#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02724	uniprotkb:P02724	intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185	intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185	psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym)	psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym)	psi-mi:"MI:0370"(tox-r dimerization assay)	Li et al. (2004)	pubmed:15067009|imex:IM-24632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-702674|imex:IM-24632-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)	refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2005/10/25	2014/10/16	rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606	rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606	intact-crc:4D648E7397B5F33C|rigid:Xn4ykcPqN4S73+wD4FbPSgaTGuU	false	sufficient binding region:94-114|mutation decreasing interaction:102-102|tag:c-c|tag:n-n	sufficient binding region:94-114|sufficient binding region:102-102|tag:c-c|tag:n-n	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P08514	uniprotkb:P08514	intact:EBI-702693|uniprotkb:O95366|uniprotkb:Q14443|uniprotkb:B2RCY8|uniprotkb:Q17R67|ensembl:ENSP00000262407	intact:EBI-702693|uniprotkb:O95366|uniprotkb:Q14443|uniprotkb:B2RCY8|uniprotkb:Q17R67|ensembl:ENSP00000262407	psi-mi:ita2b_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIb(gene name synonym)|uniprotkb:GPalpha IIb(gene name synonym)|uniprotkb:ITGA2B(gene name)|psi-mi:ITGA2B(display_short)|uniprotkb:GP2B(gene name synonym)|uniprotkb:ITGAB(gene name synonym)	psi-mi:ita2b_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIb(gene name synonym)|uniprotkb:GPalpha IIb(gene name synonym)|uniprotkb:ITGA2B(gene name)|psi-mi:ITGA2B(display_short)|uniprotkb:GP2B(gene name synonym)|uniprotkb:ITGAB(gene name synonym)	psi-mi:"MI:0370"(tox-r dimerization assay)	Li et al. (2004)	pubmed:15067009|imex:IM-24632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-702720|imex:IM-24632-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000410.2|refseq:XP_011523051.1|ensembl:ENSG00000005961(gene)|dip:DIP-68N|ensembl:ENST00000262407(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08514|rcsb pdb:1DPK|rcsb pdb:1DPQ|rcsb pdb:1JX5|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1M8O|rcsb pdb:1RN0|rcsb pdb:1S4W|rcsb pdb:1TYE|rcsb pdb:1UV9|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2K1A|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8936459|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:NP_000410.2|refseq:XP_011523051.1|ensembl:ENSG00000005961(gene)|dip:DIP-68N|ensembl:ENST00000262407(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08514|rcsb pdb:1DPK|rcsb pdb:1DPQ|rcsb pdb:1JX5|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1M8O|rcsb pdb:1RN0|rcsb pdb:1S4W|rcsb pdb:1TYE|rcsb pdb:1UV9|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2K1A|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8936459|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Fig. 5|caution:The orientation of the alpha II b integrin transmembrane helix in the bacterial membrane of E. coli is opposite to its orientation in eukaryotic membranes.|comment:The residues preceding the the critical glycines GXXXG are important for dimerization whereas the succeeding residues were found to be substantially more mutable.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2005/10/25	2015/10/21	rogid:8JV9fiaPGQcRYp8HlTe0br3SrPg9606	rogid:8JV9fiaPGQcRYp8HlTe0br3SrPg9606	intact-crc:70981EA6D2090749|rigid:kOZ7dArUCoLoyY9gL72M8ahe9Fo	false	mutation decreasing interaction:1003-1003|mutation decreasing interaction:1006-1006|mutation decreasing interaction:1018-1018|sufficient binding region:999-1020|mutation decreasing interaction:1000-1000|mutation decreasing interaction:1003-1003|mutation decreasing interaction:1006-1006|mutation decreasing interaction:1004-1004|mutation decreasing interaction:1012-1012|mutation decreasing interaction:1017-1017|mutation decreasing interaction:1001-1001|mutation decreasing interaction strength:1002-1002|mutation decreasing interaction:1003-1003|mutation decreasing interaction:1014-1014|mutation decreasing interaction:1015-1015|mutation increasing interaction:1011-1011|mutation decreasing interaction:1012-1012|mutation decreasing interaction:1012-1012|mutation decreasing interaction:1017-1017|mutation decreasing interaction:1002-1002|mutation decreasing interaction:1002-1002|mutation decreasing interaction:1007-1007|mutation decreasing interaction:1007-1007|mutation decreasing interaction:1007-1007|mutation increasing interaction:1011-1011|mutation decreasing interaction:1013-1013|mutation decreasing interaction:1003-1003	sufficient binding region:999-1020	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P08514	uniprotkb:P08514	intact:EBI-702693|uniprotkb:O95366|uniprotkb:Q14443|uniprotkb:B2RCY8|uniprotkb:Q17R67|ensembl:ENSP00000262407	intact:EBI-702693|uniprotkb:O95366|uniprotkb:Q14443|uniprotkb:B2RCY8|uniprotkb:Q17R67|ensembl:ENSP00000262407	psi-mi:ita2b_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIb(gene name synonym)|uniprotkb:GPalpha IIb(gene name synonym)|uniprotkb:ITGA2B(gene