#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92918	uniprotkb:O89100	intact:EBI-881|intact:EBI-28975476|ensembl:ENSP00000465039|ensembl:ENSP00000489001	intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681	psi-mi:m4k1_human(display_long)|uniprotkb:HPK1(gene name synonym)|uniprotkb:MAP4K1(gene name)|psi-mi:MAP4K1(display_short)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym)	psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lewitzky et al. (2004)	pubmed:15100220|mint:MINT-5217009	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7173395|mint:MINT-60783	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009112.1|refseq:NP_001036065.1|ensembl:ENST00000396857|ensembl:ENSP00000380066|ensembl:ENSP00000465039|ensembl:ENSP00000489001|ensembl:ENST00000634494|ensembl:ENSP00000489158|dip:DIP-31019N|ensembl:ENSG00000104814(gene)|ensembl:ENSG00000282928(gene)|ensembl:ENST00000591517(transcript)|ensembl:ENST00000634395(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:Q92918|rcsb pdb:6CQD|rcsb pdb:6CQE|rcsb pdb:6CQF|rcsb pdb:6NFY|rcsb pdb:6NFZ|rcsb pdb:6NG0|rcsb pdb:7KAC|rcsb pdb:7L24|rcsb pdb:7L25|rcsb pdb:7L26|rcsb pdb:7M0K|rcsb pdb:7M0L|rcsb pdb:7M0M|mint:MINT-1176231(identity)	refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1176221(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1|kd:20.8 micromolar|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/12	2014/10/16	rogid:XAnNUBaT7pFyJMbz5gbC1ahCono9606	rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090	intact-crc:601260464760893C|rigid:I7OJF6eVBYp5MvGy0yJVA3nXK9s	false	binding-associated region:459-484(MINT-1176232)	tag:?-?(MINT-1176225)|binding-associated region:256-322(MINT-1176222)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O89100	uniprotkb:P70218	intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681	intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62	psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym)	psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lewitzky et al. (2004)	pubmed:15100220|mint:MINT-5217009	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7173435|mint:MINT-60784	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1176265(identity)	ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N|mint:MINT-1176275(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1|kd:2.4 micromolar|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/12	2014/10/16	rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090	rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090	intact-crc:E2C7AF2983CF6FD5|rigid:Cs6S4/58wuclOGqAepSglYEaHUk	false	tag:?-?(MINT-1176269)|binding-associated region:256-322(MINT-1176266)	mutation decreasing interaction:468-468,470-470,471-471,473-473,476-476(MINT-1176279)|binding-associated region:465-480(MINT-1176276)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70218	uniprotkb:O89100	intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62	intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681	psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym)	psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lewitzky et al. (2004)	pubmed:15100220|mint:MINT-5217009	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7173481|mint:MINT-60785	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N|mint:MINT-1176305(identity)	refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1176295(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T2 F2|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/07/12	2014/10/16	rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090	rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090	intact-crc:6ABEF128F47B2719|rigid:Cs6S4/58wuclOGqAepSglYEaHUk	false	binding-associated region:465-480(MINT-1176306)	binding-associated region:256-322(MINT-1176296)|tag:?-?(MINT-1176299)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)