#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P56855 uniprotkb:Q14721 intact:EBI-528836 intact:EBI-528839|uniprotkb:Q14193|ensembl:ENSP00000360806|ensembl:ENSP00000489193 psi-mi:tx1_strgf(display_long)|uniprotkb:SGTx1(gene name synonym)|uniprotkb:SgTx-I(gene name synonym) psi-mi:kcnb1_human(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv2.1(gene name synonym)|uniprotkb:KCNB1(gene name)|psi-mi:KCNB1(display_short)|uniprotkb:Delayed rectifier potassium channel 1(gene name synonym) psi-mi:"MI:0401"(biochemical) Wang et al. (2004) pubmed:15051809 taxid:118974(strgf)|taxid:118974("Stromatopelma calceatum griseipes (Feather leg baboon tarantula)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-528854 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR011696(Spider potassium channel inhibitory toxin)|rcsb pdb:1LA4|go:"GO:0005615"(extracellular space)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0090729"(toxin activity) refseq:XP_006723847.1|refseq:NP_004966.1|refseq:XP_011527101.1|ensembl:ENSG00000158445(gene)|ensembl:ENST00000371741(transcript)|ensembl:ENST00000635465(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:2000671"(regulation of motor neuron apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003973(Potassium channel, voltage dependent, Kv2)|interpro:IPR004350(Potassium channel, voltage dependent, Kv2.1)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|reactome:R-HSA-1296072|reactome:R-HSA-381676 - - - kinetics:"Kd for the following mutants is : kd>10-3 for W24A, kd >5.10-4 for R3A, L5A, R22A, kd= Kd=3.10-5 for D31A."|kinetics:Kd values were obtained by fitting a four site model. taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis) kd:2.7x10^-6(molar) 2005/04/11 2014/10/16 rogid:dj4Kub1Wk8i+9ed0M0OLyvGswC4118974 rogid:m5RyubOHeZv1V7ZJPwtmP6eN/Xg9606 intact-crc:1D085885004DB9C2|rigid:YvU1UTwjMEl54kmnAQROf7yyS6A false mutation decreasing interaction:3-3|mutation decreasing interaction:5-5|mutation decreasing interaction:6-6|mutation decreasing interaction:22-22|mutation decreasing interaction:30-30|mutation decreasing interaction:31-31 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)