#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49354	uniprotkb:P49356	intact:EBI-602336|uniprotkb:Q9UDC1|uniprotkb:A6NJW0|uniprotkb:Q53XJ9|ensembl:ENSP00000303423	intact:EBI-602349|uniprotkb:B2RDX6|uniprotkb:B4E1A0|ensembl:ENSP00000246166	psi-mi:fnta_human(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:FNTA(gene name)|psi-mi:FNTA(display_short)	psi-mi:fntb_human(display_long)|uniprotkb:CAAX farnesyltransferase subunit beta(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit beta(gene name synonym)|uniprotkb:FNTB(gene name)|psi-mi:FNTB(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602363|rcsb pdb:1tn6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002018.1|ensembl:ENSG00000168522(gene)|ensembl:ENST00000302279(transcript)|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|mint:P49354|rcsb pdb:1JCQ|rcsb pdb:1LD7|rcsb pdb:1LD8|rcsb pdb:1MZC|rcsb pdb:1S63|rcsb pdb:1SA4|rcsb pdb:1TN6|rcsb pdb:2F0Y|rcsb pdb:2H6F|rcsb pdb:2H6G|rcsb pdb:2H6H|rcsb pdb:2H6I|rcsb pdb:2IEJ|rcsb pdb:3E37|reactome:R-HSA-111465|reactome:R-HSA-2514859|reactome:R-HSA-9648002	refseq:NP_002019.1|refseq:NP_001189487.1|ensembl:ENSG00000257365(gene)|ensembl:ENST00000246166(transcript)|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018342"(protein prenylation)|go:"GO:0018343"(protein farnesylation)|interpro:IPR001330(Prenyltransferase/squalene oxidase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR026872|mint:P49356|rcsb pdb:1JCQ|rcsb pdb:1LD7|rcsb pdb:1LD8|rcsb pdb:1MZC|rcsb pdb:1S63|rcsb pdb:1SA4|rcsb pdb:1TN6|rcsb pdb:2F0Y|rcsb pdb:2H6F|rcsb pdb:2H6G|rcsb pdb:2H6H|rcsb pdb:2H6I|rcsb pdb:2IEJ|rcsb pdb:3E37|reactome:R-HSA-2514859|reactome:R-HSA-9648002|go:"GO:0005965"(protein farnesyltransferase complex)	-	-	-	3d-resolution:1.80A|3d-r-factors:working 17.9%, free 19.9%|complex-properties:|isoform-comment:"the Rap2A peptide used does not match 100% the entry: DDPTASACNIQ"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:2VOoFRlMYQR1v9oiOKl1sktjaa09606	rogid:ye1bL25dNbpl0e1solLbDb5CaX49606	intact-crc:35CF65684CC9355D|rigid:WSifHg2fRAS0IB7kATPSi/Sr+ns	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49354	uniprotkb:P10114	intact:EBI-602336|uniprotkb:Q9UDC1|uniprotkb:A6NJW0|uniprotkb:Q53XJ9|ensembl:ENSP00000303423	intact:EBI-602366|uniprotkb:Q5JSC1|uniprotkb:Q5JSC2|uniprotkb:B2RCJ1|ensembl:ENSP00000245304	psi-mi:fnta_human(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:FNTA(gene name)|psi-mi:FNTA(display_short)	psi-mi:rap2a_human(display_long)|uniprotkb:RbBP-30(gene name synonym)|uniprotkb:RAP2A(gene name)|psi-mi:RAP2A(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602363|rcsb pdb:1tn6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002018.1|ensembl:ENSG00000168522(gene)|ensembl:ENST00000302279(transcript)|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|mint:P49354|rcsb pdb:1JCQ|rcsb pdb:1LD7|rcsb pdb:1LD8|rcsb pdb:1MZC|rcsb pdb:1S63|rcsb pdb:1SA4|rcsb pdb:1TN6|rcsb pdb:2F0Y|rcsb pdb:2H6F|rcsb pdb:2H6G|rcsb pdb:2H6H|rcsb pdb:2H6I|rcsb pdb:2IEJ|rcsb pdb:3E37|reactome:R-HSA-111465|reactome:R-HSA-2514859|reactome:R-HSA-9648002	refseq:NP_066361.1|ensembl:ENSG00000125249(gene)|ensembl:ENST00000245304(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035690"|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|rcsb pdb:1KAO|rcsb pdb:2RAP|rcsb pdb:3RAP	-	-	-	3d-resolution:1.80A|3d-r-factors:working 17.9%, free 19.9%|complex-properties:|isoform-comment:"the Rap2A peptide used does not match 100% the entry: DDPTASACNIQ"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:2VOoFRlMYQR1v9oiOKl1sktjaa09606	rogid:nPfR7R1+uJMxrtR91wD8gx/DKLY9606	intact-crc:35CF65684CC9355D|rigid:WSifHg2fRAS0IB7kATPSi/Sr+ns	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:Q02293	intact:EBI-602447	intact:EBI-602454|ensembl:ENSRNOP00000010588	