-?(MINT-1208308)	tag:?-?(MINT-1208302)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q63604	uniprotkb:P27671	intact:EBI-7287667|intact:MINT-1204365|uniprotkb:Q63606|uniprotkb:Q63605|ensembl:ENSRNOP00000045635	intact:EBI-645522|ensembl:ENSMUSP00000034912	psi-mi:ntrk2_rat(display_long)|uniprotkb:Ntrk2(gene name)|psi-mi:Ntrk2(display_short)|uniprotkb:Trkb(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 2(gene name synonym)|uniprotkb:TrkB tyrosine kinase(gene name synonym)	psi-mi:rgrf1_mouse(display_long)|uniprotkb:Guanine nucleotide-releasing protein(gene name synonym)|uniprotkb:Ras-specific nucleotide exchange factor CDC25(gene name synonym)|uniprotkb:CDC25Mm(gene name synonym)|uniprotkb:Rasgrf1(gene name)|psi-mi:Rasgrf1(display_short)|uniprotkb:Cdc25(gene name synonym)|uniprotkb:Grf1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365439|mint:MINT-61288	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3213|refseq:NP_001156640.1|refseq:NP_036863.1|ensembl:ENSRNOG00000018839(gene)|ensembl:ENSRNOT00000042145(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0009416"(response to light stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0009986"(cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043195"(terminal bouton)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0014047"(glutamate secretion)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060175"(brain-derived neurotrophic factor-activated receptor activity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098794"(postsynapse)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:0099551"(trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|go:"GO:0019222"(regulation of metabolic process)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0021954"(central nervous system neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030182"(neuron differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020455|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q63604|reactome:R-RNO-9026527|reactome:R-RNO-9028731|reactome:R-RNO-9032759|dip:DIP-5717N|mint:MINT-1208227(identity)	refseq:NP_035375.1|dip:DIP-41194N|ensembl:ENSMUSG00000032356(gene)|ensembl:ENSMUST00000034912(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030745|interpro:IPR035899|interpro:IPR036964|mint:P27671|rcsb pdb:2IJE|reactome:R-MMU-5673001|mint:MINT-1208221(identity)	-	function:"Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2005/07/18	2014/10/16	rogid:0ft2yR2N4GNlpCk07AUqHGE81XU10116	rogid:Y3Wcc5F9IuroG15HLFXPQkL+2is10090	intact-crc:4254AE824A465660|rigid:axpdSnmROmfxMxHCEIBkP5pwq60	false	tag:?-?(MINT-1208228)	tag:?-?(MINT-1208222)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q03351	uniprotkb:P27671	intact:EBI-7365348|intact:MINT-1208236|ensembl:ENSRNOP00000044402	intact:EBI-645522|ensembl:ENSMUSP00000034912	psi-mi:ntrk3_rat(display_long)|uniprotkb:Ntrk3(gene name)|psi-mi:Ntrk3(display_short)|uniprotkb:Trkc(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)|uniprotkb:GP145-TrkC(gene name synonym)	psi-mi:rgrf1_mouse(display_long)|uniprotkb:Guanine nucleotide-releasing protein(gene name synonym)|uniprotkb:Ras-specific nucleotide exchange factor CDC25(gene name synonym)|uniprotkb:CDC25Mm(gene name synonym)|uniprotkb:Rasgrf1(gene name)|psi-mi:Rasgrf1(display_short)|uniprotkb:Cdc25(gene name synonym)|uniprotkb:Grf1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365456|mint:MINT-61289	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001257585.1|refseq:NP_062121.1|refseq:NP_001257584.1|rgd:3214|refseq:XP_017444550.1|ensembl:ENSRNOG00000018674(gene)|ensembl:ENSRNOT00000046849(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045471"(response to