#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P50402	uniprotkb:Q9NYF8	intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533	intact:EBI-437804|ensembl:ENSP00000435210|uniprotkb:Q86WY0|uniprotkb:Q14673|uniprotkb:Q86WU6|uniprotkb:B7ZM58|uniprotkb:A2RU75|uniprotkb:E1P586	psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short)	psi-mi:bclf1_human(display_long)|uniprotkb:BCLAF1 and THRAP3 family member 1(gene name synonym)|uniprotkb:BCLAF1(gene name)|psi-mi:BCLAF1(display_short)|uniprotkb:BTF(gene name synonym)|uniprotkb:KIAA0164(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Haraguchi et al. (2004)	pubmed:15009215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-489904	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N	ensembl:ENSG00000029363(gene)|ensembl:ENST00000531224(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q9NYF8|refseq:NP_001070908.1|refseq:NP_001070909.1|refseq:NP_055554.1|refseq:NP_001287967.1	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/02/01	2014/10/16	rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606	rogid:v6qbjyjKVCv0B/olkjQfTPKWqBw9606	intact-crc:3F8C172226FC50BB|rigid:ndI3ALyxaJcPtduyB3W54y9ThEE	false	binding-associated region:154-254	binding-associated region:377-646	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:Q9NYF8	uniprotkb:P50402	intact:EBI-437804|ensembl:ENSP00000435210|uniprotkb:Q86WY0|uniprotkb:Q14673|uniprotkb:Q86WU6|uniprotkb:B7ZM58|uniprotkb:A2RU75|uniprotkb:E1P586	intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533	psi-mi:bclf1_human(display_long)|uniprotkb:BCLAF1 and THRAP3 family member 1(gene name synonym)|uniprotkb:BCLAF1(gene name)|psi-mi:BCLAF1(display_short)|uniprotkb:BTF(gene name synonym)|uniprotkb:KIAA0164(gene name synonym)	psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Haraguchi et al. (2004)	pubmed:15009215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490049	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000029363(gene)|ensembl:ENST00000531224(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q9NYF8|refseq:NP_001070908.1|refseq:NP_001070909.1|refseq:NP_055554.1|refseq:NP_001287967.1	refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N	omim:181350(see-also)	-	-	comment:Alanine substitutions that reduce the binding to less than 30% of the wild type emerin are classified as hotspots. Among these the ser54pro and deletion95-99 have been observed in patient affected by EDMD. Other substitutions that affect slightly the binding are reported as mutations.|disease:Emerin mutations ser54phe, deletion95-99 and pro183his are observed in patient affected by Emery-Dreifuss Muscular Dystrophy.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/01	2014/10/16	rogid:v6qbjyjKVCv0B/olkjQfTPKWqBw9606	rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606	intact-crc:893D94F02024845D|rigid:ndI3ALyxaJcPtduyB3W54y9ThEE	false	binding-associated region:377-920|radiolabel:?-?	binding-associated region:1-222|mutation decreasing interaction:54-54(181350)|mutation decreasing interaction:95-99(181350)|mutation:183-183(181350)|mutation decreasing interaction:70-70,72-72,74-74|mutation decreasing interaction:45-45,46-46,47-47|mutation decreasing interaction:76-76,78-78,80-80,83-83|mutation decreasing interaction:175-176|mutation decreasing interaction:192-192,195-195,196-196,194-194|mutation decreasing interaction:197-197,198-198|mutation decreasing interaction:207-207,206-206,209-209|mutation decreasing interaction:208-208,207-207|mutation decreasing interaction:214-214,217-217|mutation:34-34,35-35,36-36,37-37|mutation:112-112,113-113,118-118,120-120,122-122|mutation:122-122,123-123|mutation:145-145,146-146|mutation:165-165,164-164,167-167,170-170|mutation:179-179,180-180	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NYF8	uniprotkb:P50402	intact:EBI-437804|ensembl:ENSP00000435210|uniprotkb:Q86WY0|uniprotkb:Q14673|uniprotkb:Q86WU6|uniprotkb:B7ZM58|uniprotkb:A2RU75|uniprotkb:E1P586	intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533	psi-mi:bclf1_human(display_long)|uniprotkb:BCLAF1 and THRAP3 family member 1(gene name synonym)|uniprotkb:BCLAF1(gene name)|psi-mi:BCLAF1(display_short)|uniprotkb:BTF(gene name synonym)|uniprotkb:KIAA0164(gene name synonym)	psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short)	psi-mi:"MI:0047"(far western blotting)	Haraguchi et al. (2004)	pubmed:15009215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000029363(gene)|ensembl:ENST00000531224(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q9NYF8|refseq:NP_001070908.1|refseq:NP_001070909.1|refseq:NP_055554.1|refseq:NP_001287967.1	refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N	omim:181350(see-also)	-	-	disease:The emerin mutations have been observed in patient affected by Emery-Dreifuss Muscular Dystrophy. Only the ser54pro and deletion95-99O strongly affect this interaction.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/01	2014/10/16	rogid:v6qbjyjKVCv0B/olkjQfTPKWqBw9606	rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606	intact-crc:1021094044C940F4|rigid:ndI3ALyxaJcPtduyB3W54y9ThEE	false	tag:?-?|binding-associated region:377-920	binding-associated region:1-222|mutation decreasing interaction:54-54(181350)|mutation decreasing interaction:95-99(181350)|mutation:183-183(181350)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)