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:fntb_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit beta(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit beta(gene name synonym)|uniprotkb:Fntb(gene name)|psi-mi:Fntb(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602505|rcsb pdb:1tn7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	ensembl:ENSRNOG00000007660(gene)|ensembl:ENSRNOT00000010588(transcript)|go:"GO:0004311"(farnesyltranstransferase activity)|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018342"(protein prenylation)|go:"GO:0018343"(protein farnesylation)|go:"GO:0034097"(response to cytokine)|rgd:620119|refseq:NP_742031.1|dip:DIP-6132N|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|interpro:IPR001330(Prenyltransferase/squalene oxidase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR026872|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|go:"GO:0042060"(wound healing)|rcsb pdb:1KZR|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR|reactome:R-RNO-2514859|reactome:R-RNO-9648002	-	-	-	3d-resolution:2.30A|3d-r-factors:working 18.0%, free 20.7%|complex-properties:|comment:"the TC21 peptide used does not match 100% the entry, it has been mutated to make it more soluble: KKSKTKCVIF"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:kKCkAYNev/B1QHIQnWf0hZLviAg10116	intact-crc:8C2C04D23C28936B|rigid:eqQVz8xOUebBFOMzbD6Jm1IH05Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:P62070	intact:EBI-602447	intact:EBI-491037|uniprotkb:P17082|uniprotkb:B2R9Z3|uniprotkb:B7Z6C4|uniprotkb:B7Z7H6|ensembl:ENSP00000256196|uniprotkb:B7Z5Z2	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:rras2_human(display_long)|uniprotkb:Ras-like protein TC21(gene name synonym)|uniprotkb:Teratocarcinoma oncogene(gene name synonym)|uniprotkb:RRAS2(gene name)|psi-mi:RRAS2(display_short)|uniprotkb:TC21(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602505|rcsb pdb:1tn7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	refseq:NP_036382.2|refseq:NP_001096139.1|refseq:NP_001170786.1|refseq:NP_001170785.1|ensembl:ENSG00000133818(gene)|ensembl:ENST00000256196(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:2ERY|reactome:R-HSA-9696273	-	-	-	3d-resolution:2.30A|3d-r-factors:working 18.0%, free 20.7%|complex-properties:|comment:"the TC21 peptide used does not match 100% the entry, it has been mutated to make it more soluble: KKSKTKCVIF"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:WW/YiKaC5t0Qy03E7LQTzpIP9BY9606	intact-crc:8C2C04D23C28936B|rigid:eqQVz8xOUebBFOMzbD6Jm1IH05Y	false	-	binding-associated region:?-?|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:Q02293	intact:EBI-602447	intact:EBI-602454|ensembl:ENSRNOP00000010588	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:fntb_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit beta(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit beta(gene name synonym)|uniprotkb:Fntb(gene name)|psi-mi:Fntb(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602542|rcsb pdb:1tn8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	ensembl:ENSRNOG00000007660(gene)|ensembl:ENSRNOT00000010588(transcript)|go:"GO:0004311"(farnesyltranstransferase activity)|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018342"(protein prenylation)|go:"GO:0018343"(protein farnesylation)|go:"GO:0034097"(response to cytokine)|rgd:620119|refseq:NP_742031.1|dip:DIP-6132N|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|interpro:IPR001330(Prenyltransferase/squalene oxidase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR026872|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|go:"GO:0042060"(wound healing)|rcsb pdb:1KZR|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR|reactome:R-RNO-2514859|reactome:R-RNO-9648002	-	-	-	