ethanol)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048678"(response to axon injury)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090102"(cochlea development)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q03351|reactome:R-RNO-388844|reactome:R-RNO-9034013|reactome:R-RNO-9034793|reactome:R-RNO-9603381|dip:DIP-5718N|mint:MINT-1208339(identity)	refseq:NP_035375.1|dip:DIP-41194N|ensembl:ENSMUSG00000032356(gene)|ensembl:ENSMUST00000034912(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030745|interpro:IPR035899|interpro:IPR036964|mint:P27671|rcsb pdb:2IJE|reactome:R-MMU-5673001|mint:MINT-1208333(identity)	-	comment:mint|function:"Receptor for neurotrophin-3 (NTF3). This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLCG1. TrkC isoforms containing insertions within the kinase domain can autophosphorylate in response to NT-3, but cannot mediate downstream phenotypic responses"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2005/07/18	2014/10/16	rogid:Ej4M12oqTLvp/XK+/ScA0gARR+810116	rogid:Y3Wcc5F9IuroG15HLFXPQkL+2is10090	intact-crc:C761767CA286C7EF|rigid:+P+o9P/TSf5ZKAXzJ7DlwqGM/Rs	false	tag:?-?(MINT-1208340)	tag:?-?(MINT-1208334)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35739	uniprotkb:P27671	intact:EBI-976667|ensembl:ENSRNOP00000018961	intact:EBI-645522|ensembl:ENSMUSP00000034912	psi-mi:ntrk1_rat(display_long)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:Slow nerve growth factor receptor(gene name synonym)|uniprotkb:Ntrk1(gene name)|psi-mi:Ntrk1(display_short)|uniprotkb:Trk(gene name synonym)|uniprotkb:Trka(gene name synonym)	psi-mi:rgrf1_mouse(display_long)|uniprotkb:Guanine nucleotide-releasing protein(gene name synonym)|uniprotkb:Ras-specific nucleotide exchange factor CDC25(gene name synonym)|uniprotkb:CDC25Mm(gene name synonym)|uniprotkb:Rasgrf1(gene name)|psi-mi:Rasgrf1(display_short)|uniprotkb:Cdc25(gene name synonym)|uniprotkb:Grf1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365481|mint:MINT-61287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-177504|reactome:R-RNO-187042|reactome:R-RNO-198203|ensembl:ENSRNOG00000013953(gene)|ensembl:ENSRNOT00000018961(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|rgd:620144|refseq:NP_067600.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035094"(response to nicotine)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060384"(innervation)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P35739|reactome:R-RNO-170968|reactome:R-RNO-170984|dip:DIP-5716N|mint:MINT-1208324(identity)	refseq:NP_035375.1|dip:DIP-41194N|ensembl:ENSMUSG00000032356(gene)|ensembl:ENSMUST00000034912(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030745|interpro:IPR035899|interpro:IPR036964|mint:P27671|rcsb pdb:2IJE|reactome:R-MMU-5673001|mint:MINT-1208318(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/18	2014/10/16	rogid:jpLQn/DChXe097KfGi+Ag5nRMkw10116	rogid:Y3Wcc5F9IuroG15HLFXPQkL+2is10090	intact-crc:22F2A8D2F8285AC6|rigid:RM5C4aRxOyZ4Hh8NRqfJm0iWbiw	false	tag:?-?(MINT-1208325)	tag:?-?(MINT-1208319)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P98077	uniprotkb:P35739	intact:EBI-7256023|uniprotkb:Q9NPL5|uniprotkb:O60230|uniprotkb:Q9UCX4|intact:MINT-127694|ensembl:ENSP00000264554	intact:EBI-976667|ensembl:ENSRNOP00000018961	psi-mi:shc2_human(display_long)|uniprotkb:SHC2(gene name)|psi-mi:SHC2(display_short)|uniprotkb:SCK(gene name synonym)|uniprotkb:SHCB(gene name synonym)|uniprotkb:SHC-transforming protein B(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C2(gene name synonym)|uniprotkb:Protein Sck(gene name synonym)	psi-mi:ntrk1_rat(display_long)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:Slow nerve