#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97756	uniprotkb:P61983	intact:EBI-7277672|uniprotkb:Q794E3|uniprotkb:Q64572|intact:MINT-1203156	intact:EBI-359821|uniprotkb:A0JPM0|uniprotkb:O70457|uniprotkb:Q9UDP2|uniprotkb:P35214|uniprotkb:Q9UN99|ensembl:ENSRNOP00000001954|ensembl:ENSRNOP00000069671	psi-mi:kkcc1_rat(display_long)|uniprotkb:Camkk1(gene name)|psi-mi:Camkk1(display_short)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase alpha(gene name synonym)|uniprotkb:CaM-kinase IV kinase(gene name synonym)	psi-mi:1433g_rat(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0096"(pull down)	Davare et al. (2004)	pubmed:15469938|mint:MINT-5217211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7335054|mint:MINT-51270	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97756|rgd:62023|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_113850.1|interpro:IPR011009(Protein kinase-like)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|rcsb pdb:1CKK|reactome:R-RNO-111932|reactome:R-RNO-442729|reactome:R-RNO-9619229|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1205918(identity)	rgd:62002|refseq:NP_062249.1|ensembl:ENSRNOG00000001436(gene)|ensembl:ENSRNOT00000001954(transcript)|ensembl:ENSRNOT00000084730(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61983|reactome:R-RNO-111447|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-8854518|reactome:R-RNO-9614399|refseq:XP_006249246.2|mint:MINT-1205928(identity)	-	function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/02	2014/10/16	rogid:6d6zkDJgWyPXtcxgtgzZHFyZa4g10116	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10116	intact-crc:794D286DF0800503|rigid:DfHURdagoxc9mR+I/zsGg1BHF/8	false	mutation decreasing interaction:74-74(MINT-1205921)|tag:?-?(MINT-1205923)|binding-associated region:1-107(MINT-1205919)	binding-associated region:1-246(MINT-1205929)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P97756	uniprotkb:P61983	intact:EBI-7277672|uniprotkb:Q794E3|uniprotkb:Q64572|intact:MINT-1203156	intact:EBI-359821|uniprotkb:A0JPM0|uniprotkb:O70457|uniprotkb:Q9UDP2|uniprotkb:P35214|uniprotkb:Q9UN99|ensembl:ENSRNOP00000001954|ensembl:ENSRNOP00000069671	psi-mi:kkcc1_rat(display_long)|uniprotkb:Camkk1(gene name)|psi-mi:Camkk1(display_short)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase alpha(gene name synonym)|uniprotkb:CaM-kinase IV kinase(gene name synonym)	psi-mi:1433g_rat(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0096"(pull down)	Davare et al. (2004)	pubmed:15469938|mint:MINT-5217211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7335084|mint:MINT-51272	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97756|rgd:62023|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_113850.1|interpro:IPR011009(Protein kinase-like)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|rcsb pdb:1CKK|reactome:R-RNO-111932|reactome:R-RNO-442729|reactome:R-RNO-9619229|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1205939(identity)	rgd:62002|refseq:NP_062249.1|ensembl:ENSRNOG00000001436(gene)|ensembl:ENSRNOT00000001954(transcript)|ensembl:ENSRNOT00000084730(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61983|reactome:R-RNO-111447|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-8854518|reactome:R-RNO-9614399|refseq:XP_006249246.2|mint:MINT-1205943(identity)	-	function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/02	2014/10/16	rogid:6d6zkDJgWyPXtcxgtgzZHFyZa4g10116	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10116	intact-crc:6A4F838BC48272E8|rigid:DfHURdagoxc9mR+I/zsGg1BHF/8	false	-	tag:?-?(MINT-1205947)|binding-associated region:1-246(MINT-1205944)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97756	uniprotkb:P61983	intact:EBI-7277672|uniprotkb:Q794E3|uniprotkb:Q64572|intact:MINT-1203156	intact:EBI-359821|uniprotkb:A0JPM0|uniprotkb:O70457|uniprotkb:Q9UDP2|uniprotkb:P35214|uniprotkb:Q9UN99|ensembl:ENSRNOP00000001954|ensembl:ENSRNOP00000069671	psi-mi:kkcc1_rat(display_long)|uniprotkb:Camkk1(gene name)|psi-mi:Camkk1(display_short)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase alpha(gene name synonym)|uniprotkb:CaM-kinase IV kinase(gene name synonym)	psi-mi:1433g_rat(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0096"(pull down)	Davare et al. (2004)	pubmed:15469938|mint:MINT-5217211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7335124|mint:MINT-51271	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97756|rgd:62023|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_113850.1|interpro:IPR011009(Protein kinase-like)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|rcsb pdb:1CKK|reactome:R-RNO-111932|reactome:R-RNO-442729|reactome:R-RNO-9619229|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1205995(identity)	rgd:62002|refseq:NP_062249.1|ensembl:ENSRNOG00000001436(gene)|ensembl:ENSRNOT00000001954(transcript)|ensembl:ENSRNOT00000084730(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61983|reactome:R-RNO-111447|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-8854518|reactome:R-RNO-9614399|refseq:XP_006249246.2|mint:MINT-1206003(identity)	-	function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/02/02	2014/10/16	rogid:6d6zkDJgWyPXtcxgtgzZHFyZa4g10116	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10116	intact-crc:CD428FC4602BF39A|rigid:DfHURdagoxc9mR+I/zsGg1BHF/8	false	O-phospho-L-serine:74-74(MINT-1205996)|tag:?-?(MINT-1205998)	tag:?-?