3d-resolution:2.25A|3d-r-factors:working 19.3%, free 21.8%|complex-properties:|comment:"the H-Ras peptide used does not match 100% the entry: GCVLS"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:kKCkAYNev/B1QHIQnWf0hZLviAg10116	intact-crc:0A78171644557114|rigid:zDfjiB1zWLPd+SCOnLzP2z6gNbU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:P01112	intact:EBI-602447	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602542|rcsb pdb:1tn8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	-	-	-	3d-resolution:2.25A|3d-r-factors:working 19.3%, free 21.8%|complex-properties:|comment:"the H-Ras peptide used does not match 100% the entry: GCVLS"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	intact-crc:0A78171644557114|rigid:zDfjiB1zWLPd+SCOnLzP2z6gNbU	false	-	binding-associated region:?-?|mutation:185-185	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:Q02293	intact:EBI-602447	intact:EBI-602454|ensembl:ENSRNOP00000010588	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:fntb_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit beta(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit beta(gene name synonym)|uniprotkb:Fntb(gene name)|psi-mi:Fntb(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602577|rcsb pdb:1tno	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	ensembl:ENSRNOG00000007660(gene)|ensembl:ENSRNOT00000010588(transcript)|go:"GO:0004311"(farnesyltranstransferase activity)|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018342"(protein prenylation)|go:"GO:0018343"(protein farnesylation)|go:"GO:0034097"(response to cytokine)|rgd:620119|refseq:NP_742031.1|dip:DIP-6132N|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|interpro:IPR001330(Prenyltransferase/squalene oxidase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR026872|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|go:"GO:0042060"(wound healing)|rcsb pdb:1KZR|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR|reactome:R-RNO-2514859|reactome:R-RNO-9648002	-	-	-	3d-resolution:2.70A|3d-r-factors:working 19.4%, free 21.1%|complex-properties:|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:kKCkAYNev/B1QHIQnWf0hZLviAg10116	intact-crc:C13A5DE150228045|rigid:/IUYjZXx3AQ6Hz7tNrbxvKkaZ5k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:P01116-2	intact:EBI-602447	intact:EBI-367427|uniprotkb:P01118-1|ensembl:ENSP00000308495	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:p01116-2(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:RASK2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)|uniprotkb:K-Ras4B(isoform synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602577|rcsb pdb:1tno	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	intact:EBI-367415(rask_human)|ensembl:ENSG00000133703(gene)|ensembl:ENST00000311936(transcript)|uniprotkb:P01116-2(isoform-parent)	-	-	isoform-comment:"Variant in position: 152:V->G (in NS3). Variant in position: 153:D->V (in CFC2 and NS3, exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein). Variant in position: 156:F->I (in NS3/CFC2). Variant in position: 156:F->L (found in a patient with Costello syndrome, exhibits an increase in intrinsic and guanine nucleotide exchange factor catalyzed nucleotide exchange in combination with an impaired GTPase-activating protein-stimulated GTP hydrolysis but functional in interaction with effectors)."	