#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q804T2 uniprotkb:Q91569 intact:EBI-7313630|intact:MINT-1205148 intact:EBI-3645511 psi-mi:q804t2_xenla(display_long)|uniprotkb:mark3.L(gene name)|psi-mi:mark3.L(display_short)|uniprotkb:mark3(gene name synonym) psi-mi:q91569_xenla(display_long)|uniprotkb:prkci.L(gene name)|psi-mi:prkci.L(display_short)|uniprotkb:prkci(gene name synonym) psi-mi:"MI:0045"(experimental interaction detection) Kusakabe et al. (2004) pubmed:15343271|imex:IM-13897|mint:MINT-5217183 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7313623|mint:MINT-51169|imex:IM-13897-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR033628|interpro:IPR028375|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001084256.1|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0005524"(ATP binding)|go:"GO:0030425"(dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:MINT-1205170(identity) interpro:IPR034877|interpro:IPR017892|interpro:IPR034661|refseq:NP_001084068.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:MINT-1205163(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3|resulting-ptm:phosphorylation@593 alanine scanning|resulting-ptm:phosphorylation@646 alanine scanning|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/01/26 2014/10/16 rogid:nCEBBDniJWylxV2+kSuCSh1oavU8355 rogid:yZOSeH4hmdgnF6NXuV7EV/qaYi88355 intact-crc:6ABC8A623D288820|rigid:J3VG1wgnhoiifMkXj7At2H4Q3H8 false tag:?-?(MINT-1205171) tag:?-?(MINT-1205164) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O57468 uniprotkb:Q804T2 intact:EBI-6993118|intact:MINT-92096 intact:EBI-7313630|intact:MINT-1205148 psi-mi:o57468_xenla(display_long)|uniprotkb:ywhae.S(gene name)|psi-mi:ywhae.S(display_short)|uniprotkb:ywhae(gene name synonym)|uniprotkb:XELAEV_18014582mg(orf name) psi-mi:q804t2_xenla(display_long)|uniprotkb:mark3.L(gene name)|psi-mi:mark3.L(display_short)|uniprotkb:mark3(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Kusakabe et al. (2004) pubmed:15343271|imex:IM-13897|mint:MINT-5217183 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7313688|mint:MINT-51166|imex:IM-13897-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|refseq:NP_001080705.1|interpro:IPR023410|interpro:IPR036815|mint:MINT-1205202(identity) interpro:IPR033628|interpro:IPR028375|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001084256.1|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0005524"(ATP binding)|go:"GO:0030425"(dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:MINT-1205215(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" comment:"PKC activity is required for the binding of Par-1 to 14-3-3. PKC inhibitors (Staurosporine and Bis I) negatively affect the binding of Par-1 to 14-3-3 (F2D)"|figure legend:F2A F2B F2D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/01/26 2014/10/16 rogid:aheyncyigwZXhSFEKIVYAWFMk6E8355 rogid:nCEBBDniJWylxV2+kSuCSh1oavU8355 intact-crc:7239C0F9E6211EED|rigid:Y5MIflznDCJlWicRs7WmxaJ1Hfk false mutation disrupting interaction:199-199(MINT-1205206)|tag:?-?(MINT-1205210)|binding-associated region:1-255(MINT-1205203)|mutation disrupting interaction:183-183|mutation decreasing interaction:214-214 tag:?-?(MINT-1205216) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O57468 uniprotkb:Q8QGV3 intact:EBI-6993118|intact:MINT-92096 intact:EBI-12556945 psi-mi:o57468_xenla(display_long)|uniprotkb:ywhae.S(gene name)|psi-mi:ywhae.S(display_short)|uniprotkb:ywhae(gene name synonym)|uniprotkb:XELAEV_18014582mg(orf name) psi-mi:q8qgv3_xenla(display_long)|uniprotkb:mark2.L(gene name)|psi-mi:mark2.L(display_short)|uniprotkb:MARK2(gene name synonym)|uniprotkb:mark2(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Kusakabe et al. (2004) pubmed:15343271|imex:IM-13897|mint:MINT-5217183 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7313757|mint:MINT-51170|imex:IM-13897-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|refseq:NP_001080705.1|interpro:IPR023410|interpro:IPR036815|mint:MINT-1205193(identity) go:"GO:0005524"(ATP binding)|go:"GO:0030425"(dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:NP_001080425.1|interpro:IPR028375|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|mint:MINT-1205184(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2005/01/26 2016/10/10 rogid:aheyncyigwZXhSFEKIVYAWFMk6E8355 rogid:PwQkXXQ136KWj/Vxhe7r64/IP/48355 intact-crc:DB078F4001FD908E|rigid:mARGm1Lm3Z3hoIwUWzTgGre2pZE false tag:?-?(MINT-1205194) mutation disrupting interaction:646-646(MINT-1205185)|tag:?-?(MINT-1205188)|mutation disrupting interaction:646-646,593-593|mutation disrupting interaction:593-593 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)