(MINT-1206007)|binding-associated region:1-246(MINT-1206004)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97756	uniprotkb:P68511	intact:EBI-7277672|uniprotkb:Q794E3|uniprotkb:Q64572|intact:MINT-1203156	intact:EBI-444647|uniprotkb:P11576|uniprotkb:P70198|ensembl:ENSRNOP00000075701	psi-mi:kkcc1_rat(display_long)|uniprotkb:Camkk1(gene name)|psi-mi:Camkk1(display_short)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase alpha(gene name synonym)|uniprotkb:CaM-kinase IV kinase(gene name synonym)	psi-mi:1433f_rat(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0096"(pull down)	Davare et al. (2004)	pubmed:15469938|mint:MINT-5217211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7335165|mint:MINT-51274	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97756|rgd:62023|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_113850.1|interpro:IPR011009(Protein kinase-like)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|rcsb pdb:1CKK|reactome:R-RNO-111932|reactome:R-RNO-442729|reactome:R-RNO-9619229|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1205958(identity)	rgd:3978|refseq:NP_037184.1|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-5625740|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|ensembl:ENSRNOG00000055471(gene)|ensembl:ENSRNOT00000085735(transcript)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68511|reactome:R-RNO-111447|dip:DIP-299N|mint:MINT-1205964(identity)	-	function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/02/02	2014/10/16	rogid:6d6zkDJgWyPXtcxgtgzZHFyZa4g10116	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10116	intact-crc:69C7919B3F950B9D|rigid:R54e97ZvgCrrqotb5ezBfVBsSKw	false	tag:?-?(MINT-1205959)	tag:?-?(MINT-1205968)|binding-associated region:1-245(MINT-1205965)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97756	uniprotkb:P61983	intact:EBI-7277672|uniprotkb:Q794E3|uniprotkb:Q64572|intact:MINT-1203156	intact:EBI-359821|uniprotkb:A0JPM0|uniprotkb:O70457|uniprotkb:Q9UDP2|uniprotkb:P35214|uniprotkb:Q9UN99|ensembl:ENSRNOP00000001954|ensembl:ENSRNOP00000069671	psi-mi:kkcc1_rat(display_long)|uniprotkb:Camkk1(gene name)|psi-mi:Camkk1(display_short)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase alpha(gene name synonym)|uniprotkb:CaM-kinase IV kinase(gene name synonym)	psi-mi:1433g_rat(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0096"(pull down)	Davare et al. (2004)	pubmed:15469938|mint:MINT-5217211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7335195|mint:MINT-51269	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97756|rgd:62023|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_113850.1|interpro:IPR011009(Protein kinase-like)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|rcsb pdb:1CKK|reactome:R-RNO-111932|reactome:R-RNO-442729|reactome:R-RNO-9619229|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1205978(identity)	rgd:62002|refseq:NP_062249.1|ensembl:ENSRNOG00000001436(gene)|ensembl:ENSRNOT00000001954(transcript)|ensembl:ENSRNOT00000084730(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61983|reactome:R-RNO-111447|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-8854518|reactome:R-RNO-9614399|refseq:XP_006249246.2|mint:MINT-1205984(identity)	-	function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:The antibody used was pan 14-3-3 which recognize all isoforms, since the authors show later in the same paper the interaction with 14-3-3 gamma specifically we used it here to described this interaction, although other isoform might also be involved.|comment:homomint|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/02/02	2014/10/16	rogid:6d6zkDJgWyPXtcxgtgzZHFyZa4g10116	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10116	intact-crc:61F1F187BD2DE645|rigid:DfHURdagoxc9mR+I/zsGg1BHF/8	false	tag:?-?(MINT-1205979)	binding-associated region:1-246(MINT-1205985)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P97756	uniprotkb:P61983	intact:EBI-7277672|uniprotkb:Q794E3|uniprotkb:Q64572|intact:MINT-1203156	intact:EBI-359821|uniprotkb:A0JPM0|uniprotkb:O70457|uniprotkb:Q9UDP2|uniprotkb:P35214|uniprotkb:Q9UN99|ensembl:ENSRNOP00000001954|ensembl:ENSRNOP00000069671	psi-mi:kkcc1_rat(display_long)|uniprotkb:Camkk1(gene name)|psi-mi:Camkk1(display_short)|uniprotkb:Calcium/calmodulin-dependent protein kinase kinase alpha(gene name synonym)|uniprotkb:CaM-kinase IV kinase(gene name synonym)	psi-mi:1433g_rat(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Davare et al. (2004)	pubmed:15469938|mint:MINT-5217211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7335238|mint:MINT-51273	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P97756|rgd:62023|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_113850.1|interpro:IPR011009(Protein kinase-like)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|rcsb pdb:1CKK|reactome:R-RNO-111932|reactome:R-RNO-442729|reactome:R-RNO-9619229|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1206017(identity)	rgd:62002|refseq:NP_062249.1|ensembl:ENSRNOG00000001436(gene)|ensembl:ENSRNOT00000001954(transcript)|ensembl:ENSRNOT00000084730(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61983|reactome:R-RNO-111447|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-8854518|reactome:R-RNO-9614399|refseq:XP_006249246.2|mint:MINT-1206021(identity)	-	function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/02/02	2014/10/16	rogid:6d6zkDJgWyPXtcxgtgzZHFyZa4g10116	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10116	intact-crc:25CF7624833275C3|rigid:DfHURdagoxc9mR+I/zsGg1BHF/8	false	-	binding-associated region:1-246(MINT-1206022)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)