growth factor receptor(gene name synonym)|uniprotkb:Ntrk1(gene name)|psi-mi:Ntrk1(display_short)|uniprotkb:Trk(gene name synonym)|uniprotkb:Trka(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365497|mint:MINT-61292	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036567.2|ensembl:ENSG00000129946(gene)|ensembl:ENST00000264554(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029591|interpro:IPR035676|interpro:IPR036860|mint:P98077|reactome:R-HSA-167044|reactome:R-HSA-4420097|reactome:R-HSA-5673001|mint:MINT-1208375(identity)	reactome:R-RNO-177504|reactome:R-RNO-187042|reactome:R-RNO-198203|ensembl:ENSRNOG00000013953(gene)|ensembl:ENSRNOT00000018961(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|rgd:620144|refseq:NP_067600.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035094"(response to nicotine)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060384"(innervation)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P35739|reactome:R-RNO-170968|reactome:R-RNO-170984|dip:DIP-5716N|mint:MINT-1208367(identity)	-	comment:mint|function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6D|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/18	2014/10/16	rogid:PmKkJMQ7VWn3xqbkGvzsnk2gVGI9606	rogid:jpLQn/DChXe097KfGi+Ag5nRMkw10116	intact-crc:F92C62CD568A178E|rigid:Un7muObNa2gzpTlIuvAR1LUIaHg	false	tag:?-?(MINT-1208376)	tag:?-?(MINT-1208370)|mutation decreasing interaction:547-547(MINT-1208368)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P98077	uniprotkb:P35739	intact:EBI-7256023|uniprotkb:Q9NPL5|uniprotkb:O60230|uniprotkb:Q9UCX4|intact:MINT-127694|ensembl:ENSP00000264554	intact:EBI-976667|ensembl:ENSRNOP00000018961	psi-mi:shc2_human(display_long)|uniprotkb:SHC2(gene name)|psi-mi:SHC2(display_short)|uniprotkb:SCK(gene name synonym)|uniprotkb:SHCB(gene name synonym)|uniprotkb:SHC-transforming protein B(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C2(gene name synonym)|uniprotkb:Protein Sck(gene name synonym)	psi-mi:ntrk1_rat(display_long)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:Slow nerve growth factor receptor(gene name synonym)|uniprotkb:Ntrk1(gene name)|psi-mi:Ntrk1(display_short)|uniprotkb:Trk(gene name synonym)|uniprotkb:Trka(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Robinson et al. (2005)	pubmed:15513915|mint:MINT-5217273	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7365583|mint:MINT-61290	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036567.2|ensembl:ENSG00000129946(gene)|ensembl:ENST00000264554(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029591|interpro:IPR035676|interpro:IPR036860|mint:P98077|reactome:R-HSA-167044|reactome:R-HSA-4420097|reactome:R-HSA-5673001|mint:MINT-1208358(identity)	reactome:R-RNO-177504|reactome:R-RNO-187042|reactome:R-RNO-198203|ensembl:ENSRNOG00000013953(gene)|ensembl:ENSRNOT00000018961(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|rgd:620144|refseq:NP_067600.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035094"(response to nicotine)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060384"(innervation)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:P35739|reactome:R-RNO-170968|reactome:R-RNO-170984|dip:DIP-5716N|mint:MINT-1208350(identity)	-	comment:mint|function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6D|comment:mint	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/07/18	2014/10/16	rogid:PmKkJMQ7VWn3xqbkGvzsnk2gVGI9606	rogid:jpLQn/DChXe097KfGi+Ag5nRMkw10116	intact-crc:7BE15F70068D9602|rigid:Un7muObNa2gzpTlIuvAR1LUIaHg	false	tag:?-?(MINT-1208359)	mutation decreasing interaction:547-547(MINT-1208351)|tag:?-?(MINT-1208353)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)