#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8X1E6 uniprotkb:Q9Y7W4 intact:EBI-7148504|uniprotkb:A0A1D8PPZ3|intact:MINT-1173599|uniprotkb:Q5AC19 intact:EBI-7148532|uniprotkb:A0A1D8PH82|uniprotkb:Q59ZR0|intact:MINT-1173580|uniprotkb:Q59ZJ5|uniprotkb:Q59ZJ6 psi-mi:cdc37_canal(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Cell division control protein 37(gene name synonym)|uniprotkb:CaO19.5531(orf name)|uniprotkb:CAALFM_C602610CA(locus name) psi-mi:bur1_canal(display_long)|uniprotkb:CRK1(gene name)|psi-mi:CRK1(display_short)|uniprotkb:BUR1(gene name synonym)|uniprotkb:CaO19.3523/3524(orf name)|uniprotkb:CaO19.11006(orf name)|uniprotkb:CAALFM_C204930CA(locus name) psi-mi:"MI:0397"(two hybrid array) Ni et al. (2004) pubmed:15013782|imex:IM-14046|mint:MINT-5216955 taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7148525|mint:MINT-62404|imex:IM-14046-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035690"|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|refseq:XP_719095.1|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|interpro:IPR004918(Cdc37)|mint:MINT-1173614(identity) refseq:XP_714883.2|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1173605(identity) - comment:mint|function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity|comment:"Stoichiometry: 1.0" comment:mint|function:"Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice"|comment:"Stoichiometry: 1.0" figure legend:F3A|comment:a weaker interaction is observed with full length crk1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2017/05/26 rogid:AMrHp+spNlYP6cs3aHfC7UzUVCk237561 rogid:ewxlcR6xfi9co5ZRT14RwBv5Npc237561 intact-crc:DB39029E526D8CD0|rigid:8lLaYL7RmnD54olQ5KqZvrEmozA false tag:?-?(MINT-1173615) tag:?-?(MINT-1173609)|binding-associated region:1-370(MINT-1173606) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8X1E6 uniprotkb:A0A1D8PN90 intact:EBI-7148504|uniprotkb:A0A1D8PPZ3|intact:MINT-1173599|uniprotkb:Q5AC19 intact:EBI-7148602|intact:MINT-1173649 psi-mi:cdc37_canal(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Cell division control protein 37(gene name synonym)|uniprotkb:CaO19.5531(orf name)|uniprotkb:CAALFM_C602610CA(locus name) psi-mi:a0a1d8pn90_canal(display_long)|uniprotkb:STI1(gene name)|psi-mi:STI1(display_short)|uniprotkb:CAALFM_C501820WA(orf name)|uniprotkb:orf19.3192(locus name) psi-mi:"MI:0397"(two hybrid array) Ni et al. (2004) pubmed:15013782|imex:IM-14046|mint:MINT-5216955 taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7148616|mint:MINT-62407|imex:IM-14046-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035690"|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|refseq:XP_719095.1|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|interpro:IPR004918(Cdc37)|mint:MINT-1173661(identity) go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|refseq:XP_714608.2|mint:MINT-1173667(identity) - comment:mint|function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F6|comment:a weaker interaction is observed with full length Sti1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2019/02/25 rogid:AMrHp+spNlYP6cs3aHfC7UzUVCk237561 rogid:CYQaB1ReoPJ4BKvQAUihPEffpzo237561 intact-crc:8D6A960EFA7BDD4B|rigid:lSqqp3hpM3oj6+BFBHiKUNHTaNU false tag:?-?(MINT-1173662) tag:?-?(MINT-1173671)|binding-associated region:188-544(MINT-1173668) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y7W4 uniprotkb:Q8X1E6 intact:EBI-7148532|uniprotkb:A0A1D8PH82|uniprotkb:Q59ZR0|intact:MINT-1173580|uniprotkb:Q59ZJ5|uniprotkb:Q59ZJ6 intact:EBI-7148504|uniprotkb:A0A1D8PPZ3|intact:MINT-1173599|uniprotkb:Q5AC19 psi-mi:bur1_canal(display_long)|uniprotkb:CRK1(gene name)|psi-mi:CRK1(display_short)|uniprotkb:BUR1(gene name synonym)|uniprotkb:CaO19.3523/3524(orf name)|uniprotkb:CaO19.11006(orf name)|uniprotkb:CAALFM_C204930CA(locus name) psi-mi:cdc37_canal(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Cell division control protein 37(gene name synonym)|uniprotkb:CaO19.5531(orf name)|uniprotkb:CAALFM_C602610CA(locus name) psi-mi:"MI:0398"(two hybrid pooling approach) Ni et