#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13873	uniprotkb:P07759	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527318|uniprotkb:Q62257|uniprotkb:Q8VCH3|uniprotkb:Q91W80|uniprotkb:Q91X80	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:spa3k_mouse(display_long)|uniprotkb:Contrapsin(gene name synonym)|uniprotkb:SPI-2(gene name synonym)|uniprotkb:Serpina3k(gene name)|psi-mi:Serpina3k(display_short)|uniprotkb:Mcm2(gene name synonym)|uniprotkb:Spi2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	interpro:IPR042178|interpro:IPR042185|interpro:IPR036186|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_035588.2|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|mint:P07759	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:Mw34ptn1r1vYkkikLF0wyI/1rR410090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q8R298	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527344|ensembl:ENSMUSP00000078579|ensembl:ENSMUSP00000157848	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:q8r298_mouse(display_long)|uniprotkb:Vmn1r234(gene name)|psi-mi:Vmn1r234(display_short)|uniprotkb:V1rf1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_598959.1|ensembl:ENSMUSG00000057203(gene)|ensembl:ENSMUST00000079633(transcript)|ensembl:ENSMUST00000235895(transcript)|go:"GO:0005550"(pheromone binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016503"(pheromone receptor activity)|go:"GO:0019236"(response to pheromone)|interpro:IPR004072(Vomeronasal receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:qmQdGfRmNTDkMBl6X4KvQACqPy410090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q9CZ01	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527336	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:q9cz01_mouse(display_long)|uniprotkb:Zfp788(gene name)|psi-mi:Zfp788(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	interpro:IPR036236|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:eVYDxN+8HK0Bb4jZyuH2f3Pm7G410090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:P99024	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-350896|uniprotkb:P05218|uniprotkb:Q3TFB6|uniprotkb:Q3THH9|uniprotkb:Q3TIL1|uniprotkb:Q3UAV4|uniprotkb:Q3UF52|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|uniprotkb:B1B178|ensembl:ENSMUSP00000001566	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:tbb5_mouse(display_long)|uniprotkb:Tubb5(gene name)|psi-mi:Tubb5(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_035785.1|interpro:IPR023123|interpro:IPR036525|interpro:IPR018316|interpro:IPR037103|mint:P99024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6798695|reactome:R-MMU-8854518|ensembl:ENSMUSG00000001525(gene)|ensembl:ENSMUST00000001566(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051225"(spindle assembly)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q6ZQF0	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527248|uniprotkb:Q6P6P0|uniprotkb:Q80Y33|uniprotkb:Q8BUI0|uniprotkb:Q8BUK1|uniprotkb:Q8R348|uniprotkb:Q91VX3|uniprotkb:Q922X8|ensembl:ENSMUSP00000035164	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:topb1_mouse(display_long)|uniprotkb:DNA topoisomerase II-binding protein 1(gene name synonym)|uniprotkb:Topbp1(gene name)|psi-mi:Topbp1(display_short)|uniprotkb:Kiaa0259(gene name synonym)|uniprotkb:DNA topoisomerase II-beta-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_795953.2|ensembl:ENSMUSG00000032555(gene)|ensembl:ENSMUST00000035164(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR044737|rcsb pdb:5U6K|reactome:R-MMU-5685938|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69473|refseq:XP_006511770.1	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:5LhKSrOCf8HROVlXy9mKpHmdPqE10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:P68404	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q91WJ0	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527215|ensembl:ENSMUSP00000108921	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:frs3_mouse(display_long)|uniprotkb:FRS2-beta(gene name synonym)|uniprotkb:Frs3(gene name)|psi-mi:Frs3(display_short)|uniprotkb:Frs2b(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	ensembl:ENSMUSG00000023266(gene)|ensembl:ENSMUST00000113296(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|reactome:R-MMU-5654693|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273|refseq:NP_659188.1|refseq:XP_006523531.1|refseq:XP_006523532.1	