#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P15882 uniprotkb:Q28199 intact:EBI-718947|uniprotkb:B3KNU6|uniprotkb:Q53SD6|uniprotkb:Q53SH5|uniprotkb:Q96FB0|uniprotkb:A8K1M6|uniprotkb:B4DV19|ensembl:ENSP00000386741 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:chin_human(display_long)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym)|uniprotkb:CHN1(gene name)|psi-mi:CHN1(display_short)|uniprotkb:ARHGAP2(gene name synonym)|uniprotkb:CHN(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Qi et al. (2004) pubmed:15013773|mint:MINT-5216949|imex:IM-14044 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7146023|mint:MINT-62397|imex:IM-14044-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001020372.2|refseq:NP_001193531.1|refseq:NP_001813.1|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|interpro:IPR035840|interpro:IPR036860|interpro:IPR037860|mint:P15882|rcsb pdb:2OSA|rcsb pdb:3CXL|reactome:R-HSA-9013148|reactome:R-HSA-9013149|ensembl:ENSG00000128656(gene)|ensembl:ENST00000409900(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|dip:DIP-42177N|mint:MINT-1173420(identity) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2|mint:MINT-1173416(identity) imex:IM-14044-1(imex secondary) comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/08/31 2014/10/16 rogid:84hAAd7YQd4QiItoC14jdT4CnRU9606 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:E0E59D85B0750CE3|rigid:ziyg3bMh88ekvyU+p3UQ0tVZTXA false tag:?-?(MINT-1173421) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0113"(western blot) uniprotkb:Q28199 uniprotkb:P15882 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 intact:EBI-718947|uniprotkb:B3KNU6|uniprotkb:Q53SD6|uniprotkb:Q53SH5|uniprotkb:Q96FB0|uniprotkb:A8K1M6|uniprotkb:B4DV19|ensembl:ENSP00000386741 psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:chin_human(display_long)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym)|uniprotkb:CHN1(gene name)|psi-mi:CHN1(display_short)|uniprotkb:ARHGAP2(gene name synonym)|uniprotkb:CHN(gene name synonym) psi-mi:"MI:0428"(imaging technique) Qi et al. (2004) pubmed:15013773|mint:MINT-5216949|imex:IM-14044 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7146113|mint:MINT-62396|imex:IM-14044-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2|mint:MINT-1173432(identity) refseq:NP_001020372.2|refseq:NP_001193531.1|refseq:NP_001813.1|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|interpro:IPR035840|interpro:IPR036860|interpro:IPR037860|mint:P15882|rcsb pdb:2OSA|rcsb pdb:3CXL|reactome:R-HSA-9013148|reactome:R-HSA-9013149|ensembl:ENSG00000128656(gene)|ensembl:ENST00000409900(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|dip:DIP-42177N|mint:MINT-1173437(identity) imex:IM-354(imex secondary) comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2005/08/31 2014/10/16 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 rogid:84hAAd7YQd4QiItoC14jdT4CnRU9606 intact-crc:CACFCB163203B716|rigid:ziyg3bMh88ekvyU+p3UQ0tVZTXA false - tag:?-?(MINT-1173438) - - psi-mi:"MI:0661"(experimental participant identification) psi-mi:"MI:0661"(experimental participant identification) uniprotkb:P15882 uniprotkb:Q28199 intact:EBI-718947|uniprotkb:B3KNU6|uniprotkb:Q53SD6|uniprotkb:Q53SH5|uniprotkb:Q96FB0|uniprotkb:A8K1M6|uniprotkb:B4DV19|ensembl:ENSP00000386741 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:chin_human(display_long)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym)|uniprotkb:CHN1(gene name)|psi-mi:CHN1(display_short)|uniprotkb:ARHGAP2(gene name synonym)|uniprotkb:CHN(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Qi et al. (2004) pubmed:15013773|mint:MINT-5216949|imex:IM-14044 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7146138|mint:MINT-62392|imex:IM-14044-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001020372.2|refseq:NP_001193531.1|refseq:NP_001813.1|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR017356(N-chimaerin)|interpro:IPR020454|interpro:IPR035840|interpro:IPR036860|interpro:IPR037860|mint:P15882|rcsb pdb:2OSA|rcsb pdb:3CXL|reactome:R-HSA-9013148|reactome:R-HSA-9013149|ensembl:ENSG00000128656(gene)|ensembl:ENST00000409900(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|dip:DIP-42177N|mint:MINT-1173456(identity) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2|mint:MINT-1173450(identity) imex:IM-354(imex secondary) comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2014/10/16 rogid:84hAAd7YQd4QiItoC14jdT4CnRU9606 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:B1D0EED95760BA39|rigid:ziyg3bMh88ekvyU+p3UQ0tVZTXA false tag:?-?(MINT-1173460)|binding-associated region:361-459(MINT-1173457) tag:?-?