al. (2004) pubmed:15013782|imex:IM-14046|mint:MINT-5216955 taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7148650|mint:MINT-62401|imex:IM-14046-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_714883.2|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1173627(identity) go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035690"|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|refseq:XP_719095.1|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|interpro:IPR004918(Cdc37)|mint:MINT-1173636(identity) - comment:mint|function:"Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice"|comment:"Stoichiometry: 1.0" comment:mint|function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2017/05/26 rogid:ewxlcR6xfi9co5ZRT14RwBv5Npc237561 rogid:AMrHp+spNlYP6cs3aHfC7UzUVCk237561 intact-crc:8B0DC90A91A8E842|rigid:8lLaYL7RmnD54olQ5KqZvrEmozA false tag:?-?(MINT-1173631)|binding-associated region:1-370(MINT-1173628) tag:?-?(MINT-1173639)|binding-associated region:93-508(MINT-1173637) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y7W4 uniprotkb:A0A1D8PN90 intact:EBI-7148532|uniprotkb:A0A1D8PH82|uniprotkb:Q59ZR0|intact:MINT-1173580|uniprotkb:Q59ZJ5|uniprotkb:Q59ZJ6 intact:EBI-7148602|intact:MINT-1173649 psi-mi:bur1_canal(display_long)|uniprotkb:CRK1(gene name)|psi-mi:CRK1(display_short)|uniprotkb:BUR1(gene name synonym)|uniprotkb:CaO19.3523/3524(orf name)|uniprotkb:CaO19.11006(orf name)|uniprotkb:CAALFM_C204930CA(locus name) psi-mi:a0a1d8pn90_canal(display_long)|uniprotkb:STI1(gene name)|psi-mi:STI1(display_short)|uniprotkb:CAALFM_C501820WA(orf name)|uniprotkb:orf19.3192(locus name) psi-mi:"MI:0398"(two hybrid pooling approach) Ni et al. (2004) pubmed:15013782|imex:IM-14046|mint:MINT-5216955 taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7148693|mint:MINT-62406|imex:IM-14046-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_714883.2|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1173744(identity) go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|refseq:XP_714608.2|mint:MINT-1173753(identity) - comment:mint|function:"Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice"|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F6|comment:no interaction is observed with full length Sti1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2019/02/25 rogid:ewxlcR6xfi9co5ZRT14RwBv5Npc237561 rogid:CYQaB1ReoPJ4BKvQAUihPEffpzo237561 intact-crc:0668CFC336087961|rigid:s2B4cvJsX3hzlStqn2U0XjpPNUM false tag:?-?(MINT-1173748)|binding-associated region:1-370(MINT-1173745) binding-associated region:188-544(MINT-1173754)|tag:?-?(MINT-1173757) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8X1E6 uniprotkb:Q9Y7W4 intact:EBI-7148504|uniprotkb:A0A1D8PPZ3|intact:MINT-1173599|uniprotkb:Q5AC19 intact:EBI-7148532|uniprotkb:A0A1D8PH82|uniprotkb:Q59ZR0|intact:MINT-1173580|uniprotkb:Q59ZJ5|uniprotkb:Q59ZJ6 psi-mi:cdc37_canal(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Cell division control protein 37(gene name synonym)|uniprotkb:CaO19.5531(orf name)|uniprotkb:CAALFM_C602610CA(locus name) psi-mi:bur1_canal(display_long)|uniprotkb:CRK1(gene name)|psi-mi:CRK1(display_short)|uniprotkb:BUR1(gene name synonym)|uniprotkb:CaO19.3523/3524(orf name)|uniprotkb:CaO19.11006(orf name)|uniprotkb:CAALFM_C204930CA(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ni et al. (2004) pubmed:15013782|imex:IM-14046|mint:MINT-5216955 taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7148759|mint:MINT-62403|imex:IM-14046-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035690"|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|refseq:XP_719095.1|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|interpro:IPR004918(Cdc37)|mint:MINT-1173692(identity) refseq:XP_714883.2|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1173683(identity) - comment:mint|function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity|comment:"Stoichiometry: 1.0" comment:mint|function:"Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice"|comment:"Stoichiometry: 1.0" figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2017/05/26 rogid:AMrHp+spNlYP6cs3aHfC7UzUVCk237561 rogid:ewxlcR6xfi9co5ZRT14RwBv5Npc237561 intact-crc:AE54A89748D02D79|rigid:8lLaYL7RmnD54olQ5KqZvrEmozA false binding-associated region:93-508(MINT-1173693)|tag:?