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:Zk+c/fbZSq3bpikfHTna9g2T1cw10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:P49891	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527242	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:st1e1_mouse(display_long)|uniprotkb:Sulfotransferase, estrogen-preferring(gene name synonym)|uniprotkb:Sult1e1(gene name)|psi-mi:Sult1e1(display_short)|uniprotkb:Ste(gene name synonym)|uniprotkb:Est(gene name synonym)|uniprotkb:Estrogen sulfotransferase, testis isoform(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	interpro:IPR000863(Sulphotransferase)|rcsb pdb:1AQU|rcsb pdb:1AQY|rcsb pdb:1BO6|go:"GO:0004062"(aryl sulfotransferase activity)|go:"GO:0004304"(estrone sulfotransferase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006068"(ethanol catabolic process)|go:"GO:0006711"(estrogen catabolic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0008146"(sulfotransferase activity)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0047894"(flavonol 3-sulfotransferase activity)|go:"GO:0050294"(steroid sulfotransferase activity)|go:"GO:0050427"(3'-phosphoadenosine 5'-phosphosulfate metabolic process)|go:"GO:0051923"(sulfation)|reactome:R-MMU-156584|interpro:IPR027417	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:tmOV1A1bF43VAZ1hZc5SQDd94Qg10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q9Z0L3-5	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527302	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:q9z0l3-5(display_long)|uniprotkb:Oc90(gene name)|psi-mi:Oc90(display_short)|uniprotkb:Onc-95(gene name synonym)|uniprotkb:Pla2ll(gene name synonym)|uniprotkb:Otoconin-95(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	intact:EBI-527274(oc90_mouse)	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:wQzbS1P9w/7Ua5MRnxCRtzLtOds10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:P23927	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-299046|ensembl:ENSMUSP00000034562|ensembl:ENSMUSP00000149759|ensembl:ENSMUSP00000149803|ensembl:ENSMUSP00000150669|uniprotkb:Q64325	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:cryab_mouse(display_long)|uniprotkb:Cryab(gene name)|psi-mi:Cryab(display_short)|uniprotkb:Crya2(gene name synonym)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:P23(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	ensembl:ENSMUSG00000032060(gene)|ensembl:ENSMUST00000034562(transcript)|ensembl:ENSMUST00000214962(transcript)|ensembl:ENSMUST00000216755(transcript)|ensembl:ENSMUST00000217475(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043292"(contractile fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P23927|reactome:R-MMU-3371571|refseq:XP_006510033.1|refseq:NP_034094.1|refseq:NP_001276711.1|refseq:NP_001276713.1|refseq:NP_001276714.1|dip:DIP-31060N	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:LOp5smbeRceV8/P+Eaoh7p+24Vw10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:P50428	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527264|uniprotkb:Q9DC66|ensembl:ENSMUSP00000127646	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:arsa_mouse(display_long)|uniprotkb:Cerebroside-sulfatase(gene name synonym)|uniprotkb:Arsa(gene name)|psi-mi:Arsa(display_short)|uniprotkb:As2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_033843.2|go:"GO:0008484"(sulfuric ester hydrolase activity)|go:"GO:0009268"(response to pH)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0051597"(response to methylmercury)|interpro:IPR000917(Sulphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR024607|mint:P50428|reactome:R-MMU-1660662|reactome:R-MMU-1663150|reactome:R-MMU-6798695|ensembl:ENSMUSG00000022620(gene)|ensembl:ENSMUST00000165199(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004065"(arylsulfatase activity)|go:"GO:0004098"(cerebroside-sulfatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007417"(central nervous system development)|go:"GO:0007584"(response to nutrient)	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:1bll3gqFxqCr/dJ0pO7EwsZCVQo10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:O35607	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527224|ensembl:ENSMUSP00000084701	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:bmpr2_mouse(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:BRK-3(gene name synonym)|uniprotkb:Bmpr2(gene