3d-resolution:2.70A|3d-r-factors:working 19.4%, free 21.1%|complex-properties:|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:vHSaLYCo0d2r24erApiG/TCTmBc9606	intact-crc:C13A5DE150228045|rigid:/IUYjZXx3AQ6Hz7tNrbxvKkaZ5k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:Q02293	intact:EBI-602447	intact:EBI-602454|ensembl:ENSRNOP00000010588	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:fntb_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit beta(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit beta(gene name synonym)|uniprotkb:Fntb(gene name)|psi-mi:Fntb(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602597|rcsb pdb:1tnb	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	ensembl:ENSRNOG00000007660(gene)|ensembl:ENSRNOT00000010588(transcript)|go:"GO:0004311"(farnesyltranstransferase activity)|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018342"(protein prenylation)|go:"GO:0018343"(protein farnesylation)|go:"GO:0034097"(response to cytokine)|rgd:620119|refseq:NP_742031.1|dip:DIP-6132N|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|interpro:IPR001330(Prenyltransferase/squalene oxidase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR026872|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|go:"GO:0042060"(wound healing)|rcsb pdb:1KZR|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR|reactome:R-RNO-2514859|reactome:R-RNO-9648002	-	-	-	3d-resolution:2.85A|3d-r-factors:working 18.9%, free 21.0%|complex-properties:|comment:"the TC21 peptide used does not match 100% the entry, it has been mutated to make it more soluble: KKSKTKCVIF"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2016/03/15	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:kKCkAYNev/B1QHIQnWf0hZLviAg10116	intact-crc:F7657EECC138E5F3|rigid:Ket6xq8qTgtg7wStaEnrfZRchV0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	intact:EBI-11621988	intact:EBI-602447	-	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:tc21(display_short)|psi-mi:EBI-11621988(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602597|rcsb pdb:1tnb	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	-	-	-	-	3d-resolution:2.85A|3d-r-factors:working 18.9%, free 21.0%|complex-properties:|comment:"the TC21 peptide used does not match 100% the entry, it has been mutated to make it more soluble: KKSKTKCVIF"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2016/03/15	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:jEIFJcYGEX93CUc8BE0QUSpFPX49606	intact-crc:F7657EECC138E5F3|rigid:Ket6xq8qTgtg7wStaEnrfZRchV0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:P53610	intact:EBI-602447	intact:EBI-602610|ensembl:ENSRNOP00000004723	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:pgtb1_rat(display_long)|uniprotkb:Geranylgeranyl transferase type I subunit beta(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit beta(gene name synonym)|uniprotkb:Pggt1b(gene name)|psi-mi:Pggt1b(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602623|rcsb pdb:1tnb	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	rgd:621754|refseq:NP_112344.1|dip:DIP-33953N|ensembl:ENSRNOG00000003541(gene)|ensembl:ENSRNOT00000004723(transcript)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018342"(protein prenylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|interpro:IPR001330(Prenyltransferase/squalene oxidase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR041960|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1S64|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ	-	-	-	3d-resolution:2.85A|3d-r-factors:working 18.9%, free 21.0%|complex-properties:|comment:"the TC21 peptide used does not match 100% the entry, it has been mutated to make it more soluble: KKKSKTKCVIF"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:HMmkJChHJBKSr0qvcEMgjITMZBk10116	intact-crc:ED66EF2BF0C41DBA|rigid:/JRB6bK+nQDUXxcOqLGEy6/r9J8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:P62070	intact:EBI-602447	intact:EBI-491037|uniprotkb:P17082|uniprotkb:B2R9Z3|uniprotkb:B7Z6C4|uniprotkb:B7Z7H6|ensembl:ENSP00000256196|uniprotkb:B7Z5Z2	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:rras2_human(display_long)|uniprotkb:Ras-like protein TC21(gene name synonym)|uniprotkb:Teratocarcinoma oncogene(gene