(MINT-1173451) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P15882-2 uniprotkb:Q28199 intact:EBI-7146177|intact:MINT-1173412|ensembl:ENSP00000295497 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:p15882-2(display_long)|uniprotkb:CHN1(gene name)|psi-mi:CHN1(display_short)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:ARHGAP2(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:CHN(gene name synonym)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Qi et al. (2004) pubmed:15013773|mint:MINT-5216949|imex:IM-14044 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7146170|imex:IM-14044-4|mint:MINT-62395 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-718947(isoform-parent)|ensembl:ENSG00000128656(gene)|ensembl:ENST00000295497(transcript)|mint:MINT-1173479(identity) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2|mint:MINT-1173471(identity) imex:IM-353(imex secondary) comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/08/31 2014/10/16 rogid:X3rCb53CZojiAZk/fjHpOz9BRuk9606 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:6189C516AB176D5A|rigid:u9w8O8kjWvC3DizqUMPTSA359ZQ false tag:?-?(MINT-1173480) tag:?-?(MINT-1173474)|binding-associated region:145-170(MINT-1173472) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P15882-2 uniprotkb:Q28199 intact:EBI-7146177|intact:MINT-1173412|ensembl:ENSP00000295497 intact:EBI-307814|uniprotkb:Q0II69|uniprotkb:Q28865|uniprotkb:Q29462|ensembl:ENSBTAP00000052270 psi-mi:p15882-2(display_long)|uniprotkb:CHN1(gene name)|psi-mi:CHN1(display_short)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:ARHGAP2(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:CHN(gene name synonym)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym) psi-mi:cd5r1_bovin(display_long)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0397"(two hybrid array) Qi et al. (2004) pubmed:15013773|mint:MINT-5216949|imex:IM-14044 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7146250|imex:IM-14044-5|mint:MINT-62393 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-718947(isoform-parent)|ensembl:ENSG00000128656(gene)|ensembl:ENST00000295497(transcript)|mint:MINT-1173499(identity) go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|ensembl:ENSBTAG00000004475(gene)|ensembl:ENSBTAT00000056064(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0002020"(protease binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-BTA-399956|reactome:R-BTA-6804756|refseq:NP_776937.2|mint:MINT-1173491(identity) imex:IM-353(imex secondary) comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2014/10/16 rogid:X3rCb53CZojiAZk/fjHpOz9BRuk9606 rogid:r9TF1JLenz6Wq8eP4HFLnskLGu09913 intact-crc:808592DEAFC91AF3|rigid:u9w8O8kjWvC3DizqUMPTSA359ZQ false tag:?-?(MINT-1173500) binding-associated region:145-291(MINT-1173492)|tag:?-?(MINT-1173494) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P15882-2 uniprotkb:Q13319 intact:EBI-7146177|intact:MINT-1173412|ensembl:ENSP00000295497 intact:EBI-7146273|ensembl:ENSP00000304250|uniprotkb:Q4ZFW6|intact:MINT-1173509 psi-mi:p15882-2(display_long)|uniprotkb:CHN1(gene name)|psi-mi:CHN1(display_short)|uniprotkb:A-chimaerin(gene name synonym)|uniprotkb:ARHGAP2(gene name synonym)|uniprotkb:Alpha-chimerin(gene name synonym)|uniprotkb:CHN(gene name synonym)|uniprotkb:N-chimerin(gene name synonym)|uniprotkb:Rho GTPase-activating protein 2(gene name synonym) psi-mi:cd5r2_human(display_long)|uniprotkb:CDK5R2(gene name)|psi-mi:CDK5R2(display_short)|uniprotkb:NCK5AI(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 2(gene name synonym)|uniprotkb:p39(gene name synonym)|uniprotkb:p39I(gene name synonym) psi-mi:"MI:0397"(two hybrid array) Qi et al. (2004) pubmed:15013773|mint:MINT-5216949|imex:IM-14044 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7146302|mint:MINT-62394|imex:IM-14044-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-718947(isoform-parent)|ensembl:ENSG00000128656(gene)|ensembl:ENST00000295497(transcript)|mint:MINT-1173528(identity) ensembl:ENSG00000171450(gene)|ensembl:ENST00000302625(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001764"(neuron migration)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030426"(growth cone)|go:"GO:0043005"(neuron projection)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|reactome:R-HSA-9031628|refseq:NP_003927.1|mint:MINT-1173522(identity) imex:IM-355(intact-secondary) comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:Activator of CDK5/TPKII|comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/08/31 2014/10/16 rogid:X3rCb53CZojiAZk/fjHpOz9BRuk9606 rogid:axWZriVni23dWsu4CTHCMsT1jtI9606 intact-crc:C1F6624296C90F84|rigid:cXRPRqCnEfBn45wtDBPz9HT8bQA false tag:?-?(MINT-1173529) tag:?-?(MINT-1173523) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)