name)|psi-mi:Bmpr2(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	ensembl:ENSMUSG00000067336(gene)|ensembl:ENSMUST00000087435(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|refseq:NP_031587.1|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000333(Activin type II receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O35607|reactome:R-MMU-201451	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:4Dbgj6TEhtrX/9jydmufYNfEh1M10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:O88712	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-604547|ensembl:ENSMUSP00000078682|uniprotkb:Q3TAT1|uniprotkb:Q3TDL5|uniprotkb:Q3TUM5|uniprotkb:Q91WI6|uniprotkb:Q91YX3|uniprotkb:Q9QYG2	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:ctbp1_mouse(display_long)|uniprotkb:Ctbp1(gene name)|psi-mi:Ctbp1(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0051726"(regulation of cell cycle)|ensembl:ENSMUSG00000037373(gene)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|ensembl:ENSMUST00000079746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029752|go:"GO:0003682"(chromatin binding)|interpro:IPR029753|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR036291|go:"GO:0005737"(cytoplasm)|interpro:IPR043322|go:"GO:0006342"|mint:O88712|reactome:R-MMU-3769402|reactome:R-MMU-3899300|reactome:R-MMU-4641265|go:"GO:0008134"(transcription factor binding)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|refseq:NP_001185788.1|refseq:NP_001185789.1|refseq:NP_001185790.1|refseq:NP_038530.1|refseq:NP_001297464.1|dip:DIP-33907N	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:l2rq9ypazCscM/WbocEKgQZcEBo10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q9D6Z1	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527254|uniprotkb:Q3UD45|uniprotkb:Q8BVL1|uniprotkb:Q8VDT2|uniprotkb:Q99LT8|uniprotkb:Q9CT15|ensembl:ENSMUSP00000099487	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:nop56_mouse(display_long)|uniprotkb:Nop56(gene name)|psi-mi:Nop56(display_short)|uniprotkb:Nol5a(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_077155.2|ensembl:ENSMUSG00000027405(gene)|ensembl:ENSMUST00000103198(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:Q9D6Z1|reactome:R-MMU-6791226	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:5darNL7hBt/XPnvcm0hiVxx7WDY10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q99KG1	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527329	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:q99kg1_mouse(display_long)|uniprotkb:Hnrpr(gene name synonym)|uniprotkb:Hnrnpr(gene name)|psi-mi:Hnrnpr(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	interpro:IPR035979|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043679"(axon terminus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR034411|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR041337	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:MddJ/OWsImjwkinNBYG8E3Bf2JY10090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:P08607	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527325|uniprotkb:Q91X48|ensembl:ENSMUSP00000027657	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:c4bpa_mouse(display_long)|uniprotkb:C4bpa(gene name)|psi-mi:C4bpa(display_short)|uniprotkb:C4bp(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527210	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:XP_011246208.1|ensembl:ENSMUSG00000026405(gene)|ensembl:ENSMUST00000027657(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|mint:P08607|refseq:NP_031602.3	go:"GO:0030509"(BMP signaling pathway)	-	-	caution:"The participant EBI-527224(O35607) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-350896(P99024) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:iA1cRxMsz2QEIk3GEhT5YlNnM3010090	intact-crc:9B36233E6B16D2DC|rigid:KRt4wFe9vddCsNdSrXc66c9BEDw	false	binding-associated region:175-529(IPR000719)|glutathione s tranferase tag:n-n|glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q61056	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527610|uniprotkb:O35722	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:trpc1_mouse(display_long)|uniprotkb:Transient receptor protein 1(gene name synonym)|uniprotkb:Trp-related protein 1(gene name synonym)|uniprotkb:Trpc1(gene name)|psi-mi:Trpc1(display_short)|uniprotkb:Trp1(gene name synonym)|uniprotkb:Trrp1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	