name synonym)|uniprotkb:RRAS2(gene name)|psi-mi:RRAS2(display_short)|uniprotkb:TC21(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602623|rcsb pdb:1tnb	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	refseq:NP_036382.2|refseq:NP_001096139.1|refseq:NP_001170786.1|refseq:NP_001170785.1|ensembl:ENSG00000133818(gene)|ensembl:ENST00000256196(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:2ERY|reactome:R-HSA-9696273	-	-	-	3d-resolution:2.85A|3d-r-factors:working 18.9%, free 21.0%|complex-properties:|comment:"the TC21 peptide used does not match 100% the entry, it has been mutated to make it more soluble: KKKSKTKCVIF"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:WW/YiKaC5t0Qy03E7LQTzpIP9BY9606	intact-crc:ED66EF2BF0C41DBA|rigid:/JRB6bK+nQDUXxcOqLGEy6/r9J8	false	-	binding-associated region:?-?|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01116-2	uniprotkb:Q04631	intact:EBI-367427|uniprotkb:P01118-1|ensembl:ENSP00000308495	intact:EBI-602447	psi-mi:p01116-2(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:RASK2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)|uniprotkb:K-Ras4B(isoform synonym)	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602641|rcsb pdb:1tno	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-367415(rask_human)|ensembl:ENSG00000133703(gene)|ensembl:ENST00000311936(transcript)|uniprotkb:P01116-2(isoform-parent)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	-	isoform-comment:"Variant in position: 152:V->G (in NS3). Variant in position: 153:D->V (in CFC2 and NS3, exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein). Variant in position: 156:F->I (in NS3/CFC2). Variant in position: 156:F->L (found in a patient with Costello syndrome, exhibits an increase in intrinsic and guanine nucleotide exchange factor catalyzed nucleotide exchange in combination with an impaired GTPase-activating protein-stimulated GTP hydrolysis but functional in interaction with effectors)."	-	caution:"The participant EBI-602447(Q04631) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|3d-resolution:2.70A|3d-r-factors:working 19.4%, free 21.1%|complex-properties:|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:vHSaLYCo0d2r24erApiG/TCTmBc9606	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	intact-crc:1CBF275FED70641F|rigid:L0utYuKLgsozhrDu0KqRWqud5f0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q04631	uniprotkb:P62745	intact:EBI-602447	intact:EBI-602647|uniprotkb:P01121|uniprotkb:Q5U0H6|uniprotkb:Q7RTN5|uniprotkb:Q7RTR9|uniprotkb:Q9CUV7|uniprotkb:B2R692|ensembl:ENSP00000272233	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:rhob_human(display_long)|uniprotkb:Rho cDNA clone 6(gene name synonym)|uniprotkb:RHOB(gene name)|psi-mi:RHOB(display_short)|uniprotkb:ARH6(gene name synonym)|uniprotkb:ARHB(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602673|rcsb pdb:1tnu	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	refseq:NP_004031.1|ensembl:ENSG00000143878(gene)|ensembl:ENST00000272233(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010008"(endosome membrane)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62745|rcsb pdb:2FV8|rcsb pdb:6HXU|rcsb pdb:6SGE|reactome:R-HSA-114604|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-9013026|interpro:IPR003578(Ras small GTPase, Rho type)	-	-	-	caution:"The participant EBI-602447(Q04631) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|3d-resolution:2.70A|3d-r-factors:working 19.3%, free 21.2%|complex-properties:|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	rogid:Ek7MCYtpm3JJ78E6nwU/Q9rWZmQ9606	intact-crc:7718B52ED66DF34B|rigid:D6Fk2IFaM3k4YxIwJfgGVtn2BLQ	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P59768	uniprotkb:Q04631	