-?(MINT-1173695) tag:?-?(MINT-1173687)|binding-associated region:1-370(MINT-1173684) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y7W4 uniprotkb:Q8X1E6 intact:EBI-7148532|uniprotkb:A0A1D8PH82|uniprotkb:Q59ZR0|intact:MINT-1173580|uniprotkb:Q59ZJ5|uniprotkb:Q59ZJ6 intact:EBI-7148504|uniprotkb:A0A1D8PPZ3|intact:MINT-1173599|uniprotkb:Q5AC19 psi-mi:bur1_canal(display_long)|uniprotkb:CRK1(gene name)|psi-mi:CRK1(display_short)|uniprotkb:BUR1(gene name synonym)|uniprotkb:CaO19.3523/3524(orf name)|uniprotkb:CaO19.11006(orf name)|uniprotkb:CAALFM_C204930CA(locus name) psi-mi:cdc37_canal(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Cell division control protein 37(gene name synonym)|uniprotkb:CaO19.5531(orf name)|uniprotkb:CAALFM_C602610CA(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ni et al. (2004) pubmed:15013782|imex:IM-14046|mint:MINT-5216955 taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7148732|mint:MINT-62402|imex:IM-14046-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_714883.2|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1173704(identity) go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035690"|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|refseq:XP_719095.1|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|interpro:IPR004918(Cdc37)|mint:MINT-1173713(identity) - comment:mint|function:"Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice"|comment:"Stoichiometry: 1.0" comment:mint|function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity|comment:"Stoichiometry: 1.0" figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2017/05/26 rogid:ewxlcR6xfi9co5ZRT14RwBv5Npc237561 rogid:AMrHp+spNlYP6cs3aHfC7UzUVCk237561 intact-crc:BB2B42966E991F98|rigid:8lLaYL7RmnD54olQ5KqZvrEmozA false binding-associated region:1-370(MINT-1173705)|tag:?-?(MINT-1173708) tag:?-?(MINT-1173716)|binding-associated region:93-508(MINT-1173714) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8X1E6 uniprotkb:Q9Y7W4 intact:EBI-7148504|uniprotkb:A0A1D8PPZ3|intact:MINT-1173599|uniprotkb:Q5AC19 intact:EBI-7148532|uniprotkb:A0A1D8PH82|uniprotkb:Q59ZR0|intact:MINT-1173580|uniprotkb:Q59ZJ5|uniprotkb:Q59ZJ6 psi-mi:cdc37_canal(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Cell division control protein 37(gene name synonym)|uniprotkb:CaO19.5531(orf name)|uniprotkb:CAALFM_C602610CA(locus name) psi-mi:bur1_canal(display_long)|uniprotkb:CRK1(gene name)|psi-mi:CRK1(display_short)|uniprotkb:BUR1(gene name synonym)|uniprotkb:CaO19.3523/3524(orf name)|uniprotkb:CaO19.11006(orf name)|uniprotkb:CAALFM_C204930CA(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ni et al. (2004) pubmed:15013782|imex:IM-14046|mint:MINT-5216955 taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") taxid:237561(canal)|taxid:237561("Candida albicans (strain SC5314 / ATCC MYA-2876)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7148812|mint:MINT-62405|imex:IM-14046-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035690"|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|refseq:XP_719095.1|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|interpro:IPR004918(Cdc37)|mint:MINT-1173734(identity) refseq:XP_714883.2|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:MINT-1173725(identity) - comment:mint|function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity|comment:"Stoichiometry: 1.0" comment:mint|function:"Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice"|comment:"Stoichiometry: 1.0" figure legend:F3B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2017/05/26 rogid:AMrHp+spNlYP6cs3aHfC7UzUVCk237561 rogid:ewxlcR6xfi9co5ZRT14RwBv5Npc237561 intact-crc:45673A2D88507BB1|rigid:8lLaYL7RmnD54olQ5KqZvrEmozA false tag:?-?(MINT-1173735) tag:?-?(MINT-1173729)|binding-associated region:1-370(MINT-1173726) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)