dip:DIP-33928N|refseq:NP_001298052.1|refseq:NP_035773.1|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043034"(costamere)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046541"(saliva secretion)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-MMU-3295583|reactome:R-MMU-5578775|reactome:R-MMU-983695	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:ffnovDVdw3HKGX/dtbo5gVu27kc10090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q07174	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-309771|ensembl:ENSMUSP00000025078	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:m3k8_mouse(display_long)|uniprotkb:Map3k8(gene name)|psi-mi:Map3k8(display_short)|uniprotkb:Cot(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)|uniprotkb:Tpl2(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_031772.1|ensembl:ENSMUSG00000024235(gene)|go:"GO:0007049"(cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENSMUST00000025078(transcript)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|reactome:R-MMU-389357|reactome:R-MMU-5684264|go:"GO:0002376"(immune system process)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:iIYjcxEFNTRfKgArCfTKH9Frf+410090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q64731	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527449|ensembl:ENSMUSP00000137732|uniprotkb:B2RQ86	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:foxl1_mouse(display_long)|uniprotkb:Forkhead-related protein FKHL11(gene name synonym)|uniprotkb:Transcription factor FKH-6(gene name synonym)|uniprotkb:Foxl1(gene name)|psi-mi:Foxl1(display_short)|uniprotkb:Fkh6(gene name synonym)|uniprotkb:Fkhl11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	ensembl:ENSMUSG00000097084(gene)|ensembl:ENSMUST00000181609(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007495"(visceral mesoderm-endoderm interaction involved in midgut development)|go:"GO:0007507"(heart development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061146"(Peyer's patch morphogenesis)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_032050.2	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:MEkTxU4u+f5vs+KLg7lmfV7BSJU10090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q9JHK4	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527539|uniprotkb:Q9JLX2|ensembl:ENSMUSP00000128668|ensembl:ENSMUSP00000133032|ensembl:ENSMUSP00000154725	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:pgta_mouse(display_long)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym)|uniprotkb:Rab geranylgeranyltransferase subunit alpha(gene name synonym)|uniprotkb:Rab geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Rabggta(gene name)|psi-mi:Rabggta(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_062392.1|ensembl:ENSMUSG00000040472(gene)|ensembl:ENSMUST00000163889(transcript)|ensembl:ENSMUST00000169237(transcript)|ensembl:ENSMUST00000227061(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR032675|interpro:IPR032955|interpro:IPR036254|reactome:R-MMU-6803205|reactome:R-MMU-8873719|refseq:XP_006519357.1|refseq:XP_006519358.1	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:/Yl79eDn96BBOfsvVHz8KboYxF810090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q9DA73	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527437|ensembl:ENSMUSP00000060309	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:ccd89_mouse(display_long)|uniprotkb:Ccdc89(gene name)|psi-mi:Ccdc89(display_short)|uniprotkb:Boip(gene name synonym)|uniprotkb:Bc8 orange-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_081574.1|ensembl:ENSMUSG00000044362(gene)|ensembl:ENSMUST00000061391(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR043450|mint:Q9DA73	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:6GbE22BdHgQg6zAR/3KnHTLiWrc10090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q91YR1	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527441|uniprotkb:Q52L77|uniprotkb:Q80X09|uniprotkb:O09132|ensembl:ENSMUSP00000023087	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:twf1_mouse(display_long)|uniprotkb:Protein A6(gene name synonym)|uniprotkb:Twf1(gene name)|psi-mi:Twf1(display_short)|uniprotkb:Ptk9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	dip:DIP-33923N|refseq:NP_032997.3|ensembl:ENSMUSG00000022451(gene)|ensembl:ENSMUST00000023087(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043538"(regulation of actin phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028458|interpro:IPR029006|mint:Q91YR1|rcsb