intact:EBI-602681|uniprotkb:Q6P9A9|uniprotkb:Q5JPE2|ensembl:ENSP00000334448|ensembl:ENSP00000451102|ensembl:ENSP00000451231|ensembl:ENSP00000451576|ensembl:ENSP00000452014|ensembl:ENSP00000484021	intact:EBI-602447	psi-mi:gbg2_human(display_long)|uniprotkb:G gamma-I(gene name synonym)|uniprotkb:GNG2(gene name)|psi-mi:GNG2(display_short)	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602690|rcsb pdb:1tny	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230702.1|refseq:NP_001230703.1|refseq:NP_444292.1|refseq:XP_011535148.1|refseq:XP_016876865.1|refseq:XP_016876866.1|refseq:XP_006720236.1|dip:DIP-33949N|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WWZ|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX3|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|rcsb pdb:7MBX|rcsb pdb:7MBY|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENSG00000186469(gene)|ensembl:ENST00000335281(transcript)|ensembl:ENST00000554736(transcript)|ensembl:ENST00000555472(transcript)|ensembl:ENST00000556752(transcript)|ensembl:ENST00000556766(transcript)|ensembl:ENST00000615906(transcript)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|rcsb pdb:6KPF|rcsb pdb:6KPG|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6K42|rcsb pdb:6OS9|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:4KFM|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6K41	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	-	-	-	caution:"The participant EBI-602447(Q04631) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|3d-resolution:2.70A|3d-r-factors:working 19.3%, free 21.2%|complex-properties:|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:8asTjDtSU6sCPSMwcXMbV340Rt49606	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	intact-crc:8CECAC58C702182E|rigid:eUTOOyK21f+YHc900QL2o3O6dlA	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60953-2	uniprotkb:Q04631	intact:EBI-287394|uniprotkb:P21181-4|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-602447	psi-mi:p60953-2(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)|uniprotkb:Placental(isoform synonym)	psi-mi:fnta_rat(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Fnta(gene name)|psi-mi:Fnta(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Reid et al. (2004)	pubmed:15451670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602701|rcsb pdb:1tnz	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-81752(cdc42_human)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)	rgd:2625|refseq:NP_036979.1|reactome:R-RNO-9648002|reactome:R-RNO-111465|reactome:R-RNO-2514859|dip:DIP-6131N|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1FPP|rcsb pdb:1FT1|rcsb pdb:1FT2|rcsb pdb:1FTI|rcsb pdb:1HZ7|rcsb pdb:1JCR|rcsb pdb:1JCS|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1KZR|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:1N94|rcsb pdb:1N95|rcsb pdb:1N9A|rcsb pdb:1NI1|rcsb pdb:1NL4|rcsb pdb:1O1R|rcsb pdb:1O1S|rcsb pdb:1O1T|rcsb pdb:1O5M|rcsb pdb:1QBQ|rcsb pdb:1QE2|rcsb pdb:1S64|rcsb pdb:1SA5|rcsb pdb:1TN7|rcsb pdb:1TN8|rcsb pdb:1TNB|rcsb pdb:1TNO|rcsb pdb:1TNU|rcsb pdb:1TNY|rcsb pdb:1TNZ|rcsb pdb:1X81|rcsb pdb:2BED|rcsb pdb:2FTI|rcsb pdb:2R2L|rcsb pdb:2ZIR|rcsb pdb:2ZIS|rcsb pdb:3DPY|rcsb pdb:3E30|rcsb pdb:3E32|rcsb pdb:3E33|rcsb pdb:3E34|rcsb pdb:3EU5|rcsb pdb:3EUV|rcsb pdb:3FTI|rcsb pdb:3KSL|rcsb pdb:3KSQ|rcsb pdb:3PZ4|rcsb pdb:4GTM|rcsb pdb:4GTO|rcsb pdb:4GTP|rcsb pdb:4GTQ|rcsb pdb:4GTR	-	-	-	caution:"The participant EBI-602447(Q04631) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|3d-resolution:2.90A|3d-r-factors:working 19.9%, free 21.8%|complex-properties:|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/06/15	2014/10/16	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:UqizMu5QoGM8WNj6siMYHNrE41Y10116	intact-crc:7A770AC55FAF15CD|rigid:iKD9w7U2PeGGhZn5+7xkxyvFz80	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)