name)|psi-mi:ITGA2B(display_short)|uniprotkb:GP2B(gene name synonym)|uniprotkb:ITGAB(gene name synonym)	psi-mi:ita2b_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIb(gene name synonym)|uniprotkb:GPalpha IIb(gene name synonym)|uniprotkb:ITGA2B(gene name)|psi-mi:ITGA2B(display_short)|uniprotkb:GP2B(gene name synonym)|uniprotkb:ITGAB(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Li et al. (2004)	pubmed:15067009|imex:IM-24632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-702780|imex:IM-24632-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000410.2|refseq:XP_011523051.1|ensembl:ENSG00000005961(gene)|dip:DIP-68N|ensembl:ENST00000262407(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08514|rcsb pdb:1DPK|rcsb pdb:1DPQ|rcsb pdb:1JX5|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1M8O|rcsb pdb:1RN0|rcsb pdb:1S4W|rcsb pdb:1TYE|rcsb pdb:1UV9|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2K1A|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8936459|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:NP_000410.2|refseq:XP_011523051.1|ensembl:ENSG00000005961(gene)|dip:DIP-68N|ensembl:ENST00000262407(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08514|rcsb pdb:1DPK|rcsb pdb:1DPQ|rcsb pdb:1JX5|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1M8O|rcsb pdb:1RN0|rcsb pdb:1S4W|rcsb pdb:1TYE|rcsb pdb:1UV9|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2K1A|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8936459|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Fig. 7A|complex-properties:The oligomerization of alpha II b integrin fragment containing the transmembrane region and the cytoplasmic region is only detected as a dimer on SDS-PAGE. The mutation Leu1011Ala increases the oligomerization and a faint band of trimer is also detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/10/25	2014/10/16	rogid:8JV9fiaPGQcRYp8HlTe0br3SrPg9606	rogid:8JV9fiaPGQcRYp8HlTe0br3SrPg9606	intact-crc:1EB177E943C83CC7|rigid:kOZ7dArUCoLoyY9gL72M8ahe9Fo	false	sufficient binding region:989-1039|mutation increasing interaction:1011-1011|mutation decreasing interaction:1007-1007	sufficient binding region:989-1039|mutation increasing interaction:1011-1011|mutation decreasing interaction:1007-1007	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P08514	uniprotkb:P08514	intact:EBI-702693|uniprotkb:O95366|uniprotkb:Q14443|uniprotkb:B2RCY8|uniprotkb:Q17R67|ensembl:ENSP00000262407	intact:EBI-702693|uniprotkb:O95366|uniprotkb:Q14443|uniprotkb:B2RCY8|uniprotkb:Q17R67|ensembl:ENSP00000262407	psi-mi:ita2b_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIb(gene name synonym)|uniprotkb:GPalpha IIb(gene name synonym)|uniprotkb:ITGA2B(gene name)|psi-mi:ITGA2B(display_short)|uniprotkb:GP2B(gene name synonym)|uniprotkb:ITGAB(gene name synonym)	psi-mi:ita2b_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIb(gene name synonym)|uniprotkb:GPalpha IIb(gene name synonym)|uniprotkb:ITGA2B(gene name)|psi-mi:ITGA2B(display_short)|uniprotkb:GP2B(gene name synonym)|uniprotkb:ITGAB(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Li et al. (2004)	pubmed:15067009|imex:IM-24632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-702806|imex:IM-24632-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000410.2|refseq:XP_011523051.1|ensembl:ENSG00000005961(gene)|dip:DIP-68N|ensembl:ENST00000262407(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08514|rcsb pdb:1DPK|rcsb pdb:1DPQ|rcsb pdb:1JX5|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1M8O|rcsb pdb:1RN0|rcsb pdb:1S4W|rcsb pdb:1TYE|rcsb pdb:1UV9|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2K1A|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8936459|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:NP_000410.2|refseq:XP_011523051.1|ensembl:ENSG00000005961(gene)|dip:DIP-68N|ensembl:ENST00000262407(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08514|rcsb pdb:1DPK|rcsb pdb:1DPQ|rcsb pdb:1JX5|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1M8O|rcsb pdb:1RN0|rcsb pdb:1S4W|rcsb pdb:1TYE|rcsb pdb:1UV9|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2K1A|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8936459|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	complex-properties:The data of oligomerization of alpha II b integrin fragment containing the transmembrane region and the cytoplasmic region is best fitted with a monomer-dimer equilibrium. The mutant Leu1011Ala data could also be fitted with a monomere-dimer-trimer equilibrium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/10/25	2014/10/16	rogid:8JV9fiaPGQcRYp8HlTe0br3SrPg9606	rogid:8JV9fiaPGQcRYp8HlTe0br3SrPg9606	intact-crc:2DF7B33D9A6AE929|rigid:kOZ7dArUCoLoyY9gL72M8ahe9Fo	false	mutation increasing interaction:1011-1011|mutation decreasing interaction:1003-1003|mutation decreasing interaction:1007-1007|sufficient binding region:989-1039	sufficient binding region:989-1039|mutation increasing interaction:1011-1011|mutation decreasing interaction:1003-1003|mutation decreasing interaction:1007-1007	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)