pdb:1M4J|rcsb pdb:2D8B|rcsb pdb:2HD7|rcsb pdb:3DAW|rcsb pdb:6RSW|rcsb pdb:6YP9|rcsb pdb:7DS2|rcsb pdb:7DS4|rcsb pdb:7DS6|rcsb pdb:7DS8|rcsb pdb:7DSB|reactome:R-MMU-9013418	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:GgCN343v3YPfA5sIWax5s80Yjuc10090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:P19973	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527499|uniprotkb:P97339|uniprotkb:Q04950|uniprotkb:Q62022|uniprotkb:Q62023|uniprotkb:Q62024|uniprotkb:Q8CD28|uniprotkb:Q99L65|uniprotkb:A2A6J5|uniprotkb:A2A6J6|ensembl:ENSMUSP00000018963|ensembl:ENSMUSP00000101588	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:lsp1_mouse(display_long)|uniprotkb:52 kDa phosphoprotein(gene name synonym)|uniprotkb:Lymphocyte-specific antigen WP34(gene name synonym)|uniprotkb:S37 protein(gene name synonym)|uniprotkb:Lsp1(gene name)|psi-mi:Lsp1(display_short)|uniprotkb:Pp52(gene name synonym)|uniprotkb:S37(gene name synonym)|uniprotkb:Wp34(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_001258437.1|refseq:NP_001258439.1|refseq:NP_001129543.1|refseq:NP_062264.1|ensembl:ENSMUSG00000018819(gene)|ensembl:ENSMUST00000018963(transcript)|ensembl:ENSMUST00000105968(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR002211(Lymphocyte-specific protein)|interpro:IPR006018(Caldesmon and lymphocyte specific protein)|mint:P19973	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:z1O5bTtKNXWpE7NpZK5XiSCowps10090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q9DC61	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527530|uniprotkb:Q3TF19|ensembl:ENSMUSP00000075762	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:mppa_mouse(display_long)|uniprotkb:Alpha-MPP(gene name synonym)|uniprotkb:P-55(gene name synonym)|uniprotkb:Pmpca(gene name)|psi-mi:Pmpca(display_short)|uniprotkb:Inpp5e(gene name synonym)|uniprotkb:Inactive zinc metalloprotease alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_775272.1|ensembl:ENSMUSG00000026926(gene)|ensembl:ENSMUST00000076431(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006508"(proteolysis)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR037715|mint:Q9DC61|reactome:R-MMU-8949664	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:gNx6vEfGhgEGltOqH5c1g62tvjg10090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:P00536	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527464|uniprotkb:F6UHW1|uniprotkb:Q61886|uniprotkb:Q61887|uniprotkb:Q78EH5|uniprotkb:E9PV67|ensembl:ENSMUSP00000100789	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:mos_mouse(display_long)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Mos(gene name)|psi-mi:Mos(display_short)|uniprotkb:Proto-oncogene c-Mos(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_064405.2|ensembl:ENSMUSG00000078365(gene)|ensembl:ENSMUST00000105158(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:LFnif9JWSc5HUPuLh9QreMwPWo810090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q69ZS0	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527557|uniprotkb:Q91Z03|uniprotkb:Q9QY54|uniprotkb:Q9QY55|ensembl:ENSMUSP00000075376	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:pzrn3_mouse(display_long)|uniprotkb:Semaphorin cytoplasmic domain-associated protein 3(gene name synonym)|uniprotkb:Pdzrn3(gene name)|psi-mi:Pdzrn3(display_short)|uniprotkb:Kiaa1095(gene name synonym)|uniprotkb:Semcap3(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PDZRN3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_061372.2|ensembl:ENSMUSG00000035357(gene)|ensembl:ENSMUST00000075994(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:6DNBma4UhPxDp0pSa41YPlVXAPE10090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q9JK48	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527471|uniprotkb:Q6A059|uniprotkb:Q8CDS9|uniprotkb:Q8VI52|uniprotkb:Q9CT31|uniprotkb:Q3TYR7|ensembl:ENSMUSP00000129800	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:shlb1_mouse(display_long)|uniprotkb:Kiaa0491(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein B1(gene name synonym)|uniprotkb:Sh3glb1(gene name)|psi-mi:Sh3glb1(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527429	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_062337.1|ensembl:ENSMUSG00000037062(gene)|ensembl:ENSMUST00000163279(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042171"(lysophosphatidic acid acyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0090148"(membrane fission)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028503|interpro:IPR035695|interpro:IPR036028|mint:Q9JK48|rcsb pdb:1X43|refseq:NP_001268966.1|refseq:NP_001268971.1	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2019/07/08	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:NTyirT004c0cotBvIxsLVQz9a+A10090	intact-crc:E7EAE2012AECD3E3|rigid:98oFZkpMK1DVawXJkyP8zbvoMEk	false	binding-associated region:501-1038|glutathione s tranferase tag:n-n|flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q07174	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-309771|ensembl:ENSMUSP00000025078	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:m3k8_mouse(display_long)|uniprotkb:Map3k8(gene name)|psi-mi:Map3k8(display_short)|uniprotkb:Cot(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)|uniprotkb:Tpl2(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527684	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_031772.1|ensembl:ENSMUSG00000024235(gene)|go:"GO:0007049"(cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENSMUST00000025078(transcript)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|reactome:R-MMU-389357|reactome:R-MMU-5684264|go:"GO:0002376"(immune system process)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:iIYjcxEFNTRfKgArCfTKH9Frf+410090	intact-crc:82B5E16C49092F7F|rigid:gKTiwErnWuc+ZdIpBV6Ll7FP2xU	false	his tag:c-c|glutathione s tranferase tag:n-n|binding-associated region:175-1038	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q60805	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527716|uniprotkb:Q62194|ensembl:ENSMUSP00000014505	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:mertk_mouse(display_long)|uniprotkb:Receptor tyrosine kinase MerTK(gene name synonym)|uniprotkb:Mertk(gene name)|psi-mi:Mertk(display_short)|uniprotkb:Mer(gene name synonym)|uniprotkb:Proto-oncogene c-Mer(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527684	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_032613.1|ensembl:ENSMUSG00000014361(gene)|ensembl:ENSMUST00000014505(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006909"(phagocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0016028"(rhabdomere)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060068"(vagina development)|go:"GO:0097350"(neutrophil clearance)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|reactome:R-MMU-202733	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:3qKC2IBJSQJFZwrK4Hjh2KcIMWo10090	intact-crc:82B5E16C49092F7F|rigid:gKTiwErnWuc+ZdIpBV6Ll7FP2xU	false	his tag:c-c|glutathione s tranferase tag:n-n|binding-associated region:175-1038	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q8VCT4	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527705|uniprotkb:Q91ZV9|uniprotkb:Q924V8|uniprotkb:Q9ULY1|ensembl:ENSMUSP00000034172	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:est1d_mouse(display_long)|uniprotkb:Ces1d(gene name)|psi-mi:Ces1d(display_short)|uniprotkb:Carboxylesterase 3(gene name synonym)|uniprotkb:Ces1(gene name synonym)|uniprotkb:Ces3(gene name synonym)|uniprotkb:Fatty acid ethyl ester synthase(gene name synonym)|uniprotkb:Triacylglycerol hydrolase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527684	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_444430.2|ensembl:ENSMUSG00000056973(gene)|ensembl:ENSMUST00000034172(transcript)|go:"GO:0004771"(sterol esterase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019626"(short-chain fatty acid catabolic process)|go:"GO:0030339"(fatty-acyl-ethyl-ester synthase activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0046464"(acylglycerol catabolic process)|go:"GO:0047376"(all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0080030"(methyl indole-3-acetate esterase activity)|go:"GO:0090205"(positive regulation of cholesterol metabolic process)|go:"GO:0120188"(regulation of bile acid secretion)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR019826|interpro:IPR029058|mint:Q8VCT4|reactome:R-MMU-2022377|reactome:R-MMU-211945	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:FgyvDjsaGbFGuW9+8XDp5SnjUBg10090	intact-crc:82B5E16C49092F7F|rigid:gKTiwErnWuc+ZdIpBV6Ll7FP2xU	false	his tag:c-c|glutathione s tranferase tag:n-n|binding-associated region:175-1038	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q13873	uniprotkb:Q9EPN1	