#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04941	uniprotkb:P32246	intact:EBI-608347|ensembl:ENSP00000365505|uniprotkb:A6NDT7|uniprotkb:Q32MM8	intact:EBI-608322|ensembl:ENSP00000296140|uniprotkb:Q86VA9	psi-mi:plp2_human(display_long)|uniprotkb:Intestinal membrane A4 protein(gene name synonym)|uniprotkb:Differentiation-dependent protein A4(gene name synonym)|uniprotkb:PLP2(gene name)|psi-mi:PLP2(display_short)|uniprotkb:A4(gene name synonym)	psi-mi:ccr1_human(display_long)|uniprotkb:Macrophage inflammatory protein 1-alpha receptor(gene name synonym)|uniprotkb:RANTES-R(gene name synonym)|uniprotkb:HM145(gene name synonym)|uniprotkb:LD78 receptor(gene name synonym)|uniprotkb:CCR1(gene name)|psi-mi:CCR1(display_short)|uniprotkb:CMKBR1(gene name synonym)|uniprotkb:CMKR1(gene name synonym)|uniprotkb:SCYAR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15474493	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-608343	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102007(gene)|ensembl:ENST00000376327(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019956"(chemokine binding)|interpro:IPR008253(Marvel)|refseq:NP_002659.1	ensembl:ENSG00000163823(gene)|ensembl:ENST00000296140(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0035717"("chemokine (C-C motif) ligand 7 binding")|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002236(C-C chemokine receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32246|rcsb pdb:1Y5D|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|interpro:IPR034321|refseq:NP_001286.1|dip:DIP-5832N	go:"GO:0005886"(plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0006935"(chemotaxis)	-	-	disease:sarcoma|figure legend:"Fig. 1. Yeast two-hybrid interaction of the CCR1 C terminus with PLP2/A4. (A) Yeast Y190 cells cotransformed with bait and prey plasmids were streaked on SD medium without tryptophan and leucine as indicated. Colony filter assay was carried out using X-gal as a substrate."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/07/01	2014/10/16	rogid:mQOlRVDVw9W4XWAzftif1tnKEdU9606	rogid:m8grSofEywwJfUzrRCNNjYrq6ps9606	intact-crc:E34077E01E809874|rigid:dpF4IIAQABYIKJCDzKkfi/z62y0	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P32246	uniprotkb:Q04941	intact:EBI-608322|ensembl:ENSP00000296140|uniprotkb:Q86VA9	intact:EBI-608347|ensembl:ENSP00000365505|uniprotkb:A6NDT7|uniprotkb:Q32MM8	psi-mi:ccr1_human(display_long)|uniprotkb:Macrophage inflammatory protein 1-alpha receptor(gene name synonym)|uniprotkb:RANTES-R(gene name synonym)|uniprotkb:HM145(gene name synonym)|uniprotkb:LD78 receptor(gene name synonym)|uniprotkb:CCR1(gene name)|psi-mi:CCR1(display_short)|uniprotkb:CMKBR1(gene name synonym)|uniprotkb:CMKR1(gene name synonym)|uniprotkb:SCYAR1(gene name synonym)	psi-mi:plp2_human(display_long)|uniprotkb:Intestinal membrane A4 protein(gene name synonym)|uniprotkb:Differentiation-dependent protein A4(gene name synonym)|uniprotkb:PLP2(gene name)|psi-mi:PLP2(display_short)|uniprotkb:A4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lee et al. (2004)	pubmed:15474493	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-608366	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163823(gene)|ensembl:ENST00000296140(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0035717"("chemokine (C-C motif) ligand 7 binding")|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002236(C-C chemokine receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32246|rcsb pdb:1Y5D|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|interpro:IPR034321|refseq:NP_001286.1|dip:DIP-5832N	ensembl:ENSG00000102007(gene)|ensembl:ENST00000376327(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019956"(chemokine binding)|interpro:IPR008253(Marvel)|refseq:NP_002659.1	go:"GO:0005886"(plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0006935"(chemotaxis)	-	-	disease:sarcoma|figure legend:"Fig. 2. Interaction of the CCR1 C-terminus with PLP2/A4 in mammalian cells. (A) Association of PLP2/A4 with CCR1 in HEK293. PLP2/A4 in pcDNA3.1 and CCR1 in pRC/CMV were cotransfected into HEK293 cells. PLP2/A4 was immunoprecipitated from cell lysate using a rabbit polyclonal anti-c-Myc antibody. Mock was used in a parallel experiment to confirm the specificity of the immunoprecipitation. Coprecipitated CCR1 proteins were detected using a monoclonal Flag antibody. T, total; S, supernatant; P, pellet; and HEK293 cells were treated with Lkn-1/CCL15 at the final concentration of 10 ng/ml for the indicated times before immunoprecipitation."	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/07/01	2014/10/16	rogid:m8grSofEywwJfUzrRCNNjYrq6ps9606	rogid:mQOlRVDVw9W4XWAzftif1tnKEdU9606	intact-crc:BDB7AC6BA4129662|rigid:dpF4IIAQABYIKJCDzKkfi/z62y0	false	flag tag:?-?	myc tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q04941	uniprotkb:P32246	intact:EBI-608347|ensembl:ENSP00000365505|uniprotkb:A6NDT7|uniprotkb:Q32MM8	intact:EBI-608322|ensembl:ENSP00000296140|uniprotkb:Q86VA9	psi-mi:plp2_human(display_long)|uniprotkb:Intestinal membrane A4 protein(gene name synonym)|uniprotkb:Differentiation-dependent protein A4(gene name synonym)|uniprotkb:PLP2(gene name)|psi-mi:PLP2(display_short)|uniprotkb:A4(gene name synonym)	psi-mi:ccr1_human(display_long)|uniprotkb:Macrophage inflammatory protein 1-alpha receptor(gene name synonym)|uniprotkb:RANTES-R(gene name synonym)|uniprotkb:HM145(gene name synonym)|uniprotkb:LD78 receptor(gene name synonym)|uniprotkb:CCR1(gene name)|psi-mi:CCR1(display_short)|uniprotkb:CMKBR1(gene name synonym)|uniprotkb:CMKR1(gene name synonym)|uniprotkb:SCYAR1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Lee et al. (2004)	pubmed:15474493	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-608384	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102007(gene)|ensembl:ENST00000376327(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019956"(chemokine binding)|interpro:IPR008253(Marvel)|refseq:NP_002659.1	ensembl:ENSG00000163823(gene)|ensembl:ENST00000296140(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0035717"("chemokine (C-C motif) ligand 7 binding")|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002236(C-C chemokine receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32246|rcsb pdb:1Y5D|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|interpro:IPR034321|refseq:NP_001286.1|dip:DIP-5832N	go:"GO:0005886"(plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0006935"(chemotaxis)	-	-	disease:sarcoma|figure legend:Fig. 3.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/07/01	2014/10/16	rogid:mQOlRVDVw9W4XWAzftif1tnKEdU9606	rogid:m8grSofEywwJfUzrRCNNjYrq6ps9606	intact-crc:DEF9874A662A43B1|rigid:dpF4IIAQABYIKJCDzKkfi/z62y0	false	his tag:?-?|myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)