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-527731|uniprotkb:Q8C931|uniprotkb:Q9EPM9|uniprotkb:Q9EPN0|uniprotkb:Q9WVM9|ensembl:ENSMUSP00000029374	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:nbea_mouse(display_long)|uniprotkb:Lysosomal-trafficking regulator 2(gene name synonym)|uniprotkb:Nbea(gene name)|psi-mi:Nbea(display_short)|uniprotkb:Lyst2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-527684	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_085098.1|ensembl:ENSMUSG00000027799(gene)|ensembl:ENSMUST00000029374(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0008104"(protein localization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR010508(Protein of unknown function DUF1088)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023362|interpro:IPR031570|interpro:IPR036322|interpro:IPR036372|mint:Q9EPN1|refseq:XP_006501586.1	go:"GO:0030509"(BMP signaling pathway)	-	-	comment:"Species of BMPR2 (human) not in paper, personal communication by author"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:NWSzMiK/aQ6zHqkCxAoWJSqnrvA10090	intact-crc:82B5E16C49092F7F|rigid:gKTiwErnWuc+ZdIpBV6Ll7FP2xU	false	his tag:c-c|glutathione s tranferase tag:n-n|binding-associated region:175-1038	tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P68404	uniprotkb:Q13873	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	go:"GO:0030509"(BMP signaling pathway)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:9306F341866087E2|rigid:m7/8SOO4mANPkSVWOnoVPi9JAkE	false	-	glutathione s tranferase tag:n-n|flag tag:c-c|binding-associated region:175-529(IPR000719)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13873	uniprotkb:P68404	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528132	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	go:"GO:0030509"(BMP signaling pathway)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	intact-crc:05015E294BC7FAB4|rigid:m7/8SOO4mANPkSVWOnoVPi9JAkE	false	his tag:c-c|binding-associated region:175-1038|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08607	uniprotkb:Q13873	intact:EBI-527325|uniprotkb:Q91X48|ensembl:ENSMUSP00000027657	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:c4bpa_mouse(display_long)|uniprotkb:C4bpa(gene name)|psi-mi:C4bpa(display_short)|uniprotkb:C4bp(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246208.1|ensembl:ENSMUSG00000026405(gene)|ensembl:ENSMUST00000027657(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|mint:P08607|refseq:NP_031602.3	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	go:"GO:0030509"(BMP signaling pathway)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:iA1cRxMsz2QEIk3GEhT5YlNnM3010090	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:5ABF3DA2DF2A5EB1|rigid:E3vzv56qnM5mOCS5WGVazVOhWyU	false	-	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:175-1038	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08607	uniprotkb:Q13873	intact:EBI-527325|uniprotkb:Q91X48|ensembl:ENSMUSP00000027657	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:c4bpa_mouse(display_long)|uniprotkb:C4bpa(gene name)|psi-mi:C4bpa(display_short)|uniprotkb:C4bp(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528159	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246208.1|ensembl:ENSMUSG00000026405(gene)|ensembl:ENSMUST00000027657(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|mint:P08607|refseq:NP_031602.3	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	go:"GO:0030509"(BMP signaling pathway)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/08	2014/10/16	rogid:iA1cRxMsz2QEIk3GEhT5YlNnM3010090	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:271E8F499804DBD8|rigid:E3vzv56qnM5mOCS5WGVazVOhWyU	false	-	glutathione s tranferase tag:n-n|flag tag:c-c|binding-associated region:175-529	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P68404	uniprotkb:Q13873	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0096"(pull down)	Hassel et al. (2004)	pubmed:15188402	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528173	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	go:"GO:0030509"(BMP signaling pathway)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2005/04/08	2014/10/16	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:137D3B626732E834|rigid:m7/8SOO4mANPkSVWOnoVPi9JAkE	false	-	glutathione s tranferase tag:n-n|flag tag:c-c|binding-associated region:175-529|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)